2022 American Transplant Congress
Increasing Proportion of High-Risk Cytomegalovirus (CMV) Donor Positive/recipient Negative (D+R-) Serostatus in Solid Organ Transplant Recipients (SOTRs)
*Purpose: CMV D+R- serostatus is independently associated with worse long-term graft and patient survival across many organ transplant types despite current prevention and treatment strategies.…2022 American Transplant Congress
Suppressive Effect of De Novo Everolimus on Primary Cytomegalovirus Infection in Kidney Transplant Recipient
*Purpose: It has been reported that everolimus (EVR) administration reduces the incidence of cytomegalovirus (CMV) infection, but clinical outcome in CMV-seronegative recipients with EVR-based regimen…2022 American Transplant Congress
Mass Cytometry Reveals Single-cell Kinetics Of Cytotoxic Lymphocyte Evolution In Cmv-infected Renal Transplant Patients
*Purpose: Cytomegalovirus (CMV) infection is associated with graft rejection in renal transplantation. Memory-like NK cells expressing NKG2C and lacking FcεRIγ are established during CMV infection.*Methods:…2022 American Transplant Congress
Cytomegalovirus Prophylaxis in Pediatric Liver Transplantation: A Comparison of Strategies Across the SPLIT Consortium
*Purpose: To compare the effectiveness of short (180d) cytomegalovirus (CMV) prophylaxis in pediatric liver transplantation (pLTX).*Methods: A prospective cohort study of primary pLTX (≤18 yrs…2022 American Transplant Congress
Evaluation of Prophylactic Valganciclovir Dosing in Kidney Transplant Recipients at an Urban Transplant Institution
*Purpose: Dosing and duration of cytomegalovirus (CMV) prophylaxis with valganciclovir (VGC) in kidney transplant (KT) recipients is variable by transplant center. Prior studies have shown…2022 American Transplant Congress
Circulating Plasma Proteomics Analysis of CMV Infection in Kidney Transplantation
1UCSF, San Francisco, CA, 2UCLA, Los Angeles, CA, 3Harvard Medical School, Boston, MA
*Purpose: Cytomegalovirus (CMV) infection is a threat to kidney transplantation. We studied circulating host proteome perturbations due to CMV infection in kidney transplantation as it…2022 American Transplant Congress
Does a Second Transplant Increase the Risk for CMV Infection? An Evaluation of the Incidence of CMV Viremia in the Previously Transplanted Kidney Recipient
*Purpose: Cytomegalovirus (CMV) viremia is a common complication of kidney transplant recipients (KTR) with significant morbidity/mortality. Patients who receive multiple transplants are potentially at a…2022 American Transplant Congress
Impact of Dysgeusia on Transplant Recipients with Refractory Cytomegalovirus with/without Resistance Receiving Maribavir: Post-Hoc Analyses from a Phase 3 Randomized Trial
*Purpose: In a Phase 3 study (SOLSTICE; NCT02931539), maribavir (MBV) was superior to investigator-assigned therapies (IAT; val/ganciclovir, foscarnet, or cidofovir) for CMV clearance at Wk…2022 American Transplant Congress
Impact of Cytomegalovirus Infection on mRNA Expression Utilizing the Molecular Microscope in Heart Transplant Recipients
Cardiology, Baylor University Medical Center, Dallas, TX
*Purpose: Little is known about the effect of CMV infection on transplant messenger RNA expression utilizing the molecular microscope (MMDx) in the absence of acute…2022 American Transplant Congress
Assessment of Letermovir as Universal Prophylaxis for Cytomegalovirus Infection in Lung Transplant Recipients
*Purpose: Cytomegalovirus (CMV) poses a significant concern in the post-operative management of lung transplant (LT) recipients. Current recommended prophylactic strategies with ganciclovir (GCV) or valganciclovir…
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