2020 American Transplant Congress
HLA Cross-Dressing of Dendritic Cells by Maternal Exosomes is Associated with PD-L1 Expression in Newborns
1University of Wisconsin-Madison, Madison, WI, 2Fred Hutchinson Cancer Research Center, Seattle, WA
*Purpose: Recipients of a kidney transplant from a haplo-identical sibling had accelerated early acute rejection episodes, followed by improved long-term graft survival if the transplant…2020 American Transplant Congress
Agonistic Anti-CD272 Antibody (6B2) Suppressed Donor Specific Antibody Through Inducible Regulatory T Cells
*Purpose: The co-inhibitory receptor B and T lymphocyte attenuator (BTLA; CD272) is a coinhibitory molecule and may play an important role in alloimmune responses. We…2020 American Transplant Congress
Three Year Post Co-Stimulation Blocking Agent (Belatacept) Switch Outcomes of Kidney Transplant Patients Diagnosed with Post-Transplant Thrombotic Microangiopathy
*Purpose: Thrombotic microangiopathy (TMA) can happen after kidney transplant. It may occur de novo or as a recurrent disease. De novo is usually associated with…2020 American Transplant Congress
Belatacept Removal by Plasmapheresis: Kinetics, Dose Adjustments and Clinical Recommendations
*Purpose: Belatacept (BELA), a protein immunosuppressant, has limited available pharmacokinetic (PK) data. Available PK data, limited to product development analyses, shows moderate intrapatient variability with…2020 American Transplant Congress
Human Live Donor Liver Transplantation is Associated with Pd-l1 Expression on Donor-Exosome-Acquiring Host Dendritic Cells
Surgery- Transplantation, University of Wisconsin-Madison, Madison, WI
*Purpose: Liver transplantation (LTx) has been associated with the phenomenon of “cross-dressing” of recipient dendritic cells (DCs) by donor exosome-derived MHC antigens, and acquisition of…2020 American Transplant Congress
IL-10 Signaling in T Cells is Essential for Induction of Transplant Tolerance
Plastic Surgery, Johns Hopkins University, Baltimore, MD
*Purpose: Induction of long term transplant survival by “costimulation blockade” (CoB) is achieved through deletion of abortively activated alloreactive T cells and generation of graft…2020 American Transplant Congress
Outcomes and Experience with Belatacept in Pediatric Kidney Transplantation
1Emory University, Atlanta, GA, 2Children's Healthcare of Atlanta, Atlanta, GA
*Purpose: Belatacept is a selective co-stimulation blocker used in adult renal transplantation and has shown improvement in glomerular filtration rate (GFR) compared to calcineurin inhibitors…2020 American Transplant Congress
CD11b is a Novel Alternate Receptor for CD154 During Alloimmunity
*Purpose: For decades, blockade of CD40-CD154 has been shown to be a highly effective means of inhibiting alloreactive T cell responses and inducing long-term graft…2020 American Transplant Congress
Post-Transplantation Lymph Node Fibrosis: Significant Implications in Transplant Tolerance
1Brigham and Women's Hospital, Boston, MA, 2University of Maryland School of Medicine, Boston, MA
*Purpose: Lymph nodes (LNs) have been regarded as primary activation sites for alloimmunity following transplantation, but our group has revealed an additional dimension to their…2020 American Transplant Congress
CD137 Signaling in Regulatory Dendritic Cells Is Required for Suppressing a Systemic Inflammation in the bm12-Inducible Model of Systemic Lupus Erythematosus
*Purpose: Although CD137 is well known as a costimulatory receptor in T cells, limited information is available for its immunoregulatory function. Here, we report that…
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