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American Transplant Congress abstracts

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Articles tagged "Cytomeglovirus"

  • 2018 American Transplant Congress

    Transplantation Tolerance Prevents CMV Reactivation and Preserves Kidney Allograft Function in a D+/R- Transplant Setting

    A. Dangi,1 J-.J. Wang,2 M. Burnette,1 Z. Zhang,2 X. Luo.1,2

    1Division of Nephrology and Hypertension, Department of Medicine, Northwestern University, Chicago, IL; 2Comprehensive Transplant Center, Department of Surgery, Northwestern University, Chicago, IL.

    Background: Immune responses to cytomegalovirus (CMV) infection may precipitate acute/chronic graft rejection in immunocompromised transplant recipients. CMV infection can be primary or its reactivation from…
  • 2018 American Transplant Congress

    High Grade Cytomegalovirus Viremia Events in Solid Organ Transplant Recipients: Description and Quality Improvement

    M. Spinner,1 V. Athans,1 C. Koval.2

    1Dept. of Pharmacy, Cleveland Clinic, Cleveland, OH; 2Dept. of Infectious Diseases, Cleveland Clinic, Cleveland, OH.

    Background: High grade cytomegalovirus viremia (HGCMVV) often results in symptomatic disease requiring IV antiviral therapy and is associated with CMV recurrence and resistance. We postulated…
  • 2018 American Transplant Congress

    Ten Years of Low-Dose Valganciclovir; Evaluating the Incidence and Risk Factors of CMV in Kidney Transplant Recipients

    S. El Hajj, J. Azzi, M. Kim, S. Gabardi.

    Pharmacy, Cleveland Clinic Abu Dhabi, Abu Dhabi, United Arab Emirates; Kidney Transplant, Brigham and Women's Hospital, Boston; Kidney Transplant, Brigham and Women's Hospital, Boston.

    Introduction: Cytomegalovirus (CMV) remains one the most clinically relevant and frequent post-transplant infections. Despite the availability of effective antiviral drugs, CMV continues to be of…
  • 2018 American Transplant Congress

    Macrophage Depletion of RCMV-Latently Infected Allografts Ameliorates Accelerated Chronic Cardiac Rejection

    J. Burg,1 N. Haese,2 T. Andoh,2 C. Kreklywich,2 I. Jones,2 S. Orloff,1 D. Streblow.2

    1Abdominal Organ Transplantation, OHSU, Portland, OR; 2VGTI, OHSU, Portland, OR.

    PurposeLatent donor rat cytomegalovirus (RCMV) infection accelerates chronic rejection (CR) in a heterotopic rat heart transplant model. RCMV latency is associated with an influx of…
  • 2018 American Transplant Congress

    Mayo Clinic's First Face Transplant: 17 Months On

    H. Amer, S. Jowsey-Gregoire, C. Rosen, R. Razonable, K. Reid, M. Gandhi, L. Ewoldt, B. Edwards, S. Mardini.

    The Essam and Dalal Obaid Reconstructive Transplant Center and the William J von Liebig Center for Transplantation and Clinical Regeneration, Mayo Clinic, Rochester, MN.

    Mayo Clinic established a reconstructive transplant program as an extension of clinical practice in 2010. A 31-year-old Caucasian male had significant functional limitations and disfigurement…
  • 2018 American Transplant Congress

    Defective Innate Immune Response to Opportunistic Pathogens in Cytomegalovirus-Infected Monocytes

    P. Sen, A. R. Wilkie, R. Fernandes, R. J. Lane, S. E. Hickman, T. K. Means, E. R. Rosenberg, D. M. Coen, J. A. Fishman, J. El Khoury.

    Transplant and Immunocompromised Group, Division of Infectious Diseases, Massachusetts General Hospital, Boston, MA; Department of Biological Chemistry and Pharmacology, Harvard Medical School, Boston, MA.

    Human cytomegalovirus (CMV) is the most common infection encountered in transplantation and is an important cause of morbidity and mortality in both solid organ and…
  • 2018 American Transplant Congress

    Pneumocystis jiroveci Pneumonia (PJP) in Kidney and Pancreas Transplant Recipients in the Present Era of Routine Post-Transplant Prophylaxis: Risk Factors and Outcomes

    N. Garg, M. Jorgenson, M. Birschbach, J. Descourouez, S. Parajuli, B. Astor, A. Djamali, D. Mandelbrot.

    University of Wisconsin, Madison.

    PJP after transplant (TX) is associated with substantial morbidity and mortality. In the present era of universal and routine implementation of PJP prophylaxis (PPX) during…
  • 2018 American Transplant Congress

    NKG2C+CD57+ NK (G2C+57+) Cells Expanded by CMV Infection Are Highly Responsive to Allo-Antibody (Ab)-Mediated NK Cell Stimulation

    B. Shin,1 D. Puliyanda,2 H. Pizzo,2 S. Jordan,2 M. Toyoda.1

    1Transplant Immunology Laboratory, Cedars-Sinai Medical Center, Los Angeles, CA; 2Comprehensive Transplant Center, Cedars-Sinai Medical Center, Los Angeles, CA.

    Introduction: Active CMV infection is known to be associated with risk for ABMR in allograft recipients. Ab-dependent cellular cytotoxicity (ADCC) primarily mediated by NK cells…
  • 2017 American Transplant Congress

    Evaluation of Cytomegalovirus Prophylaxis Regimens in Intestinal Transplant Recipients: A Single Center Experience.

    M. Eley,1 M. Keck,1 D. Collier,2 M. Vacha.1

    1Department of Pharmaceutical and Nutrition Care, Nebraska Medicine, Omaha, NE; 2College of Pharmacy: Department of Pharmacy Practice, University Of Nebraska Medical Center, Omaha, NE

    Purpose: To evaluate the incidence of cytomegalovirus (CMV) infection in intestinal transplant recipients after a change in an antiviral regimen.Methods: This was a retrospective review…
  • 2017 American Transplant Congress

    Ganciclovir Resistant Cytomegalovirus Infection in Abdominal Tansplant Recipients.

    J. Fose, M. Jorgenson, K. Rolling, E. McCreary, D. Mandelbrot, J. Smith.

    University of Wisconsin Hospital and Clinics, Madison

    Purpose: Single center evaluation of ganciclovir-resistant cytomegalovirus (GR-CMV) incidence, treatment and outcomes.Methods: Review of adult abdominal transplant (aSOT) recipients from 1/1/1995-12/31/2015 with documented GR-CMV infection.Results:…
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