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Articles tagged "Cytomeglovirus"

  • 2017 American Transplant Congress

    Kidney Transplant Allocation with CMV Matching Reduces CMV Infection and Related Costs.

    J. Lockridge,1 E. Langewisch,2 D. Basuli,1 A. Olyaei,3 C. Shaut,4 D. Norman.1

    1Division of Nephrology, Department of Medicine, Oregon Health and Science University, Portland, OR; 2Nephrology, University of Nebraska, Omaha, NE; 3Pharmacy, Oregon Health and Sciences University, Portland, OR; 4Immunogenetics and Transplant, Oregon Health and Sciences University, Portland, OR

    Cytomegalovirus (CMV) infection is a major cause of morbidity, mortality, and shortened graft survival in kidney transplant recipients. Efforts to prevent CMV infection have traditionally…
  • 2017 American Transplant Congress

    Reproducibility of the Cobas CMV Test (cobas CMV) and Clinical Concordance with the Cobas Ampliprep / Cobas TaqMan CMV Test (CAP/CTM CMV).

    P. Baum,1 J. Yao,2 A. Butcher,1 P. Hemyari,1 A. Valsamakis,3 S. Young.4

    1Roche Diagnostics, Pleasanton, CA; 2Mayo, Rochester, MN; 3JHMI, Baltimore, MD; 4Tricore, Albuquerque, NM

    cobas CMV is a new, automated, high-throughput assay for use on the cobas 6800/8800 systems that quantifies CMV DNA in EDTA-plasma. It can be run…
  • 2017 American Transplant Congress

    Kidney Allocation Using CMV Matching Optimizes Low and High Risk Profiles for Prevention of CMV Infection in Kidney Transplant Recipients.

    J. Lockridge,1 E. Langewisch,2 D. Basuli,1 A. Olyaei,3 C. Shaut,4 D. Norman.1

    1Division of Nephrology, Department of Medicine, Oregon Health and Science University, Portland, OR; 2Nephrology, University of Nebraska, Omaha, NE; 3Pharmacy, Oregon Health and Sciences University, Portland, OR; 4Immunogenetics and Transplant, Oregon Health and Sciences University, Portland, OR

    Cytomegalovirus (CMV) confers a major impact on morbidity, mortality, and graft survival in kidney transplant recipients. Efforts to prevent CMV disease and infection have traditionally…
  • 2017 American Transplant Congress

    Cytomegalovirus Renal Infection: Rare Manifestation of a Common Post-Transplant Viral Infection — A Case Series.

    M. Posadas Salas, J. Thompson, T. Ngo, S. Self.

    MUSC, Charleston, SC

    Cytomegalovirus is the most common viral infection in organ transplant recipients. CMV disease commonly manifests as meningoencephalitis, pneumonitis, hepatitis, and colitis. Kidney involvement of CMV…
  • 2017 American Transplant Congress

    Contribution of New Generation Sequencing to CMV Resistance Analysis in Renal Transplant Recipients (on Behalf of the CMV Resist Group).

    C. Danthu,1 M. Gomes-Mayeras,1 D. Andouard,2 E. Munteanu,1 R. Moulinas,1,4 G. Ligat,2 S. Hantz,1,2 J. Rerolle,3 F. Garnier,1 M. Essig,3 S. Alain.1,2,4

    1National Reference Center for CMV-Virology, CHU Limoges, Limoges, France; 2UMR Inserm 1092, Université Limoges, Limoges, France; 3Nephrology, CHU Limoges, Limoges, France; 4GenoLim/Biscem Genomic Platform, Université Limoges, Limoges, France

    Results from the French Cohorts 2006-2010 and OrphaVic (NCTNCT02067169) indicates that fifty percent of graft failures in renal recipients infected by HCMV after treatment with…
  • 2017 American Transplant Congress

    Cost Effectiveness of Post-Prophylaxis Screening Strategies for Cytomegalovirus Viremia in CMV D+R- Kidney Transplant Recipients.

    C. Puttarajappa,1 S. Hariharan,1 K. Smith.2

    1Renal-Electrolyte Division, University of Pittsburgh, Pittsburgh, PA; 2Section of Decision Sciences, Department of Medicine, University of Pittsburgh, Pittsburgh, PA

    Purpose: To assess cost-effectiveness(CE) of screening for CMV after 6 months of valganciclovir prophylaxis in CMV high-risk (D+R-) kidney transplant recipients.Methods: A Markov model was…
  • 2017 American Transplant Congress

    Immediate vs Delayed Initiation of CMV Prophylaxis…Safe and Cost Beneficial?

    L. Cotiguala, A. Carlson, C. Truax, B. Sirandas, I. Hall, L. Smith.

    University of Utah Health Care, Salt Lake City, UT

    Background: Recommendations differ on when to initiate valganciclovir (VGCV) for CMV prophylaxis (ppx) after tx. Current labeling states within 10 days of tx. We evaluated…
  • 2017 American Transplant Congress

    Prospective Randomized Trial for Predicting CMV Infection According to Baseline CMV-Specific T-Cell Immunity in Kidney Transplant Patients.

    M. Jarque,2 E. Melilli,1 A. Gutierez,3 F. Moreso,4 L. Guirado,5 A. Manonelles,1 J. Cruzado,1,2 S. Luque,2 E. Crespo,2 N. Montero,1 F. Diekman,6 J. Grinyó,1,2 O. Bestard.1

    1Nephrology Dep, Bellvitge Hospital, Barcelona, Spain; 2Nephrology Laboratory, IDIBELL, Barcelona, Spain; 3Kidney Transplant Unit, Hospital Miguel Servet, Zaragoza, Spain; 4Kidney Transplant Unit, Hospital Vall d'Hebrón, Barcelona, Spain; 5Kidney Transplant Unit, Fundació Puigvert, Barcelona, Spain; 6Kidney Transplant Unit, Hospital Clínic, Barcelona, Spain

    Background: Despite the use of either anti-viral prophylaxis (PF) or preemptive (PE) therapy given based on donor/recipient IgG-serostatus, Cytomegalovirus (CMV) reactivation persists after kidney transplantation…
  • 2017 American Transplant Congress

    Utility of “High-Dose” Ganciclovir in High Viral Load CMV Infection in Transplant Recipients.

    M. Alfares, R. Avery, N. Turki, K. Alfares, S. Mehta, R. Boger, A. Valsamakis.

    Transplant & Oncology Infectious Disease, Johns Hopkins, Baltimore, MD; Transplant & Oncology Infectious Disease, Johns Hopkins, Baltimore, MD; Transplant & Oncology Infectious Disease, Johns Hopkins, Baltimore, MD; Transplant & Oncology Infectious Disease, Johns Hopkins, Baltimore, MD; Transplant & Oncology Infectious Disease, Johns Hopkins, Baltimore, MD; Pediatric Infectious Disease, Johns Hopkins, Baltimore, MD; Pathology, Johns Hopkins, Baltimore, MD

    Background: High-dose ganciclovir (GCV) is often used for treatment of high viral load CMV, but few data exist on virologic outcomes and risk of neutropenia.…
  • 2017 American Transplant Congress

    Rates of CMV Infection in Kidney Transplant Recipients Who Received Subtherapeutic Valganciclovir Prophylaxis.

    K. Belfield, E. Cohen, M. Malinis, A. Baghban.

    Department of Pharmacy, Yale-New Haven Hospital, New Haven, CT; Department of Medicine, Yale-New Haven Hospital, New Haven, CT

    Purpose: The aim of this study was to compare the rate of cytomegalovirus (CMV) infection after kidney transplantation in high and intermediate risk patients who…
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