2020 American Transplant Congress
Treg Use PD-1 for Lymphatic Migration
*Purpose: Regulatory T cell (Treg) lymphatic migration is important for immune tolerance. Treg express both programmed death-1 (PD-1) and its ligand PD-L1, which are important…2020 American Transplant Congress
Hemodialysis (HD) Treatment Associates with Increased Risk of Delayed Graft Function (DGF) after Renal Transplantation (RT) and Augmented Cd4 and Cd8 T Cell Proliferation Compared to Peritoneal Dialysis (PD)
*Purpose: Delayed graft function (DGF) is a common event after RT that increases the risk of acute rejection and early graft loss. The impact of…2020 American Transplant Congress
Suppressing Laminin Alpha5 Creates Tolerogenic Niches for Allograft Survival
1UMB, Baltimore, MD, 2Harvard University, Boston, MA
*Purpose: Laminin α5 (Lama5) regulates CD4 T cell migration and function. We hypothesized that stromal Lama5 regulates the structure of the lymph node (LN) microenvironment…2020 American Transplant Congress
Evaluation of Pre-Transplant T Cell Exhaustion as a Mechanism for Immune Dysfunction and Recipient Risk of Death Following Liver Transplant
*Purpose: Cirrhosis-related immune dysfunction likely contributes to early mortality following liver transplant (LT) resulting from infections. We previously identified a pre-transplant biomarker panel for immune…2020 American Transplant Congress
Lymph Node Stromal Laminin Alpha5 Regulates Antigen Specific T Cell Adaptive Immunity
1UMB, Baltimore, MD, 2Harvard University, Boston, MA
*Purpose: Laminin α5 (Lama5) is associated with immunity and regulates T cell entry and responses within the lymph node (LN). We hypothesized that stromal Lama5…2020 American Transplant Congress
Can Cxcr3+Cd62l–Cd4+ T Cells Serve as Early Warning Sentinels for Subclinical Rejections after Vascularized Composite Allotransplantation (vca)?
*Purpose: New microsurgical techniques and powerful immunosuppressive drugs have made it possible for severely injured patients to receive VCA to replace limbs, hands, or faces,…2020 American Transplant Congress
Circulating Tissue Specific Exosomes Enable Noninvasive Diagnosis of Acute Cellular Rejection in Clinical Heart Transplantation
*Purpose: There is a critical need for development of noninvasive biomarkers for allograft surveillance and diagnosis of rejection in heart transplant patients, as endomyocardial biopsy…2020 American Transplant Congress
T Cells from Highly Sensitized Kidney Transplant Patients Display Distinct TCR Repertoires
1RIMUHC, Montreal, QC, Canada, 2McGill University, Montreal, QC, Canada
*Purpose: Sensitization to HLA antigens limits patient’s access to renal transplantation and causes higher risk of acute rejection and graft loss. T-cells, B-cells and donor-specific…2020 American Transplant Congress
The Fibrinogen-Like Protein 2 Molecule Influences the Development of Thymic Regulatory T-Cells
*Purpose: Transplantation is the primary treatment for patients with end-stage organ failure. However, long-term outcomes are limited by immunosuppressant toxicities and chronic graft rejection. Identifying…2019 American Transplant Congress
CD4 T Cell-Derived NGAL Mediates Experimental Acute Kidney Injury
*Purpose: Neutrophil gelatinase-associated lipocalin (NGAL) is a potential biomarker for early detection of acute kidney injury (AKI) in human, but the mechanistic role for NGAL…
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