ATC Abstracts

American Transplant Congress abstracts

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Articles tagged "CD4"

  • 2020 American Transplant Congress

    Lymph Node Stromal Laminin Alpha5 Regulates Antigen Specific T Cell Adaptive Immunity

    L. Li1, M. Shirkey1, W. Piao1, Y. Xiong1, V. Saxena1, T. Zhang1, C. Paluskievicz1, J. Zhao2, R. Abdi2, J. S. Bromberg1

    1UMB, Baltimore, MD, 2Harvard University, Boston, MA

    *Purpose: Laminin α5 (Lama5) is associated with immunity and regulates T cell entry and responses within the lymph node (LN). We hypothesized that stromal Lama5…
  • 2020 American Transplant Congress

    Can Cxcr3+Cd62l–Cd4+ T Cells Serve as Early Warning Sentinels for Subclinical Rejections after Vascularized Composite Allotransplantation (vca)?

    M. Kim1, D. Fisher1, J. Loo1, J. Skitzki1, E. Repasky2

    1Surgical Oncology, Roswell Park Comprehensive Cancer Center, Buffalo, NY, 2Immunology, Roswell Park Comprehensive Cancer Center, Buffalo, NY

    *Purpose: New microsurgical techniques and powerful immunosuppressive drugs have made it possible for severely injured patients to receive VCA to replace limbs, hands, or faces,…
  • 2020 American Transplant Congress

    Circulating Tissue Specific Exosomes Enable Noninvasive Diagnosis of Acute Cellular Rejection in Clinical Heart Transplantation

    L. Korutla1, R. Hu1, C. Romano1, M. Molina1, C. Sciortino2, C. Mullan3, R. McGargle2, H. Kagawa2, A. Kilic2, A. Naji4, P. Vallabhajosyula3

    1Surgery, University of Pennsylvania, Philadelphia, PA, 2Surgery, University of Pittsburgh Medical Center, Pittsburgh, PA, 3Surgery, Yale University, New Haven, CT, 4University of Pennsylvania, Philadelphia, PA

    *Purpose: There is a critical need for development of noninvasive biomarkers for allograft surveillance and diagnosis of rejection in heart transplant patients, as endomyocardial biopsy…
  • 2020 American Transplant Congress

    T Cells from Highly Sensitized Kidney Transplant Patients Display Distinct TCR Repertoires

    S. Negi1, M. Li1, A. Rutman2, S. Paraskevas1, C. Polychronakos1, J. Tchervenkov1

    1RIMUHC, Montreal, QC, Canada, 2McGill University, Montreal, QC, Canada

    *Purpose: Sensitization to HLA antigens limits patient’s access to renal transplantation and causes higher risk of acute rejection and graft loss. T-cells, B-cells and donor-specific…
  • 2020 American Transplant Congress

    The Fibrinogen-Like Protein 2 Molecule Influences the Development of Thymic Regulatory T-Cells

    C. Lam1, S. Moshkelgosha1, G. A. Levy2, A. Chruscinski3, S. C. Juvet4

    1Latner Thoracic Surgery Research Laboratories, University Health Network, Toronto, ON, Canada, 2Multi Organ Transplant Program, University Health Network, Toronto, ON, Canada, 3Toronto General Hospital Research Institute (TGHRI), University Health Network, Toronto, ON, Canada, 4Toronto General Hospital Research Institute, University Health Network, Toronto, ON, Canada

    *Purpose: Transplantation is the primary treatment for patients with end-stage organ failure. However, long-term outcomes are limited by immunosuppressant toxicities and chronic graft rejection. Identifying…
  • 2020 American Transplant Congress

    Targeting CD4+ T Cell Metabolism Prolongs Graft Survival Age-Specifically

    Y. Nian, J. Iske, K. Minami, R. Maenosono, T. Heinbokel, A. Elkhal, S. G. Tullius

    Division of Transplant Surgery and Transplant Surgery Research Laboratory, Harvard Medical School, Boston, MA

    *Purpose: If and how aging affects T-cell metabolism and alloimmune response is unclear. Here, we show that T-cell metabolism changes drastically in aging. Most notably,…
  • 2020 American Transplant Congress

    Neuropilin 2 is a Novel Coinhibitory Molecule That Suppresses Alloimmune Responses Following Transplantation

    J. Wedel, J. Lee, N. Kochupurakkal, E. Chernov, M. Poreddy, K. Liu, S. Kong, D. Bielenberg, H. Nakayama, D. M. Briscoe

    Boston Children's Hospital, Boston, MA

    *Purpose: We have previously reported that signaling via the transmembrane receptor neuropilin 2 (NRP2) regulates PI3K/mTOR/Akt activity in several human cell lines. Furthermore, it is…
  • 2020 American Transplant Congress

    Laminin Alpha5 Regulates T Cell Entry and Distribution in Lymph Nodes in Immunity

    L. Li1, M. Shirkey1, W. Piao1, Y. Xiong1, V. Saxena1, T. Zhang1, C. Paluskievicz1, J. Zhao2, R. Abdi2, J. S. Bromberg1

    1UMB, Baltimore, MD, 2Harvard University, Boston, MA

    *Purpose: Laminin α5 (Lama5) and α4 (Lama4) are lymph node (LN) stromal fibers whose expression ratio influences CD4+ T cell migration and stimulation. We hypothesized…
  • 2020 American Transplant Congress

    Treg Use PD-1 for Lymphatic Migration

    W. Piao1, L. Li1, K. Hippen2, Y. Zhang3, Y. Xiong1, V. Saxena1, C. Paluskievicz1, M. WillsonShirkey1, B. Blazar4, L. Riella5, J. Bromberg6

    1Surgery, U of Maryland, Baltimore, MD, 2U of Minnesota, Minneapolis, MN, 3U of Maryland, Minneapolis, MD, 4U of Minnesota, Minneapolis, MA, 5Harvard U, Boston, MA, 6Surgery and Microbiology and Immunology, U of Maryland, Baltimore, MD

    *Purpose: Regulatory T cell (Treg) lymphatic migration is important for immune tolerance. Treg express both programmed death-1 (PD-1) and its ligand PD-L1, which are important…
  • 2019 American Transplant Congress

    Treg-Lymphatic Crosstalk: Lymphotoxin Signals as Modulators of Immunity and Suppression

    W. Piao1, L. Li2, V. Saxena2, Y. Xiong2, C. Paluskievicz2, J. Bromberg3

    1Microbiology and Immunology, U. Maryland, Baltimore, baltimore, MD, 2Surgery, U. Maryland, Baltimore, Baltimore, MD, 3Surgery and Microbiology and Immunology, U. Maryland, Baltimore, Baltimore, MD

    *Purpose: Little is known about the molecular cues that regulate the entry of leukocytes across lymphatic vessels. Regulatory T cells (Treg) express high amounts of…
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