Articles tagged "Donors"

2018 American Transplant Congress
Intensified Immunosuppression Improves Early Renal Allograft Function after Transplantation in a Porcine Model with Extended Asystolic Warm Ischemic Time
M. Xu,¹ X. Wang,¹ S. Garcia-Aroz,¹ B. Banan,¹ B. Rabe,¹ Z. Zhang,¹ J. Jia,¹ G. Upadhya,¹ P. Manning,² J. Gaut,³ Y. Lin,¹ W. Chapman.¹
¹Department of Surgery, Section of Abdominal Transplantation, Washington University School of Medicine, St. Louis, MO; ²Arch Oncology, St. Louis, MO; ³Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO.
PURPOSE: Extensive ischemia-reperfusion injury significantly increases the immunogenicity of renal allograft which may be associated with increased risk of acute rejection (AR). This study investigated…
2018 American Transplant Congress
Reliability of Deceased Donor Procurement Biopsy Images at the Time of Kidney Allocation
S. Mansour,¹ E. Hall,² P. Reese,³ Y. Jia,¹ H. Thiessen-Philbrook,¹ G. Moeckel,¹ F. Weng,⁴ P. Revelo,² M. Khalighi,² A. Trivedi,⁵ M. Doshi,⁶ B. Schroppel,⁷ C. Parikh.¹
¹Yale University School of Medicine, New Haven; ²University of Utah School of Medicine, Salt Lake City; ³Perelman School of Medicine at the University of Pennsylvania, Philadelphia; ⁴Saint Barnabas Medical Center, Livingston; ⁵Hartford Hospital, Hartford; ⁶Wayne State University, Detroit; ⁷University Hospital, Ulm, Germany.
Histological findings of procurement deceased-donor kidney biopsies contribute to organ allocation decisions. Representative images of pathology on biopsy slides are often uploaded into United Network…
2018 American Transplant Congress
Self-Reported Post-Surgical Pain Following Living Kidney Donation
A. Fleishman,¹ J. Schold,² P. Morrissey,³ J. Whiting,⁴ J. Vella,⁴ L. Kayler,⁵ D. Katz,⁶ J. Jones,⁶ B. Kaplan,⁷ M. Pavlakis,¹ D. Mandelbrot,⁸ J. Rodrigue.¹
¹Beth Israel Deaconess Medical Center, Boston; ²Cleveland Clinic, Boston; ³Rhode Island Hospital, Providence; ⁴Maine Medical Center, Portland; ⁵University of Buffalo, Buffalo; ⁶University of Iowa, Iowa City; ⁷May Clinic, Scottsdale; ⁸University of Wisconsin, Madison.
The Kidney Donor Outcomes Cohort (KDOC) is an NIH-funded observational cohort study evaluating outcomes in living kidney donors (LKDs) at 6 US centers. LKDs completed…
2018 American Transplant Congress
Predicting Early and Late eGFR Variability in Kidney Transplant Recipients
K. Soliman, D. Taber, S. Zemin, V. Rao.
Department of Medicine and Department of Surgery, MUSC, Charleston, SC.
Introduction: eGFR variability is a known risk factor for graft loss. It is unclear what modifiable factors are significantly associated with this variability and if…
2018 American Transplant Congress
Outcomes of Renal Transplants from Donors with Positive Blood or Urine Cultures
L. Chen,¹ D. Kamiyama,² L. Francalacci,¹ E. Zhu,² M. Donnelley,² N. Clayton,² K. Alman,¹ A. De Mattos,¹ J. Brown.³
¹Transplant Nephrology, UC Davis Medical Center, Sacramento, CA; ²Pharmacy, UC Davis Medical Center, Sacramento, CA; ³Infectious Diseases, UC Davis Medical Center, Sacramento, CA.
OBJECTIVES: To evaluate outcomes in renal transplant recipients who received organs from donors with positive blood or urine cultures.METHODS: We performed a retrospective, single-center study…
2018 American Transplant Congress
Use of Hepatitis-C Treatments after Kidney Transplantation: Impact of the Direct-Acting Antiviral Era
K. Lentine, D. Axelrod,² R. Bloom,³ H. Xiao,¹ D. Segev,⁴ T. Alhamad,⁵ H. Randall,¹ R. Ouseph,¹ V. Dharnidharka,⁵ D. Brennan,⁴ N. Lam,⁶ A. Naik,⁷ G. Hess,⁸ B. Kaiske,⁹ M. Schnitzler.¹
¹Saint Louis U, St. Louis; ²Lahey, Burlington; ³U Penn, Philadelphia; ⁴Johns Hopkins, Baltimore; ⁵Washington U, St. Louis; ⁶U Alberta, Edmonton, Canada; ⁷U Michigan, Ann Arbor; ⁸Hennepin, Minneapolis; ⁹Symphony Health, Conshohocken.
