ATC Abstracts

American Transplant Congress abstracts

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Articles tagged "CD4"

  • 2015 American Transplant Congress

    Dramatic Primary Expansion of Indirect CD4 T Cells to Allogeneic APCs In Vivo

    N. Bishop,1 M. Nelsen,1 M. Coulombe,2 R. Gill.2

    1Immunology, University of Colorado Denver, Aurora, CO; 2Surgery, University of Colorado Denver, Aurora, CO.

    An ongoing question regarding the primary allograft response is the relative contribution of the 'direct' (donor MHC-restricted) versus 'indirect' (host MHC-restricted) pathways of T cell…
  • 2015 American Transplant Congress

    Germinal Centre Autoimmunity Mediates Progression of Allograft Vasculopathy, With Essential Help Provided By T Follicular Cells

    M. Qureshi, R. Motallebzadeh, M. Chhabra, M. Negus, S. Rehakova, E. Bolton, J. Bradley, G. Pettigrew.

    Dept of Surgery, University of Cambridge, Cambridge, United Kingdom.

    Introduction: : In our previous work we have shown that donor CD4 T cells within heart grafts initiate anti-nuclear autoantibody responses. Here we clarify the…
  • 2015 American Transplant Congress

    Feasibility of Regulatory T Cell Cryopreservation and Banking for Clinical Therapeutic Applications

    K. Gołąb,1 O. Savari,1 S. Ramachandran,1 Z. Tekin,1 M. Tibudan,1 J. Millis,1 P. Trzonkowski,2 P. Witkowski.1

    1Surgery, University of Chicago, Chicago, IL; 2Immunology, Medical University of Gdansk, Gdansk, Poland.

    Feasibility of clinical application of regulatory T cells (Tregs) in clinical transplantation would be improved if Tregs or pre-enriched cells for Treg isolation could be…
  • 2015 American Transplant Congress

    The Preservation Technique Modulates the Immunological Milieu in Lung Transplantation and Affects the Pro-/ Anti-Inflammatory Balance

    M. Seyda,1 B. Wiegmann,3 B. Mueller,2 C. Neudoerfl,1 A. Akhdar,1 K. Daemen,1 A. Haverich,3,4 G. Warnecke,3,4 C. Falk.3,5

    1Inst. of Transplant Immunology, IFB-Tx, Hanover Medical School, Hanover, Germany; 2MorphoSys, Munich, Germany; 3Cardiothoracic, Transplantation and Vascular Surgery, Hanover Medical School, Hanover, Germany; 4German Center for Lung Research, Gießen, Germany; 5German Center for Infection Research, Braunschweig, Germany.

    Little is known regarding the influence of different preservation techniques (i.e. cold static storage with Perfadex® or Celsior® solution) on the immunological milieu, especially lung-resident…
  • 2015 American Transplant Congress

    Mononuclear Cell Infiltrates Characterization in Scar Tissue from a Bilateral Forearm Transplant Patient: Findings to Think

    J. Furuzawa-Carballeda,1 M. Iglesias,2 J. Alberu,3 A. Gamboa,4 P. Butrón,2 M. Morán-Romero,2 Y. Esquivel.1

    1Immunology, INCMNSZ, Mexico City, Mexico; 2Plastic Surgery, INCMNSZ, Mexico, Mexico; 3Transplants, INCMNSZ, Mexico, Mexico; 4Pathology, INCMNSZ, Mexico City, Mexico.

    Herein we report the cell infiltrating pattern in scar tissue resected at the junction of the VCA and the tissue corresponding to the recipient arm,…
  • 2015 American Transplant Congress

    Characterization of a Nude Mouse Model of Allosensitization Conditioned by Adoptive Transfer of Follicular T Helper Cells

    I. Kim, N.-N. Chai, S. Jordan, A. Klein, G. Wu.

    Comprehensive Transplant Center, Cedars-Sinai Medical Center, Los Angeles, CA.

    Background Follicular T helper (Tfh) cells play a critical role in follicular B cell activation and maturation during antibody responses to allograft. Here we report…
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