Articles tagged "COVID-19"

2022 American Transplant Congress
Impact of Immunosuppressive Medications on SARS-CoV-2 Vaccination Response in Kidney Transplant Patients
O. Sogbein¹, A. Rizvi², M. Mujtaba³, M. Kueht⁴, J. Fair⁴, A. Gamilla-Crudo³, S. Hussain⁵
¹Internal Medicine, Division of Nephrology, University of Texas Medical Branch, Galveston, TX, ²Internal Medicine, Nephrology, University of Texas Medical Branch at Galveston, Galveston, TX, ³University of Texas Medical Branch, Galveston, TX, ⁴Surgery, University of Texas Medical Branch, Galveston, TX, ⁵University of Texas Medical Branch, Houston, TX
*Purpose: The COVID-19 pandemic portends significant morbidity and mortality in immunocompromised individuals. Vaccination against COVID-19 among immunocompromised population is an essential step to minimize deadly…
2022 American Transplant Congress
High TTV Load Before First Vaccine Dose is Associated with Poor Serological Response to Covid-19 Vaccination in Lung Transplant Recipients
C. C. Van Leer Buter¹, R. A. Hoek², E. A. Verschuuren³, R. D. de Vries⁴, D. van Baarle¹, M. van der Heiden¹, H. G. Niesters¹, C. GeurtsvanKessel⁴
¹Dept. of Medical Microbiology, University Medical Center Groningen, Groningen, Netherlands, ²Dept. of Pulmonary Medicine, Erasmus Medical Center, Rotterdam, Netherlands, ³Dept. of Pulmonary Diseases,, University Medical Center Groningen, Groningen, Netherlands, ⁴Dept. of Viroscience, Erasmus Medical Center, Rotterdam, Netherlands
*Purpose: Torque tenovirus (TTV), a highly prevalent virus which is not known to cause pathology in humans, is currently being investigated as a marker of…
2022 American Transplant Congress
Effect of Sars-CoV-2 Delta Variant on Post-Vaccination COVID-19 Infection in Solid Organ Transplant Recipients
E. Tuttle¹, J. Moon², T. J. Grazia³, T. Sam⁴, S. Mathai³
¹Pulmonary and Critical Care Department, Baylor University Medical Center, Dallas, TX, ²Department of Internal Medicine, Baylor University Medical Center, Dallas, TX, ³Center for Advanced Heart and Lung Disease, Baylor University Medical Center, Dallas, TX, ⁴Department of Pharmacy, Baylor University Medical Center, Dallas, TX
*Purpose: In July 2021, the SARS-CoV-2 Delta variant emerged as the dominant strain in the North Texas area. We reviewed COVID-19 infections post-vaccination in Solid Organ…
2022 American Transplant Congress
Risk Factors Associated with ICU Admission and Death in Patients Hospitalized with COVID-19 Differ Between Solid Organ Transplant and Non-Solid Organ Transplant Patients
J. Schaenman, H. Byford, T. R. Grogan, Y. Motwani, O. Beaird, M. Kamath, E. Lum, K. Meneses, D. Sayah, D. Vucicevic, S. Saab
David Geffen School of Medicine at UCLA, Los Angeles, CA
*Purpose: Despite the large numbers of reports on patient risk factors for poor clinical outcomes with COVID-19, little is known about how these risks may…
2022 American Transplant Congress
Outcomes of COVID-19 in Solid Organ Transplant Recipients in Canada 2020-2021: A Prospective, Multicenter Cohort Study
V. G. Hall¹, G. Alahmadi², J. T. Solera², T. Marinelli², H. Cardinal³, G. Prasad⁴, S. A. De Serres⁵, D. Isaac⁶, R. Mainra⁷, C. Lamarche⁸, R. Sapir-Pichhadze⁹, S. Gilmour¹⁰, A. Humar², D. Kumar²
¹University Health Network/Toronto General Hospital, Toronto, ON, Canada, ²UHN, Toronto, ON, Canada, ³UMontreal, Montreal, QC, Canada, ⁴StMH, Toronto, ON, Canada, ⁵Laval U, Quebec, QC, Canada, ⁶UCalgary, Calgary, AB, Canada, ⁷USaskatchewan, Saskatoon, SK, Canada, ⁸HMR, Montreal, QC, Canada, ⁹McGill U, Montreal, QC, Canada, ¹⁰SCH, Edmonton, AB, Canada
