2017 American Transplant Congress
Exosomes Containing IL35 Are Secreted by Donor-Specific Regulatory T Cells and Cause Linked-Suppression.
Introduction: We previously reported that donor specific splenocytes transfusion (DST) plus anti-CD40L costimulatory blockade treatment causes allo-specific regulation approximately 5 weeks after the tolerization. The…2017 American Transplant Congress
Evolution of CCR4highCD4+ Subpopulations in Renal Graft Blood After Steroid Withdrawal: A Prospective, Randomized, Controlled Study in Parallel Groups. Preliminary Results.
Introduction:Steroids are a mainstay of immunosuppression after kidney transplant (KT). The infiltration into the graft of active T cells following KT depends on the expression…2016 American Transplant Congress
Outcomes of Solid Organ Transplantation from an HIV Positive Donor to Negative Recipients.
Purpose:There are few case reports about outcomes of solid organ transplantation from human immunodeficiency virus (HIV)-positive donor to HIV-negative recipient. We would like to share…2016 American Transplant Congress
Necroptosis Is Involved in CD4+ T-Cell Mediated Microvascular Endothelial Cell Death and Chronic Cardiac Allograft Rejection.
Heart transplantation is potentially the only viable option for patients with end-stage heart failure. Despite advances in immunosuppressive therapies, cardiac allograft chronic rejection is a…2016 American Transplant Congress
Molecular Significance of Microvascular Inflammation and C4d Negative Transplant Glomerulopathy.
Background: Transplant glomerulopathy (TGP) is frequently found in the setting of chronic antibody mediated rejection along with microvascular inflammation (MVI) (peritubular capillaritis+glomerulitis score > 1)…2016 American Transplant Congress
The Property of Modulatory T Cells Generated by Mixed Lymphocyte Culture with CD154 Blockade.
Center for Transplantation Science, Massachusetts General Hospital, Boston, MA.
Background:Regulatory T cell (Treg) immunotherapy has been applied to minimize the immunosuppressive drugs in clinical transplantation. To avoid contamination of CD4+CD25- T cells, only highly…2016 American Transplant Congress
Aryl Hydrocarbon Receptor Expression Increases in Skin Graft-infiltrating Th1 and Treg Cells.
Surgery, University of Wisconsin, Madison, WI.
Hypothesis: The expression of the aryl hydrocarbon receptor (AHR), a transcription factor activated by a variety of exogenous and endogenous ligands including the typtophan-metabolite kynuenine,…2016 American Transplant Congress
In Vitro Reactivity of CD4+ T Cells Subsets from Hosts with Antigen Specific Transplant Tolerance Mediated by CD4+CD25+T Cells.
Immune Tolerance Laboratory, UNSW Australia, Sydney, NSW, Australia.
In animals with transplant tolerance without lympho-hemopoietic chimerism peripheral T cells reactive to donor are not deleted, but their capacity to effect rejection is inhibited…2015 American Transplant Congress
Sequential Monitoring and Stability of Ex Vivo-Expanded Autologous and Non-Autologous Regulatory T Cells Following Infusion in Non-Human Primates
1University of Pittsburgh, pittsburgh, PA; 2University of Wisconsin, Madison.
Ex vivo-expanded cynomolgus monkey CD4+CD25+CD127- regulatory T cells (Treg) maintained Foxp3 demethylation status at the Treg-Specific Demethylation Region (TSDR), and potently suppressed T cell proliferation…2015 American Transplant Congress
Adoptive Transfer of T Cell Receptor-Transgenic (TCR-Tg) Cells Alters Endogenous Immune Responses During Acute Rejection
University of Chicago, Chicago, IL.
In addition to the therapeutic use of adoptive transfer of T cells to combat viral infections and malignancies in humans, adoptive transfer of T cell…
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