Articles tagged "COVID-19"

2022 American Transplant Congress
A Third Dose of SARS-CoV-2 Vaccine Increases Neutralizing Antibodies Against Variants of Concern in Solid Organ Transplant Recipients
A. H. Karaba¹, X. Zhu¹, T. Ling¹, K. H. Wang¹, A. G. Rittenhouse¹, O. Akinde¹, Y. Eby¹, J. E. Ruff¹, J. N. Blankson¹, A. T. Abedon¹, J. L. Alejo¹, A. L. Cox¹, J. R. Bailey¹, E. A. Thompson¹, S. L. Klein¹, D. S. Warren¹, J. M. Garonzik-Wang², B. J. Boyarsky¹, I. Sitaras¹, A. Pekosz¹, D. L. Segev¹, A. A. Tobian¹, W. A. Werbel¹
¹Johns Hopkins University, Baltimore, MD, ²University of Wisconsin School of Medicine and Health, Madison, WI
*Purpose: Vaccine-induced SARS-CoV-2 antibody responses are attenuated in solid organ transplant recipients (SOTRs) and breakthrough infections are more common. Additional SARS-CoV-2 vaccine doses increase anti-spike…
2022 American Transplant Congress
Sensitization and BK Viremia; Risk Following Sub-Clinical COVID-19 Infection in Pediatric Kidney Transplant Recipients
E. Benz¹, M. Chandran², J. Chuita¹, K. McKinnon¹, A. Sikora¹, M. Bock¹, E. Blanchette¹
¹Children's Hospital Colorado, Aurora, CO, ²University of North Carolina, Chapel Hill, NC
*Purpose: In contrast to high morbidity and mortality of COVID-19 infection (COVIDi) in adult kidney transplant (KT) recipients, these sequelae appear to be muted in…
2022 American Transplant Congress
Early Clinical Experience With Nirmatrelvir/ritonavir For Treatment Of Covid-19 In Solid Organ Transplant Recipients
D. Salerno¹, D. Jennings², N. Lange³, D. Kovac¹, T. Shertel¹, J. Chen⁴, J. Hedvat⁵, J. Scheffert¹, R. S. Brown⁶, M. Pereira⁷
¹NewYork-Presbyterian Hospital, New York, NY, ²Long Island University, Brooklyn, NY, ³Pharmacy, NewYork-Presbyterian Hospital, New York, NY, ⁴Columbia University Irving Medical Center, Fort Lee, NJ, ⁵New York Presbyterian Hospital, Tenafly, NJ, ⁶Weill Cornell Medicine, New York, NY, ⁷New York Presbyterian Hospital, New York, NY
*Purpose: Nirmatrelvir/ritonavir use has not yet been described in solid organ transplant recipients (SOTR) who become infected with COVID-19. The objective of our study was…
2022 American Transplant Congress
Outcomes After Covid-19 Infection in Transplant Recipients
K. L. Freels¹, K. Saharia², J. Baddley², N. Costa³, S. Niederhaus⁴
¹University of Maryland School of Medicine, Baltimore, MD, ²Medicine, University of Maryland School of Medicine, Baltimore, MD, ³Medicine, Georgetown University, Washington, DC, ⁴Surgery, University of Maryland School of Medicine, Baltimore, MD
*Purpose: The purpose of this study is to evaluate outcomes of readmission, rejection, graft dysfunction, graft failure, and death in SOT recipients (SOTR) after COVID-19…
2022 American Transplant Congress
An Analysis of Serological Response and Infection Outcomes Following Oxford Astra-Zeneca (azd1222) and Pfizer-Biontech (mRNA BNT162b2) SARS-CoV-2 Vaccines in Kidney and Pancreas Transplant Patients
A. Asderakis¹, U. Khalid¹, G. Koimtzis¹, M. Ponsford², L. Szabó¹, L. Grant², S. Jolles², I. Humphreys³
¹Cardiff Transplant Unit, University Hospital of Wales, Cardiff, United Kingdom, ²Immunodeficiency Centre for Wales, University Hospital of Wales, Cardiff, United Kingdom, ³Division of Infection and Immunity, Cardiff University, Cardiff, United Kingdom
*Purpose: SARS-CoV-2 is associated with high mortality among transplant recipients. This study aims to compare the humoral responses between the Oxford-Astra-Zeneca(AZ) and BNT162b2(Pfizer-BioNTech) vaccines in…
2022 American Transplant Congress
Knowledge, Attitude, and Practices Regarding Covid-19 Among Solid Organ Transplant Patients at a Transplant Center in the United States: A Cross-Sectional Study
