Articles tagged "Donors, marginal"

2020 American Transplant Congress
Hepatologist and Surgeon Experiences Counseling Liver Transplant Candidates for an Organ Offer Decision
C. Schaffhausen¹, M. Bruin², S. Chu³, S. Chinnakotla⁴, J. R. Lake⁵, A. K. Israni⁶
¹Hennepin Heathcare Research Institute (HHRI), Minneapolis, MN, ²College of Design, University of Minnesota (UMN), Minneapolis, MN, ³College of Design, UMN, Minneapolis, MN, ⁴Department of Surgery, UMN, Minneapolis, MN, ⁵Division of Gastroenterology, Hepatology, and Nutrition, UMN, Minneapolis, MN, ⁶Department of Medicine, Hennepin Healthcare, UMN, Minneapolis, MN
*Purpose: Liver transplant candidates receive counseling during evaluations to understand donor risk factors. After long periods on the waitlist, candidates who receive an offer for…
2020 American Transplant Congress
Highly Effective Short Course Therapy to Prevent Infection after Transplantation from HCV-Infected Organ Donors to Uninfected Recipients across Multiple Organ Types
A. Humar¹, M. Cypel¹, D. Kumar¹, H. Dahari², R. Vanin Pinto Ribeiro¹, N. Marks¹, N. Kamkar¹, I. Bahinskaya¹, F. Onofrio³, M. A. Zahoor³, O. Cerrochi³, K. Tinckam¹, S. J. Kim¹, T. W. Reichman¹, M. McDonald¹, T. K. Waddell¹, G. Sapisochin¹, M. Selzner¹, S. Keshavjee¹, H. L. Janssen³, B. E. Hansen³, L. Singer¹, J. Feld³
¹Transplant Centre, Toronto General Hospital, Toronto, ON, Canada, ²Loyala University, Chicago, IL, ³Toronto General Hospital, Toronto, ON, Canada
*Purpose: An increasing percentage of potential organ donors are infected with hepatitis C virus (HCV). Establishment of HCV infection in uninfected recipients is near-universal with…
2020 American Transplant Congress
Comparison of Specificity and Sensitivity of Clinical Viability Criteria to Assess Transplantability of High-Risk Donor Livers
H. Mergental¹, J. Hodson², R. W. Laing¹, Y. L. Boteon¹, J. Attard¹, L. Wallis³, A. Schlegel¹, P. Muiesan¹, M. Abradelo¹, M. P. Perera¹, D. Mirza⁴, S. C. Afford³
¹Liver Unit, Queen Elizabeth Hospital, Birmingham, United Kingdom, ²Department of Statistics, Queen Elizabeth Hospital, Birmingham, United Kingdom, ³Centre for Liver and Gastroenterology Research, University of Birmingham, Birmingham, United Kingdom, ⁴Liver Unit, Darius Mirza, Birmingham, United Kingdom
*Purpose: Normothermic machine perfusion (NMP) of the liver allows objective assessment before transplantation. To date, Birmingham (BC), Cambridge (CC) and Groningen Criteria (GC; Table 1A)…
2020 American Transplant Congress
One Organ Procurement Organization Coordinates 43% of All Uncontrolled Donation after Circulatory Determination of Death Donors Recovered in the United States Over 24 Years
R. D. Hasz, S. M. West, H. M. Nathan
Gift of Life Donor Program, Philadelphia, PA
*Purpose: An IOM report published in 2006 estimated that 22,000 potential uncontrolled Donation after Circulatory Determination of Death (uDCDD) donors die each year in the…
2020 American Transplant Congress
The Effect of Donor Transaminase Levels on Graft Survival Following Liver Transplantation: An OPTN Database Analysis
I. A. Ziogas¹, P. N. Martins², S. P. Alexopoulos¹, L. K. Matsuoka¹, S. K. Geevarghese¹, L. D. Gorden¹, S. J. Karp¹, J. D. Perkins³, M. I. Montenovo¹
¹Vanderbilt University Medical Center, Nashville, TN, ²UMass Memorial Medical Center, Worcester, MA, ³University of Washington, Seattle, WA
