2022 American Transplant Congress
Risk Factors Associated with ICU Admission and Death in Patients Hospitalized with COVID-19 Differ Between Solid Organ Transplant and Non-Solid Organ Transplant Patients
David Geffen School of Medicine at UCLA, Los Angeles, CA
*Purpose: Despite the large numbers of reports on patient risk factors for poor clinical outcomes with COVID-19, little is known about how these risks may…2022 American Transplant Congress
Outcomes of COVID-19 in Solid Organ Transplant Recipients in Canada 2020-2021: A Prospective, Multicenter Cohort Study
*Purpose: To understand the outcomes and changes in disease severity of COVID-19 in Solid Organ Transplant (SOT) recipients over time in the context of therapeutic…2022 American Transplant Congress
Humoral Response After a Third Dose of Sars-CoV-2 mRNA Vaccine in Transplant Recipients
Brigham & Women's Hospital, Boston, MA
*Purpose: Prior studies demonstrated an increased immune response post-3rd COVID-19 vaccine dose when given 1-month post-2nd dose in solid organ transplant recipients (SOT). This study…2022 American Transplant Congress
Sirolimus Use Is Associated With An Improved Immune Response To Covid-19 Vaccination In Kidney Transplant Recipients
*Purpose: Kidney transplant recipients (KTRs) are highly vulnerable to severe COVID-19, however are poorly protected by vaccination. Additional vaccine doses have achieved limited improvements in…2022 American Transplant Congress
Impact Of Nirmatrelvir-Ritonavir On Tacrolimus Concentrations
1University of Rochester Medical Center, Rochester, NY, 2Tampa General Hospital, Tampa, FL
*Purpose: Ritonavir (RTV), a component of the oral antiviral agent nirmatrelvir-RTV (Paxlovid) for COVID-19 infection, increases tacrolimus concentrations through strong competitive inhibition of gastrointestinal and…2022 American Transplant Congress
Immunogenicity and Safety of SARS-CoV-2 Vaccines and Breakthrough Infections Among Solid Organ Transplant Recipients: Systematic Review and Meta-Analysis
*Purpose: The SARS-CoV-2 pandemic has had a significant impact on the field of solid organ transplant(SOT). Immunization against SARS-CoV-2 is globally available since 2021. SOT…2022 American Transplant Congress
The Prevalence of Anti-SARS-CoV-2 Antibodies After COVID-19 is Similar in Kidney Transplant Recipients to Non-Transplanted Patients, and the Clinical Severity is a Predictor of Seroconversion
Nephrology Division - Hospital do Rim, Universidade Federal de São Paulo, São Paulo, Brazil
*Purpose: To evaluate the seroconversion rate in kidney transplant recipients (KTR), compared to two non-transplanted groups of patients, and identify predictors of seroconversion in COVID-19…2022 American Transplant Congress
Simultaneous Lung and Kidney Transplant in a Young Patient with COVID-19
*Purpose: Lung transplant is the last resort for COVID-19 refractory ARDS. Dual organ transplant is seen as a relative contraindication at many institutions. We describe…2022 American Transplant Congress
Analysis of Sars-Cov-2-Specific T-Cell Responses Using Novel Single-Cell Multiplexed Isolight in Covid-19 Convalescents
1Northwestern University, Chicago, IL, 2IsoPlexis, Branford, CT
*Purpose: COVID-19 has poor outcomes in transplant recipients with reduced antibody responses. However, the exact cellular immune response against SARS-CoV-2 remains largely unclear. We developed…2022 American Transplant Congress
Third Dose of SARS-CoV-2 mRNA Vaccines Significantly Increases Delta (B.1.617.2) Variant Anti-Spike Antibody Levels in Kidney Transplant Recipients
1Massachusetts General Hospital, Boston, MA, 2Brigham and Women's Hospital, Boston, MA
*Purpose: Emerging SARS-CoV-2 variants may be associated with a higher risk of breakthrough infections compared to wild-type (WT) virus in kidney transplant recipients (KTRs). The…
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