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Articles tagged "COVID-19"

  • 2022 American Transplant Congress

    A Prospective Randomised, Controlled Trial Switching Sirolimus For Mycophenolate To Enhance Immunological Responses To Third Dose Covid-19 Vaccination In Kidney Transplant Recipients With Poor Baseline Humoral Immunity

    M. J. Tunbridge1, G. Perkins2, T. Salehi1, B. Grubor-Bauk3, B. Sim1, T. Ying4, J. J. Singer5, S. C. Barry6, P. Hissaria7, S. Chadban8, P. T. Coates1

    1Central and Northern Adelaide Renal and Transplant Services, Royal Adelaide Hospital, Adelaide, Australia, 2School of Biological Sciences, University of Adelaide, Adelaide, Australia, 3Basil Hetzel Institute, University of Adelaide, Adelaide, Australia, 4University of Sydney, Lilyfield, Ne, Australia, 5Kidney Node Laboratory, Charles Perkins Centre, The University of Sydney, The University of Sydney, Australia, 6School of Medical Sciences, University of Adelaide, Adelaide, Australia, 7Department of Immunology, Royal Adelaide Hospital, Adelaide, Australia, 8Department of Nephrology, Royal Prince Alfred Hospital, Sydney, Australia

    *Purpose: Kidney transplant recipients (KTR) have inadequate responses to 2-dose COVID vaccination schedules and are at increased risk of severe COVID-19. Formation of T cell…
  • 2022 American Transplant Congress

    Higher Proinflammatory Cytokines Are Associated with Increased Antibody Titer After a Third Dose of SARS-CoV-2 Vaccine in Solid Organ Transplant Recipients

    A. H. Karaba1, X. Zhu1, S. E. Benner1, O. Akinde1, Y. Eby1, K. H. Wang1, S. Saraf2, J. M. Garonzik-Wang3, S. L. Klein1, J. R. Bailey1, A. L. Cox1, J. N. Blankson1, C. M. Durand1, D. L. Segev1, W. A. Werbel1, A. A. Tobian1

    1Johns Hopkins University, Baltimore, MD, 2National Institute of Allergy and Infectious Diseases, Bethesda, MD, 3University of Wisconsin School of Medicine and Health, Madison, WI

    *Purpose: Solid organ transplant recipients (SOTRs) are at increased risk for severe COVID-19 and exhibit lower antibody responses to SARS-CoV-2 vaccines. This study aimed to…
  • 2022 American Transplant Congress

    Covid19 in Pediatric Kidney Transplant Recipients: Incidence, Outcomes, and Response to Vaccine

    A. Moudgil, K. Sgambat, Y. Shi, M. Meyers, C. Petyak, L. Midgley

    Nephrology, Children's National Med. Ctr., Washington, DC

    *Purpose: At the onset of pandemic, no information was available on response of pediatric kidney transplant (PKTX) recipients to COVID19. When COVID19 vaccines became available,…
  • 2022 American Transplant Congress

    Lung Transplantation For COVID Acute Respiratory Distress Syndrome: A Pediatric And Adult Case Series

    C. Arendale1, D. Kumar2, P. S. Garcha3, C. Kutac4, G. Loor1, A. Rana1, J. Goss1, N. Galvan1

    1Michael E. DeBakey Department of Surgery, Baylor College of Medicine, Houston, TX, 2Department of Biochemistry, Baylor College of Medicine, Houston, TX, 3Department of Medicine, Baylor College of Medicine, Houston, TX, 4Baylor St. Luke’s Medical Center, Houston, TX

    *Purpose: Lung transplantation (LTx) has been shown to be a viable treatment for irreversible lung disease caused by COVID-19. Given the limited data on the…
  • 2022 American Transplant Congress

    Better Antibody Response After a Dose of Ad.26.cov2.s vs MRNA Vaccines in Seronegative Transplant Recipients After 2-Dose MRNA Vaccination

    J. L. Alejo1, T. Chiang1, J. Mitchell1, A. Abedon1, L. Thomas1, A. Chang1, S. Bae1, R. Avery1, A. Tobian1, A. Massie1, M. Levan1, D. Warren1, J. Garonzik-Wang2, D. Segev1, W. Werbel1

    1JHU, Baltimore, MD, 2U of Wisconsin, Madison, WI

    *Purpose: To compare antibody response to a third dose (D3) of SARS-CoV-2 vaccine in solid organ transplant recipients (SOTRs) with negative or low-positive antibody levels…
  • 2022 American Transplant Congress

    Clinical Characteristics Of Serologic Non-responders To Covid-19 Booster Vaccination In A Cohort Of Solid Organ Transplant Recipients.

