ATC Abstracts

American Transplant Congress abstracts

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Articles tagged "CD4"

  • 2018 American Transplant Congress

    The Mark of Zorro: IL35-Coated Exosomes Cross-Dress and Exhaust Recipient T & B Cells during Transplant Tolerance

    W. Burlingham,1 J. Sullivan,1 D. Lema,1 Y. Tomita,2 Y. Zhou,1 D. Vignali.3

    1Surgery, University of Wisconsin, Madison, WI; 2Surgery, Tokyo Women's Hospital, Tokyo, Japan; 3Immunology, University of Pittsburgh Medical Center, Pittsburgh, PA.

    The folk-hero "Zorro" left his mark on by a sword-slashed "Z". In transplant recipients, rare Tregs also leave a mark on their conventional T &…
  • 2018 American Transplant Congress

    Allogeneic T Follicular and T Conventional Responses Assessed by Proliferation, Cytokine Production, and TCR Clonality

    C. Macedo,1 M. Yamada,1 X. Gu,1 M. Suchoroski,2 D. Hamm,2 M. Kaplan,2 D. Metes.1

    1Thomas E. Starzl Transplantation Institute, Pittsburgh; 2Adaptive Biotechnologies, Seattle.

    Background: Human CD4+ T cell allo-immunity plays pivotal roles during cellular and humoral allograft rejection. Our previous analysis showed that allo-reactive precursors were present in…
  • 2018 American Transplant Congress

    OX40 Costimulation Prevents Induction of Foxp3+ Tregs through Upregulation of Novel Repressors of Foxp3 Gene Expression

    X. Zhang,1 X. Xiao,1 P. Lan,1 J. Li,1 Y. Dou,1 W. Chen,1 N. Ishii,2 S. Chen,1 E. Taparowsky,3 X. Li.1,4

    1Immunobiology & Transplant Research Center, Houston Methodist Hospital, Houston, TX; 2Department of Microbiology and Immunology, Tohoku University, Sendai, Japan; 3Department of Biological Sciences, Perdue University, Lafayette, IN; 4Department of Surgery, Weill Cornell Medical College of Cornell University, New York, NY.

    Foxp3+ Tregs are essential for the induction of transplant tolerance and OX40 costimulation is known to break transplant tolerance. The exact mechanism of OX40 in…
  • 2018 American Transplant Congress

    Assessment of Immune Cell Profiles in HLA-Sensitized (HS) & Non-HS Patients (Pts) with End Stage Renal Disease (ESRD)

    S. Ge,1 M. Chu,1 E. Ortiz,1 A. Vo,2 D. Lovato,1 S. Jordan,2 M. Toyoda.1

    1Transplant Immunology Laboratory, Cedars-Sinai Medical Center, Los Angeles, CA; 2Comprehensive Transplant Center, Cedars-Sinai Medical Center, Los Angeles, CA.

    Background: Chronic inflammation is often seen in pts w/ ESRD. HLA-sensitization may create or be driven by the cytokines responsible for chronic inflammation. Here we…
  • 2018 American Transplant Congress

    TLR2 with TCR Signaling Mobilizes Treg Lymphatic Migration

    W. Piao, Y. Xiong, L. Li, V. Saxena, J. Bromberg.

    UMB, MD.

    Background: Regulatory T cells (Treg) express high levels of lymphotoxin (LT) and bind the LT receptor (LTβR) on lymphatic endothelial cells (LEC). This receptor-ligand interaction…
  • 2017 American Transplant Congress

    Tracking the In Vitro Phenotype and Proliferative Capacity of CD57+ CD4 T Cells.

    J. Espinosa,1 J. Lockley,1 F. Shaw,1 R. Osborne,1 M. Joshi,1 T. Woody,1 M. Ellis,1 B. Hollister,1 J. Cheeseman,1 R. Townsend,2 A. Kirk.1

    1Duke University, Durham; 2Bristol-Meyers Squibb, Princeton

    CD57+PD1- CD4 T cells are primed effectors with increased expression of adhesion molecules capable of infiltrating allografts and mediating belatacept-resistant rejection (BRR). Whether CD57 is…
  • 2017 American Transplant Congress

    Glomerular CD45 Immunostaining in Post Perfusion Graft Biopsies Predicting Rejection.

    A. Yuvaraj, A. Prasad, K. Gopalakrishnan, N. Krishnan.

    Renal Transplant Unit, University Hospitals Coventry, Coventry, United Kingdom

    Introduction: Recipients of incompatible renal allografts remain at risk of developing AMR after transplantation. Current microarray analysis of allograft biopsies showed similar disturbances in AMR…
  • 2017 American Transplant Congress

    Immunosuppressive Ability of NFkB Inhibitor: Withaferin A.

    M. Kanak,1 Y. Shindo,1 M. Levy,1,2 B. Naziruddin.3

    1Transplant Surgery, Virginia Commonwealth University, Richmond, VA; 2Hume-Lee Transplant Center, VCU Health System, Richmond, VA; 3Simmons Transplant Institute, Baylor Scott and White Health, Dallas, TX

    BackgroundThe advent of steroid-free protocol by the Edmonton group encouraged islet transplant as a therapy for Type-1 Diabetes. However, long-term dysfunction in islet transplantation is…
  • 2017 American Transplant Congress

    Antiretroviral Therapy Modification of HIV+ Patients Listed for Kidney Transplantation.

    D. Lee,1 G. Malat,3 T. Bias,1 S. Epstein,1 L. Levin Mizrahi,2 M. Harhay,2 S. Talluri,2 K. Ranganna.2

    1Division of Infectious Diseases and HIV Medicine, Drexel University College of Medicine, Philadelphia; 2Division of Nephrology, Drexel University College of Medicine, Philadelphia; 3Department of Surgery, Drexel University College of Medicine, Philadelphia

    Introduction:HIV+ individuals can receive kidney transplant (KT) safely and effectively but face additional challenges from potential drug interactions between antiretroviral therapy (ART) and immunosuppression(IS). Little…
  • 2017 American Transplant Congress

    NK Cells Respond to CMV Lysate by Inducing IFNγ and CD107a Surface Expression in an Antibody-Dependent Manner: This Represents a Cytokine Flow Cytometry (CFC) Assay That Could Assess Antibody-Dependent Cell-Mediated Cytotoxicity (ADCC) as a Marker of CMV Immunity in Transplant Recipients.

    S. Ge, C. Maggie, B.-H. Shin, A. Karasyov, S. Jordan, M. Toyoda.

    Transplant Immunology Laboratory and Comprehensive Transplant Center, Cedars-Sinai Medical Center, Los Angeles, CA

    Background: Viral infections represent significant morbidity factors for transplant recipients. Tools to assess the efficacy of viral-specific responses are lacking. ADCC is the major antibody-mediated…
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