*Purpose: The scarcity of organs for liver transplantation (LT) does not meet the increased demand for donor grafts. Although the outcomes of LT utilizing grafts…
2020 American Transplant Congress
Safety of A2 Incompatible Kidney Transplantation in Donors with Acute Kidney Injury
Y. Al Azzi, L. Liriano-Ward, G. Nair, M. Ajaimy, J. Graham, C. Pynadath, P. Nandigam, A. Colovai, A. Campbell, S. Greenstein, M. Kinkhabwala, J. Rocca, E. Akalin
Abdominal Transplant, Montefiore Medical Center, New York, NY
*Purpose: Kidneys with donor acute kidney injury (AKI) are frequently discarded. We aimed to study the outcomes of A2 incompatible kidney transplantation from donors with…
2020 American Transplant Congress
DCD vs DBD Liver Transplantation: Equivalent Charges and Similar Survival- An Effective Expansion of the Donor Pool
N. Singh, K. Helfrich, M. Alebrahim, C. Akateh, K. Mumtaz, A. Logan, A. Schenk, S. Black, E. Elkhammas, K. Washburn, A. El-Hinnawi
Ohio State University, Columbus, OH
*Purpose: The shortage of allografts available for liver transplantation (LT) has prompted the need for expansion of donor pool to include donation after circulatory death…
2020 American Transplant Congress
End-Hypothermic Oxygenated Machine Perfusion after Static Cold Storage versus Static Cold Storage Alone in Kidneys from Extended Criteria Brain-Dead Donors: An International Randomized Controlled Trial
P. Husen¹, C. Boffa², I. Jochmans³, C. Krikke⁴, L. Davies², H. Hofker⁴, J. Pirenne³, R. Ploeg², A. Paul¹
¹General, Visceral and Transplantation Surgery, University Hospital Essen, Essen, Germany, ²Nuffield Department of Surgical Sciences, University of Oxford, Oxford, United Kingdom, ³University Hospitals Leuven, Leuven, Belgium, ⁴University Medical Center Groningen, Groningen, Netherlands
*Purpose: A prospective, randomized, single-blinded, multicenter trial comparing the effect of short-term 'in house' oxygenated hypothermic machine preservation (End-HMPO2) following static cold storage (SCS) versus…
2020 American Transplant Congress
Normothermic Machine Perfusion of Extended Criteria Donor Livers: Identification of Protein Biomarkers Predictive of Graft Viability and Post-Transplant Complications
L. L. Wallace¹, J. Attard¹, Y. Boteon¹, R. Laing¹, J. Yu², T. Perera³, D. Mirza³, H. Mergental³, S. Afford¹
¹Centre for Liver and Gastrointestinal Research, University of Birmingham and the NIHR Biomedical Research Centre, UHB NHS Foundation Trust, Birmingham, United Kingdom, ²School of Biosciences, Advanced Mass Spectrometry Facility, University of Birmingham, Birmingham, United Kingdom, ³Liver Unit, The Queen Elizabeth Hospital, Birmingham, United Kingdom
*Purpose: The Viability Testing and Transplantation of mArginal donor Livers Clinical Trial (VITTAL) demonstrated the capacity of Normothermic Machine Perfusion (NMP) to increase the proportion…
2020 American Transplant Congress
KDPI-Based Kidney Discard Risk Assessment
S. Mehrotra¹, M. Barah², K. Bui³
¹IEMS Department, MEAS, Northwestern University, Evanston, IL, ²IEMS Department, Northwestern University, Evanston, IL, ³Department of Mathematics, University of California, Irvine, Irvine, CA
*Purpose: Despite the vital need, 3,553 (19%) deceased-donor kidneys were discarded in 2018 in the current US allocation system. The discard rate has remained at…