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Articles tagged "Cytomeglovirus"

  • 2017 American Transplant Congress

    Association of BK and CMV Viremia with Pancreas Allograft Survival Among Adults Receiving Simultaneous Pancreas and Kidney Transplant: The Wisconsin Allograft Recipient Database (WisARD).

    F. Aziz, B. Astor, S. Parajuli, N. Garg, B. Muth, D. Mandelbrot, A. Djamali, D. Kaufman, J. Odorico, H. Sollinger, M. Mohamed.

    Department of Medicine, University of Wisconsin, Madison, WI

    Knowing impact of BKV viremia and CMV infection on pancreas allograft outcome post Simultaneous Pancreas and Kidney transplant (SPK) may improve allograft long-term survival and…
  • 2016 American Transplant Congress

    Do Morbidly Obese Patients Have an Increased Risk of Infection Post-Kidney Transplant?

    S. Strout, N. Pilch, T. Veasey, R. Miller, J. Fleming, H. Meadows, C. Mardis, B. Mardis, P. Baliga, A. Posadas, J. McGillicuddy, D. Taber.

    Medical University of South Carolina, Charleston, SC.

    Purpose: Obesity has been associated with significant morbidity in the kidney transplant population. The aim of this study was to assess the impact of obesity…
  • 2016 American Transplant Congress

    CMV Monitoring Reduces Risk of Clinical Complications in Kidney Transplant Recipients.

    A. Gilbert, M. Cooper, J. Verbesey, R. Ghasemian, P. Abrams, J. Moore, M. Grafals, J. Chahine, S. Punnett, E. Hall, I. Anzak, B. Javaid.

    MedStar Georgetown Transplant Institute, Georgetown University School of Medicine, Washington, DC.

    Objective: Review the advantages of CMV viral load monitoring in preventing CMV associated complications in kidney transplant recipientsMethods: All individuals who underwent a kidney transplant…
  • 2016 American Transplant Congress

    Assessing Return of CMV Specific Cellular Immunity Using the T-SPOT.CMV Soon After Kidney Transplant with Thymoglobulin.

    C. Kotton.

    Infectious Disease, Massachusetts General Hospital, Boston, MA.

    Background: We do not currently have sufficient predictive tools to determine risk of CMV infection after organ transplantation. Recent data suggest that assays of the…
  • 2016 American Transplant Congress

    CMV-Accelerated Cardiac Allograft Rejection Is Associated with Dysregulation of Sphingolipid Metabolomics.

    J. Burg,1 T. Andoh,2 N. Haese,2 C. Kreklywich,2 K. Watters,3 T. Metz,3 S. Orloff,1 D. Streblow.2

    1Abdominal Organ Transplantation, OHSU, Portland, OR; 2VGTI, OHSU, Portland, OR; 3Biological Sciences Division, PNNL, Richland, WA.

    PurposeCytomegalovirus (CMV) infection accelerates transplant vascular sclerosis (TVS) and chronic rejection (CR) in solid organ transplants. Sphingolipid metabolism plays an immunomodulatory role in transplant rejection,…
  • 2016 American Transplant Congress

    Direct Detection of T and B Memory Lymphocytes Reveals HCMV Exposure That Serum Antibodies Fail to Identify.

    S. Sundararaman, F. Terlutter, T. Nowacki, R. Caspell, P. Lehmann.

    Research and Development, Cellular Technology Ltd, Shaker Hts, OH.

    It is essential to identify donors who have not been infected with HCMV in order to avoid transmission of HCMV to human recipients of transfusion…
  • 2016 American Transplant Congress

    Association of Cytomegalovirus-Specific T Cell-Mediated Immunity with the Risk of CMV Infection Occurrence in Kidney Transplant Recipients.

    D. Dęborska-Materkowska,1 A. Perkowska-Ptasińska,1 A. Sadowska,1 D. Sitarek,1 J. Gozdowska,1 M. Ciszek,2 M. Serwańska-Świętek,3 A. Jóźwik,3 P. Domagała,3 A. Kwiatkowski,3 M. Durlik.1

    1Department of Transplantation Medicine, Nephrology and Internal Diseases, Warsaw Medical University, Warsaw, Poland; 2Department of Immunology, Transplantology and Internal Diseases, Warsaw Medical University, Warsaw, Poland; 3Department of General and Transplantation Surgery, Warsaw Medical University, Warsaw, Poland.

    Introduction CMV remains the significant cause of morbidity in transplant recipients. Despite universal prophylaxis, late CMV infection occurs in high proportion of kidney transplant recipients.…
  • 2016 American Transplant Congress

    Characterization of Resistant Cytomegalovirus in Lung Transplant Recipients in the Modern Era.

    S. Hammad, L. Shah, M. Restivo, H. Robbins, J. Scheffert.

    NewYork-Presbyterian Hospital, New York, NY.

    Cytomegalovirus (CMV) remains a major cause of morbidity and mortality in lung transplant recipients (LTR) and the emergence of resistant CMV (rCMV) has increased. The…
  • 2016 American Transplant Congress

    Tissue Priming of Plasmacytoid Dendritic Cells Enhances Their Phagocytosis and Lowers the Threshold for Subsequent Toll-Like Receptor 7/9 Activation.

    J. Ruben,1 G. Garcia-Romo,1 E. Breman,1 S. van der Kooij,1 A. Redeker,2 R. Arens,2 C. van Kooten.1

    1Nephrology, Leiden University Medical Centre, Leiden, Netherlands; 2Immunohematology and Blood Transfusion, Leiden University Medical Centre, Leiden, Netherlands.

    Plasmacytoid dendritic cells (pDC) have a pivotal role in clearing viral infections, and can regulate tolerance or immunity depending on their activation status. We have…
  • 2016 American Transplant Congress

    Human MicroRNA Responses Are Predictive of CMV Reactivation Following Solid Organ Transplant.

    S. Han,1 D. Kumar,1 V. Ferreira,1 S. Husain,1 N. Mueller,2 A. Humar,1 M. Mian,1 P. Ashton.1

    1Multi Organ Transplant Program, University Health Network, Toronto, Canada; 2Swiss Transplant Cohort Study, University Hospital Zurich, Zurich, Switzerland.

    Background: Human microRNA (miRNA) can suppress gene expression through binding to the 3' untranslated region (UTR) of the target mRNA. In silico analysis shows that,…
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