2019 American Transplant Congress
Endothelial Cell Replacement – A Closer Step to Personalized, Tissue-Engineered Transplants
Rabin Medical Center, Petah-Tiqwa, Israel
*Purpose: Whole organ perfusion decellularization has been proposed as a promising method for the generation of non-immunogenic organs from allogeneic or xenogeneic donors. However, the…2019 American Transplant Congress
Endothelial Cell Cytoskeleton Rearrangement (ECCSKR) and Endothelial to Mesenchymal Transition (EndoMT) in Liver Allografts Following Acute Rejection (AR): Its Significance on the Development of Liver Fibrosis (LF) and Graft Survival
1Pathology, Baskent University, Ankara, Turkey, 2Transplantation, Baskent University, Ankara, Turkey
*Purpose: Endothelial cell (EC) cytoskeleton is critical for EC adhesion and permeability. CSKR initiates permeability and influx of leukocytes which in turn leads to increased…2019 American Transplant Congress
MHC Molecule-Ablated Human Endothelial Cells Form Alloimmune-Evasive Microvessels
*Purpose: “Off the shelf” tissue-engineered organs will require use of allogeneic cell sources. Allogeneic human endothelial cells (ECs), necessary for organ perfusion, can initiate graft…2019 American Transplant Congress
Mitochondrial Permeability Regulates Heart Graft Ischemia – Reperfusion Injury and Rejection
*Purpose: A growing body of evidence indicates that mitochondrial permeability transition pore (mPTP) formation plays a crucial role in necroptosis - a programmed form of…2019 American Transplant Congress
Novel Activation Responses by Endothelial Cells within the Pro-Tolerogenic Intragraft Microenvironment
*Purpose: Current paradigms indicate that endothelial cells (EC) within allografts participate in the initiation and progression of allograft rejection. However, little is known about their…2019 American Transplant Congress
Treg-Lymphatic Crosstalk: Lymphotoxin Signals as Modulators of Immunity and Suppression
*Purpose: Little is known about the molecular cues that regulate the entry of leukocytes across lymphatic vessels. Regulatory T cells (Treg) express high amounts of…2019 American Transplant Congress
Apoptotic Exosome-Like Vesicles Induce Endothelial Cell Plasticity and Accelerate Allograft Vascular Remodeling
1CRCHUM, Montreal, QC, Canada, 2IRIC, Montreal, QC, Canada
*Purpose: Acute vascular rejection of allografts is associated with endothelial apoptosis which in turn contributes to the development of transplant vasculopathy. We previously showed that…2019 American Transplant Congress
Predominant Role of Microvascular over Tubular Injury as Driver of Progressive Renal Damage and Fibrosis Post Ischemia Reperfusion Injury
*Purpose: Ischemia-reperfusion injury (IRI) is a major risk factor for allograft dysfunction and chronic renal failure. Although tubular epithelial cells (TEC) are considered the main…2019 American Transplant Congress
Cytomegalovirus (CMV) Infection Induces an Angiogenic Response through Hepatic Stellate Cells (HSCs) and Leads to Early Post-Transplant Liver Fibrosis (LF) and Poor Graft Survival
1Pathology, Baskent University, Ankara, Turkey, 2Transplantation, Baskent University, Ankara, Turkey
*Purpose: The ability of the CMV to infect the endothelial cells (ECs) is critical. CMV can increase EC adhesion, permeability, and create a pro-inflammatory environment…2019 American Transplant Congress
Normothermic Ex Situ Liver Perfusion with Different Clinical Perfusates and Their Effect on Pig Liver Transplant Outcomes in a Donation after Circulatory Death Model
Toronto General Hospital, Toronto, ON, Canada
*Purpose: Human-albumin/Dextran (HA-D), Bovine-gelatin (BG) and packed red blood cells plus plasma have been used in European and North-American clinical trials of normothermic ex-situ liver…
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