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American Transplant Congress abstracts

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Articles tagged "COVID-19"

  • 2022 American Transplant Congress

    Risk Factors Associated with ICU Admission and Death in Patients Hospitalized with COVID-19 Differ Between Solid Organ Transplant and Non-Solid Organ Transplant Patients

    J. Schaenman, H. Byford, T. R. Grogan, Y. Motwani, O. Beaird, M. Kamath, E. Lum, K. Meneses, D. Sayah, D. Vucicevic, S. Saab

    David Geffen School of Medicine at UCLA, Los Angeles, CA

    *Purpose: Despite the large numbers of reports on patient risk factors for poor clinical outcomes with COVID-19, little is known about how these risks may…
  • 2022 American Transplant Congress

    Outcomes of COVID-19 in Solid Organ Transplant Recipients in Canada 2020-2021: A Prospective, Multicenter Cohort Study

    V. G. Hall1, G. Alahmadi2, J. T. Solera2, T. Marinelli2, H. Cardinal3, G. Prasad4, S. A. De Serres5, D. Isaac6, R. Mainra7, C. Lamarche8, R. Sapir-Pichhadze9, S. Gilmour10, A. Humar2, D. Kumar2

    1University Health Network/Toronto General Hospital, Toronto, ON, Canada, 2UHN, Toronto, ON, Canada, 3UMontreal, Montreal, QC, Canada, 4StMH, Toronto, ON, Canada, 5Laval U, Quebec, QC, Canada, 6UCalgary, Calgary, AB, Canada, 7USaskatchewan, Saskatoon, SK, Canada, 8HMR, Montreal, QC, Canada, 9McGill U, Montreal, QC, Canada, 10SCH, Edmonton, AB, Canada

    *Purpose: To understand the outcomes and changes in disease severity of COVID-19 in Solid Organ Transplant (SOT) recipients over time in the context of therapeutic…
  • 2022 American Transplant Congress

    Humoral Response After a Third Dose of Sars-CoV-2 mRNA Vaccine in Transplant Recipients

    A. E. Woolley, N. Sharma, G. Zhou, A. Kim, E. Ryan, M. Joyce, H. Goldberg, M. Givertz, M. Mehra, E. Woodcome, V. Durney, S. Marshall, K. Townsend, A. Coppolino, S. Tullius, S. Malek, H. Mallidi, L. Baden, A. Chandraker

    Brigham & Women's Hospital, Boston, MA

    *Purpose: Prior studies demonstrated an increased immune response post-3rd COVID-19 vaccine dose when given 1-month post-2nd dose in solid organ transplant recipients (SOT). This study…
  • 2022 American Transplant Congress

    Sirolimus Use Is Associated With An Improved Immune Response To Covid-19 Vaccination In Kidney Transplant Recipients

    G. B. Perkins1, M. Tunbridge2, T. Salehi2, C. Chai1, C. M. Hope1, P. Garcia-Valtanen1, J. J. Singer3, P. R. Hurtado2, S. C. Barry1, B. Grubor-Bauk1, P. Hissaria2, S. J. Chadban3, P. Coates1

    1University of Adelaide, Adelaide, Australia, 2Royal Adelaide Hospital, Adelaide, Australia, 3Royal Prince Alfred Hospital, Sydney, Australia

    *Purpose: Kidney transplant recipients (KTRs) are highly vulnerable to severe COVID-19, however are poorly protected by vaccination. Additional vaccine doses have achieved limited improvements in…
  • 2022 American Transplant Congress

    Impact Of Nirmatrelvir-Ritonavir On Tacrolimus Concentrations

    S. Fredrick1, B. Wise2, L. Bowman2, D. DeWolfe1, J. Taylor1, J. Melaragno1

    1University of Rochester Medical Center, Rochester, NY, 2Tampa General Hospital, Tampa, FL

    *Purpose: Ritonavir (RTV), a component of the oral antiviral agent nirmatrelvir-RTV (Paxlovid) for COVID-19 infection, increases tacrolimus concentrations through strong competitive inhibition of gastrointestinal and…
  • 2022 American Transplant Congress

