ATC Abstracts

American Transplant Congress abstracts

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Articles tagged "Dosage"

  • 2019 American Transplant Congress

    Not All Poor Metabolizers Are Clinically Equal: Evaluating Weight-Based Tacrolimus Outcomes in CYP3A Loss of Function Variants

    A. Q. Maldonado, W. Irish, T. E. Asempa, J. Gooden, M. L. Davis, C. Haisch, H. Jones, D. Leeser, L. Rebellato

    Vidant Medical Center - Transplant Services, Greenville, NC

    *Purpose: CYP3A polymorphisms are an important pharmacotherapeutic consideration due to the extensive CYP metabolism of tacrolimus (TAC) and variable expression among different races. The CPIC…
  • 2019 American Transplant Congress

    Dosing Requirements Of Astagraf Xl In African American Kidney Transplant Recipients Converted From Twice-daily Tacrolimus (aaaktrs)

    J. N. Fleming, M. A. Posadas-Salas, D. J. Taber

    Medical University of South Carolina, Charleston, SC

    *Purpose: Pharmacokinetics from clinical studies demonstrated similar drug exposure (AUC) and correlation between trough (C0) and AUC between tacrolimus IR and Astagraf XL, which led…
  • 2019 American Transplant Congress

    Efficacy of Filgrastim in Solid Organ Transplant Recipients

    M. Spinner1, K. Gaffney1, S. Gundling2

    1Pharmacy, Cleveland Clinic, Cleveland, OH, 2University of Pittsburgh School of Pharmacy, Pittsburgh, PA

    *Purpose: Neutropenia frequently occurs after solid organ transplantation (SOT) due to immunosuppression, antiviral prophylaxis, or viral infections. Immunosuppression reduction or antiviral prophylaxis minimization can lead…
  • 2019 American Transplant Congress

    Association Between Cumulative Pre-transplant Amiodarone Dose And Post-transplant Outcomes After Heart Transplantation

    K. Lang1, M. Sullivan2, P. Simone1, S. Patel1, L. M. Lourenco1

    1Pharmacy, University of Chicago Medicine, Chicago, IL, 2Pharmacy, Northwestern Medicine, Chicago, IL

    *Purpose: Previous studies have demonstrated a correlation between pre-transplant amiodarone use and post-operative bradycardia, primary graft dysfunction, and mortality in heart transplant (HT) recipients; this…
  • 2019 American Transplant Congress

    Neutralization of Interlukin-6 by ALD518-P18 (Murine Clazakizumab) Attenuates Donor Specific Antibody Responses in a Mouse Model of Allogeneic Sensitization: A Report of Dosage Finding Study

    I. Kim, G. Wu, N. Chai, T. Brennan, A. Klein, S. Jordan

    Cedars-Sinai Med Ctr, Los Angeles, CA

    *Purpose: Interleukin-6 (IL-6) is a proinflammatory cytokine involved in mediating both T-cell and B-cell responses in allograft rejection. In previous studies, we demonstrated that inhibition…
  • 2019 American Transplant Congress

    Oral Ribavirin Therapy for Respiratory Syncytial Virus (RSV) in Lung Transplant Recipients: The Impact of Policy Implementation on Cost and Appropriate Use

    B. Berak, N. Sulejmani, A. Jantz, T. Larson, S. Davis, B. Summers

    Henry Ford Hospital, Detroit, MI

    *Purpose: RSV is a leading cause of viral infections in lung transplant recipients and is associated with significant morbidity and mortality. While the role of…
  • 2019 American Transplant Congress

    Use of an Ideal Body Weight-Based Rabbit Anti-Thymocyte Globulin Dosing Protocol in Kidney Transplant Recipients to Decrease Cost and Maintain Outcomes at a Large Academic Medical Center

    L. J. Myhre1, R. J. Bubik1, K. T. Peterson1, H. A. Personett1, S. A. Crow1, P. G. Dean2

    1Pharmacy, Mayo Clinic, Rochester, MN, 2Transplantation Surgery, Mayo Clinic, Rochester, MN

    *Purpose: This quality improvement study sought to assess if rejection post-transplant was increased following implementation of an ideal body weight (IBW)-based dosing protocol for patients…
  • 2019 American Transplant Congress

    The Dry Weight Revealed!, What Transplanted Kidneys Teach Us about the (Dry Weight).

    M. Hamid1, S. Oyewolle-Eletu2, G. Gudleski2, K. Speta3, J. Kumar1, S. Chang1

    1Nephrology-Transplant, State University of New York at Buffalo (SUNY) Buffalo, Buffalo, NY, 2Jacob's School of Medicine, State University of New York at Buffalo (SUNY) Buffalo, Buffalo, NY, 3Nephrology-Transplant, Erie County Medical Center, Buffalo, NY

    *Purpose: Volume overload in patients with ESRD/CKD V patients is associated with worse operative outcomes and potentially higher rate of delayed graft function, in addition…
  • 2018 American Transplant Congress

    Outpatient Prophylactic Valganciclovir Dose Optimization Post-Renal Transplant

    M. Spinner,1 V. Athans,1 C. Koval.2

    1Dept. of Pharmacy, Cleveland Clinic, Cleveland, OH; 2Dept. of Infectious Diseases, Cleveland Clinic, Cleveland, OH.

    Purpose: Renal function rapidly changes post-transplant requiring dose adjustment of CMV prophylaxis. We describe valganciclovir (VGCV) dosing accuracy in the outpatient setting and its associated…
  • 2018 American Transplant Congress

    Innovative Strategies to Accommodate Increased Patient Volume in an Outpatient Transplant Infusion Center

    J. Estrada, M. Tyrell, J. Choi, J. Jagolino, S. Jordan.

    Comprehensive Transplant Center, Cedars Sinai Medical Center, Los Angeles, CA.

    Purpose: To accommodate the increasing volume of patients scheduled for infusions at the Comprehensive Transplant Center(CTC) Infusion suite. It began as a two chair unit…
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