Hepatitis C virus (HCV) infection in kidney transplant (KTx) donors or recipients has correlated with adverse outcomes, partly due to limited treatment options. Development of…
2018 American Transplant Congress
Livers from Donation after Circulatory Death Donors Can Be Safely Used for Retransplantation
O. van Leeuwen,¹ M. van Reeven,² J. Erdmann,³ H. Metselaar,⁴ A. van den Berg,⁵ B. van Hoek,⁶ W. Polak,² R. Porte.¹
¹Department of Surgery, University Medical Center Groningen, Groningen, Netherlands; ²Department of Surgery, Erasmus Medical Center, Rotterdam, Netherlands; ³Department of Surgery, Leiden University Medical Center, Leiden, Netherlands; ⁴Department of Gastroenterology and Hepatology, Erasmus Medical Center, Rotterdam, Netherlands; ⁵Department of Gastroenterology and Hepatology, University Medical Center Groningen, Groningen, Netherlands; ⁶Department of Gastroenterology and Hepatology, Leiden University Medical Center, Leiden, Netherlands.
Introduction: After donation after circulatory death (DCD) liver transplantation (LT), non-anastomotic biliary strictures (NAS) and early allograft dysfunction (EAD) are more frequently observed than after…
2018 American Transplant Congress
Hard-To-Place Kidney Offers: System- Level Predictors of Discard
L. Kayler,¹ J. Nie,² K. Noyes,² M. Leeman,³ R. Narvaez.¹
¹Dept of Surgery, University at Buffalo, Buffalo, NY; ²Dept of Epidemiology and Environmental Health, University at Buffalo, Buffalo, NY; ³Jacobs School of Medicine and Biomedical Sciences, University at Buffalo, Buffalo, NY.
Background: Deceased-donor kidney discard rates remain high. Inefficiencies in the allocation of hard-to-place kidneys may be contributing to discard suggesting that system-level factors represent opportunities…
2018 American Transplant Congress
Diffuse Optical Non-Invasive Organ Risk (DONOR) Indexing Using Diffuse Reflectance Spectroscopy for Pre-Transplant Evaluation
H. Borron,¹ D. Piao,² A. Hawxby,³ H. Wright,³ E. Rubin.⁴
¹College of Medicine, University of Oklahoma, Oklahoma City, OK; ²School of Electrical and Computer Engineering, Oklahoma State University, Stillwater, OK; ³Oklahoma Transplant Center, University of Oklahoma Health Sciences Center, Oklahoma City, OK; ⁴Pathology, University of Oklahoma, Oklahoma City, OK.
Purpose: Due to large transplant waitlists, a rapid, non-invasive method to evaluate organ quality for transplantation is needed. Diffuse optical spectroscopy (DOSi) is an optical…
2018 American Transplant Congress
Comparison of Continuous Normothermic Ex Vivo Kidney Perfusion to Hypothermic Preservation Methods in Pig Kidneys Donated after Cardiac Death
M. Hamar,^1,2 P. Urbanellis,¹ D. Kollmann,¹ I. Linares,¹ M. Kaths,¹ D. Bagli,³ A. Konvalinka,⁴ I. Mucsi,¹ A. Ghanekar,¹ L. Robinson,² M. Selzner.¹
¹Multi Organ Transplant Program, TGH, Toronto, ON, Canada; ²Division of Nephrology, The Hospital of Sick Children, Toronto, ON, Canada; ³Dept. of Surgery (Urology) & Physiology, The Hospital of Sick Children, Toronto, ON, Canada; ⁴Dept. of Medicine and Institute of Medical Science, UHN and Univ. of Toronto, Toronto, ON, Canada.
Background: Strategies to decrease preservation-related injury in renal grafts donated after circulatory death urgently needed. This highlights the importance of direct comparison of dynamic preservation…

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