Articles tagged "Donors, marginal"

2021 American Transplant Congress
Allograft Discard Risk Index for Heart Transplantation
R. M. Reul¹, A. A. Saleem¹, C. N. Keller¹, T. H. Malik¹, J. A. Goss², A. A. Rana²
¹Office of Student Affairs, Baylor College of Medicine, Houston, TX, ²Michael E. DeBakey Department of Surgery, Baylor College of Medicine, Houston, TX
*Purpose: The number of patients awaiting heart transplantation (HTx) substantially exceeds the number of donor hearts transplanted each year, yet nearly 70% of consented donor…
2021 American Transplant Congress
Transplanting Hepatitis C Infected Organs Into Uninfected Recipients: A Pharmacy Perspective
M. L. Holt, A. James, K. Gutierrez, T. Sparkman, J. Banbury, D. Jones
University of Alabama at Birmingham Hospital, Birmingham, AL
*Purpose: Due to direct acting antivirals (DAAs), hepatitis C virus (HCV) positive patients are now resources for organ transplantation in HCV negative recipients. Our institution…
2021 American Transplant Congress
Long Term Outcomes of Kidney Transplantation from Deceased Donors with Terminal Acute Kidney Injury
J. Rogers¹, R. Stratta², A. Farney², G. Orlando², C. Jay², A. Reeves-Daniel³, A. Mena-Gutierrez³, N. Sakhovskaya³, K. Gurung², B. Sharda², J. Rogers²
¹Surgery, Wake Forest School of Medicine, Winston Salem, NC, ²Surgery, Wake Forest Baptist Medical Center, Winston Salem, NC, ³Internal Medicine, Wake Forest Baptist Medical Center, Winston Salem, NC
*Purpose: Long term outcomes of kidney transplantation from deceased donors with terminal acute kidney injury (AKI) are not well defined.*Methods: Single center retrospective review of…
2021 American Transplant Congress
Donor Factors Associated with In-field Decline of Heart Allografts
L. Piechura, F. Yazdchi, M. Harloff, H. Shim, M. Keshk, A. Coppolino, III, D. Rinewalt, H. Mallidi
Brigham and Women's Hospital, Boston, MA
*Purpose: The decline of organs upon assessment within the field complicates optimal organ and resource utilization. We aimed to investigate if certain donor factors were…
2021 American Transplant Congress
Indocyanine Green Fluorescence Imaging Allows Quantification of Ischemic Injury During Porcine Normothermic Ex Situ Perfusion
T. Goto, Y. Noguchi, S. Ganesh, L. Mazilescu, T. Reichman, N. Selzner, M. Selzner
Ajmera Transplant Program, Department of Surgery, Toronto General Hospital, Toronto, ON, Canada
*Purpose: Normothermic Ex Situ Liver Perfusion (NEsLP) is a novel preservation technique for the storage and assessment of grafts retrieved after Donation after Cardio-circulatory Death…
2021 American Transplant Congress
Kidney Transplantation from Marginal Donors: An Increased Risk of Urinary Complication. Study from 10279 Patients
B. Mesnard¹, M. Leroy², J. Hunter³, D. Kervella¹, M. Timsit⁴, L. Badet⁵, P. Glemain¹, E. Morelon⁵, F. Buron⁵, M. Le Quintrec-Donnette⁶, V. Pernin⁶, M. Ladriere⁷, S. Girerd⁷, C. Legendre⁴, A. Sicard⁸, L. Albano⁸, S. De Vergie¹, C. Kerleau¹, T. Prudhomme⁹, J. Rigaud¹, D. Cantarovich¹, G. Blanchot¹, G. Karam¹, M. Giral¹, S. Ville¹, J. Branchereau¹
