Articles tagged "COVID-19"

2022 American Transplant Congress
A Prospective Randomised, Controlled Trial Switching Sirolimus For Mycophenolate To Enhance Immunological Responses To Third Dose Covid-19 Vaccination In Kidney Transplant Recipients With Poor Baseline Humoral Immunity
M. J. Tunbridge¹, G. Perkins², T. Salehi¹, B. Grubor-Bauk³, B. Sim¹, T. Ying⁴, J. J. Singer⁵, S. C. Barry⁶, P. Hissaria⁷, S. Chadban⁸, P. T. Coates¹
¹Central and Northern Adelaide Renal and Transplant Services, Royal Adelaide Hospital, Adelaide, Australia, ²School of Biological Sciences, University of Adelaide, Adelaide, Australia, ³Basil Hetzel Institute, University of Adelaide, Adelaide, Australia, ⁴University of Sydney, Lilyfield, Ne, Australia, ⁵Kidney Node Laboratory, Charles Perkins Centre, The University of Sydney, The University of Sydney, Australia, ⁶School of Medical Sciences, University of Adelaide, Adelaide, Australia, ⁷Department of Immunology, Royal Adelaide Hospital, Adelaide, Australia, ⁸Department of Nephrology, Royal Prince Alfred Hospital, Sydney, Australia
*Purpose: Kidney transplant recipients (KTR) have inadequate responses to 2-dose COVID vaccination schedules and are at increased risk of severe COVID-19. Formation of T cell…
2022 American Transplant Congress
Higher Proinflammatory Cytokines Are Associated with Increased Antibody Titer After a Third Dose of SARS-CoV-2 Vaccine in Solid Organ Transplant Recipients
A. H. Karaba¹, X. Zhu¹, S. E. Benner¹, O. Akinde¹, Y. Eby¹, K. H. Wang¹, S. Saraf², J. M. Garonzik-Wang³, S. L. Klein¹, J. R. Bailey¹, A. L. Cox¹, J. N. Blankson¹, C. M. Durand¹, D. L. Segev¹, W. A. Werbel¹, A. A. Tobian¹
¹Johns Hopkins University, Baltimore, MD, ²National Institute of Allergy and Infectious Diseases, Bethesda, MD, ³University of Wisconsin School of Medicine and Health, Madison, WI
*Purpose: Solid organ transplant recipients (SOTRs) are at increased risk for severe COVID-19 and exhibit lower antibody responses to SARS-CoV-2 vaccines. This study aimed to…
2022 American Transplant Congress
Covid19 in Pediatric Kidney Transplant Recipients: Incidence, Outcomes, and Response to Vaccine
A. Moudgil, K. Sgambat, Y. Shi, M. Meyers, C. Petyak, L. Midgley
Nephrology, Children's National Med. Ctr., Washington, DC
*Purpose: At the onset of pandemic, no information was available on response of pediatric kidney transplant (PKTX) recipients to COVID19. When COVID19 vaccines became available,…
2022 American Transplant Congress
Lung Transplantation For COVID Acute Respiratory Distress Syndrome: A Pediatric And Adult Case Series
C. Arendale¹, D. Kumar², P. S. Garcha³, C. Kutac⁴, G. Loor¹, A. Rana¹, J. Goss¹, N. Galvan¹
¹Michael E. DeBakey Department of Surgery, Baylor College of Medicine, Houston, TX, ²Department of Biochemistry, Baylor College of Medicine, Houston, TX, ³Department of Medicine, Baylor College of Medicine, Houston, TX, ⁴Baylor St. Luke’s Medical Center, Houston, TX
*Purpose: Lung transplantation (LTx) has been shown to be a viable treatment for irreversible lung disease caused by COVID-19. Given the limited data on the…
2022 American Transplant Congress
Better Antibody Response After a Dose of Ad.26.cov2.s vs MRNA Vaccines in Seronegative Transplant Recipients After 2-Dose MRNA Vaccination
J. L. Alejo¹, T. Chiang¹, J. Mitchell¹, A. Abedon¹, L. Thomas¹, A. Chang¹, S. Bae¹, R. Avery¹, A. Tobian¹, A. Massie¹, M. Levan¹, D. Warren¹, J. Garonzik-Wang², D. Segev¹, W. Werbel¹
¹JHU, Baltimore, MD, ²U of Wisconsin, Madison, WI
*Purpose: To compare antibody response to a third dose (D3) of SARS-CoV-2 vaccine in solid organ transplant recipients (SOTRs) with negative or low-positive antibody levels…
2022 American Transplant Congress
Clinical Characteristics Of Serologic Non-responders To Covid-19 Booster Vaccination In A Cohort Of Solid Organ Transplant Recipients.
