2019 American Transplant Congress
Sphingosine 1-Phosphate Receptors and CCR7 Sequentially Coordinate T Cell Migration
*Purpose: CCR7 plays critical roles in T cell migration to CCL21 across lymphatic endothelial cells from tissues to lymph nodes (LN). S1PR1 and S1PR4 are…2019 American Transplant Congress
Promoting Mitochondrial Fusion Alters the Interaction between Endothelial Cells and T Cells in Models of Transplantation
Medical University of South Carolina, Charleston, SC
*Purpose: As semi-professional antigen-presenting cells, microvascular endothelial cells (mECs) play a central role in mediating allograft rejection. Cold storage and ischemia reperfusion injury increases mEC…2019 American Transplant Congress
Treg Lymphotoxin and Lymphatic Endothelial Cell Lymphotoxin Receptor Interactions Are Required for Treg Stability and Allograft Protection
*Purpose: Regulatory T cells (Treg) restrain allograft rejection through suppressor functions that are dependent upon expression of the transcription factor Foxp3, their proper migration, and…2019 American Transplant Congress
Cryopreserved Human Iliac Arteries Allografts: Different Thawing Rates Affect on Their Structural Changes and Mechanical Properties
*Purpose: The rate of thawing of cryopreserved human iliac arteries allografts (CHIAA) directly affects the severeness of structural changes that occur during this process. This…2019 American Transplant Congress
Laminin Dependent T Cell Migration Determines Allograft Survival
Surgery, U. Maryland, Baltimore, Baltimore, MD
*Purpose: Differential expression of lymph node (LN) stromal laminins α5β1γ1 (511) and α4β1γ1 (411) is associated with tolerance and immunity, respectively. We investigated the hypothesis…2019 American Transplant Congress
Protection of the Donor Kidney Vascular Endothelium by Ex-Vivo Perfusion with a Pan-Caspase Inhibitor
*Purpose: Orthotopic kidney transplantation is a life-saving therapeutic option for patients with end stage organ failure. Pulsatile perfusion (PP) of deceased donor kidneys is increasingly…2019 American Transplant Congress
Depleting Laminin α5 in Lymph Node Stromal Cells Promotes Transplant Tolerance
Surgery, U. Maryland, Baltimore, Baltimore, MD
*Purpose: Expression of stromal laminin α5β1γ1 (511) in lymph nodes (LN) is associated with immunity, while laminin α4β1γ1 (411) is associated with tolerance. The laminins…2019 American Transplant Congress
Achieving Robust Targeting of Antibody-Conjugated Nanoparticles Delivered during Ex Vivo Machine Perfusion of Human Kidneys
*Purpose: In this study we seek to improve targeted nanoparticle (NP) delivery during ex-vivo normothermic machine perfusion through fibrinolysis for more homogenous treatment of human…2019 American Transplant Congress
Endothelial Cell Replacement – A Closer Step to Personalized, Tissue-Engineered Transplants
Rabin Medical Center, Petah-Tiqwa, Israel
*Purpose: Whole organ perfusion decellularization has been proposed as a promising method for the generation of non-immunogenic organs from allogeneic or xenogeneic donors. However, the…2019 American Transplant Congress
Endothelial Cell Cytoskeleton Rearrangement (ECCSKR) and Endothelial to Mesenchymal Transition (EndoMT) in Liver Allografts Following Acute Rejection (AR): Its Significance on the Development of Liver Fibrosis (LF) and Graft Survival
1Pathology, Baskent University, Ankara, Turkey, 2Transplantation, Baskent University, Ankara, Turkey
*Purpose: Endothelial cell (EC) cytoskeleton is critical for EC adhesion and permeability. CSKR initiates permeability and influx of leukocytes which in turn leads to increased…
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