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American Transplant Congress abstracts

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Articles tagged "Efficacy"

  • 2018 American Transplant Congress

    Qualitative Analysis of Facebook Posts Created via the Donor Application

    J. Konel, S. Weeks, K. Kumar, D. Helfer, D. Segev, J. Garonzik Wang, M. Henderson, A. Cameron.

    Johns Hopkins, Baltimore.

    The Donor App is a smartphone app that helps transplant candidates create a Facebook (FB) post telling their story about organ failure and their need…
  • 2018 American Transplant Congress

    Pancreas Retransplantation: Outcomes of This Technical and Immunological Challenge over 38 Patients

    F. Paret,1 D. Cantarovich,2 G. Karam,3 T. Batard,4 M. Nedelec,5 J. Branchereau.6

    1Urology and Transplantation, CHU Nantes, Nantes, France; 2Nephrology and Transplantation, CHU Nantes, Nantes, France.

    IntroductionPancreas transplantation is now a mastered technique for patients suffering from severe diabetes. However, a significant number of grafts are lost for technical and immunological…
  • 2018 American Transplant Congress

    BETA-2 Score is an Excellent Tool for Monitoring of Islet Allograft Function and Early Detection of Transplant Dysfunction

    P. Bachul,1 J. Gołębiewska,2 L. Basto,1 M. Kijek,1 N. Fillman,1 K. Cieply,1 K. Golab,1 L-.J. Wang,1 M. Tibudan,1 C. Thomas,1 A. Dębska-Ślizień,2 J. Fung,1 P. Witkowski.1

    1Surgery, University of Chicago, Chicago; 2Nephrology, Medical University of Gdańsk, Gdańsk, Poland.

    After validation of BETA-2 scores in our cohort of patients in relation to standard stimulation tests, we decided to assess the practical utility of BETA-2…
  • 2018 American Transplant Congress

    Hospitality Houses and Transplant Patients: Assessing the Impact of a Hospitality House Dedicated to Transplant Patients and Their Families

    T. Giordano,1 J. Campbell,2 J. Weinstock,3 H. Nathan.3

    1Social Work, Gift of Life Family House, Philadelphia, PA; 2Campbell-Collaboratives, LLC, Ardmore, PA; 3Executive Leadership, Gift of Life Donor Program, Philadelphia, PA.

    Hospitality houses exclusively for transplant patients and their families are a relatively new concept and their connection to medical outcomes is untested. One hospitality house…
  • 2018 American Transplant Congress

    Anti-Thymocyte Globulin vs. Alemtuzumab: A Comparison of Long-Term Outcomes among Renal Transplant Recipients

    E. Loncharic, A. Dodson, K. Gutierrez.

    Department of Pharmacy, The University of Alabama at Birmingham, Birmingham, AL.

    Background: Two lymphocyte depleting agents are currently available for renal transplant induction: alemtuzumab (C1H) and rabbit anti-thymocyte globulin (rATG). Studies comparing long-term outcomes between C1H…
  • 2018 American Transplant Congress

    Long-Term Efficacy and Safety of Prolonged-Release Tacrolimus in Stable Pediatric Allograft Recipients Converted from Immediate-Release Tacrolimus

    N. Undre,1 J. Rubik,2 D. Debray,3 D. Kelly,4 F. Iserin,5 N. Webb,6 P. Czubkowski,2 K. Vondrak,7 A-.L. Sellier-Leclerc,8 S. Riva,9 B. Tönshoff,10 L. D'Antiga,11 S. Marks,12 R. Reding,13 G. Kazeem.1

    1Astellas Pharma Europe Ltd, Chertsey, United Kingdom; 2Children's Memorial Health Institute, Warsaw, Poland; 3APHP-Hôpital Universitaire Necker, Paris, France; 4Birmingham Children's Hospital, Birmingham, United Kingdom; 5University Hospital Necker Enfants Malades, Paris, France; 6Manchester University Foundation Trust, Manchester, United Kingdom; 7University Hospital Motol, Prague, Czech Republic; 8Hôpital Femme-Mère-Enfant, Bron Cedex, France; 9ISMETT-IRCCSS, Palermo, Italy; 10University Children's Hospital, Heidelberg, Germany; 11Hospital Papa Giovanni XXIII, Bergamo, Italy; 12Great Ormond Street Hospital for Children, London, United Kingdom; 13Cliniques Universitaires Saint-Luc UCL, Brussels, Belgium.

