ATC Abstracts

American Transplant Congress abstracts

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Articles tagged "CD4"

  • 2020 American Transplant Congress

    Hemodialysis (HD) Treatment Associates with Increased Risk of Delayed Graft Function (DGF) after Renal Transplantation (RT) and Augmented Cd4 and Cd8 T Cell Proliferation Compared to Peritoneal Dialysis (PD)

    A. Angeletti1, C. Donadei1, G. Donati1, G. Di Certo1, D. Conte1, L. Gasperoni1, E. Pelizzaro1, C. Guglielmo1, G. Comai1, P. Cravedi2, G. La Manna1

    1DIMES, S.Orsola-Malpighi Hospital, Bologna University, Bologna, Italy, 2DIMES, Icahn School of Medicine at Mount Sinai, New York, NY, US, New York, NY

    *Purpose: Delayed graft function (DGF) is a common event after RT that increases the risk of acute rejection and early graft loss. The impact of…
  • 2020 American Transplant Congress

    Suppressing Laminin Alpha5 Creates Tolerogenic Niches for Allograft Survival

    L. Li1, M. Shirkey1, W. Piao1, Y. Xiong1, V. Saxena1, T. Zhang1, C. Paluskievicz1, J. Zhao2, R. Abdi2, J. S. Bromberg1

    1UMB, Baltimore, MD, 2Harvard University, Boston, MA

    *Purpose: Laminin α5 (Lama5) regulates CD4 T cell migration and function. We hypothesized that stromal Lama5 regulates the structure of the lymph node (LN) microenvironment…
  • 2020 American Transplant Congress

    Evaluation of Pre-Transplant T Cell Exhaustion as a Mechanism for Immune Dysfunction and Recipient Risk of Death Following Liver Transplant

    K. E. Lunsford1, N. Aware2, K. Cleveland3, D. T. Nguyen4, E. A. Graviss4, L. J. Minze3, T. N. Eagar4, X. C. Li3, R. M. Ghobrial3

    1Department of Surgery, Rutgers New Jersey Medical School, Newark, NJ, 2Department of Surgery, Houston Methodist Hosptial, Houston, TX, 3Department of Surgery, Houston Methodist Hospital, Houston, TX, 4Department of Pathology and Genomic Medicine, Houston Methodist Hospital, Houston, TX

    *Purpose: Cirrhosis-related immune dysfunction likely contributes to early mortality following liver transplant (LT) resulting from infections. We previously identified a pre-transplant biomarker panel for immune…
  • 2020 American Transplant Congress

    Lymph Node Stromal Laminin Alpha5 Regulates Antigen Specific T Cell Adaptive Immunity

    L. Li1, M. Shirkey1, W. Piao1, Y. Xiong1, V. Saxena1, T. Zhang1, C. Paluskievicz1, J. Zhao2, R. Abdi2, J. S. Bromberg1

    1UMB, Baltimore, MD, 2Harvard University, Boston, MA

    *Purpose: Laminin α5 (Lama5) is associated with immunity and regulates T cell entry and responses within the lymph node (LN). We hypothesized that stromal Lama5…
  • 2020 American Transplant Congress

    Can Cxcr3+Cd62l–Cd4+ T Cells Serve as Early Warning Sentinels for Subclinical Rejections after Vascularized Composite Allotransplantation (vca)?

    M. Kim1, D. Fisher1, J. Loo1, J. Skitzki1, E. Repasky2

    1Surgical Oncology, Roswell Park Comprehensive Cancer Center, Buffalo, NY, 2Immunology, Roswell Park Comprehensive Cancer Center, Buffalo, NY

    *Purpose: New microsurgical techniques and powerful immunosuppressive drugs have made it possible for severely injured patients to receive VCA to replace limbs, hands, or faces,…
  • 2020 American Transplant Congress

    Circulating Tissue Specific Exosomes Enable Noninvasive Diagnosis of Acute Cellular Rejection in Clinical Heart Transplantation

    L. Korutla1, R. Hu1, C. Romano1, M. Molina1, C. Sciortino2, C. Mullan3, R. McGargle2, H. Kagawa2, A. Kilic2, A. Naji4, P. Vallabhajosyula3

    1Surgery, University of Pennsylvania, Philadelphia, PA, 2Surgery, University of Pittsburgh Medical Center, Pittsburgh, PA, 3Surgery, Yale University, New Haven, CT, 4University of Pennsylvania, Philadelphia, PA

    *Purpose: There is a critical need for development of noninvasive biomarkers for allograft surveillance and diagnosis of rejection in heart transplant patients, as endomyocardial biopsy…
  • 2020 American Transplant Congress

    T Cells from Highly Sensitized Kidney Transplant Patients Display Distinct TCR Repertoires

    S. Negi1, M. Li1, A. Rutman2, S. Paraskevas1, C. Polychronakos1, J. Tchervenkov1

    1RIMUHC, Montreal, QC, Canada, 2McGill University, Montreal, QC, Canada

    *Purpose: Sensitization to HLA antigens limits patient’s access to renal transplantation and causes higher risk of acute rejection and graft loss. T-cells, B-cells and donor-specific…
  • 2020 American Transplant Congress

    The Fibrinogen-Like Protein 2 Molecule Influences the Development of Thymic Regulatory T-Cells

    C. Lam1, S. Moshkelgosha1, G. A. Levy2, A. Chruscinski3, S. C. Juvet4

    1Latner Thoracic Surgery Research Laboratories, University Health Network, Toronto, ON, Canada, 2Multi Organ Transplant Program, University Health Network, Toronto, ON, Canada, 3Toronto General Hospital Research Institute (TGHRI), University Health Network, Toronto, ON, Canada, 4Toronto General Hospital Research Institute, University Health Network, Toronto, ON, Canada

    *Purpose: Transplantation is the primary treatment for patients with end-stage organ failure. However, long-term outcomes are limited by immunosuppressant toxicities and chronic graft rejection. Identifying…
  • 2020 American Transplant Congress

    Targeting CD4+ T Cell Metabolism Prolongs Graft Survival Age-Specifically

    Y. Nian, J. Iske, K. Minami, R. Maenosono, T. Heinbokel, A. Elkhal, S. G. Tullius

    Division of Transplant Surgery and Transplant Surgery Research Laboratory, Harvard Medical School, Boston, MA

    *Purpose: If and how aging affects T-cell metabolism and alloimmune response is unclear. Here, we show that T-cell metabolism changes drastically in aging. Most notably,…
  • 2019 American Transplant Congress

    Circulating Donor Specific Antibody and Biopsy C4d Positivity in Pancreas Rejection Increase the Probability of Earlier Return to Insulin after Rejection

    S. M. Riad1, S. Jackson2, E. B. Finger3, R. Kandaswamy3

    1Medicine, University of Minnesota, Minneapolis, MN, 2Complex Care Analytics, Fairview Health Services, Minneapolis, MN, 3Surgery, University of Minnesota, Minneapolis, MN

    *Purpose: Outcome data following rejection in pancreas recipients are sparse. We sought to study the influence of C4d positivity and the presence of circulating DSA…
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