ATC Abstracts

American Transplant Congress abstracts

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Articles tagged "CD4"

  • 2017 American Transplant Congress

    Exosomes Containing IL35 Are Secreted by Donor-Specific Regulatory T Cells and Cause Linked-Suppression.

    Y. Tomita,1 W. Bracamonte-Baran,1 E. Jankowska-Gan,1 Q. Zhang,2 D. Vignali,2 W. Burlingham.1

    1Surgery, Transplant Division, University of Wisconsin-Madison, Madison, WI; 2Immunology, University of Pittsburgh, Pittsburgh

    Introduction: We previously reported that donor specific splenocytes transfusion (DST) plus anti-CD40L costimulatory blockade treatment causes allo-specific regulation approximately 5 weeks after the tolerization. The…
  • 2017 American Transplant Congress

    Evolution of CCR4highCD4+ Subpopulations in Renal Graft Blood After Steroid Withdrawal: A Prospective, Randomized, Controlled Study in Parallel Groups. Preliminary Results.

    J. Alonso-Titos,1 P. Ruiz-Esteban,1 E. Palma,1 A. Caballero,2 E. Sola,1 M. Cabello,1 T. Vazquez,1 A. Duarte,1 C. Jironda,1 D. Hernandez.1

    1Nephrology, Regional University Hospital and Malaga University, IBIMA, RD16/0009/0006, Malaga, Spain; 2Immunology, Regional University Hospital of Malaga, Malaga, Spain

    Introduction:Steroids are a mainstay of immunosuppression after kidney transplant (KT). The infiltration into the graft of active T cells following KT depends on the expression…
  • 2016 American Transplant Congress

    Molecular Significance of Microvascular Inflammation and C4d Negative Transplant Glomerulopathy.

    M. Lubetzky,1 P. O Broin,2 Y. Bao,1 E. Akalin.1

    1Transplantation, Albert Einstein College of Medicine, Bronx; 2School of Mathematics, Statistics & Applied Mathematics, National University of Ireland Galway University, Galway, Ireland.

    Background: Transplant glomerulopathy (TGP) is frequently found in the setting of chronic antibody mediated rejection along with microvascular inflammation (MVI) (peritubular capillaritis+glomerulitis score > 1)…
  • 2016 American Transplant Congress

    The Property of Modulatory T Cells Generated by Mixed Lymphocyte Culture with CD154 Blockade.

    K. Hotta, T. Oura, B. Cosimi, T. Kawai.

    Center for Transplantation Science, Massachusetts General Hospital, Boston, MA.

    Background:Regulatory T cell (Treg) immunotherapy has been applied to minimize the immunosuppressive drugs in clinical transplantation. To avoid contamination of CD4+CD25- T cells, only highly…
  • 2016 American Transplant Congress

    Aryl Hydrocarbon Receptor Expression Increases in Skin Graft-infiltrating Th1 and Treg Cells.

    J. Fechner, W. Julliard, L. Owens, J. Mezrich.

    Surgery, University of Wisconsin, Madison, WI.

    Hypothesis: The expression of the aryl hydrocarbon receptor (AHR), a transcription factor activated by a variety of exogenous and endogenous ligands including the typtophan-metabolite kynuenine,…
  • 2016 American Transplant Congress

    In Vitro Reactivity of CD4+ T Cells Subsets from Hosts with Antigen Specific Transplant Tolerance Mediated by CD4+CD25+T Cells.

    B. Hall, C. Robinson, K. Plain, N. Verma, G. Tran, N. Carter, M. Nomura, R. Boyd, S. Hodgkinson.

    Immune Tolerance Laboratory, UNSW Australia, Sydney, NSW, Australia.

    In animals with transplant tolerance without lympho-hemopoietic chimerism peripheral T cells reactive to donor are not deleted, but their capacity to effect rejection is inhibited…
  • 2016 American Transplant Congress

    Outcomes of Solid Organ Transplantation from an HIV Positive Donor to Negative Recipients.

    S.-N. Lin,1 M.-K. Tsai,1 C.-Y. Luo,2 C.-Y. Lee,1 R.-H. Hu,1 J.-M. Lee,1 H.-S. Lai.1

    1Department of Surgery, National Taiwan University Hospital, Taipei, Taiwan; 2Department of Surgery, National Cheng Kung University Hospital, Tainan, Taiwan.

    Purpose:There are few case reports about outcomes of solid organ transplantation from human immunodeficiency virus (HIV)-positive donor to HIV-negative recipient. We would like to share…
  • 2016 American Transplant Congress

    Necroptosis Is Involved in CD4+ T-Cell Mediated Microvascular Endothelial Cell Death and Chronic Cardiac Allograft Rejection.

    C. Kwok,1,2 N. Montwill,1,2 A. Pavlosky,1,2 A. Haig,2 X.-Y. Huang,1 A. Jevnikar,1,3 Z.-X. Zhang.1,2,3

    1Matthew Mailing Centre for Translational Transplant Studies, London Health Sciences Centre, London, Canada; 2Department of Pathology and Laboratory Medicine, Western University, London, Canada; 3Department of Medicine, Western University, London, Canada.

    Heart transplantation is potentially the only viable option for patients with end-stage heart failure. Despite advances in immunosuppressive therapies, cardiac allograft chronic rejection is a…
  • 2015 American Transplant Congress

    Sequential Monitoring and Stability of Ex Vivo-Expanded Autologous and Non-Autologous Regulatory T Cells Following Infusion in Non-Human Primates

    H. Zhang,1 H. Guo,1 L. Lu,1 A. Zahorchak,1 R. Wiswman,2 G. Raimondi,1 D. Cooper,1 M. Ezzelarab,1 A. Thomson.1

    1University of Pittsburgh, pittsburgh, PA; 2University of Wisconsin, Madison.

    Ex vivo-expanded cynomolgus monkey CD4+CD25+CD127- regulatory T cells (Treg) maintained Foxp3 demethylation status at the Treg-Specific Demethylation Region (TSDR), and potently suppressed T cell proliferation…
  • 2015 American Transplant Congress

    Adoptive Transfer of T Cell Receptor-Transgenic (TCR-Tg) Cells Alters Endogenous Immune Responses During Acute Rejection

    M. Miller, M. Daniels, Y. Wang, D. Yin, A. Chong, M.-L. Alegre.

    University of Chicago, Chicago, IL.

    In addition to the therapeutic use of adoptive transfer of T cells to combat viral infections and malignancies in humans, adoptive transfer of T cell…
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