2018 American Transplant Congress
Use of Proton-Pump Inhibitors is Associated with Lower Magnesium and Iron Status and Excess Mortality in Renal Transplant Recipients
BackgroundProton-pump inhibitor (PPI) use is common in renal transplant recipients (RTR). However, PPI use may induce micronutrient deficiencies and has been associated with increased mortality…2018 American Transplant Congress
Anti-IdeS Antibodies in IVIg and Its Effect on IdeS Activity
ObjectiveEvaluate how and why intravenous gamma globulin (IVIg) affects IdeS-cleavage of IgG.IntroductionIgG degrading enzyme of Streptococcus pyogenes (IdeS) cleaves human IgG in two steps, first…2018 American Transplant Congress
Influence of mTOR Inhibitors on Metabolic Outcomes One Year after Kidney Transplantation: The Role of Pre-Transplantation Diabetes
INTRODUCTION: mTOR inhibitors alter lipids and carbohydrate metabolism in kidney transplant recipients. Little is known if there is any difference between patients who were already…2018 American Transplant Congress
Human Atrial Natriuretic Peptide (hANP) in Cold Storage of Donation after Cardiac Death Livers: A New Tool for Protecting Vascular Endothelia?
Aim: Current critical shortage of donor organs has led to acceptance of donation after cardiac death (DCD) livers for transplantation. Human atrial natriuretic peptide (hANP)…2018 American Transplant Congress
Chronic Narcotic Use Increases Mortality Rates in Heart Transplantation
Transplant, Henry Ford Hospital, Detroit, MI.
Purpose: In kidney and liver transplantation, chronic narcotic use pre and post-transplant has been associated with an increased risk for rejection and early graft loss.…2018 American Transplant Congress
Incidence of Pneumonitis in Heart Transplant Patients Started on a Proliferation Signal Inhibitor
Cedars Sinai Medical Center, Los Angeles.
Purpose: Proliferation signal inhibitors(PSI) have a high discontinuation rate due to side effects. PSI induced pneumonitis has been reported in 14% in renal cell carcinoma…2018 American Transplant Congress
IVIG Induction May Be Helpful in Highly Sensitized Patients after Heart Transplantation
Cedars Sinai Medical Center, Los Angeles.
Purpose: Strategies for sensitized patients undergoing heart transplant include post-op anti-thymocyte globulin (ATG) induction therapy as well as intravenous immunoglobulin (IVIG). We sought to assess…2018 American Transplant Congress
Evidence of a Clinically Significant Drug-Drug Interaction between Cannabidiol and Tacrolimus: A Case Report
Cannabidiol (CBD), a major purified non-psychoactive component of marijuana with anticonvulsant properties, is being studied under an expanded access IND as an adjuvant treatment for…2018 American Transplant Congress
Calcineurin Inhibitors, Macrolides, and the Risk of Adverse Drug Events in Kidney Transplant Recipients
1Univ of Alberta, Edmonton, Canada; 2Univ of Calgary, Calgary, Canada; 3Saint Louis Univ, St. Louis.
Background: After kidney transplantation, calcineurin inhibitors (CNIs, cyclosporine, tacrolimus) are key components of immunosuppression but have multiple potential drug interactions. Macrolide antibiotics are often used…2018 American Transplant Congress
Effect of Direct-Acting Hepatitis C Treatment Regimens on Calcineurin Inhibitors in Liver and Kidney Transplant Patients
Duke University Hospital, Durham, NC.
Background: It has been suggested that treatment with direct-acting antivirals (DAA) for hepatitis C virus (HCV) may decrease calcineurin inhibitor (CNI) concentrations. The purpose of…
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