2015 American Transplant Congress
2B4 Expression on Human CD4+ Memory T Cells Is Associated With Functional Impairment
Emory Transplant Center, Emory University, Atlata, GA.
The SLAM family receptor 2B4 is expressed primarily on NK cells and memory CD8+ T cells. In prior studies, we found that 2B4 was upregulated…2015 American Transplant Congress
VLA-4 Blockade Inhibits Endogenous Memory CD8 T Cell-Mediated Rejection of Cardiac Allografts
Endogenous memory CD8 T cells infiltrate cardiac allografts within 24 hours of reperfusion and are activated to proliferate and produce IFN-γ in response to donor…2015 American Transplant Congress
Bridging Therapy With Belatacept in High MELD Liver Transplant Recipients
Background: Poor outcomes of high-MELD liver transplant recipients are driven by multisystem organ dysfunction. Renal failure post-transplant has been associated with mortality of greater than…2015 American Transplant Congress
Overexpression of 2B4 Inhibits the Expansion and Function of Donor-Reactive CD8+ T Cells in Selective Lymphoid Compartments
Department of Surgery, Emory University, Atlanta, GA.
2B4 is an immunoglobulin superfamily member expressed constitutively on NK cells, and inducibly on some CD8+ T cells. We recently showed in a murine skin…2015 American Transplant Congress
CD4 T Cell Mediated Help Is Required for Endogenous Memory CD8 T Cell Proliferation in Cardiac Allografts Subjected to Prolonged Cold Ischemic Storage
Endogenous memory CD8 T cells infiltrate MHC-mismatched cardiac allografts and produce IFN-γ in response to donor class І MHC within 24 hrs after graft reperfusion…2015 American Transplant Congress
CD27low NK Cells Prolong Allograft Survival in Mice By Inhibiting CD8+ T Cell Responses Through Controlling Graft-Derived Donor DCs
The underlying mechanisms by which distinct NK cell subsets promote either allograft rejection or survival remain unclear. Here, we tested the hypothesis that distinctively mature…2015 American Transplant Congress
The Immunosuppressive Effect of CTLA4Ig Monotherapy Depends On the Presence of Tregs Only at Suboptimally Low Doses
Background: CTLA4Ig/belatacept has been recently approved for immunosuppression after renal transplantation. Concerns persist, however, that a paradoxical dose-response relationship might exist for CTLA4Ig in which…2015 American Transplant Congress
Deceased Donor Kidney Transplantation Without Calcineurin Inhibitors or Steroids
1Transplant Center, Emory University, Atlanta, GA; 2Surgery, Duke University, Durham, NC.
Kidney transplantation remains limited by toxicities of calcineurin inhibitors (CNIs) and steroids. Belatacept is a less toxic CNI alternative delivered by monthly intravenous infusion, but…2015 American Transplant Congress
Interleukin-1 Receptor Signaling by Graft Stromal Cells Regulates Donor-Reactive CD8 T Cell Responses to Cardiac Allografts
Allograft reperfusion induces inflammation that directs the infiltration of memory T cells into the allograft and their activation to express functions mediating graft injury. The…2015 American Transplant Congress
Lower Frequency of Regulatory T-Cells After Conversion from CNIs or mTORi to Belatacept in a Prospective Matched Controlled Study in Renal Allograft Recipients
Nephrology, Charité Universitätsmedizin Berlin, Berlin, Germany.
Objective: Regulatory T-cells (Tregs) are considered to play a crucial role in maintaining control of immune response following renal transplantation (Tx). So far, only limited…
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