2022 American Transplant Congress
The Impact of Early Graft Infiltrating TCF-1LowPD-1HighCD8+ T Cells in Delayed Fc Nonbinding Anti-CD3 Antibody Protocol in the Sensitized Mouse Model
*Purpose: Fc nonbinding anti(a)-CD3 antibody has a unique effect that delayed treatment protocol induces a transplant tolerance. Delayed protocol allows early graft infiltrating cells which…2022 American Transplant Congress
The Intracellular Tacrolimus Concentration in CD3+ T Lymphocytes and CD14+ Monocytes and Its Association with Kidney Transplant Rejection
Erasmus MC, Rotterdam, Netherlands
*Purpose: The intracellular tacrolimus concentration in peripheral blood mononuclear cells (PBMCs) (TAC[PBMC]) was proposed to better represent active concentration than pre-dose whole blood concentration (C0).…2021 American Transplant Congress
The Efficacy of Delayed Fc-nonbinding Anti-CD3 Antibody Treatment in Sensitized Allogeneic Mouse Heart Transplantation
*Purpose: Delayed treatment with Fc-nonbinding anti-CD3 antibody (ab) permits early graft infiltrating cells to promotes a transplant tolerance. However, graft infiltrating cells immediate after transplantation…2020 American Transplant Congress
T and B Lymphocyte Dynamics after Genetically-Modified Pig-To-Baboon Kidney Xenotransplantation with an Anti-CD40mAb-Based Immunosuppressive Regimen
1Surgery, University of Alabama at birmingham, Birmingham, AL, 2Revivicor, Blacksburg, VA, VA
*Purpose: We have evaluated recovery of T and B lymphocytes and their subsets after depletion by anti-thymocyte globulin (ATG) and an anti-CD20mAb (Rituximab), followed by…2020 American Transplant Congress
Immunohistochemical and Molecular Detection of NK Cells in Kidney Allografts with Antibody Mediated Rejection
Pathology, University of Michigan, Ann Arbor, MI
*Purpose: Molecular signatures specific to Natural Killer (NK) cells are closely associated with antibody mediated rejection (AMR) in transplant biopsies. We have developed an immunohistochemical…2019 American Transplant Congress
Pre-Treatment Lymphocyte Status in HCC Patients Associates with DEB-TACE Response and Correlates with Increased Regulatory Immune Cells
*Purpose: Hepatocellular carcinoma (HCC) recurrence after transplantation is associated with higher tumor grade on explant, failure to respond to DEB-TACE, and pretreatment lymphopenia. We prospectively…2019 American Transplant Congress
Case Series: Anti-Thymocyte Globulin as a Treatment for Steroid-Refractory Severe Acute Hepatitis in Children
*Purpose: Pediatric severe acute hepatitis (SAH), when not attributed to acetaminophen toxicity, is commonly hypothesized to be caused by a non-typeable viral infection and/or immune…2019 American Transplant Congress
Dichotomous Role Of Donor T Cells In The Efficacy Of Tolerogenic Therapies For Transplant Rejection
Plastic Surgery, Johns Hopkins University, Baltimore, MD
*Purpose: Costimulation blockade-based regimens are a promising strategy to promote transplant tolerance. However, their efficacy is affected by multiple factors, many of which remain unknown.…2019 American Transplant Congress
Chloroquine’s Effect on T cell Proliferation
*Purpose: An anti-malarial agent, Chloroquine (CQ), has been widely used for the treatment of rheumatoid arthritis and lupus. Although the precise mechanisms of CQ are…2017 American Transplant Congress
Integrated Magnetic-Electrochemical Exosome (iMEX) Technology to Detect Rejection in Kidney Transplant Recipients.
Transplantation Research Center, Harvard Medical School, Boston; Exosome Diagnostic Inc, Cambridge
Methods for monitoring clinical rejection including increases in serum creatinine and urinary protein excretion may not reflect subclinical rejection. Similarly repeat biopsy may result in…
American Transplant Congress abstracts