2018 American Transplant Congress
Brain Death Conditions Intensify Inflammation and Impair Metabolic Gene Expression
University of Wisconsin, Madison.
Rationale: Inflammation observed in Brain Death (BD) donors is linked to reduced graft function and survival compared to living donors (LD). Detailed analyses of non-human…2017 American Transplant Congress
Circulating Inflammatory Factors in Deceased Organ Donors Result in Innate Immune Activation.
Surgery, Duke University, Durham, NC
Background: Superior outcomes of living-donor compared to deceased-donor transplants may be related to increased graft immunogenicity at the time of transplant. Donor brain death results…2017 American Transplant Congress
Successful Induction of Tolerance of Fully Allogeneic Lung Graft with Adenosine A2A Receptor (A2AR) Agonist in MHC-Defined CLAWN Miniature Swine.
Center for Advanced Biomedical Science and Swine Research, Kagoshima University, Kagoshima, Japan
Introduction: A2AR agonist is known to potently attenuate lung ischemia-reperfusion injury. However, the long-term effects of A2AR agonist on lung allograft survival remain unclear especially…2017 American Transplant Congress
Release of HMGB1 in Serum and Urine of Brain-Death Donors Is Associated with Delayed Graft Function (DGF) of the Kidney.
Delayed kidney graft function (DGF) following a kidney transplant is associated with worse graft survival and higher rejection risk. Risk factors for DGF have been…2017 American Transplant Congress
Ornithine Transcarbamylase Deficiency (OTC) in the Donor Liver, the Importance of Ascertaining the Cause of Death in the Brain Dead Donor.
The importance of ascertaining the cause of brain death in the donor is vital . We present a case of cadaveric liver donation (seg 2…2017 American Transplant Congress
Brain-Dead Donors Terminal Inflammation Is Associated to Delayed Graft Function in Kidney Transplant Recipients.
BACKGROUND: in kidney transplantation recipients, increased biomarkers of systemic inflammation before and after the transplant are associated to worse short- and long-term renal outcomes. However,…2017 American Transplant Congress
What Are “Normal” CSF Findings in the Non-Infected Brain Dead Organ Donor?
Abnormalities in CSF in deceased organ donors may suggest infection and lead to refusal of organs by transplant centers, particularly if a viral process is…2017 American Transplant Congress
Prediction of Evolution Toward Brain Death in Acute Neurocritical Patients Identified as Potential Organ Donors.
Objective: Reliable prediction of brain death (BD) is of specific interest for organ donation after brain death(DBD). We sought to establish a score based on…2017 American Transplant Congress
Patterns of Monocyte Differentiation and Activation in a Non-Human Primate Model of Brain Death.
Surgery - Division of Transplantation, University of Wisconsin-Madison, Madison, WI
Brain-death (BD) induces a systemic inflammatory response known to impair tissue perfusion and promote graft immunogenicity. Monocytes play a significant role in the regulation of…2016 American Transplant Congress
The Impact of Total Ischaemic Time, Donor Age and the Pathway of Donor Death on Graft Outcomes After Deceased Donor Kidney Transplantation.
Prolonged ischaemia is a known risk factor for delayed graft function and its interaction with donor characteristics, the pathways of donor death and graft outcomes…
American Transplant Congress abstracts