Session Time: 6:00pm-7:00pm
Presentation Time: 6:00pm-7:00pm
Location: Halls C&D
There are few case reports about outcomes of solid organ transplantation from human immunodeficiency virus (HIV)-positive donor to HIV-negative recipient. We would like to share our experience in this specific situation.
On August, 24th, 2011, due to erroneous communication between OPO and laboratory staff, one HIV-positive young man passed pre-transplantation evaluation after brain death announcement. Five patients received his organs for transplantation including 1 for the heart, 1 for the lung, 1 for the liver and 2 for the kidneys. All 5 HIV negative recipients received HAART within 48 hours after transplantation. Medical records of the five patients were reviewed from August, 2011 to October, 2015. The patient survival rate and graft survival rate were considered as the primary outcome. Rejection episodes, adverse drug events, organ function, CD4 T cell count and HIV viral load of the recipients were the secondary outcomes.
During the 4-year follow-up, HIV viral load in all the 5 recipients were reported “undetectable” within 2 weeks after transplantation except the lung recipient, who was not HIV-free until one month after transplantation. CD4 T cell in all 5 recipients were higher than 200/mcL with no incidence of opportunistic infection. So far, HIV viral load kept undetectable in all recipients with adequate CD4 T cells. Episodes of mild cellular rejection happened in the heart recipient at 43 months and the liver recipient at 3 months. All the patients are surviving and all transplant organs are of good function, but the lung recipient encountered drug-related renal injury caused by tenofovir and tacrolimus. However, the heart recipient was found to have cardiac allograft vasculopathy, coronary artery disease by cardiac catheterization at 12 months.
With HAART, all 5 HIV-negative recipients accepted the solid organ transplantation from the HIV-positive donor with normal CD4 T-cell counts. The patient and graft survival at 4 years were both 100%.
CITATION INFORMATION: Lin S.-N, Tsai M.-K, Luo C.-Y, Lee C.-Y, Hu R.-H, Lee J.-M, Lai H.-S. Outcomes of Solid Organ Transplantation from an HIV Positive Donor to Negative Recipients. Am J Transplant. 2016;16 (suppl 3).
To cite this abstract in AMA style:Lin S-N, Tsai M-K, Luo C-Y, Lee C-Y, Hu R-H, Lee J-M, Lai H-S. Outcomes of Solid Organ Transplantation from an HIV Positive Donor to Negative Recipients. [abstract]. Am J Transplant. 2016; 16 (suppl 3). https://atcmeetingabstracts.com/abstract/outcomes-of-solid-organ-transplantation-from-an-hiv-positive-donor-to-negative-recipients/. Accessed October 20, 2020.
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