¹Department of Urology, Chu Nantes, Nantes Université, ITUN, Nantes, France, Nantes, France, ²Department of Urology, Chu Nantes, Nantes Université, France, Nantes, France, ³Department of Urology, Nuffield Department of Surgical Science ,Oxford, Oxford, United Kingdom, ⁴Service de transplantation rénale, Hôpital Necker AP-HP, Paris, France, ⁵Service de transplantation, néphrologie et immunologie clinique, Hôpital Edouard Herriot, Hospices de Lyon, Lyon, France, ⁶Service de néphrologie-soins intensifs-dialyse et transplantation, Hôpital Lapeyronie, Montpellier, France, ⁷Service de transplantation rénale, CHU Brabois, Nancy, France, ⁸Service de néphrologie, Hôpital Pasteur, Nice, France, ⁹Service urologie, andrologie et transplantation rénale, Hôpital Rangeuil, CHU de Toulouse, Toulouse, France
*Purpose: Due to the increasing need of kidneys suitable for transplantation, we have expanded the donor population to include marginal donors (Extended criteria donor, controlled…
2021 American Transplant Congress
Allograft Discard Risk Index for Lung Transplantation
R. M. Reul, G. Loor, P. S. Garcha, A. A. Rana
Baylor College of Medicine, Houston, TX
*Purpose: The demand for donor lungs continues to outpace the supply, yet nearly 80% of donor lungs consented for lung transplantation (LTx) are discarded.*Methods: We…
2021 American Transplant Congress
Hepatic Ferroptosis in Cold Stress and Warm Ischemia-reperfusion: A Novel Therapeutic Target in Liver Transplantation
H. Kojima¹, H. Hirao¹, K. Kadono¹, T. Ito¹, K. J. Dery¹, S. Kageyama², K. Nakamura³, F. M. Kaldas¹, D. G. Farmer¹, J. W. Kupiec-Weglinski¹
¹UCLA Medical Center, Los Angeles, CA, ²Kyoto University, Kyoto, Japan, ³Nishi-Kobe Medical Center, Kyoto, Japan
*Purpose: Ferroptosis, a newly discovered programmed cell death platform, due to iron-dependent accumulation of lipid peroxides, has been reported to aggravate ischemia-reperfusion (IR) injury in…
2021 American Transplant Congress
Can an Organ Survive for More Than 100 Years Between Donor and Recipient
R. Gruessner, J. Renz, A. C. Gruessner
SUNY Downstate Medical Center, Brooklyn, NY
*Purpose: It has been hypothesized that parenchymal grafts have a longer life expectancy than the cardio-cerebro-vascular system. We investigated the occurrence of deceased-donor liver (DDOLT),…
2020 American Transplant Congress
Multi-Center, Open-Label Trial of Pre-Emptive Glecaprevir/Pibrentasvir (G/P) to Treat Recipients of Transplanted Kidneys from Deceased Donors with Hepatitis C Virus (MYTHIC)
M. Sise¹, D. Goldberg², J. Kort³, D. Schaubel⁴, R. Alloway⁵, C. Durand⁶, R. Fontana⁷, J. Friedewald⁸, R. Brown⁹, S. Prenner¹⁰, R. Landis⁴, P. Reese¹¹, R. Chung¹
¹Internal Medicine - Nephrology, MGH, Boston, MA, ²Hepatology and Transplantation, U Miami, Miami, FL, ³Abbvie, Chicago, IL, ⁴Department of Biostatistics, U Penn, Philadelphia, PA, ⁵Department of Internal Medicine - Nephrology and Hypertension, U Cincinnati, Cincinnati, OH, ⁶Department of Medicine, JHU, Baltimore, MD, ⁷Internal Medicine - Gastroenterology, U Michigan, Ann Arbor, MI, ⁸Internal Medicine - Nephrology and Hypertension, Northwestern, Chicago, IL, ⁹Internal Medicine - Hepatology, Weill Cornell, NYC, NY, ¹⁰Internal Medicine - Gastroenterology, U Penn, Philadelphia, PA, ¹¹Transplant Nephrology, U Penn, Philadelphia, PA
*Purpose: Kidneys from Hepatitis C virus (HCV)-infected deceased donors continue to be discarded at high rates despite small, successful studies of HCV-viremic donors into uninfected…