ATC Abstracts

American Transplant Congress abstracts

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Articles tagged "Efficacy"

  • 2016 American Transplant Congress

    Novel Effect of miR-26a:Mdm2:p53 Pathway on Mouse Liver Regeneration.

    J. Zhou, W. Ju, X. Yuan, X. Jiao, D. Wang, X. Zhu, X. He.

    Organ Transplant Center, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong, China.

    BACKGROUND: The deficiency of liver regeneration needs to be addressed in the fields of liver surgery, split liver transplantation and living donor liver transplantation. Researches…
  • 2016 American Transplant Congress

    ESM1 Gene Promotes Hepatocyte Proliferation Through NF-κB Signal Pathway.

    J. Zhou, W. Ju, X. Jiao, X. Zhu, X. He.

    Organ Transplant Center, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong, China.

    BACKGROUND: Effective and timely liver regeneration is pivotal in the prevention of fetal small-for-size syndrome after living donor liver transplantation or split liver transplantation. Our…
  • 2016 American Transplant Congress

    Chimeric Cell Transplantation for Treatment of Duchenne Muscular Dystrophy: A Preliminary Report.

    E. Szilagyi, E. Bryndza Tfaily, J. Cwykiel, M. Siemionow.

    Orthopaedic Surgery, University of Illinois at Chicago, Chicago.

    Background: Transplant of Chimeric Cells, created via ex vivo fusion of donor and recipient cells, represents a promising cell therapy option in the field of…
  • 2016 American Transplant Congress

    Human Epineural Allograft Conduits Supported with Mesenchymal Stem Cells Enhance Peripheral Nerve Regeneration: A Preliminary Report.

    M. Siemionow, M. Strojny, W. Malewski, J. Cwykiel, M. Cyran.

    Department of Orthopaedics, University of Illinois at Chicago, Chicago, IL.

    PURPOSE: Due to the limitations of current surgical methods of long nerve defect repair, new therapeutic approaches are needed to enhance nerve regeneration. Nerve allografts…
  • 2015 American Transplant Congress

    Electronic Health Service to Improve Therapeutic Drug Monitoring of Immunosuppressants

    M. Barten,1 J. Garbade,2 I. Hausladen,2 F. Mohr.2

    1Cardiovascular Surgery, University Heart Center Hamburg, Hamburg, Germany; 2Cardiac Surgery, University Leipzig Heart Center, Leipzig, Germany.

    PurposeTherapeutic drug monitoring (TDM) of immunosuppressants is critical to avoid rejection or toxic side effects by under- or over-immunosuppression after heart transplantation (HTx). Hence, in…
  • 2015 American Transplant Congress

    Efficacy of Low Dose Chemoprophylaxis for Coccidioidomycosis Infection in Liver Transplantation Recipients

    R. El Ramahi,2 S. Habib,1 S. Rosen,3 S. Farran,3 C. Walker,3 J. Shubeilat,4 S. Yost,5 O. McCotter,6 M. Cassal,6 A. Rana,7 T. Boyer,1 T. Zangeneh.2

    1Liver Research Institute, Divisions of Gastroenterology, Hepatology and Transplantation, Department of Medicine, University of Arizona, Tucson, AZ; 2Division of Infectious Disease, Department of Medicine, University of Arizona, Tucson, AZ; 3Internal Medicine Residency Program, Department of Medicine, University of Arizona, Tucson, AZ; 4Division of Infectious Disease, Department of Medicine, University of Massachusetts, Worcester, MA; 5Division of Transplantation, School of Pharmacy, University of Arizona, Tucson, AZ; 6Office of Border Health, Arizona Department of Health Services, Tucson, AZ; 7Division of Transplantation, Department of Surgery, University of Arizona, Tucson, AZ.

    Introduction:Coccidioidomycosis(CM) infection rate of 6.9% has been reported in solid organ transplantation recipients living in endemic Southwestern U.S.Aim:Assess the risk of CM infection in liver…
  • 2015 American Transplant Congress

    Targeting Complement Pathways During Ischemia and Reperfusion: Implications for the Prevention of Delayed Graft Function

    Z. Yu,1 S. Qi,2 M. Lasaro,1 K. Bouchard,1 C. Dow,1 K. Moore,1 Z. Wu,2 A. Barama,2 J. Xu,2 K. Johnson,1 A. Marozsan,1 Y. Wang.1

    1Pre-Clinical Sciences, Alexion Pharmaceutical Inc., Cheshire, CT; 2Department of Surgery, Hôpital Notre Dame and Université de Montréal, Montréal, QC, Canada.

    Complement system plays a critical role in ischemia-reperfusion injury (IRI), and contributes to DGF. The aim of this study was to evaluate the effects of…
  • 2015 American Transplant Congress

    Early Conversion to Everolimus in De Novo Kidney Transplant Recipients: 12-Month Results from the ELEVATE Study

    J. de Fijter, H. Holdaas, A. Speziale, G. Junge, Z. Wang, J. Cruzado, M. van der Giet.

    For the ELEVATE Study, Leiden, Netherlands.

    Purpose: Long-term exposure to calcineurin inhibitors (CNIs) contributes to unfavorable long-term outcomes, including inferior renal function and premature graft loss with vascular lesions, glomerulosclerosis and…
  • 2015 American Transplant Congress

    Everolimus and Early Calcineurin Inhibitor Withdrawal Is Associated With Superior Renal Function: 5-Year Follow-Up of the Randomized PROTECT Liver Transplantation Study

    M. Sterneck, G. Kaiser, N. Heyne, N. Richter, F. Rauchfuss, A. Pascher, P. Schemmer, L. Fischer, C. Klein, S. Nadalin, F. Lehner, U. Settmacher, D. Gotthardt, M. Loss, S. Ladenburger, P. Wimmer, M. Dworak, H. Schlitt.

    PROTECT Study Group, Novartis Pharma GmbH, Germany.

    Purpose: At the end of the 12-month (M) PROTECT core study (NCT00378014), de novo liver transplant recipients (LTxR) who switched from a calcineurin inhibitor (CNI)…
  • 2015 American Transplant Congress

    Treatment of Hepatitis C Virus in Kidney Transplant Recipients With Direct Acting Anti-Viral Agents: Early Results in 12 Cases

    A. Sharfuddin,1 T. Taber,1 M. Mujtaba,1 M. Yaqub,1 D. Mishler,1 P. Kwo,2 R. Vuppalanchi.2

    1Medicine/Nephrology, Indiana University, Indianapolis; 2Medicine/Hepatology, Indiana University, Indianapolis.

    Background: Recently approved direct acting antiviral agents (DAA) for treatment of HCV are interferon sparing allowing an attractive treatment option for kidney transplant recipient with…
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