F. N. Zervou¹, K. Khalil¹, T. Lao¹, D. Wood², S. Jonche¹, A. Mattoo¹
¹Transplant Institute, NYU Langone Health, New York, NY, ²New York University Langone Health, Brooklyn, NY
*Purpose: The purpose of this study was to assess the clinical characteristics of serologic non-responders to COVID-19 booster vaccination in a cohort of solid organ…
2022 American Transplant Congress
Heterologous Vaccine Schedule Against Sars-CoV-2 with 2 Doses of Inactivated Virus and a Booster of mRNA BNT162b2 in Kidney Transplant Recipients
M. Seija¹, F. Rammauro², J. Santiago¹, N. Orihuela³, C. Zulberti³, D. Machado⁴, C. Recalde⁴, J. Noboa¹, R. Astesiano¹, F. Yandian¹, A. Guerisoli¹, A. Morra³, D. Cassinelli¹, A. Pippolo¹, B. De Aramburu¹, C. Coelho¹, P. González¹, R. Romero¹, R. Rodriguez-Teja⁴, G. Acuña⁴, V. Rabaza⁴, N. Perg⁴, R. Cordero⁴, S. Orihuela³, L. Curi³, E. Burgstaller⁴, O. Noboa¹, O. Pritsch², M. Nin¹, S. Bianchi⁵
¹Centro de Nefrología, Hospital de Clínicas. Facultad de Medicina UdeLaR, Montevideo, Uruguay, ²Departamento de Inmunobiología, Facultad de Medicina, UdeLaR, Montevideo, Uruguay, ³Hospital Italiano, Montevideo, Uruguay, ⁴Hospital Evangélico, Montevideo, Uruguay, ⁵Departamento de Fisiopatología, Facultad de Medicina UdeLar, Montevideo, Uruguay
*Purpose: Emerging evidence suggests that 3 doses of SARS-CoV-2 mRNA vaccine enhance immunity in kidney transplant (KT) patients. However, few studies have focused on humoral…
2022 American Transplant Congress
Effect of Mycophenolate Mofetil Dosing on Antibody Response to SARS-CoV-2 Vaccination in Heart and Lung Transplant Recipients
J. Mitchell¹, T. P. Chiang¹, J. Alejo¹, A. Chang¹, A. Abedon¹, R. Avery¹, A. Tobian¹, A. Massie¹, M. Levan¹, D. Warren¹, J. Garonzik-Wang², D. Segev¹, W. Werbel¹
¹Johns Hopkins University, Baltimore, MD, ²University of Wisconsin-Madison, Madison, WI
*Purpose: Mycophenolate mofetil (MMF) use is associated with decreased antibody response to the SARS-CoV-2 mRNA vaccine series in heart and lung transplant recipients (HLTRs). Higher…
2022 American Transplant Congress
Blood Transcriptomes of Kidney Recipients with Covid-19 Demonstrate Deficient Adaptive Immune Activation
K. Banu¹, Z. Sun², Y. A. Azzi³, M. M. Rana⁴, A. Reghuvaran¹, G. Carrara⁵, S. Hartell⁴, W. Asch¹, W. Zhang⁴, Z. Zhang², E. Akalin³, P. Cravedi², P. Heeger², K. Banu¹
¹Nephrology, Yale University, New Haven, CT, ²Icahn School of Medicine at Mount Sinai, New York, NY, ³Montefiore Medical Center, New York, NY, ⁴Nephrology, Icahn School of Medicine at Mount Sinai, New York, NY, ⁵Icahn School of Medicine at Mount Sinai, New Haven, CT
*Purpose: Kidney transplant recipients (KTRs) have poor outcomes compared to non-KTRs with acute COVID-19. To provide insight into management of immunosuppression (IS) during COVID-19, we…
2022 American Transplant Congress
Metagenomic Next-Generation Sequencing Reveals the Profile of Viral Infections in Kidney Transplant Recipients During the Covid-19 Pandemic
X. Tian, W. Duan, C. Zhang, X. Wu, T. Yan
Henan Province People's Hospital, Zhengzhou, Henan Province, China
*Purpose: To study the clinical application of metagenomic next-generation sequencing (mNGS) in the detection of viral infections in kidney transplant recipients (KTRs) during the COVID-19…