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Articles tagged "Brain death"

  • 2019 American Transplant Congress

    Staged Procedure In Simultaneous Liver And Kidney Transplant -the “Swedish” Experience

    A. Gravetz

    Transplant Surgery, Swedish Medical Center, Seattle, WA

    *Purpose: As many as 30% of liver transplant candidates have renal insufficiency requiring a combined liver and kidney transplantation. The prolonged and complex simultaneous liver-kidney…
  • 2019 American Transplant Congress

    Donor Management in Donation after Brain Death: A Window of Opportunity – Are Pro-Inflammatory Mediators the Target and What is the Effect of Duration of Brain Death?

    K. D. Bera1, J. Tabak2, M. L. Lo Faro1, R. J. Ploeg1

    1Nuffield Department of Surgical Sciences, University of Oxford, Oxford, United Kingdom, 2University of Exeter, Exeter, United Kingdom

    *Purpose: Donation after brain death (BD) is a crucial source of transplanted organs - uncertainty remains how duration of BD contributes to outcomes: This study…
  • 2019 American Transplant Congress

    Determinants of Allograft Injury during Procurement in Deceased Donors

    E. Taber-Hight1, R. Cauwels2, E. Eidbo2, A. S. Paramesh3, R. Squires4, T. Taber1

    1Nephrology, Indiana University, Indianapolis, IN, 2AOPO, Vienna, VA, 3Louisiana Organ Procurement Agency, New Orleans, LA, 4University of Oklahoma, Oklahoma City, OK

    *Purpose: With the ever enlarging list of potential recipients on the transplant list, the need for deceased donor organs has become critical. Avoiding injury to…
  • 2019 American Transplant Congress

    Exendin-4 for Donor Treatment in a Brain-Death Model of Kidney Transplantation

    H. Yang1, L. Luo1, X. Li1, C. Long1, Y. Shi2, Y. Xiong3, M. Chen4, J. Gao5, H. Li6, Z. Wang6

    1Department of Organ Transplantation, People's Hospital of Jiangxi Province, Nanchang, China, 2Department of Pathology, Central Hospital of Wuhan, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China, 3Department of Neurology, People's Hospital of Jiangxi Province, Nanchang, China, 4Department of Vascular Surgery, People's Hospital of Jiangxi Province, Nanchang, China, 5Department of Vascular Surgery, People's hospital of Jiangxi Province, Nanchang, China, 6Department of Urologic Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China

    *Purpose: Renal grafts from brain death donors associated with poorer graft outcomes after kidney transplantation, hemodynamic and inflammatory mechanisms can account for brain death induce…
  • 2019 American Transplant Congress

    Targeting Pyroptosis in Brain-Dead Donors Improves Renal Function after Transplantation in Rat

    H. Yang1, Y. Shi2, X. Li1, L. Luo1, C. Long1, Y. Xiong3, M. Chen4, J. Gao4, H. Li5, Z. Wang5

    1Department of Organ Transplantation, People's Hospital of Jiangxi Province, Nanchang, China, 2Department of Pathology, Central Hospital of Wuhan, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China, 3Department of Neurology, People's Hospital of Jiangxi Province, Nanchang, China, 4Department of Vascular Surgery, People's Hospital of Jiangxi Province, Nanchang, China, 5Department of Urologic Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China

    *Purpose: Pyroptosis is a form of programmed cell death include necrosis, nuclear condensation, and release of proinflammatory after caspase-1 activation. It is unknown whether pyroptosis…
  • 2019 American Transplant Congress

    Significant Implications of Prior Transplantation on Treatment and Outcomes of Patients Suffering from Traumatic Brain Injury

    L. Mugge, W. Qu, C. Gallagher, A. Caras, N. Henkel, O. Ekwenna, J. Ortiz

    The University of Toledo Medical Center, Toledo, OH

    *Purpose: Recent events in the media and sporting industry highlight traumatic brain injury (TBI) as a major health concern, having implications in many areas of…
  • 2018 American Transplant Congress

    Targeted Donor Complement Blockade after Brain-Death Prevents Delayed Graft Function but Not Progression to Antibody-Mediated Rejection in a Non-Human Primate Model of Kidney Allo-Transplantation

    J. Danobeitia,1 T. Zens,1 L. Zitur,1 P. Chlebeck,1 J. Torrealba,3 D. Burguete, E. Van Amersfoort,2 A. Relan,2 A. D'Alessandro,1 L. Fernandez.1

    1Surgery, University of Wisconsin-Madison, Madison, WI; 2Pharming Group N.V, Leiden, Netherlands.

    Introduction: Donor brain death (BD) triggers a complement-mediated inflammatory response linked to renal injury which has been associated to delayed graft function (DGF) and the…
  • 2018 American Transplant Congress

    Unraveling the Neuroimmunological Pathways Surrounding Brain Death: Systematic Study of Clinically Relevant Serum Biomarker Changes during Donor Management from Admission to Procurement

    K. Bera, M. LoFaro, H. Huang, S. Maslau, R. Ploeg.

    Nuffield Department of Surgical Sciences, University of Oxford, Oxford, United Kingdom.

    Donation after brain death (BD) remains an important source of transplanted organs worldwide and it has been shown that BD causes a hostile environment with…
  • 2018 American Transplant Congress

    Improving the Organ Donation Referral Process through Telemedicine

    M. Groveman,1 M. Perry,2 I. Berman,2 N. Benavides,1 A. Friedman.1

    1LiveOnNY, NY; 2Northwell Health, New Hyde Park.

    Development of a Tele-ICU serving multiple institutions within our donor service area stimulated a collaborative performance improvement project. To improve the referral and timeliness rates…
  • 2018 American Transplant Congress

    Extended Criteria Donors Have Higher Expression of Inflammatory Genes Than Standard Donors

    M. Abbud-Filho,1,2,3 M. Fernandes-Charpiot,1,2 M. Baptista,1,2 H. Caldas,1,2 G. Florim.1

    1Medicine, Laboratory of Immunology and Experimental Transplantation - LITEX, Medical School of Sao Jose do Rio Preto, Sao Jose do Rio Preto, Sao Paulo, Brazil; 2Transplant, Kidney Transplant Unit, Hospital de Base, FAMERP/FUNFARME, Sao Jose do Rio Preto, Sao Paulo, Brazil; 3Urology and Nephrology Institute, Sao Jose do Rio Preto, Sao Paulo, Brazil.

    Background.Changes to an organ occur at the time of brain death where a series of inflammatory modify occur within the organ. Because it is not…
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