Articles tagged "Co-stimulation"

2020 American Transplant Congress
Stability of T Reg with Combination of mTOR Inhibitors with Belatacept in Reducing Risk of Acute Rejection in Kidney Transplant
J. Shoji, J. Leung, Q. Tang, F. Vincenti
University of California San Francisco (UCSF), San Francisco, CA
*Purpose: Belatacept is a costimulatory blocker that is used as de novo maintenance immunosuppression in kidney transplantation to avoid toxic effects of calcineurin inhibitors and…
2020 American Transplant Congress
Co-Stimulatory Blockade Immunosuppression Facilitates Lung Allograft Acceptance Through an Increase in Local IL-5 Production by Type 2 Innate Lymphoid Cells
Y. Guo, Z. Mei, A. Hata, B. Mahgoub, D. Li, A. Manafi, A. Banerjee, A. Gelman, D. Kreisel, A. Krupnick
Surgery, University of Virginia, Charlottesville, VA
*Purpose: We have recently demonstrated that co-stimulatory blockade (CSB)-induced mouse lung allograft acceptance depends on a rapid influx of eosinophils that function to downregulate T…
2020 American Transplant Congress
Belatacept Conversion is Safe and Effective in Adolescent and Young Adult Kidney Transplant Recipients
A. Moudgil, C. Petyak, K. Sgambat
Nephrology, Children's National Med. Ctr., Washington, DC
*Purpose: Though tacrolimus (TAC) is a cornerstone of maintenance immunosuppression in kidney transplant recipients, some patients have significant side effects related to TAC. Conversion from…
2020 American Transplant Congress
Effect of Low vs Standard Dosage of Anti-Thymocyte Globulin Induction Therapy on the Co-Inducible Molecules (Cd28, CTLA-4, ICOS, PD-1) Expression Pattern in T Regulatory Cell
G. Queipo¹, A. Hernandez-Mendoza¹, M. Estrada-Matus², M. Fonseca-Sanchez¹, F. Oviedo¹, L. García-Cobarruvias³, J. Prieto Chávez⁴, L. Pizarro⁵, L. Morales-Buenrostro⁶
¹Human Genetics, Hospital General de Mexico-Eduardo Liceaga Facultad de Medicina UNAM, Mexico City, Mexico, ²Nephrology, Instituno Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, Mexico, ³Transplant Unit, Hospital General de Mexico-Eduardo Liceaga, Mexico City, Mexico, ⁴Flow Cytometry Core, Mexican Social Security Institute, Mexico City, Mexico, ⁵Unit on Immunochemistry, Medical Research, Specialties Hospital of the National Medical Centre “SigloXXI”, Mexico City, Mexico, ⁶Nephrology, Instituto Nacional de Ciencias Medicas y Nutrición Salvador Zubirán, Mexico City, Mexico
*Purpose: Two thymoglobulin (TG) dosages effect on the Tregulatory cell (Treg) and describe the behavior of the co-stimulatory pathways in terms of FIM and gene…
2020 American Transplant Congress
Activation of the ICOS/ICOS-Ligand Pathway in Antibody-Mediated Kidney Graft Rejection
V. Cantaluppi¹, G. Merlotti¹, M. Quaglia¹, G. Rosso¹, N. Clemente¹, G. Cappellano¹, A. Chiocchetti¹, G. Castellano², U. Dianzani¹, G. Camussi³
¹Nephrology and Kidney Transplantation Unit, University of Piemonte Orientale (UPO), Novara, Italy, ²Nephrology, Dialysis and Kidney Transplantation Unit, University of Foggia, Foggia, Italy, ³Department of Medical Sciences, University of Torino, Torino, Italy
*Purpose: The costimulatory pathway ICOS/ICOS-Ligand may represent a new therapeutic target in antibody-mediated rejection (ABMR), the major cause of long term kidney graft failure. The…
2020 American Transplant Congress
Obesity and Terminally Differentiated T Cells in Pediatric Kidney Transplantation