    F. N. Zervou1, K. Khalil1, T. Lao1, D. Wood2, S. Jonche1, A. Mattoo1

    1Transplant Institute, NYU Langone Health, New York, NY, 2New York University Langone Health, Brooklyn, NY

    *Purpose: The purpose of this study was to assess the clinical characteristics of serologic non-responders to COVID-19 booster vaccination in a cohort of solid organ…
  • 2022 American Transplant Congress

    Heterologous Vaccine Schedule Against Sars-CoV-2 with 2 Doses of Inactivated Virus and a Booster of mRNA BNT162b2 in Kidney Transplant Recipients

    M. Seija1, F. Rammauro2, J. Santiago1, N. Orihuela3, C. Zulberti3, D. Machado4, C. Recalde4, J. Noboa1, R. Astesiano1, F. Yandian1, A. Guerisoli1, A. Morra3, D. Cassinelli1, A. Pippolo1, B. De Aramburu1, C. Coelho1, P. González1, R. Romero1, R. Rodriguez-Teja4, G. Acuña4, V. Rabaza4, N. Perg4, R. Cordero4, S. Orihuela3, L. Curi3, E. Burgstaller4, O. Noboa1, O. Pritsch2, M. Nin1, S. Bianchi5

    1Centro de Nefrología, Hospital de Clínicas. Facultad de Medicina UdeLaR, Montevideo, Uruguay, 2Departamento de Inmunobiología, Facultad de Medicina, UdeLaR, Montevideo, Uruguay, 3Hospital Italiano, Montevideo, Uruguay, 4Hospital Evangélico, Montevideo, Uruguay, 5Departamento de Fisiopatología, Facultad de Medicina UdeLar, Montevideo, Uruguay

    *Purpose: Emerging evidence suggests that 3 doses of SARS-CoV-2 mRNA vaccine enhance immunity in kidney transplant (KT) patients. However, few studies have focused on humoral…
  • 2022 American Transplant Congress

    Effect of Mycophenolate Mofetil Dosing on Antibody Response to SARS-CoV-2 Vaccination in Heart and Lung Transplant Recipients

    J. Mitchell1, T. P. Chiang1, J. Alejo1, A. Chang1, A. Abedon1, R. Avery1, A. Tobian1, A. Massie1, M. Levan1, D. Warren1, J. Garonzik-Wang2, D. Segev1, W. Werbel1

    1Johns Hopkins University, Baltimore, MD, 2University of Wisconsin-Madison, Madison, WI

    *Purpose: Mycophenolate mofetil (MMF) use is associated with decreased antibody response to the SARS-CoV-2 mRNA vaccine series in heart and lung transplant recipients (HLTRs). Higher…
  • 2022 American Transplant Congress

    Blood Transcriptomes of Kidney Recipients with Covid-19 Demonstrate Deficient Adaptive Immune Activation

    K. Banu1, Z. Sun2, Y. A. Azzi3, M. M. Rana4, A. Reghuvaran1, G. Carrara5, S. Hartell4, W. Asch1, W. Zhang4, Z. Zhang2, E. Akalin3, P. Cravedi2, P. Heeger2, K. Banu1

    1Nephrology, Yale University, New Haven, CT, 2Icahn School of Medicine at Mount Sinai, New York, NY, 3Montefiore Medical Center, New York, NY, 4Nephrology, Icahn School of Medicine at Mount Sinai, New York, NY, 5Icahn School of Medicine at Mount Sinai, New Haven, CT

    *Purpose: Kidney transplant recipients (KTRs) have poor outcomes compared to non-KTRs with acute COVID-19. To provide insight into management of immunosuppression (IS) during COVID-19, we…
  • 2022 American Transplant Congress

    Metagenomic Next-Generation Sequencing Reveals the Profile of Viral Infections in Kidney Transplant Recipients During the Covid-19 Pandemic

    X. Tian, W. Duan, C. Zhang, X. Wu, T. Yan

    Henan Province People's Hospital, Zhengzhou, Henan Province, China

    *Purpose: To study the clinical application of metagenomic next-generation sequencing (mNGS) in the detection of viral infections in kidney transplant recipients (KTRs) during the COVID-19…
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