ATC Abstracts

American Transplant Congress abstracts

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Articles tagged "Endothelial cells"

  • 2019 American Transplant Congress

    Lymphotoxin Beta Receptor in Lymphatic Endothelial Cells Regulates Treg Migration and Allograft Protection

    V. Saxena, W. Piao, L. Li, C. M. Paluskievicz, Y. Xiong, T. Simon, J. S. Bromberg

    U Maryland, Baltimore, MD

    *Purpose: Lymphotoxin beta receptor (LTβR) mediated signaling in lymphatic endothelium cells (LEC) is important for migration of regulatory T cells (Treg) to afferent lymphatic vessels…
  • 2019 American Transplant Congress

    Endothelial Cells Do Not Regulate Expression of CD46, CD55 and CD59 in the Presence of Anti-HLA Class I and 11 Antibodies

    A. Babu1, T. Pham2, M. Hamdorf2, V. Jucaud2, M. Everly2, S. Daga3, D. Mitchell4

    1Transplant Institute, Henry Ford Hospitals, Detroit, MI, 2Terasaki Research Institute, Los Angeles, CA, 3University of Warwick, Coventry, United Kingdom, 4Medical Sciences, University of Warwick, Coventry, United Kingdom

    *Purpose: Anti-HLA antibodies, both pre-formed and de novo are associated with worse graft survival. Complement activation is an important mechanism of antibody mediated immunological injury.…
  • 2019 American Transplant Congress

    Platelets Augment Granzyme K Production By Macrophages In Antibody-mediated Rejection

    J. Dhar, K. Keslar, R. Fan, N. Dvorina, W. Baldwin

    Cleveland Clinic Main Campus, Lerner Research Institute, Cleveland, OH

    *Purpose: When antibodies bind to MHC antigens on endothelial cells a cascade of responses is initiated including exocytosis of adhesion molecules followed by attachment and…
  • 2019 American Transplant Congress

    Lymphotoxin Beta Receptor Determines Lymph Node Structure for Treg Migration and Suppression of Graft Rejection

    V. Saxena, W. Piao, L. Li, C. M. Paluskievicz, Y. Xiong, T. Simon, J. S. Bromberg

    U Maryland, Baltimore, MD

    *Purpose: Lymphotoxin beta receptor (LTβR) mediated signaling in lymphatic endothelium cells (LEC) is important for migration of regulatory T cells (Treg) to afferent lymphatic vessels…
  • 2019 American Transplant Congress

    Intact Lymphatics Are Essential for Costimulation Blockade-Induced Lung Allograft Survival

    L. Wang1, H. Reed2, R. Han1, M. Kahn2, W. W. Hancock1

    1Children's Hospital of Philadelphia, Philadelphia, PA, 2University of Pennsylvania, Philadelphia, PA

    *Purpose: Blocking lymphangiogenesis is thought to diminish immune responses to donor tissues. However, lung transplantation (Tx), which involves airway and vascular but not lymphatic anastomoses,…
  • 2019 American Transplant Congress

    Serum Adipocyte Fatty Acid Binding Protein Level is Negatively Associated with Vascular Reactivity Index Measured by Digital Thermal Monitoring in Kidney Transplant Patients

    M. Lee1, B. Hsu2

    1Surgery, Hualien Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, Hualien, Taiwan, 2Nephrology, Hualien Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, Hualien, Taiwan

    *Purpose: Adipocyte fatty acid-binding protein (A-FABP) is abundantly found in mature adipocytes, activated macrophages, and dendritic cells and is involved in lipid metabolism, metabolic and…
  • 2019 American Transplant Congress

    Multiplexed Droplet Single-Cell RNA-Sequencing for Cellular Profiling of Transplant Rejection

    A. Schroeder, T. Sigdel, I. Damm, S. Sur, G. Hartoularos, J. Ye, M. Sarwal

    Department of Surgery, UCSF, San Francisco, CA

    *Purpose: Multiplexed droplet single-cell RNA-sequencing (mdscRNA-seq) has been utilized across many tissue types for fast and paralleled transcriptomic profiling. However, maintaining sample identity for differential…
  • 2019 American Transplant Congress

    Sphingosine 1-Phosphate Receptors and CCR7 Sequentially Coordinate T Cell Migration

    Y. Xiong1, W. Piao1, C. Brinkman1, J. Kulinski2, A. Olivera2, A. Cartier3, T. Hla4, K. Hippen5, B. Blazar5, S. Schwab6, J. Bromberg1

    1Surgery, UMB, Baltimore, MD, 2NIH, Bethesda, MD, 3Boston Children's hospital, Boston, MA, 4Boston Children's hospital, Boston, MD, 5U.Minnesota, Minneapolis, MN, 6NYU, NY, NY

    *Purpose: CCR7 plays critical roles in T cell migration to CCL21 across lymphatic endothelial cells from tissues to lymph nodes (LN). S1PR1 and S1PR4 are…
  • 2019 American Transplant Congress

    Promoting Mitochondrial Fusion Alters the Interaction between Endothelial Cells and T Cells in Models of Transplantation

    D. T. Tran, C. Atkinson, S. N. Nadig

    Medical University of South Carolina, Charleston, SC

    *Purpose: As semi-professional antigen-presenting cells, microvascular endothelial cells (mECs) play a central role in mediating allograft rejection. Cold storage and ischemia reperfusion injury increases mEC…
  • 2019 American Transplant Congress

    Treg Lymphotoxin and Lymphatic Endothelial Cell Lymphotoxin Receptor Interactions Are Required for Treg Stability and Allograft Protection

    V. Saxena, W. Piao, L. Li, C. M. Palusckievicz, Y. Xiong, T. Simon, J. S. Bromberg

    U Maryland, Baltimore, MD

    *Purpose: Regulatory T cells (Treg) restrain allograft rejection through suppressor functions that are dependent upon expression of the transcription factor Foxp3, their proper migration, and…
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