L. Wang, H. Oduor, M. Abualfoul, P. Acharya, M. Pagadala
Methodist Dallas Medical Center, Dallas, TX
*Purpose: To evaluate the knowledge, attitude, and practices (KAP) of patients who have undergone kidney and/or liver solid organ transplants (SOTs) during the COVID-19 pandemic.*Methods:…
2022 American Transplant Congress
B Cells Fit for Germinal Center Activity Predict Response to a Third Dose of SARS-CoV-2 Vaccine in Solid Organ Transplant Recipients
E. A. Thompson¹, A. H. Karaba¹, K. Cascino¹, K. Roznik¹, T. Chiang¹, L. Biavatti¹, A. T. Abedon¹, J. L. Alejo¹, S. L. Klein¹, J. N. Blankson¹, D. S. Warren¹, C. X. Qin¹, J. Mitchell¹, J. M. Garonzik-Wang², B. J. Boyarsky¹, D. L. Segev¹, A. A. Tobian¹, W. A. Werbel¹, A. L. Cox¹, J. R. Bailey¹
¹Johns Hopkins University, Baltimore, MD, ²University of Wisconsin School of Medicine and Health, Madison, WI
*Purpose: While SARS-CoV-2 vaccination has dramatically reduced COVID-19 severity in the general population, fully vaccinated solid organ transplant recipients (SOTRs) demonstrate reduced seroconversion and increased…
2022 American Transplant Congress
Multicenter Effort Assessing the Effects of COVID Infection and Vaccination on HLA Antibodies in Waitlisted Patients with ESRD
G. R. Roll¹, M. Cooper², H. Gebel³, K. M. Hitchman⁴, M. Hobeika⁵, J. Houp⁶, M. Kamoun⁷, J. Killian⁸, J. Kim⁹, V. Kumar¹⁰, M. Levine¹¹, T. Lunow-Luke¹, R. Parsons¹², D. Ranch¹³, P. Stock¹⁴, S. Yi¹⁵, R. Rajalingam¹⁶
¹UCSF Medical Center, San Francisco, CA, ²MedStar Georgetown Transplant Institute, Washington, DC, ³Emory University Hospital, Atlanta, GA, ⁴Pathology and Laboratory Medicine, University of Texas Health San Antonio, San Antonio, TX, ⁵Houston Methodist, Houston, TX, ⁶University of Alabama, Birmingham, AL, ⁷Hospital Univ of Pennsylvania, Philadelphia, PA, ⁸University of Alabama at Birmingham, Birmingham, AL, ⁹Surgery, Keck Medicine of USC, Los Angeles, CA, ¹⁰University of Alabama at Birmingham Hospital, Birmingham, AL, ¹¹University of Pennsylvania, Philadelphia, Pe, ¹²Emory University School of Medicine, Atlanta, GA, ¹³UT Health San Antonio, San Antonio, TX, ¹⁴Univ of California-San Francisco, San Francisco, CA, ¹⁵Houston Methodist Hospital, Houston, TX, ¹⁶Immunogenetics and Transplantation Laboratory (ITL), San Francisco, CA
*Purpose: Although rare, infection and vaccination have been reported to result in human leukocyte antibodies (HLA). We analyzed the effect of SARS-CoV2 infection, or COVID-19…
2022 American Transplant Congress
Transplant Graft TMA Injury Post COVID-19 Vaccination
O. Sogbein, A. Rizvi, M. Mujtaba, S. Hussain
Internal Medicine, Division of Nephrology, University of Texas Medical Branch, Galveston, TX
*Purpose: Vaccination against SARS-CoV-2 is essential. Complicating this effort are reports of a suboptimal response to the SARS-CoV-2 spike protein in patients on immunosuppressive medications…
2022 American Transplant Congress
Impact of the Second Year COVID-19 Pandemic on the U.S. Kidney Transplantation: Interrupted Time Series Analysis
E. Tantisattamo¹, N. Polpichai², P. Mutirangura³, M. Tanariyakul⁴
¹Division of Nephrology, Hypertension and Kidney Transplantation, Department of Medicine, University of California Irvine School of Medicine, Orange, CA, ²Faculty of Medicine Songklanagarin Hospital, Prince of Songkla University, Songkhla, Thailand, ³Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand, ⁴Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand
*Purpose: The number of kidney transplant (KT) was decreased since the COVID-19 pandemic; however, the magnitude of the pandemic on the number of U.S. KT…