Articles tagged "Bone marrow"

2016 American Transplant Congress
Vascularized Composite Allograft Tolerance with Transient High-Dose Tacrolimus Across a Full MHC Mismatch in a Large Animal Model.
H. Wang, E. Swanson, H.-T. Cheng, J. Walch, J. Alonso-Esclante, K. Kolegraff, J. Lopez, G. Furtmuller, B. Oh, A. Quan, J. Budihardjo, S. AlFadil, S. Mulla, P. Akre, J. Sacks, S. Bonawitz, G. Raimondi, J. Shores, D. Cooney, W. Lee, G. Brandacher.
Department of Plastic Surgery, Johns Hopkins University, Baltimore, MD.
PURPOSE: Vascularized composite allografts (VCA) can enhance the quality of life of patients with severe facial or extremity injuries, and the induction of tolerance would…
2015 American Transplant Congress
A Novel Post-Transplant High-Dose Cyclophosphamide-Based Regimen to Promote Immune Tolerance After VCA
G. Furtmüller,¹ M. Fryer,¹ B. Oh,¹ S. Ganguly,² J. Izzi,³ D. Cooney,¹ G. Raimondi,¹ W. Lee,¹ L. Luznik,² G. Brandacher.¹
¹Plastic and Reconstructive Surgery, Johns Hopkins University School of Medicine, Baltimore, MD; ²Immunology - Sydney Kimmel Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD; ³Department of Research Animal Resources, Johns Hopkins University, Baltimore, MD.
Background: VCA has become a viable treatment option for devastating tissue defects. However, the life-long need of immunosuppressive medications curtails the wider use of VCA.…
2015 American Transplant Congress
Tissue Distribution, Preparation and Phenotype Characteristics of Stem Cells Originated from the Organs of Deceased Human Individuals
A. Klimczak,¹ T. Jurek,² M. Czuba,² U. Kozlowska,¹ M. Rorat,² K. Wrzeszcz.¹
¹Institute of Immunology and Experimental Therapy Polish Academy of Sciences, Wroclaw, Poland; ²Department of Forensic Medicine, Medical University, Wroclaw, Poland.
Objective: Multipotent stem cells are unique cells present in several human organs that have self-renewing properties and are able to differentiate into diverse specialized cell…
2015 American Transplant Congress
Human Hematopoietic Chimeric Cells as a Novel Approach for Tolerance Induction After Transplantation
E. Bryndza Tfaily,¹ J. Cwykiel,¹ K. Dastych,² A. Sklodowska,¹ M. Siemionow.¹
¹Orthopaedics, University of Illinois at Chicago, Chicago, IL; ²Pathology, University of Illinois at Chicago, Chicago, IL.
Background: Cellular therapies represent a new promising approach for transplant tolerance induction. One of the methods for immune response modulation in solid organ and vascularized…
2015 American Transplant Congress
Proteomic Study Identified a Distinct Panel of Protein Expression in the ATP-Competitive MTOR Kinase Inhibitor Conditioned Dendritic Cells Compared to Rapamycin
T. Ma,¹ Y. Pei,¹ Y. Han,² R. Tao.¹
¹Department of Hepatobiliary-Pancreatic Surgery, Zhejiang Provincial Peoples' Hospital, Hangzhou, Zhejiang Province, China; ²Department of Pathology, Zhejiang Provincial Peoples' Hospital, Hangzhou, Zhejiang Province, China.
Purpose: Dendritic cells (DCs) are key players in both innate and adaptive immunity, as well as in immune tolerance. The mammalian target of rapamycin (mTOR)…
2015 American Transplant Congress
Impact of CXCR4/CXCL12 Blockade on Normal Plasma Cells In Vivo
N. Moore,¹ M. Moreno Gonzales,² M. Stegall.¹
¹Department of Surgery, Division of Transplant Surgery and Department of Immunology, Mayo Clinic, Rochester, MN; ²Department of Surgery, Division of Transplant Surgery, Mayo Clinic, Rochester, MN.
Receptor/ligand interactions in stromal microenvironments play important roles in the localization, development and survival of normal antibody-secreting plasma cells. The goal of the current study…
2015 American Transplant Congress
Does PTH Play a Role in Post Kidney Transplant Leukopenia?
R. Dhawan, L. Shin, K. Lee, B. Duong, L. Aguirre, C. Parke, S. Alexopoulos, M. Smogorzewski, A. Gomez, E. Mariscal, L. Matsuoka, Y. Qazi.
Division of Transplantation, University Of Southern California. Keck Med Center, Los Angeles, CA.
Aim : Recent data suggests a role of Parathyroid hormone (PTH) on hematopoietic stem cell progenitor cells(HSPCs)[1,2]. The purpose of the study was determine the…
2015 American Transplant Congress
Human Bone Marrow Mesenchymal Stem Cell-Derived Hepatocytes Express TIMP-4 and Follistatin
J. Li,¹ J. Xin,¹ W. Ding,² S. Hao,¹ L. Jiang,¹ Q. Zhou,¹ T. Wu,¹ D. Shi,¹ L. Li.¹
¹State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, The First Affiliated Hospital, Zhejiang University School of Medicine, HangZhou, China; ²Systems Biology Division, Zhejiang-California International Nanosystems Institute, Zhejiang University, HangZhou, China.
Human bone marrow mesenchymal stem cell (hBMSC) transplantation has been expected to be an alternative regenerative technique for liver diseases. However, the mechanism by which…