Articles tagged "CD4"

2020 American Transplant Congress
Can Cxcr3⁺Cd62l^–Cd4⁺ T Cells Serve as Early Warning Sentinels for Subclinical Rejections after Vascularized Composite Allotransplantation (vca)?
M. Kim¹, D. Fisher¹, J. Loo¹, J. Skitzki¹, E. Repasky²
¹Surgical Oncology, Roswell Park Comprehensive Cancer Center, Buffalo, NY, ²Immunology, Roswell Park Comprehensive Cancer Center, Buffalo, NY
*Purpose: New microsurgical techniques and powerful immunosuppressive drugs have made it possible for severely injured patients to receive VCA to replace limbs, hands, or faces,…
2020 American Transplant Congress
Circulating Tissue Specific Exosomes Enable Noninvasive Diagnosis of Acute Cellular Rejection in Clinical Heart Transplantation
L. Korutla¹, R. Hu¹, C. Romano¹, M. Molina¹, C. Sciortino², C. Mullan³, R. McGargle², H. Kagawa², A. Kilic², A. Naji⁴, P. Vallabhajosyula³
¹Surgery, University of Pennsylvania, Philadelphia, PA, ²Surgery, University of Pittsburgh Medical Center, Pittsburgh, PA, ³Surgery, Yale University, New Haven, CT, ⁴University of Pennsylvania, Philadelphia, PA
*Purpose: There is a critical need for development of noninvasive biomarkers for allograft surveillance and diagnosis of rejection in heart transplant patients, as endomyocardial biopsy…
2020 American Transplant Congress
T Cells from Highly Sensitized Kidney Transplant Patients Display Distinct TCR Repertoires
S. Negi¹, M. Li¹, A. Rutman², S. Paraskevas¹, C. Polychronakos¹, J. Tchervenkov¹
¹RIMUHC, Montreal, QC, Canada, ²McGill University, Montreal, QC, Canada
*Purpose: Sensitization to HLA antigens limits patient’s access to renal transplantation and causes higher risk of acute rejection and graft loss. T-cells, B-cells and donor-specific…
2020 American Transplant Congress
The Fibrinogen-Like Protein 2 Molecule Influences the Development of Thymic Regulatory T-Cells
C. Lam¹, S. Moshkelgosha¹, G. A. Levy², A. Chruscinski³, S. C. Juvet⁴
¹Latner Thoracic Surgery Research Laboratories, University Health Network, Toronto, ON, Canada, ²Multi Organ Transplant Program, University Health Network, Toronto, ON, Canada, ³Toronto General Hospital Research Institute (TGHRI), University Health Network, Toronto, ON, Canada, ⁴Toronto General Hospital Research Institute, University Health Network, Toronto, ON, Canada
*Purpose: Transplantation is the primary treatment for patients with end-stage organ failure. However, long-term outcomes are limited by immunosuppressant toxicities and chronic graft rejection. Identifying…
2020 American Transplant Congress
Targeting CD4⁺ T Cell Metabolism Prolongs Graft Survival Age-Specifically
Y. Nian, J. Iske, K. Minami, R. Maenosono, T. Heinbokel, A. Elkhal, S. G. Tullius
Division of Transplant Surgery and Transplant Surgery Research Laboratory, Harvard Medical School, Boston, MA
*Purpose: If and how aging affects T-cell metabolism and alloimmune response is unclear. Here, we show that T-cell metabolism changes drastically in aging. Most notably,…
2020 American Transplant Congress
Neuropilin 2 is a Novel Coinhibitory Molecule That Suppresses Alloimmune Responses Following Transplantation
J. Wedel, J. Lee, N. Kochupurakkal, E. Chernov, M. Poreddy, K. Liu, S. Kong, D. Bielenberg, H. Nakayama, D. M. Briscoe
Boston Children's Hospital, Boston, MA
*Purpose: We have previously reported that signaling via the transmembrane receptor neuropilin 2 (NRP2) regulates PI3K/mTOR/Akt activity in several human cell lines. Furthermore, it is…
2020 American Transplant Congress
Laminin Alpha5 Regulates T Cell Entry and Distribution in Lymph Nodes in Immunity
L. Li¹, M. Shirkey¹, W. Piao¹, Y. Xiong¹, V. Saxena¹, T. Zhang¹, C. Paluskievicz¹, J. Zhao², R. Abdi², J. S. Bromberg¹
¹UMB, Baltimore, MD, ²Harvard University, Boston, MA
*Purpose: Laminin α5 (Lama5) and α4 (Lama4) are lymph node (LN) stromal fibers whose expression ratio influences CD4+ T cell migration and stimulation. We hypothesized…
2020 American Transplant Congress
Treg Use PD-1 for Lymphatic Migration
W. Piao¹, L. Li¹, K. Hippen², Y. Zhang³, Y. Xiong¹, V. Saxena¹, C. Paluskievicz¹, M. WillsonShirkey¹, B. Blazar⁴, L. Riella⁵, J. Bromberg⁶
¹Surgery, U of Maryland, Baltimore, MD, ²U of Minnesota, Minneapolis, MN, ³U of Maryland, Minneapolis, MD, ⁴U of Minnesota, Minneapolis, MA, ⁵Harvard U, Boston, MA, ⁶Surgery and Microbiology and Immunology, U of Maryland, Baltimore, MD
*Purpose: Regulatory T cell (Treg) lymphatic migration is important for immune tolerance. Treg express both programmed death-1 (PD-1) and its ligand PD-L1, which are important…
2020 American Transplant Congress
Hemodialysis (HD) Treatment Associates with Increased Risk of Delayed Graft Function (DGF) after Renal Transplantation (RT) and Augmented Cd4 and Cd8 T Cell Proliferation Compared to Peritoneal Dialysis (PD)
A. Angeletti¹, C. Donadei¹, G. Donati¹, G. Di Certo¹, D. Conte¹, L. Gasperoni¹, E. Pelizzaro¹, C. Guglielmo¹, G. Comai¹, P. Cravedi², G. La Manna¹
¹DIMES, S.Orsola-Malpighi Hospital, Bologna University, Bologna, Italy, ²DIMES, Icahn School of Medicine at Mount Sinai, New York, NY, US, New York, NY
*Purpose: Delayed graft function (DGF) is a common event after RT that increases the risk of acute rejection and early graft loss. The impact of…
2019 American Transplant Congress
Laminin Dependent T Cell Migration Determines Allograft Survival
L. Li, M. Shirkey, W. Piao, Y. Xiong, V. Saxena, T. Zhang, B. M. Cerel, C. Paluskievicz, J. S. Bromberg
Surgery, U. Maryland, Baltimore, Baltimore, MD
*Purpose: Differential expression of lymph node (LN) stromal laminins α5β1γ1 (511) and α4β1γ1 (411) is associated with tolerance and immunity, respectively. We investigated the hypothesis…