Articles tagged "COVID-19"

2022 American Transplant Congress
Multicenter Effort Assessing the Effects of COVID Infection and Vaccination on HLA Antibodies in Waitlisted Patients with ESRD
G. R. Roll¹, M. Cooper², H. Gebel³, K. M. Hitchman⁴, M. Hobeika⁵, J. Houp⁶, M. Kamoun⁷, J. Killian⁸, J. Kim⁹, V. Kumar¹⁰, M. Levine¹¹, T. Lunow-Luke¹, R. Parsons¹², D. Ranch¹³, P. Stock¹⁴, S. Yi¹⁵, R. Rajalingam¹⁶
¹UCSF Medical Center, San Francisco, CA, ²MedStar Georgetown Transplant Institute, Washington, DC, ³Emory University Hospital, Atlanta, GA, ⁴Pathology and Laboratory Medicine, University of Texas Health San Antonio, San Antonio, TX, ⁵Houston Methodist, Houston, TX, ⁶University of Alabama, Birmingham, AL, ⁷Hospital Univ of Pennsylvania, Philadelphia, PA, ⁸University of Alabama at Birmingham, Birmingham, AL, ⁹Surgery, Keck Medicine of USC, Los Angeles, CA, ¹⁰University of Alabama at Birmingham Hospital, Birmingham, AL, ¹¹University of Pennsylvania, Philadelphia, Pe, ¹²Emory University School of Medicine, Atlanta, GA, ¹³UT Health San Antonio, San Antonio, TX, ¹⁴Univ of California-San Francisco, San Francisco, CA, ¹⁵Houston Methodist Hospital, Houston, TX, ¹⁶Immunogenetics and Transplantation Laboratory (ITL), San Francisco, CA
*Purpose: Although rare, infection and vaccination have been reported to result in human leukocyte antibodies (HLA). We analyzed the effect of SARS-CoV2 infection, or COVID-19…
2022 American Transplant Congress
Transplant Graft TMA Injury Post COVID-19 Vaccination
O. Sogbein, A. Rizvi, M. Mujtaba, S. Hussain
Internal Medicine, Division of Nephrology, University of Texas Medical Branch, Galveston, TX
*Purpose: Vaccination against SARS-CoV-2 is essential. Complicating this effort are reports of a suboptimal response to the SARS-CoV-2 spike protein in patients on immunosuppressive medications…
2022 American Transplant Congress
Impact of the Second Year COVID-19 Pandemic on the U.S. Kidney Transplantation: Interrupted Time Series Analysis
E. Tantisattamo¹, N. Polpichai², P. Mutirangura³, M. Tanariyakul⁴
¹Division of Nephrology, Hypertension and Kidney Transplantation, Department of Medicine, University of California Irvine School of Medicine, Orange, CA, ²Faculty of Medicine Songklanagarin Hospital, Prince of Songkla University, Songkhla, Thailand, ³Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand, ⁴Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand
*Purpose: The number of kidney transplant (KT) was decreased since the COVID-19 pandemic; however, the magnitude of the pandemic on the number of U.S. KT…
2022 American Transplant Congress
A Third Dose of SARS-CoV-2 Vaccine Increases Neutralizing Antibodies Against Variants of Concern in Solid Organ Transplant Recipients
A. H. Karaba¹, X. Zhu¹, T. Ling¹, K. H. Wang¹, A. G. Rittenhouse¹, O. Akinde¹, Y. Eby¹, J. E. Ruff¹, J. N. Blankson¹, A. T. Abedon¹, J. L. Alejo¹, A. L. Cox¹, J. R. Bailey¹, E. A. Thompson¹, S. L. Klein¹, D. S. Warren¹, J. M. Garonzik-Wang², B. J. Boyarsky¹, I. Sitaras¹, A. Pekosz¹, D. L. Segev¹, A. A. Tobian¹, W. A. Werbel¹
¹Johns Hopkins University, Baltimore, MD, ²University of Wisconsin School of Medicine and Health, Madison, WI
*Purpose: Vaccine-induced SARS-CoV-2 antibody responses are attenuated in solid organ transplant recipients (SOTRs) and breakthrough infections are more common. Additional SARS-CoV-2 vaccine doses increase anti-spike…
2022 American Transplant Congress
Sensitization and BK Viremia; Risk Following Sub-Clinical COVID-19 Infection in Pediatric Kidney Transplant Recipients
E. Benz¹, M. Chandran², J. Chuita¹, K. McKinnon¹, A. Sikora¹, M. Bock¹, E. Blanchette¹