    Study assessed long-term efficacy/safety of prolonged-release tacrolimus (PR-T) in stable solid organ allograft recipients (aged 5–16 yrs) who participated in a multicenter, Phase II pharmacokinetics…
  • 2018 American Transplant Congress

    Immunoglobulin Replacement Therapy in Pediatric Renal Transplant Patients

    A. Lewis, M. Fasano, D. Zepeda-Orozco.

    University of Iowa Hospitals and Clinics, Iowa City, IA.

    Immunoglobulin replacement therapy decreases infection frequency in patients with primary immunodeficiency; however, there is limited data regarding the use of intravenous immunoglobulin (IVIG) or subcutaneous…
  • 2018 American Transplant Congress

    Efficacy and Safety of Immediate- and Prolonged-Release Tacrolimus in De Novo Pediatric Transplantation: Randomized Study

    K. Vondrak,1 F. Parisi,2 A. Dhawan,3 R. Grenda,4 N. Webb,5 S. Marks,6 D. Debray,7 R. Holt,8 A. Lachaux,9 D. Kelly,10 G. Kazeem,11 N. Undre.11

    1University Hospital Motol, Prague, Czech Republic; 2Osp Pediatrico Bambino Ges[ugrave], Rome, Italy; 3King's College Hospital, London, United Kingdom; 4The Children's Memorial Health Institute, Warsaw, Poland; 5Manchester University Foundation Trust, Manchester, United Kingdom; 6Great Ormond Street Hospital for Children NHS Foundation Trust, London, United Kingdom; 7APHP-Hôpital Universitaire Necker, Paris, France; 8Alder Hey Children's Hospital, Liverpool, United Kingdom; 9Université Lyon 1 et Hospices Civils de Lyon, Lyon, France; 10Birmingham Children's Hospital, Birmingham, United Kingdom; 11Astellas Pharma Europe Ltd, Chertsey, United Kingdom.

    This study assessed long-term efficacy/safety of prolonged-release tacrolimus (PR-T) vs immediate-release tacrolimus (IR-T) in de novo pediatric transplant pts. Phase II, parallel-group, multicenter, open-label study…
  • 2018 American Transplant Congress

    Effect of Everolimus with Reduced Calcineurin Inhibitor on Efficacy and Safety in De Novo Kidney Transplant Recipients: 12-Month Results from the US Cohort of TRANSFORM Study

    S. Mulgaonkar,1 Y. Qazi,1 D. Kim,1 V. Peddi,1 K. McCague,2 D. Patel,2 A. Wiseman.1

    1TRANSFORM Study Group, Livingston; 2Novartis Pharmaceuticals Corporation, East Hanover.

    Purpose: Despite remarkable short-term survival benefits, long-term outcomes in kidney transplant recipients (KTRs) remain unsatisfactory. Everolimus (EVR) may improve long-term outcomes by reducing calcineurin inhibitor…
  • 2018 American Transplant Congress

    Immunogenic HLA Mismatches and Evidence That Belatacept May Be the First Therapy Able to Prevent DQ De Novo DSA: An Analysis of the BENEFIT and BENEFIT-EXT Trial Cohorts

    M. Everly,1 V. Jucaud,1 M. Roberts,2 H. Gebel,3 R. Bray.3

    1Terasaki Research Institute, Los Angeles, CA; 2Immunology Biomarker Group, Bristol-Myers Squibb, Princeton, NJ; 3Pathology & Laboratory Medicine, Emory University School of Medicine, Atlanta, GA.

    The use of belatacept over cyclosporine is associated with lower rates of DSA development in adult kidney transplantation. However, the effect of belatacept on the…
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