2022 American Transplant Congress
Pd-1 Licenses Activated Treg for Lymphatic Migration
*Purpose: In addition to serving as fluid conduits, lymphatic vessels are critical portals for immune cell migration. Lymphatic endothelial cells (LECs) constitutively express high levels…2022 American Transplant Congress
Treg Migration and Suppression Require Engagement with Lymphotoxin Beta Receptor on Lymphatic Endothelial Cells to Protect Islet Allografts
1University of Maryland School of Medicine, Baltimore, MD, 2University of Minnesota, Minneapolis, MN
*Purpose: Treg sequential migration from graft to draining lymph nodes (dLN) via afferent lymphatics is required for Treg suppressive function. Treg lymphotoxin alpha beta (LTαβ)…2022 American Transplant Congress
Polarized Il-6 Secretion from Lymphatic Endothelial Cells Promotes Treg Conversion to Extregs
1University of Maryland School of Medicine, Baltimore, MD, 2University of Minnesota, Minneapolis, MN
*Purpose: Regulatory T cell (Treg) suppressor function and allograft protection depend on maintenance of transcription factor Foxp3 expression and lymphatic migration. Lymphatic endothelial cell (LEC)…2022 American Transplant Congress
Cd80 on Effector T Cell Binds Pd-l1 on Lymphatic Endothelial Cells to Fine Tune Migration
*Purpose: Antigen presenting cell (APC) CD80 trans-binds CD28 and CTLA4 on T cells, boosting or inhibiting immunity, respectively. CD80 has another ligand, Programmed Death-1 Ligand…2022 American Transplant Congress
Sting but Not Mtor Signaling Regulates Exogenous Mitochondrion-Induced Endothelial Cell Mitophagy
Duke University School of Medicine, Durham, NC
*Purpose: We have previously demonstrated activation and increasing mitophagy of human endothelial cells (ECs) following exogenous mitochondrion-stimulation. The objectives of this study were to evaluate…2022 American Transplant Congress
Bcl6b is a Putative Regulator of Endothelial Identity and Endmt
Pathology and Laboratory Medicine, UCLA, Los Angeles, CA
*Purpose: Loss of endothelial cell (EC) identity is central to endothelial to mesenchymal transition (EndMT) implicated in neointimal hyperplasia in transplant vasculopathy. However, the molecular…2022 American Transplant Congress
HLA-II Subclasses Behave Differently Between Themselves and Between Humans: Cues to Understand Alloreactivity
*Purpose: De novo anti-HLA-II DSAs (dnDSA) are associated with antibody-mediated rejection. However, some patients with anti-HLA-II DSAs will not develop rejection, suggesting that the development…2022 American Transplant Congress
HDAC Inhibitors Suppress Endothelial Inflammation but Alter Identity
Pathology and Laboratory Medicine, UCLA, Los Angeles, CA
*Purpose: Histone modifications such as acetylation control gene expression. Histone deacetylases (HDACs) have been proposed as an attractive therapeutic approach to counteract detrimental gene expression,…2022 American Transplant Congress
Functional Recellularized Patient Derived Endothelium; A Human Vascular Graft Approach
*Purpose: In transplantation, the endothelial lining is the first barrier between the donor organ and recipient immune system. Damaged endothelium exposes extracellular matrix (ECM) molecules…2022 American Transplant Congress
Stabilization of Cell-Cell Junctions Improves Outcomes in an Ex-Vivo Porcine Renal Ischemia-Reperfusion Injury Culture Model
*Purpose: Renal transplant is an accepted therapy for end-stage renal failure. Chronic transplant dysfunction remains the leading cause of long-term graft loss and is, in…
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