¹Children's Hospital Colorado, Aurora, CO, ²University of North Carolina, Chapel Hill, NC
*Purpose: In contrast to high morbidity and mortality of COVID-19 infection (COVIDi) in adult kidney transplant (KT) recipients, these sequelae appear to be muted in…
2022 American Transplant Congress
Early Clinical Experience With Nirmatrelvir/ritonavir For Treatment Of Covid-19 In Solid Organ Transplant Recipients
D. Salerno¹, D. Jennings², N. Lange³, D. Kovac¹, T. Shertel¹, J. Chen⁴, J. Hedvat⁵, J. Scheffert¹, R. S. Brown⁶, M. Pereira⁷
¹NewYork-Presbyterian Hospital, New York, NY, ²Long Island University, Brooklyn, NY, ³Pharmacy, NewYork-Presbyterian Hospital, New York, NY, ⁴Columbia University Irving Medical Center, Fort Lee, NJ, ⁵New York Presbyterian Hospital, Tenafly, NJ, ⁶Weill Cornell Medicine, New York, NY, ⁷New York Presbyterian Hospital, New York, NY
*Purpose: Nirmatrelvir/ritonavir use has not yet been described in solid organ transplant recipients (SOTR) who become infected with COVID-19. The objective of our study was…
2022 American Transplant Congress
Outcomes After Covid-19 Infection in Transplant Recipients
K. L. Freels¹, K. Saharia², J. Baddley², N. Costa³, S. Niederhaus⁴
¹University of Maryland School of Medicine, Baltimore, MD, ²Medicine, University of Maryland School of Medicine, Baltimore, MD, ³Medicine, Georgetown University, Washington, DC, ⁴Surgery, University of Maryland School of Medicine, Baltimore, MD
*Purpose: The purpose of this study is to evaluate outcomes of readmission, rejection, graft dysfunction, graft failure, and death in SOT recipients (SOTR) after COVID-19…
2022 American Transplant Congress
An Analysis of Serological Response and Infection Outcomes Following Oxford Astra-Zeneca (azd1222) and Pfizer-Biontech (mRNA BNT162b2) SARS-CoV-2 Vaccines in Kidney and Pancreas Transplant Patients
A. Asderakis¹, U. Khalid¹, G. Koimtzis¹, M. Ponsford², L. Szabó¹, L. Grant², S. Jolles², I. Humphreys³
¹Cardiff Transplant Unit, University Hospital of Wales, Cardiff, United Kingdom, ²Immunodeficiency Centre for Wales, University Hospital of Wales, Cardiff, United Kingdom, ³Division of Infection and Immunity, Cardiff University, Cardiff, United Kingdom
*Purpose: SARS-CoV-2 is associated with high mortality among transplant recipients. This study aims to compare the humoral responses between the Oxford-Astra-Zeneca(AZ) and BNT162b2(Pfizer-BioNTech) vaccines in…
2022 American Transplant Congress
Knowledge, Attitude, and Practices Regarding Covid-19 Among Solid Organ Transplant Patients at a Transplant Center in the United States: A Cross-Sectional Study
L. Wang, H. Oduor, M. Abualfoul, P. Acharya, M. Pagadala
Methodist Dallas Medical Center, Dallas, TX
*Purpose: To evaluate the knowledge, attitude, and practices (KAP) of patients who have undergone kidney and/or liver solid organ transplants (SOTs) during the COVID-19 pandemic.*Methods:…
2022 American Transplant Congress
B Cells Fit for Germinal Center Activity Predict Response to a Third Dose of SARS-CoV-2 Vaccine in Solid Organ Transplant Recipients
E. A. Thompson¹, A. H. Karaba¹, K. Cascino¹, K. Roznik¹, T. Chiang¹, L. Biavatti¹, A. T. Abedon¹, J. L. Alejo¹, S. L. Klein¹, J. N. Blankson¹, D. S. Warren¹, C. X. Qin¹, J. Mitchell¹, J. M. Garonzik-Wang², B. J. Boyarsky¹, D. L. Segev¹, A. A. Tobian¹, W. A. Werbel¹, A. L. Cox¹, J. R. Bailey¹
¹Johns Hopkins University, Baltimore, MD, ²University of Wisconsin School of Medicine and Health, Madison, WI
*Purpose: While SARS-CoV-2 vaccination has dramatically reduced COVID-19 severity in the general population, fully vaccinated solid organ transplant recipients (SOTRs) demonstrate reduced seroconversion and increased…