2021 American Transplant Congress
Avoiding Tacrolimus Under- and Overexposure with a Dosing Algorithm for Renal Transplant Recipients: A Single Arm Prospective Intervention Trial
*Purpose: Bodyweight-based tacrolimus dosing followed by therapeutic drug monitoring is standard clinical care after renal transplantation. However, after transplantation, a meagre 38% of patients is…2021 American Transplant Congress
Modeling of Alternative Weight-Based Dosing Strategies of LCP-Tacrolimus in De Novo Kidney Transplant Patients
*Purpose: LCP-tacrolimus (LCPT; Envarsus XR®) is a modified-release once-daily formulation approved for prophylaxis of organ rejection in de novo kidney transplant patients in combination with…2021 American Transplant Congress
Anterior Rectus Sheath versus Standard Gibson Approach to Kidney Transplantation: A Randomized Double-blinded Controlled Trial
Glickman Urological and Kidney Institute, Cleveland Clinic, Cleveland, OH
*Purpose: Purpose: The anterior rectus sheath (ARS) approach to kidney transplantation (KT) involves a small skin incision to incise the ARS and medially retract rectus…2021 American Transplant Congress
Tacrolimus Dose Requirements in Lung Transplant Recipients on Systemic Azole Antifungals: The Influence of Race and Transplant Indication
*Purpose: CYP3A5 polymorphisms, drug interactions, and alterations in gastric absorption impact tacrolimus metabolism. This is important for those at higher risk of expressing these factors,…2021 American Transplant Congress
Impact of the Transplant Clinical Pharmacist in an Outpatient Transplant Clinic
1Emory University Hospital, Atlanta, GA, 2Emory Transplant Center, Atlanta, GA
*Purpose: Pharmacist involvement in the outpatient transplant clinic setting has been correlated with improved patient outcomes in single organ cohort studies. Direct clinical pharmacist involvement…2021 American Transplant Congress
Letermovir Prophylaxis in Solid Organ Transplant – CMV Breakthrough and Tacrolimus Drug Interaction
*Purpose: Valganciclovir is the preferred drug for cytomegalovirus (CMV) prophylaxis in solid organ transplantation. A limitation to its use is profound myelosuppression. Letermovir is a…2020 American Transplant Congress
De Novo Dosing and Trough Attainment Trends of Extended-Release Tacrolimus in the Absence of Dose Adjustments
*Purpose: Initial dosing of tacrolimus extended-release tablets (LCPT) was 0.17 mg/kg/day in the pivotal trial in de novo kidney transplant recipients. Dosing subsequent to the…2020 American Transplant Congress
Safety and Efficacy of Valganciclovir for Cytomegalovirus Prophylaxis in Solid Organ Transplant Patients on Hemodialysis
Houston Methodist Hospital, Houston, TX
*Purpose: Cytomegalovirus (CMV) is the most common viral infection after solid organ transplant (SOT) and is associated with significant morbidity and mortality. Valganciclovir (VGCV) is…2020 American Transplant Congress
Exposure to Tacrolimus Trough Levels Below 6ng/ml During the First Year is Associated with Inferior Kidney Graft Survival
Department of Nephrology and Hypertension, Rabin Medical Center, Petah Tikva, Israel
*Purpose: Accumulating data indicates that sub-therapeutic levels of calcineurin inhibitors are associated with long-term graft loss. However, while widely used tacrolimus (TAC) was shown to…2020 American Transplant Congress
Comparing Weight-Based Dosing of Envarsus XR in Obese and Non-Obese Renal Transplant Recipients
North Shore University Hospital, Manhasset, NY
*Purpose: Tacrolimus has a narrow therapeutic window and significant inter- and intra-patient variability leading to variations in drug concentration. The recommended initial weight-based dose of…
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