Articles tagged "Donors"

2016 American Transplant Congress
Abrogating Donor-Derived Myd88 Signaling Impairs the Recruitment of Recipient Neutrophils and CD8 T Cells into Lung Allografts in Mice.
Z. Zheng,¹ J.-J. Wang,¹ X. Yeap,¹ X. Kang,¹ Y. Xie,¹ X. Luo,² Z. Zhang.¹
¹Comprehensive Transplant Center, Northwestern University Feinberg School of Medicine, Chicago, IL; ²Division of Nephrology and Hypertension, Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL.
Objectives: Transplant ischemia reperfusion injury (IRI) mediated primary graft dysfunction (PGD) remains the predominant cause of short- and long-term graft loss in lung transplantation. This…
2016 American Transplant Congress
Understanding the Initial Rise in Kidney Discard Rates Observed Post-KAS.
D. Stewart,¹ A. Kucheryavaya,¹ R. Brown,¹ D. Klassen,¹ N. Turgeon,² M. Aeder.³
¹UNOS, Richmond, VA; ²Emory Univ, Atlanta, GA; ³Univ Hosp Case Med Ctr, Cleveland, OH.
Background: Kidney discard rates increased by 10% -- from 18.3% to 20.2% (p=0.001) -- during the first 7 months of KAS but returned to pre-KAS…
2016 American Transplant Congress
Outcomes of Solid Organ Transplants Following Simultaneous Solid Organ and Vascularized Composite Allograft Procurements.
M. Alhefzi,¹ M. Aycart,¹ G. Sharma,² N. Krezdorn,¹ E. Bueno,¹ S. Talbot,¹ M. Carty,¹ B. Pomahac,¹ S. Tullius.³
¹Department of Surgery, Division of Plastic Surgery, Brigham and Women's Hospital, Harvard Medical School, Boston, MA; ²Department of Surgery, Brigham and Women's Hospital, Harvard Medical School, Boston, MA; ³Department of Surgery, Division of Transplant Surgery, Brigham and Women's Hospital, Harvard Medical School, Boston, MA.
Background: Current knowledge of the impact of facial vascularized composite allograft (VCA) procurement on the transplantation outcomes of the concomitantly recovered life-saving organs is limited…
2016 American Transplant Congress
Rapid Withdrawal of Donation After Cardiac Death Donors.
K. Mekeel,¹ J. Trageser,² W. Garrison,² J. Berumen,¹ L. Stocks,² A. Hemming.¹
¹Surgery, University of California-San Diego, La Jolla, CA; ²Lifesharing, San Diego, CA.
Purpose: Potential organ donors may be lost if procurement needs to occur emergently due to hemodynamic instability or family request, in particular if serologies and…
2016 American Transplant Congress
Inferior Outcomes in Hepatitis C Virus Positive Donors to Hepatitis C Virus Negative Kidney Recipients: Analysis of National Data.
H. Fattah, L. Kang, H. Dave, D. Kumar, A. King, C. Bhati, A. Sharma, G. Gupta.
Virginia Commonwealth University, Richmond, VA.
Background: Kidney transplantation (KTxp)with HCV kidneys (HCV D+)may represent a safe resource to expand the donor pool, and to reduce waiting time in patients with…
2016 American Transplant Congress
Resolution of Donor Non-Alcoholic Fatty Liver Disease Following Liver Transplantation.
A. Posner,¹ W. Twaddell,² S. Hanish,² D. Bruno,² W. Hutson,² L. Hebert,² R. Barth,² J. LaMattina.²
¹University of Maryland School of Medicine, Baltimore, MD; ²Division of Transplantation, University of Maryland School of Medicine, Baltimore, MD.
Purpose: Severe and moderate degrees of donor liver steatosis have traditionally limited the transplantation of these organs. The natural history of successfully transplanted livers with…
2016 American Transplant Congress
Hypothermic Machine Perfusion Ameliorates Vasospasm and Edema of Podocytes and Renal Tubular Epithelial Cells Through Upregulating Expression of Krüppel-Like Factors 2.
Z. Zhong,¹ D. Ko,² Y. Wang,¹ Q. Ye.¹
¹Zhongnan Hospital of Wuhan University, Institute of Hepatobiliary Diseases of Wuhan University, Wuhan, Hubei, China; ²Massachusetts General Hospital, Department of Urology, Harvard Medical School, Boston, MA.
Protective mechanisms of hypothermic machine perfusion (MP) remain largely unknown. Vascular branches of the renal arteries of 6 kidneys in 320 donors were unexpectedly injured…
2016 American Transplant Congress
Differential Effect of Delayed Graft Function (DGF) on Kidney Transplant Outcomes: When Does DGF Not Make a Difference?
M. Khan,¹ H. El-Hennawy,¹ A. Farney,¹ J. Rogers,¹ G. Orlando,¹ A. Reeves-Daniel,² A. Palanisamy,² M. Gautreaux,³ S. Iskandar,³ W. Doares,⁴ S. Kaczmorski,⁴ R. Stratta.¹
¹Surgery, Wake Forest, Winston-Salem, NC; ²Internal Medicine, Wake Forest, Winston-Salem, NC; ³Pathology, Wake Forest, Winston-Salem, NC; ⁴Pharmacy, Wake Forest, Winston-Salem, NC.
Delayed graft function (DGF), defined as need for dialysis in 1st week following kidney transplant (KT), is an early surrogate marker of organ quality and…
2016 American Transplant Congress
A Risk Quantification Score for Heart Transplants: A Heart Donor Risk Index.
A. Israni,^1,2 D. Zaun,¹ J. Snyder,¹ N. Salkowski,¹ H. Xiong,¹ B. Kasiske,^1,2 M. Colvin,^1,3 M. Colvin.^1,3
¹Scientific Registry of Transplant Recipients, Minneapolis; ²Hennepin County Medical Center, Univ of MN, Minneapolis; ³Univ of Michigan, Ann Arbor.
Background: To better risk stratify heart transplants, we developed a continuous heart donor risk index (HDRI) based on heart donors to quantify heart allograft failure.Methods:…
2016 American Transplant Congress
Kidney Donor Profile Index Trend Analyses.
D. Vikraman, K. Ravindra, S. Sanoff, W. Irish, U. Patel, D. Sudan.
Surgery, Duke University Medical Center, Durham, NC.
IntroductionIn spite of improved outcomes associated with the usage of extended criteria donor (ECD) kidneys, the number of kidney transplants (KT) using this donor population…