B. I. Shaw¹, H. Lee², C. Chan², R. B. Ettenger³, P. Grimm⁴, E. F. Reed⁵, M. Sarwal⁶, L. Stempora¹, B. Warshaw⁷, O. M. Martinez⁸, A. D. Kirk¹, E. T. Chambers⁹
¹Surgery, Duke University, Durham, NC, ²Biostatistics and Bioinformatics, Duke University, Durham, NC, ³Pediatrics, University of California, Los Angeles, Los Angeles, CA, ⁴Pediatrics, Stanford University, Palo Alto, CA, ⁵Pathology, University of California, Los Angeles, Los Angeles, CA, ⁶Surgery, University of California, San Francisco, San Francisco, CA, ⁷Pediatrics, Emory University/Children's Healthcare of Atlanta, Atlanta, GA, ⁸Surgery, Stanford University, Palo Alto, CA, ⁹Pediatrics, Duke University, Durham, NC
*Purpose: Nutritional status is known to modulate immunologic responses in non-immunosuppressed individuals. We utilized the Immune Development in Pediatric Transplantation (IMPACT) study to assess differences…
2020 American Transplant Congress
Desensitization Combining Costimulation Blockade with Proteasome Inhibition in Highly Sensitized Transplant Candidates
S. Restaino¹, D. Jennings², G. Serban³, E. Vasilescu³, G. Sayer¹, N. Uriel¹, K. Takeda⁴, Y. Naka⁴, M. Farr¹, M. V. Habal¹
¹Cardiology, Columbia University Irving Medical Center, New York, NY, ²School of Nursing, Columbia University Irving Medical Center, New York, NY, ³Pathology&Cell Biology, Columbia University Irving Medical Center, New York, NY, ⁴Cardiothoracic Surgery, Columbia University Irving Medical Center, New York, NY
*Purpose: Antibodies to human leukocyte antigens (HLA) pose a significant barrier to transplantation. Strategies to reduce allosensitization have modest efficacy and may result in antibody…
2020 American Transplant Congress
Memory T Cell-Mediated Rejection is Regulated by FcγRIIB Expression on CD8⁺ T Cells
A. B. Morris, D. F. Pinelli, D. Liu, M. L. Ford
Emory University, Atlanta, GA
*Purpose: Donor-reactive memory T cells represent a potent immunologic barrier to long-term graft survival and tolerance induction. To identify novel pathways that regulate memory T…
2020 American Transplant Congress
Impact of Belatacept Conversion on Renal Function, Histology and Gene Expression in Kidney Transplant Patients with Chronic Active Antibody-Mediated Rejection
D. Kumar¹, I. Yakubu¹, S. Paluri¹, A. Chachar¹, J. Chang², I. Moinuddin¹, L. Kamal¹, M. Levy¹, C. Bhati¹, A. King¹, P. Kimball¹, P. Halloran², G. Gupta¹
¹Virginia Commonwealth University, Richmond, VA, ²ATAGC, Edmonton, AB, Canada
*Purpose: Chronic active antibody mediated rejection (cABMR) is a major cause kidney transplant (KT) loss. Current therapies have unclear efficacy and side effects. Basic and…
2020 American Transplant Congress
Safety of Belatacept in HIV-Positive Kidney Transplant Recipients
K. El Sakhawi¹, A. Scemla², D. Bertrand³, C. Garrouste⁴, P. Malvezzi⁵, P. Grimbert¹, M. Matignon¹
¹Nephrology, APHP Henri Mondor, Créteil, France, ²Nephrology, APHP Necker Enfants Malades, Paris, France, ³Nephrology, CHU Bois Guillaume, Rouen, France, ⁴Nephrology, CHU Clermond Ferrand, Clermont Ferrand, France, ⁵Nephrology, CHU Grenoble, Grenoble, France
*Purpose: Kidney allograft survival in HIV-infected patients is lower than in the general population. Belatacept (instead of anticalcineurins (CNI)) has been shown to have a…

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