*Purpose: To understand the outcomes and changes in disease severity of COVID-19 in Solid Organ Transplant (SOT) recipients over time in the context of therapeutic…
2022 American Transplant Congress
Humoral Response After a Third Dose of Sars-CoV-2 mRNA Vaccine in Transplant Recipients
A. E. Woolley, N. Sharma, G. Zhou, A. Kim, E. Ryan, M. Joyce, H. Goldberg, M. Givertz, M. Mehra, E. Woodcome, V. Durney, S. Marshall, K. Townsend, A. Coppolino, S. Tullius, S. Malek, H. Mallidi, L. Baden, A. Chandraker
Brigham & Women's Hospital, Boston, MA
*Purpose: Prior studies demonstrated an increased immune response post-3rd COVID-19 vaccine dose when given 1-month post-2nd dose in solid organ transplant recipients (SOT). This study…
2022 American Transplant Congress
Sirolimus Use Is Associated With An Improved Immune Response To Covid-19 Vaccination In Kidney Transplant Recipients
G. B. Perkins¹, M. Tunbridge², T. Salehi², C. Chai¹, C. M. Hope¹, P. Garcia-Valtanen¹, J. J. Singer³, P. R. Hurtado², S. C. Barry¹, B. Grubor-Bauk¹, P. Hissaria², S. J. Chadban³, P. Coates¹
¹University of Adelaide, Adelaide, Australia, ²Royal Adelaide Hospital, Adelaide, Australia, ³Royal Prince Alfred Hospital, Sydney, Australia
*Purpose: Kidney transplant recipients (KTRs) are highly vulnerable to severe COVID-19, however are poorly protected by vaccination. Additional vaccine doses have achieved limited improvements in…
2022 American Transplant Congress
Impact Of Nirmatrelvir-Ritonavir On Tacrolimus Concentrations
S. Fredrick¹, B. Wise², L. Bowman², D. DeWolfe¹, J. Taylor¹, J. Melaragno¹
¹University of Rochester Medical Center, Rochester, NY, ²Tampa General Hospital, Tampa, FL
*Purpose: Ritonavir (RTV), a component of the oral antiviral agent nirmatrelvir-RTV (Paxlovid) for COVID-19 infection, increases tacrolimus concentrations through strong competitive inhibition of gastrointestinal and…
2022 American Transplant Congress
Immunogenicity and Safety of SARS-CoV-2 Vaccines and Breakthrough Infections Among Solid Organ Transplant Recipients: Systematic Review and Meta-Analysis
A. Villavicencio¹, Y. Ebisu², M. Raja³, A. P. Sanchez-Covarrubias¹, S. Anjan³, J. M. Reynolds¹, J. Simkins³, J. Camargo³, M. I. Morris³, L. Abbo⁴, G. Guerra⁵, Y. Natori⁶
¹Internal Medicine, University of Miami Miller School of Medicine, Miami, FL, ²Kameda Medical Center, Chiba, Japan, ³University of Miami Miller School of Medicine, Miami, FL, ⁴University Of Miami Miller School of Medicine, Miami, FL, ⁵University of Miami Jackson Memorial Hospital, Miami, FL, ⁶University of Miami, Pinecrest, FL
*Purpose: The SARS-CoV-2 pandemic has had a significant impact on the field of solid organ transplant(SOT). Immunization against SARS-CoV-2 is globally available since 2021. SOT…
2022 American Transplant Congress
The Prevalence of Anti-SARS-CoV-2 Antibodies After COVID-19 is Similar in Kidney Transplant Recipients to Non-Transplanted Patients, and the Clinical Severity is a Predictor of Seroconversion
L. R. Requião-Moura, R. Garcia, M. R. Nakamura, R. D. Foresto, V. Gomes, T. Ferreira, I. Meira, M. Cristelli, M. Jesus, R. Rissoni, E. Lucena, H. Tedesco-Silva, J. Medina-Pestana
Nephrology Division - Hospital do Rim, Universidade Federal de São Paulo, São Paulo, Brazil
*Purpose: To evaluate the seroconversion rate in kidney transplant recipients (KTR), compared to two non-transplanted groups of patients, and identify predictors of seroconversion in COVID-19…