2017 American Transplant Congress
Efficacy and Safety of Everolimus with Reduced Tacrolimus or Cyclosporine in Pediatric Liver Transplant Recipients: 12-Month Results from H2305 Study.
1H2305 Study Group, St Louis; 2Novartis Pharma AG, Basel, Switzerland
Purpose: Everolimus (EVR) facilitated calcineurin inhibitor (CNI) reduction has shown improved renal function (RF) without compromising efficacy in adult liver transplant recipients (LTxR). Here we…2017 American Transplant Congress
At-Home Transplant Education Increases Black and Low-Income Dialysis Patients' Transplant Knowledge, Attitudes, Informed Decision-Making, and Pursuit: An Explore Transplant @ Home Randomized Controlled Trial.
1UCLA, Los Angeles, CA; 2Missouri Kidney Program, Columbia, MO
Black and low-income dialysis patients, who face greater barriers to kidney transplant (KT), may need additional educational support. This randomized controlled trial (RCT) assessed the…2017 American Transplant Congress
Long-Term Outcomes After Liver Transplantation (tx) with Everolimus (EVR) and Mycophenolic Acid (MPA) in a Calcineurin Inhibitor-Free Regimen: The CERTITUDE Trial.
Background. Long-term outcomes under EVR with MPA and no calcineurin inhibitor are undocumented after liver tx.Methods. CERTITUDE is a prospective, multicenter, observational study of liver…2017 American Transplant Congress
Efficacy and Safety of Everolimus with Reduced-Exposure Tacrolimus and Corticosteroid Withdrawal in De Novo Pediatric Renal Transplant Recipients: 12-Month Results from the CRADLE Study.
PURPOSE: We present 12-month (M) results from the CRADLE study (NCT01544491) that assessed efficacy and safety of everolimus (EVR) with reduced-exposure tacrolimus (rTAC) and early…2017 American Transplant Congress
Subclinical Rejections in Kidney Transplant Recipients Treated with Direct Acting Antiviral Agents for Hepatitis C Treatment within 1 Year of Transplant.
Direct acting antiviral agents (DAA) have revolutionized the management of Hepatitis C virus (HCV) positive kidney transplant recipients (KTR). The optimal timing of DAA therapy…2017 American Transplant Congress
Effect of Influenza Vaccination in the Severity of Illness in Hospitalized Transplant Recipients with Laboratory-Confirmed Influenza.
Objectives: The effectiveness of influenza vaccine in solid organ transplant (SOT) recipients may be decreased due to immunosuppression. Some studies have suggested that influenza vaccination…2017 American Transplant Congress
IdeS, an IgG Endopeptidase, Effectively Cleaves Anti-HLA Antibody (Ab), Resulting in Inhibition of Anti-HLA Ab-Mediated NK Cell Activation and Ab-Dependent Cell-Mediated Cytotoxicity (ADCC) in HLA-Sensitized Kidney Transplant Patients (HS KTx Pts).
Background: Ab-mediated rejection (ABMR) is a major obstacle in HS KTx Pts. ADCC is a mechanism responsible for ABMR. IdeS cleaves all 4 human IgG…2017 American Transplant Congress
Evaluation of Low Dose Valganciclovir for the Prevention of Cytomegalovirus in Liver Transplant Recipients.
BACKGROUND: Cytomegalovirus (CMV) causes significant morbidity and mortality following orthotopic liver transplantation (OLT). Valganciclovir (VGCV) is used to prevent CMV, but at labeled doses can…2017 American Transplant Congress
Effect of HLA-DQ Mismatch on Efficacy Outcomes and Renal Function in Kidney Transplant Recipients: Subanalysis from the ELEVATE Study.
1ELEVATE Study Group, Köln, Germany; 2Novartis Pharma AG, Basel, Switzerland
Purpose: Human leukocyte antigen (HLA)-DQ mismatches are often associated with acute rejection, independent of mismatches at other loci. Previous analysis from the ELEVATE (NCT01114529) study…2017 American Transplant Congress
Effect of Everolimus-Based Regimen on Graft Outcomes in Kidney Transplant Recipients with Diabetes at Baseline: Post-Hoc Analysis from the ELEVATE Study.
1ELEVATE Study Group, Leiden, Netherlands; 2Novartis Pharma AG, Basel, Switzerland
Purpose: Presence of diabetes may have adverse impact on graft outcome in kidney transplant recipients (KTxRs). This post-hoc analysis from the ELEVATE study compared the…
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