    Immunogenicity and Safety of SARS-CoV-2 Vaccines and Breakthrough Infections Among Solid Organ Transplant Recipients: Systematic Review and Meta-Analysis

    A. Villavicencio1, Y. Ebisu2, M. Raja3, A. P. Sanchez-Covarrubias1, S. Anjan3, J. M. Reynolds1, J. Simkins3, J. Camargo3, M. I. Morris3, L. Abbo4, G. Guerra5, Y. Natori6

    1Internal Medicine, University of Miami Miller School of Medicine, Miami, FL, 2Kameda Medical Center, Chiba, Japan, 3University of Miami Miller School of Medicine, Miami, FL, 4University Of Miami Miller School of Medicine, Miami, FL, 5University of Miami Jackson Memorial Hospital, Miami, FL, 6University of Miami, Pinecrest, FL

    *Purpose: The SARS-CoV-2 pandemic has had a significant impact on the field of solid organ transplant(SOT). Immunization against SARS-CoV-2 is globally available since 2021. SOT…
  • 2022 American Transplant Congress

    The Prevalence of Anti-SARS-CoV-2 Antibodies After COVID-19 is Similar in Kidney Transplant Recipients to Non-Transplanted Patients, and the Clinical Severity is a Predictor of Seroconversion

    L. R. Requião-Moura, R. Garcia, M. R. Nakamura, R. D. Foresto, V. Gomes, T. Ferreira, I. Meira, M. Cristelli, M. Jesus, R. Rissoni, E. Lucena, H. Tedesco-Silva, J. Medina-Pestana

    Nephrology Division - Hospital do Rim, Universidade Federal de São Paulo, São Paulo, Brazil

    *Purpose: To evaluate the seroconversion rate in kidney transplant recipients (KTR), compared to two non-transplanted groups of patients, and identify predictors of seroconversion in COVID-19…
  • 2022 American Transplant Congress

    Simultaneous Lung and Kidney Transplant in a Young Patient with COVID-19

    M. Bitar1, J. G. Youssef2, S. Yau2, A. Goodarzi2, G. Youssef3

    1Houston Methodist Academic Pulmonary Medicine, Houston Methodist Hospital, Houston, TX, 2Houston Methodist Pulmonary Transplant Center, Houston Methodist Hospital, Houston, TX, 3Department of Lymphoma and Myeloma, MD Anderson Cancer Center, Houston, TX

    *Purpose: Lung transplant is the last resort for COVID-19 refractory ARDS. Dual organ transplant is seen as a relative contraindication at many institutions. We describe…
  • 2022 American Transplant Congress

    Analysis of Sars-Cov-2-Specific T-Cell Responses Using Novel Single-Cell Multiplexed Isolight in Covid-19 Convalescents

    Y. Sambandam1, J. He1, N. Vanderhyde2, L. Gallon1, J. Leventhal1, J. Mathew1

    1Northwestern University, Chicago, IL, 2IsoPlexis, Branford, CT

    *Purpose: COVID-19 has poor outcomes in transplant recipients with reduced antibody responses. However, the exact cellular immune response against SARS-CoV-2 remains largely unclear. We developed…
  • 2022 American Transplant Congress

    Third Dose of SARS-CoV-2 mRNA Vaccines Significantly Increases Delta (B.1.617.2) Variant Anti-Spike Antibody Levels in Kidney Transplant Recipients

    A. Al Jurdi1, R. B. Gassen1, T. Borges1, I. T. Lape1, L. Morena1, O. Efe1, Z. Solhjou2, R. El Fekih2, C. Kotton1, J. Azzi2, L. Riella1

    1Massachusetts General Hospital, Boston, MA, 2Brigham and Women's Hospital, Boston, MA

    *Purpose: Emerging SARS-CoV-2 variants may be associated with a higher risk of breakthrough infections compared to wild-type (WT) virus in kidney transplant recipients (KTRs). The…
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