ATC Abstracts

American Transplant Congress abstracts

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Articles tagged "Drug interaction"

  • 2022 American Transplant Congress

    Impact Of Antifungal Prophylaxis Discontinuation On Immunosuppression In Lung Transplant Recipients

    R. Huntsman, K. Neuhaus

    Pharmacy, Cleveland Clinic, Cleveland, OH

    *Purpose: The purpose of this study is to characterize the impact of antifungal discontinuation on immunosuppressant levels and incidence of acute rejection and fungal infections…
  • 2021 American Transplant Congress

    Managing the Significant Drug-Drug Interaction Between Tacrolimus and Letermovir in Solid Organ Transplant Recipients

    J. Hedvat, J. Choe, D. Salerno, J. Scheffert, D. Bley, A. Anamisis, T. Shertel, J. Lee, E. Liu, N. W. Lange

    NewYork-Presbyterian Hospital, New York, NY

    *Purpose: Letermovir does not appear to share cross-resistance with ganciclovir and is not associated with nephrotoxicity or myelosuppressive effects, making it an attractive option for…
  • 2021 American Transplant Congress

    Are Tacrolimus Concentrations Reduced with Direct-acting Antiviral Administration in Transplant Recipients?

    K. Huang, K. Farrow, M. Christian

    Pharmacy, Penn State Health Hershey Medical Center, Hershey, PA

    *Purpose: To evaluate the effects of direct-acting antivirals (DAAs) on tacrolimus trough concentrations and clinical outcome and to assess the need for a priori dose…
  • 2021 American Transplant Congress

    Iatrogenic Sodium Exposure in Hospitalized Patients with Liver Disease

    P. Klem1, R. Mbangu Kot Mbau2, B. Crowther1, V. Lewis1, S. Lin1, E. Patrick3, A. Nadrash1, K. Schoeppler1, I. Kim1

    1Pharmacy, University of Colorado Hospital, Aurora, CO, 2Pharmacy, University of Colorado Skaggs School of Pharmacy and Pharmaceutical Sciences, Aurora, CO, 3Transplant Services, University of Colorado Hospital, Aurora, CO

    *Purpose: Numerous medications administered in the hospital setting may contain hidden/additional amounts of sodium in the drug itself and via intravenous (IV) diluents or admixtures.…
  • 2021 American Transplant Congress

    Reduction in Medication Errors at Discharge in the Transplant Population via Use of Novel Pharmacist / Nursing Dual Check System

    M. Norris, S. Witek, C. Whritenour, K. Sigafus, C. Chiang, C. Sammons, D. Naveiro, A. Paredes, E. Perez-Ngai, M. Kaminski, R. Westmoreland, G. Malat

    Hospital of the University of Pennsylvania, Philadelphia, PA

    *Purpose: Medication errors are of great concern due to the risk for patient and allograft injury. The aim of this study was to evaluate the…
  • 2021 American Transplant Congress

    Influence of Immunosuppressive Drug Trough Levels on Nk Cells in Liver Transplantation

    R. Qin1, J. Qin2, C. Sun3, B. Nashan1

    1Clinic for Organ Transplantation, The First Affiliated Hospital of the University of Science and Technology of China, Hefei, China, 2Clinic for Organ Transplantation, The First Affiliated Hospital of the University of Science and Technology of China., Hefei, China, 3Division of Life and Medicine, University of Science and Technology of China, Hefei, China

    *Purpose: Natural killer (NK) cells are enriched in lymphocytes within the liver and are considered to be main regulators of liver transplantation (LT) rejection and…
  • 2021 American Transplant Congress

    Clazakizumab (clz, Anti-il-6 Antibody) Treatment Affects Il-6/il-6r Signaling by Increasing Soluble Gp130 (sgp130) in Hla-sensitized Kidney Transplant Patients (hs Ktx Pts) Treated for Chronic Antibody-mediated Rejection (cabmr)

    B. Shin, S. Ge, A. Jimenez, N. Ammerman, A. Vo, R. Zhang, S. C. Jordan, M. Toyoda

    Cedars-Sinai Medical Center, Cerritos, CA

    *Purpose: IL-6 is a pro-inflammatory cytokine responsible for chronic vascular inflammation and a promising target for cABMR modulation. IL-6/sIL-6R complex initiates more pathogenic trans-signaling pathways…
  • 2021 American Transplant Congress

    Quantifying the Interaction Between Posaconazole and Tacrolimus in Liver Transplant Recipients: A Practical Approach

    B. Lane1, U. Kaszubski1, A. Freeman1, B. Wise1, L. Hutchinson1, M. Janusek1, G. Therapondos2, H. Bohorquez3, S. Anders1

    1Pharmacy, Ochsner Medical Center, New Orleans, LA, 2Hepatology, Ochsner Medical Center, New Orleans, LA, 3Transplant Surgery, Ochsner Medical Center, New Orleans, LA

    *Purpose: The interaction between tacrolimus (FK) and posaconazole (POSA) is well documented, however the extent of this interaction and the practical management has yet to…
  • 2021 American Transplant Congress

    Implementation of a High-risk Medication Report for Waitlisted Liver Transplant Candidates

    M. M. Eiting1, H. Yeh2, M. Cote1, S. Shao1, A. B. Scherrer2, L. Dageforde2, N. Elias2, C. Rogers Marks1

    1Pharmacy, Massachusetts General Hospital, Boston, MA, 2Massachusetts General Hospital, Boston, MA

    *Purpose: Use of high-risk medications (HRMs) at the time of liver transplant may lead to delays in surgery or peri-operative complications (bleeding, drug-drug interactions (DDI),…
  • 2021 American Transplant Congress

    Pilot Evaluation of Prognosis After Liver Transplantation in Patients with a History of Hepatocellular Carcinoma and Pd-1 Inhibition

    M. Chen1, Z. Chen1, X. Lin2

    1First Affiliated Hospital of Sun Yat-sen University, Guangzhou, China, 2the Eastern Hospital of the First Affiliated Hospital of Sun Yat-sen University, Guangzhou, China

    *Purpose: The successful applications of programmed death protein-1 (PD-1) inhibitors in cancer therapy has led to an expanding use of immunotherapy in oncolog Liver transplantation…
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