ATC Abstracts

American Transplant Congress abstracts

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Articles tagged "Dosage"

  • 2018 American Transplant Congress

    Evaluation of Tacrolimus Extended-Release in African American Renal Transplant Recipients

    T. Sparkes, B. Ravichandran, C. Williams, B. Thomas, B. Masters.

    University of Maryland, Baltimore.

    Purpose: Limited data exists to guide appropriate dosing strategies for novel tacrolimus formulations, such as tacrolimus XL (Astagraf XL). This is especially true in the…
  • 2018 American Transplant Congress

    Itraconazole Prophylaxis, Trough Concentration, and Identification of Fungal Pathogens in Lung Transplant

    H. Hassouna, V. Athans, K. Brizendine.

    Cleveland Clinic Foundation, Cleveland, OH.

    Studies of prophylactic itraconazole (ITR) in lung transplant recipients (LTR) are lacking. Our purpose was to evaluate LTR who received ITR prophylaxis and the association…
  • 2018 American Transplant Congress

    Use of Surgically Placed Transversus Abdominis Plane (TAP) Block Catheter with Local Anesthetic Infusion in Renal Transplantation

    M. Dib,1 S. Borden,2 T. Schell,1 P. Stahler,1 T. Al-Qaoud,1 E. Martinez,1 E. Grodstein,1 A. D'Alessandro,1 J. Odorico,1 L. Fernandez,1 J. Mezrich,1 R. Redfield,1 D. Foley,1 D. Al-Adra,1 D. Kaufman.1

    1Surgery, University of Wisconsin-Madison, Madison, WI; 2Anesthesia, University of Wisconsin-Madison, Madison, WI.

    BackgroundRenal transplant recipients have limitations in pain management, given the nephrotoxicity of NSAIDS and contraindications to regional neuroaxial techniques. Although opioids are widely used post-transplant,…
  • 2018 American Transplant Congress

    Outpatient Prophylactic Valganciclovir Dose Optimization Post-Renal Transplant

    M. Spinner,1 V. Athans,1 C. Koval.2

    1Dept. of Pharmacy, Cleveland Clinic, Cleveland, OH; 2Dept. of Infectious Diseases, Cleveland Clinic, Cleveland, OH.

    Purpose: Renal function rapidly changes post-transplant requiring dose adjustment of CMV prophylaxis. We describe valganciclovir (VGCV) dosing accuracy in the outpatient setting and its associated…
  • 2018 American Transplant Congress

    Innovative Strategies to Accommodate Increased Patient Volume in an Outpatient Transplant Infusion Center

    J. Estrada, M. Tyrell, J. Choi, J. Jagolino, S. Jordan.

    Comprehensive Transplant Center, Cedars Sinai Medical Center, Los Angeles, CA.

    Purpose: To accommodate the increasing volume of patients scheduled for infusions at the Comprehensive Transplant Center(CTC) Infusion suite. It began as a two chair unit…
  • 2018 American Transplant Congress

    Genome-Wide Association Study of Tacrolimus Dose in Pediatric Solid Organ Transplant Recipients in the CNTRP POSITIVE Study

    S. Min,1 T. Papaz,1 T. Blydt-Hansen,3 O. Lee,1 U. Allen,1 P. Birk,2 H. Grasemann,1 L. Hamiwka,4 C. Litalien,5 V. Ng,1 R. Parekh,1 K. Tinckam,6 S. Urschel,7 B. Foster,8 S. Mital.1

    1The Hospital for Sick Children, Toronto, Canada; 2Winnipeg Children's Hospital, Winnipeg, Canada; 3BC Children's Hospital, Vancouver, Canada; 4Alberta Children's Hospital, Calgary, Canada; 5CHU Ste-Justine, Montreal, Canada; 6University Health Network, Toronto, Canada; 7Stollery Children's Hospital, Edmonton, Canada; 8Montreal Children's Hospital, Montreal, Canada.

    PURPOSE: There are significant challenges in achieving therapeutic tacrolimus (Tac) concentrations after transplant. We explored variants associated with tacrolimus dose requirements in pediatric solid organ…
  • 2018 American Transplant Congress

    Cytomegalovirus Prophylaxis Following Alemtuzumab Induction in High Risk Renal Transplant Recipients Experiencing Delayed Graft Function

    S. Freedman, B. Ravichandran, B. Masters, E. Heil, K. Saharia, J. Bromberg, A. Haririan, T. Sparkes.

    University of Maryland, Baltimore.

    Purpose: There is limited data to support the use of valganciclovir in patients on dialysis. This study assessed the efficacy of valganciclovir 450 mg twice…
  • 2017 American Transplant Congress

    Association with Tacrolimus Intraindividual Variability, Acute Microinflammation Based on 1 Year-Transplanted Kidney Biopsy After Transplantation, and Biopsy-Proven Acute Rejection.

    S.-Y. Kim, S.-I. Min, W. Cho, S. Cho, M.-J. Cho, S. Ahn, S.-K. Min, J. Ha.

    Surgery, Seoul National University College of Medicine, Seoul, Korea

    Background: The purpose of this study was to investigate relationship between tacrolimus intraindividual variability (IIV), acute microinflammation (AMI) based on 1 year-transplanted kidney biopsy, and…
  • 2017 American Transplant Congress

    Impact of Antihypertensive (AHT) Choice and Advagraf® Dose on Interstitial Fibrosis/Tubular Atrophy (IF/TA) and IF/TA Progression in Renal Allografts 24 Months Post-Transplantation (Tx).

    S. Cockfield,1 D. Rush,2 S. Wilson,3 J. Howell,4 FKC-014 Study Group.

    1University of Alberta Hospital, Edmonton, AB, Canada; 2Health Sciences Centre, Winnipeg, MB, Canada; 3Astellas Pharma Global Development, Northbrook, IL; 4Astellas Pharma Global Development, Markham, ON, Canada

    IF/TA may be delayed using ACEi- or ARB-type AHTs, which target the renin-angiotensin system (RAS), as well as by optimizing tacrolimus (TAC) exposure. The effect…
  • 2017 American Transplant Congress

    Higher Tacrolimus Blood Levels Predict Better Graft Survival in Kidney Recipients with De Novo DSA.

    M.-A. Béland,1 R. Noël,1 I. Côté,1 I. Lapointe,1 E. Wagner,2 J. Riopel,3 E. Latulippe,3 O. Désy,1 S. Béland,1 I. Houde,1 S. De Serres.1

    1Renal Division, CHU de Quebec, Laval University, Quebec City, QC, Canada; 2Immunology and Histocompatibility, CHU de Quebec, Laval University, Quebec City, QC, Canada; 3Pathology, CHU de Quebec, Laval University, Quebec City, QC, Canada

    Background: De novo anti-HLA donor specific antibodies (dnDSA) are associated with poorer outcomes in kidney transplant recipients. Nonetheless, their monitoring post transplant is not widespread,…
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