ATC Abstracts

American Transplant Congress abstracts

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Articles tagged "Dosage"

  • 2020 American Transplant Congress

    A Novel Formula to Determine Optimal Immunosuppression in Renal Transplant Recipients Treated with Tacrolimus and Mycophenolate Mofetil: Towards Individualized Immunosuppression

    O. Pankewycz1, M. Laftavi1, E. Onan2, D. Rucker1, D. Wang1, K. Bhuta1, R. Gruessner3, A. Gruessner3

    1SUNY, Upstate Medical University, Syracuse, NY, 2Cukurova University, Adana, Turkey, 3SUNY, Downstate Medical University, New York, NY

    *Purpose: Tacrolimus (TAC) and mycophenolic acid (MPA) remain the most commonly used drug combination for kidney transplant immunosuppression. Adequate drug dosing is challenging due to…
  • 2020 American Transplant Congress

    Late Intra-Patient Tacrolimus Variability Predicts De Novo Donor-Specific Antibody and Graft Loss

    J. Lee1, E. Kim1, S. Yang2, S. Kim1, H. Choi3, B. Kim4, M. Ju5, M. Kim2, S. Kim2, Y. Kim2, K. Huh2

    1Department of Transplantation Surgery, Severance Hospital, Seoul, Korea, Republic of, 2Department of Transplantation Surgery, Severance Hospital, Yonsei University College of Medicine, Seoul, Korea, Republic of, 3Department of Internal Medicine, Gangnam Severance Hospital, Yonsei University College of Medicine, Seoul, Korea, Republic of, 4Department of Internal Medicine, Severance Hospital, Seoul, Korea, Republic of, 5Department of Surgery, Gangnam Severance Hospital, Yonsei University College of Medicine, Seoul, Korea, Republic of

    *Purpose: Intra-patient variability (IPV) of tacrolimus level has been associated with poor outcomes after kidney transplantation. However, these findings were limited mainly to measurements early…
  • 2020 American Transplant Congress

    Dosing and Outcomes of Conversion to Extended-Release Tacrolimus in Heart and Lung Transplant Recipients

    C. Doligalski1, K. Walter1, P. Chang2, L. J. Lobo2

    1University of North Carolina Medical Center, Chapel Hill, NC, 2Department of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC

    *Purpose: Extended release tacrolimus (LCP-Tac) is a novel once daily formulation with improved pharmacokinetic parameters compared to immediate release tacrolimus (IR-Tac). LCP-Tac use in renal…
  • 2020 American Transplant Congress

    De Novo Dosing of LCP-Tacrolimus Using Conservative Weight-Based Strategy Resulted in Supratherapeutic Trough Levels in Majority of Patients

    J. Dann, J. Geyston, M. Wassimi, K. Brayman, A. Doyle

    University of Virginia Health System, Charlottesville, VA

    *Purpose: Due to ongoing national drug shortages, our center transitioned to de novo use of LCP-tacrolimus (LCPT) in kidney transplant patients using a conservative dosing…
  • 2020 American Transplant Congress

    De Novo Dosing and Trough Attainment Trends of Extended-Release Tacrolimus in the Absence of Dose Adjustments

    M. J. Moritz1, D. R. Stevens2, U. Meier-Kriesche2, T. A. Horwedel2

    1Department of Surgery, Lehigh Valley Health Network, Allentown, PA, 2Veloxis Pharmaceuticals, Cary, NC

    *Purpose: Initial dosing of tacrolimus extended-release tablets (LCPT) was 0.17 mg/kg/day in the pivotal trial in de novo kidney transplant recipients. Dosing subsequent to the…
  • 2020 American Transplant Congress

    Safety and Efficacy of Valganciclovir for Cytomegalovirus Prophylaxis in Solid Organ Transplant Patients on Hemodialysis

    D. E. Ecabert, C. Pham, B. J. Pierce, W. L. Musick

    Houston Methodist Hospital, Houston, TX

    *Purpose: Cytomegalovirus (CMV) is the most common viral infection after solid organ transplant (SOT) and is associated with significant morbidity and mortality. Valganciclovir (VGCV) is…
  • 2020 American Transplant Congress

    Exposure to Tacrolimus Trough Levels Below 6ng/ml During the First Year is Associated with Inferior Kidney Graft Survival

    T. Agur, B. Rozen-Zvi, R. Rahamimov

    Department of Nephrology and Hypertension, Rabin Medical Center, Petah Tikva, Israel

    *Purpose: Accumulating data indicates that sub-therapeutic levels of calcineurin inhibitors are associated with long-term graft loss. However, while widely used tacrolimus (TAC) was shown to…
  • 2020 American Transplant Congress

    Comparing Weight-Based Dosing of Envarsus XR in Obese and Non-Obese Renal Transplant Recipients

    N. Breslin, N. Jandovitz, V. Nair, M. Abate, L. Teperman

    North Shore University Hospital, Manhasset, NY

    *Purpose: Tacrolimus has a narrow therapeutic window and significant inter- and intra-patient variability leading to variations in drug concentration. The recommended initial weight-based dose of…
  • 2019 American Transplant Congress

    Not All Poor Metabolizers Are Clinically Equal: Evaluating Weight-Based Tacrolimus Outcomes in CYP3A Loss of Function Variants

    A. Q. Maldonado, W. Irish, T. E. Asempa, J. Gooden, M. L. Davis, C. Haisch, H. Jones, D. Leeser, L. Rebellato

    Vidant Medical Center - Transplant Services, Greenville, NC

    *Purpose: CYP3A polymorphisms are an important pharmacotherapeutic consideration due to the extensive CYP metabolism of tacrolimus (TAC) and variable expression among different races. The CPIC…
  • 2019 American Transplant Congress

    Dosing Requirements Of Astagraf Xl In African American Kidney Transplant Recipients Converted From Twice-daily Tacrolimus (aaaktrs)

    J. N. Fleming, M. A. Posadas-Salas, D. J. Taber

    Medical University of South Carolina, Charleston, SC

    *Purpose: Pharmacokinetics from clinical studies demonstrated similar drug exposure (AUC) and correlation between trough (C0) and AUC between tacrolimus IR and Astagraf XL, which led…
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