Articles tagged "Cytomeglovirus"

2018 American Transplant Congress
Mayo Clinic's First Face Transplant: 17 Months On
H. Amer, S. Jowsey-Gregoire, C. Rosen, R. Razonable, K. Reid, M. Gandhi, L. Ewoldt, B. Edwards, S. Mardini.
The Essam and Dalal Obaid Reconstructive Transplant Center and the William J von Liebig Center for Transplantation and Clinical Regeneration, Mayo Clinic, Rochester, MN.
Mayo Clinic established a reconstructive transplant program as an extension of clinical practice in 2010. A 31-year-old Caucasian male had significant functional limitations and disfigurement…
2018 American Transplant Congress
Defective Innate Immune Response to Opportunistic Pathogens in Cytomegalovirus-Infected Monocytes
P. Sen, A. R. Wilkie, R. Fernandes, R. J. Lane, S. E. Hickman, T. K. Means, E. R. Rosenberg, D. M. Coen, J. A. Fishman, J. El Khoury.
Transplant and Immunocompromised Group, Division of Infectious Diseases, Massachusetts General Hospital, Boston, MA; Department of Biological Chemistry and Pharmacology, Harvard Medical School, Boston, MA.
Human cytomegalovirus (CMV) is the most common infection encountered in transplantation and is an important cause of morbidity and mortality in both solid organ and…
2018 American Transplant Congress
Pneumocystis jiroveci Pneumonia (PJP) in Kidney and Pancreas Transplant Recipients in the Present Era of Routine Post-Transplant Prophylaxis: Risk Factors and Outcomes
N. Garg, M. Jorgenson, M. Birschbach, J. Descourouez, S. Parajuli, B. Astor, A. Djamali, D. Mandelbrot.
University of Wisconsin, Madison.
PJP after transplant (TX) is associated with substantial morbidity and mortality. In the present era of universal and routine implementation of PJP prophylaxis (PPX) during…
2018 American Transplant Congress
NKG2C+CD57+ NK (G2C+57+) Cells Expanded by CMV Infection Are Highly Responsive to Allo-Antibody (Ab)-Mediated NK Cell Stimulation
B. Shin,¹ D. Puliyanda,² H. Pizzo,² S. Jordan,² M. Toyoda.¹
¹Transplant Immunology Laboratory, Cedars-Sinai Medical Center, Los Angeles, CA; ²Comprehensive Transplant Center, Cedars-Sinai Medical Center, Los Angeles, CA.
Introduction: Active CMV infection is known to be associated with risk for ABMR in allograft recipients. Ab-dependent cellular cytotoxicity (ADCC) primarily mediated by NK cells…
2018 American Transplant Congress
Viral-Specific Cytotoxic T-Cell (Viral-Tc) Responses in Highly-HLA-Sensitized Patients (HS) Maintained on Tacrolimus and Everolimus Post-HLAi Kidney Transplant
S. Ge,¹ M. Chu,¹ A. Karasyov,¹ D. Lovato,¹ J. Kahwaji,² A. Vo,¹ J. Choi,¹ S. Louie,¹ S. Jordan,¹ M. Toyoda.¹
¹Comprehensive Transplant Center, Cedars-Sinai Medical Center, Los Angeles, CA; ²Kidney Transplantation, Kaiser Permanente Medical Center, Los Angeles, CA.
Introduction: Viral infections represent significant infectious complications post- kidney transplant which may be increased with desensitization. CMV, EBV and BKV infections are the most prevalent.…
2018 American Transplant Congress
CMV and BKV Infections after Kidney Transplantation: Combined Tacrolimus/everolimus Strategy Using Antithymocyte Globulin Induction
T. Jouve,^1,4 R. Germi,^2,4 B. Janbon,¹ G. Fiard,^3,4 P. Malvezzi,¹ L. Rostaing.^1,4
¹Nephrology, Dialysis, Apheresis, Transplantation Unit, Grenoble University Hospital, Grenoble, France; ²Virology Unit, Grenoble University Hospital, Grenoble, France; ³Urology Unit, Grenoble University Hospital, Grenoble, France; ⁴Medical Sciences, Grenoble University, Grenoble, France.
Cytomegalovirus (CMV) and BK Virus (BKV) infections are frequent complications after kidney transplantation. A combined regimen of calcineurin inhibitor (CNI) and mTOR inhibitors (mTORi) reduces…
2018 American Transplant Congress
Altered Function of Cytomegalovirus Specific T Cells in Transplant Recipients
L. Higdon,¹ J. Trofe-Clark,² S. Liu,¹ N. Saligrama,¹ K. Margulies,² M. Davis,¹ J. Maltzman.^1,3
¹Stanford U, Stanford, CA; ²U Pennsylvania, Philadelphia, PA; ³VA Palo Alto, Palo Alto, CA.
Background: Cytomegalovirus (CMV) reactivation is associated with increased morbidity and mortality in transplant recipients. CMV establishes latency for the host's lifetime and frequently reactivates. Immunosuppression,…
2018 American Transplant Congress
Clinical Significance of Tacrolimus Trough Level at the Early Period after Kidney Transplantation
W. Park,^1,2 S. Yeo,¹ S. Kang,^1,2 H. Park,¹ K. Jin,^1,2 S. Park,^1,2 S. Han.^1,2
¹Internal Medicine, Keimyung University School of Medicine, Daegu, Republic of Korea; ²Keimyung University Kidney Institute, Daegu, Republic of Korea.
Background:The stable immunosuppressant level at the early period after kidney transplantation (KT) is one of the most important factors to decide the prognosis of KT.…
2018 American Transplant Congress
The TRANSFORM Study: Infection Outcomes with Everolimus Plus Reduced Calcineurin Inhibitor and Mycophenolate Plus Standard Calcineurin Inhibitor Regimens in De Novo Kidney Transplant Recipients
F. Vincenti, J. Cruzado, S. Mulgaonkar, V. Garcia, D. Kuypers, M. Buchler, F. Citterio, U. Huynh-Do, W-.L. Luo, P. Bernhardt, C. Sommerer.
TRANSFORM Study Group, Novartis Pharma AG, Basel, Switzerland.
Purpose: Post-transplant (Tx) bacterial and viral infections are known to affect graft and patient survival. Accumulating evidence supports the protective effect of everolimus (EVR) against…
2018 American Transplant Congress
Primary Cytomegalovirus Infection in Seronegative Kidney Transplant Patients is Associated with Prolonged Cold Ischemic Time of Seropositive Donor Organs
C. Falk,^1,7 F. Schlott,^2,7 K. Katsrintaki,^1,7 D. Steubl,³ W. Puppe,⁴ C. Blume,⁵ H. Haller,⁶ L. Renders,³ U. Heemann,³ D. Busch,² M. Neuenhahn.^2,7
¹Institute of Transplant Immunology, IFB-Tx, Hannover Medical School, Hannover, Germany; ²Institute for Medical Microbiology, Immunology and Hygiene, Technical University Munich, Munich, Germany; ³Department of Nephrology, Technical University Munich, Munich, Germany; ⁴Institute of Virology, Hannover Medical School, Hannover, Germany; ⁵Institute of Technical Chemistry, Leibniz University Hannover, Hannover, Germany; ⁶Department of Nephrology and Hypertension, Hannover Medical School, Hannover, Germany; ⁷DZIF TTU-IICH, DZIF, Hannover / Munich, Germany.
Introduction: Human Cytomegalovirus (CMV) infection is still a major risk factor for immunocompromised patients, e.g. kidney recipients. Based on the CMV serostatus of donor (D)…