ATC Abstracts

American Transplant Congress abstracts

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Articles tagged "Dosage"

  • 2020 American Transplant Congress

    De Novo Dosing and Trough Attainment Trends of Extended-Release Tacrolimus in the Absence of Dose Adjustments

    M. J. Moritz1, D. R. Stevens2, U. Meier-Kriesche2, T. A. Horwedel2

    1Department of Surgery, Lehigh Valley Health Network, Allentown, PA, 2Veloxis Pharmaceuticals, Cary, NC

    *Purpose: Initial dosing of tacrolimus extended-release tablets (LCPT) was 0.17 mg/kg/day in the pivotal trial in de novo kidney transplant recipients. Dosing subsequent to the…
  • 2020 American Transplant Congress

    Safety and Efficacy of Valganciclovir for Cytomegalovirus Prophylaxis in Solid Organ Transplant Patients on Hemodialysis

    D. E. Ecabert, C. Pham, B. J. Pierce, W. L. Musick

    Houston Methodist Hospital, Houston, TX

    *Purpose: Cytomegalovirus (CMV) is the most common viral infection after solid organ transplant (SOT) and is associated with significant morbidity and mortality. Valganciclovir (VGCV) is…
  • 2020 American Transplant Congress

    Exposure to Tacrolimus Trough Levels Below 6ng/ml During the First Year is Associated with Inferior Kidney Graft Survival

    T. Agur, B. Rozen-Zvi, R. Rahamimov

    Department of Nephrology and Hypertension, Rabin Medical Center, Petah Tikva, Israel

    *Purpose: Accumulating data indicates that sub-therapeutic levels of calcineurin inhibitors are associated with long-term graft loss. However, while widely used tacrolimus (TAC) was shown to…
  • 2020 American Transplant Congress

    Comparing Weight-Based Dosing of Envarsus XR in Obese and Non-Obese Renal Transplant Recipients

    N. Breslin, N. Jandovitz, V. Nair, M. Abate, L. Teperman

    North Shore University Hospital, Manhasset, NY

    *Purpose: Tacrolimus has a narrow therapeutic window and significant inter- and intra-patient variability leading to variations in drug concentration. The recommended initial weight-based dose of…
  • 2020 American Transplant Congress

    Assessment of Time to Therapeutic Tacrolimus Levels Following Renal Transplantation in a Non-Weight-Based Dosing Model

    J. Banbury1, A. Dodson1, C. Lin2, K. Gutierrez1

    1University of Alabama at Birmingham Hospital, Birmingham, AL, 2Center for Clinical and Translational Science, University of Alabama at Birmingham, Birmingham, AL

    *Purpose: The optimal initial dose for tacrolimus (TAC) after renal transplant (RT) remains controversial with limited evidence comparing weight-based and conservative strategies. Recent literature suggests…
  • 2020 American Transplant Congress

    Less Bleeding Associated with Apixaban versus Other Direct Acting Oral Anticoagulation in Solid Organ Transplant Recipients

    M. Thornberg1, J. Scheffert1, D. Jennings2, J. Hedvat1, N. Lange1, H. Robbins3, D. Salerno1

    1NewYork-Presbyterian Hospital, Department of Pharmacy, New York, NY, 2Long Island University School of Pharmacy, Brooklyn, NY, 3Columbia Irving University Medical Center, Department of Medicine, New York, NY

    *Purpose: Owing to their fixed dosing and favorable drug interaction profiles, direct acting oral anticoagulants (DOACs) have supplanted warfarin as the standard of care for…
  • 2020 American Transplant Congress

    A Single Centre Experience of Conversion from Immediate Release Tacrolimus (IR-tac) to Extended Release Envarsus

    S. Chong1, E. Kent2, C. Beligaswatta2, P. Gudka2, C. Magee2, M. Harber2, R. Motallebzadeh1, G. Jones2

    1Centre for Transplantation, Department of Renal Medicine, University College London & Royal Free London NHS Foundation Trust​, London, United Kingdom, 2Department of Renal Medicine, University College London & Royal Free London NHS Foundation Trust​, London, United Kingdom

    *Purpose: IR-Tac is first line maintenance immunosuppression in kidney transplant recipients. Its rapid absorption of 1-2 hours can lead to peak levels (Tmax ) within…
  • 2020 American Transplant Congress

    Impact of Donor Race on Tacrolimus Dose Requirement for Liver Transplant Recipients

    N. Nesselhauf1, S. January1, J. Hagopian1, K. Progar1, A. Khan2

    1Pharmacy, Barnes-Jewish Hospital, St. Louis, MO, 2Surgery, Washington University School of Medicine, St. Louis, MO

    *Purpose: It is well described that there is interpatient variability in tacrolimus dose requirements among transplant recipients. CYP3A5 plays a role in this variability. Black…
  • 2019 American Transplant Congress

    Not All Poor Metabolizers Are Clinically Equal: Evaluating Weight-Based Tacrolimus Outcomes in CYP3A Loss of Function Variants

    A. Q. Maldonado, W. Irish, T. E. Asempa, J. Gooden, M. L. Davis, C. Haisch, H. Jones, D. Leeser, L. Rebellato

    Vidant Medical Center - Transplant Services, Greenville, NC

    *Purpose: CYP3A polymorphisms are an important pharmacotherapeutic consideration due to the extensive CYP metabolism of tacrolimus (TAC) and variable expression among different races. The CPIC…
  • 2019 American Transplant Congress

    Dosing Requirements Of Astagraf Xl In African American Kidney Transplant Recipients Converted From Twice-daily Tacrolimus (aaaktrs)

    J. N. Fleming, M. A. Posadas-Salas, D. J. Taber

    Medical University of South Carolina, Charleston, SC

    *Purpose: Pharmacokinetics from clinical studies demonstrated similar drug exposure (AUC) and correlation between trough (C0) and AUC between tacrolimus IR and Astagraf XL, which led…
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