Articles tagged "Brain death"

2019 American Transplant Congress
Determinants of Allograft Injury during Procurement in Deceased Donors
E. Taber-Hight¹, R. Cauwels², E. Eidbo², A. S. Paramesh³, R. Squires⁴, T. Taber¹
¹Nephrology, Indiana University, Indianapolis, IN, ²AOPO, Vienna, VA, ³Louisiana Organ Procurement Agency, New Orleans, LA, ⁴University of Oklahoma, Oklahoma City, OK
*Purpose: With the ever enlarging list of potential recipients on the transplant list, the need for deceased donor organs has become critical. Avoiding injury to…
2019 American Transplant Congress
Exendin-4 for Donor Treatment in a Brain-Death Model of Kidney Transplantation
H. Yang¹, L. Luo¹, X. Li¹, C. Long¹, Y. Shi², Y. Xiong³, M. Chen⁴, J. Gao⁵, H. Li⁶, Z. Wang⁶
¹Department of Organ Transplantation, People's Hospital of Jiangxi Province, Nanchang, China, ²Department of Pathology, Central Hospital of Wuhan, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China, ³Department of Neurology, People's Hospital of Jiangxi Province, Nanchang, China, ⁴Department of Vascular Surgery, People's Hospital of Jiangxi Province, Nanchang, China, ⁵Department of Vascular Surgery, People's hospital of Jiangxi Province, Nanchang, China, ⁶Department of Urologic Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
*Purpose: Renal grafts from brain death donors associated with poorer graft outcomes after kidney transplantation, hemodynamic and inflammatory mechanisms can account for brain death induce…
2019 American Transplant Congress
Targeting Pyroptosis in Brain-Dead Donors Improves Renal Function after Transplantation in Rat
H. Yang¹, Y. Shi², X. Li¹, L. Luo¹, C. Long¹, Y. Xiong³, M. Chen⁴, J. Gao⁴, H. Li⁵, Z. Wang⁵
¹Department of Organ Transplantation, People's Hospital of Jiangxi Province, Nanchang, China, ²Department of Pathology, Central Hospital of Wuhan, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China, ³Department of Neurology, People's Hospital of Jiangxi Province, Nanchang, China, ⁴Department of Vascular Surgery, People's Hospital of Jiangxi Province, Nanchang, China, ⁵Department of Urologic Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
*Purpose: Pyroptosis is a form of programmed cell death include necrosis, nuclear condensation, and release of proinflammatory after caspase-1 activation. It is unknown whether pyroptosis…
2019 American Transplant Congress
Significant Implications of Prior Transplantation on Treatment and Outcomes of Patients Suffering from Traumatic Brain Injury
L. Mugge, W. Qu, C. Gallagher, A. Caras, N. Henkel, O. Ekwenna, J. Ortiz
The University of Toledo Medical Center, Toledo, OH
*Purpose: Recent events in the media and sporting industry highlight traumatic brain injury (TBI) as a major health concern, having implications in many areas of…
2019 American Transplant Congress
Innate Immunity in Brain Dead Donors: Implications of Necroptosis in Kidney Allograft Outcomes
A. Ang¹, A. Zmijewska², T. M. Stevens³, J. Murphy¹, R. B. Mannon²
¹School of Medicine, UAB, Birmingham, AL, ²Medicine/Nephrology, UAB, Birmingham, AL, ³Pathology, UAB, Birmingham, AL
*Purpose: Regulated necrosis (necroptosis) has been implicated in renal injury from nephrotoxic agents and ischemia. With the use of suboptimal brain dead donors (BDDs) to…
2019 American Transplant Congress
Donor Brain Death Affects Tolerance Induction in Non-Human Primates
W. Sommer¹, J. M. O², K. B. Pruner³, J. T. Paster³, A. Bean³, A. Dehnadi³, I. M. Hanekamp³, I. Rosales⁴, R. N. Smith⁴, R. B. Colvin⁴, G. Benichou³, J. S. Allan³, T. Kawai³, J. C. Madsen⁵
¹Department of Cardiothoracic Surgery, Hannover Medical School, Hannover, Germany, ²Center for Transplantation Sciences, Massachusets General Hospital, Boston, MA, ³Center for Transplantation Sciences, Massachusetts General Hospital, Boston, MA, ⁴Department of Pathology, Massachusetts General Hospital, Boston, MA, ⁵Center fro Transplantation Sciences, Massachusetts General Hospital, Boston, MA
*Purpose: Induction of durable allograft acceptance in combined heart/kidney transplantation in non-human primates is possible by applying a mixed chimerism-based conditioning protocol. However, the impact…
2018 American Transplant Congress
Unraveling the Neuroimmunological Pathways Surrounding Brain Death: Systematic Study of Clinically Relevant Serum Biomarker Changes during Donor Management from Admission to Procurement
K. Bera, M. LoFaro, H. Huang, S. Maslau, R. Ploeg.
Nuffield Department of Surgical Sciences, University of Oxford, Oxford, United Kingdom.
Donation after brain death (BD) remains an important source of transplanted organs worldwide and it has been shown that BD causes a hostile environment with…
2018 American Transplant Congress
Improving the Organ Donation Referral Process through Telemedicine
M. Groveman,¹ M. Perry,² I. Berman,² N. Benavides,¹ A. Friedman.¹
¹LiveOnNY, NY; ²Northwell Health, New Hyde Park.
Development of a Tele-ICU serving multiple institutions within our donor service area stimulated a collaborative performance improvement project. To improve the referral and timeliness rates…
2018 American Transplant Congress
Extended Criteria Donors Have Higher Expression of Inflammatory Genes Than Standard Donors
M. Abbud-Filho,^1,2,3 M. Fernandes-Charpiot,^1,2 M. Baptista,^1,2 H. Caldas,^1,2 G. Florim.¹
¹Medicine, Laboratory of Immunology and Experimental Transplantation - LITEX, Medical School of Sao Jose do Rio Preto, Sao Jose do Rio Preto, Sao Paulo, Brazil; ²Transplant, Kidney Transplant Unit, Hospital de Base, FAMERP/FUNFARME, Sao Jose do Rio Preto, Sao Paulo, Brazil; ³Urology and Nephrology Institute, Sao Jose do Rio Preto, Sao Paulo, Brazil.
Background.Changes to an organ occur at the time of brain death where a series of inflammatory modify occur within the organ. Because it is not…
2018 American Transplant Congress
Brain Death Conditions Intensify Inflammation and Impair Metabolic Gene Expression
L. Zitur, P. Chlebeck, S. Odorico, T. Zens, J. Danobeitia, M. Eerhart, J. Reyes, A. D'Alessandro, K. Brunner, S. Capuano, L. Fernandez.
University of Wisconsin, Madison.
Rationale: Inflammation observed in Brain Death (BD) donors is linked to reduced graft function and survival compared to living donors (LD). Detailed analyses of non-human…