Articles tagged "Bioengineering"

2017 American Transplant Congress
Technically Successful Miniaturization of Blood Hemofilters for an Artificial Kidney via Bioengineering Techniques.
R. Forbes,¹ C. Kensinger,¹ S. Karp,¹ J. Groszek,¹ A. Buck,² D. Colvin,² S. Roy,³ W. Fissell.¹
¹Vanderbilt University Medical Center, Nashville; ²Institute of Imagine Science, Vanderbilt University, Nashville; ³University of California San Francisco, San Francisco
Background: Creating flow channel pathways for an implantable artificial kidney with minimal risk of thrombosis is particularly difficult when miniaturizing into a multilayer bio-hybrid device.…
2016 American Transplant Congress
A Novel Humanized Mouse Model Incorporating Non-Fetal Tissue.
M. Brown, I. Norman, Y. Zhou, W. Lou, J. Sullivan, W. Burlingham.
Surgery/Transplant Division, University of Wisconsin-Madison, Madison, WI.
Pre-clinical research into allogeneic tissue transplantation therapies, as well as patient-specific regenerative medicine studies, require animal models that closely mimic the typical patient's immune response.…
2016 American Transplant Congress
Mechanisms of Cellular Repopulation within Healthy or Intrinsically Scarred Kidney Extracellular Matrix Scaffolds.
J. Uzarski,¹ C. Deaton,⁵ H. Ward,² A. Wandinger-Ness,³ W. Miller,⁴ J. Wertheim.¹
¹Comprehensive Transplant Center, Northwestern University Feinberg School of Medicine, Chicago, IL; ²Department of Internal Medicine, University of New Mexico HSC, Albuquerque, NM; ³Department of Pathology, University of New Mexico HSC, Albuquerque, NM; ⁴Department of Chemical and Biological Engineering, Northwestern University, Evanston, IL; ⁵Department of Biology, University of Mexico, Albuquerque, NM.
Background: While the number of wait-listed patients suffering from kidney failure continues to rise, the number of kidney transplants performed each year has remained stagnant.…
2016 American Transplant Congress
Decellularized Rat Liver Scaffolds Support Multilineage Xenogenic and Heterogenic Cell Growth.
W. Hassanein, U. Dhru, J. Woodall, M. Uluer, A. Cimeno, D. Parsell, C. Rivera, S. Klepfer, C. Drachenberg, R. Barth, J. LaMattina.
University of Maryland School of Medicine, Baltimore, MD.
Background:Recent years have seen a proliferation of methods leading to successful organ decellularization. Nonetheless, the ability to reproducibly generate a robust recellularized construct remains challenging.…
2016 American Transplant Congress
In Vivo and In Vitro Characterization of 1.5 mm Ba²⁺-Alginate Macro-Encapsulated Cynomolgus Monkey Islets.
M. Bochenek,¹ J. McGarrigle,¹ J. Mendoza-Elias,¹ E. Marchese,¹ M. Nourmohammadzadeh,¹ Y. Wang,¹ A. Khan,¹ M. Omami,¹ C.-C. Yeh,¹ I. Lacik,² B. Strand,³ J. Oberholzer.¹
¹Transplant Surgery, University of Iliinois at Chicago, Chicago, IL; ²Biomaterials Research, Polymer Institute of the Slovak Academy of Sciences, Bratislava, Slovakia (Slovak Republic); ³Biotechnology, Norwegian University of Science and Technology, Trondheim, Norway.
Introduction:Micro-encapsulation of islets for the treatment of Type I diabetes has shown limited efficacy in small-scale clinical trials. The lack of success may be related…
2016 American Transplant Congress
Microfluidics to Characterize Leukocyte Trafficking into Allografts and the Resolution of Inflammation.
L. Boneschansker,^1,2 D. Irimia,² D. Briscoe.¹
¹Transplant Research Program, Boston Children's Hospital, Boston; ²MGH, Boston.
Pro-resolution mediators such as resolvins and axonal guidance receptor-ligand interactions are increasingly recognized to regulate leukocyte trafficking into sites of inflammation. The implication of this…
2015 American Transplant Congress
Bioengineering Liver Allografts through Organ Scaffold Recellularization
J. Woodall, J. Langford, C. Klassen, J. Harrison, D. Parsell, U. Dhru, R. Barth, J. LaMattina.
University of Maryland School of Medicine, Baltimore.
Bioengineering livers using organ scaffolds offers an approach to increasing allograft availability for end stage liver disease. Recellularized liver scaffolds will require multiple differentiated cell…
2015 American Transplant Congress
Murine Veno-Arterial Extracorporeal Membrane Oxygenation (mVA-ECMO): A Novel Tool to Study the Molecular Biology of Mechanical Circulatory Support
A. Schenk,¹ J. Fallon,¹ M. Farrell,¹ R. Halter,² J. Yun.³
¹Surgery, Dartmouth Hitchcock Medical Center, Lebanon, NH; ²Thayer School of Engineering, Dartmouth College, Hanover, NH; ³Cardiothoracic Surgery, Yale New-Haven Hospital, New Haven, CT.
PURPOSE: In recent years, clinical use of veno-arterial extracorporeal membrane oxygenation (VA-ECMO) has grown. Extracorporeal circulation is an essential component of heart and lung transplantation,…
2015 American Transplant Congress
Tissue Engineering Human Kidneys for Costimulation Blockade
L. Brasile,¹ N. Henry,¹ A. Meyer,¹ B. Stubenitsky.²
¹BREONICS, Inc., Watervliet, NY; ²Surgery, University of Utrecht, Utrecht, Netherlands.
Methods for preserving organs have employed hypothermic conditions. At these temperatures metabolism is 4% of normal. Tissue engineering of organs cannot be done without significant…
2015 American Transplant Congress
Human iPS Cell-Derived Pancreatic β-Cells Correct Hyperglycemia in Diabetic Mice
G. Manzar,^1,2,3 E.-M. Kim,^1,2 P. Rotti,³ N. Zavazava.^1,2,3
¹Internal Medicine, University of Iowa, Iowa City, IA; ²VA Medical Center, Iowa City, IA; ³Biomedical Engineering, University of Iowa, Iowa City, IA.
Type I diabetes (T1D) is an autoimmune disorder that leads to the destruction of pancreatic β-cells. The consequences of T1D are dysregulation of metabolism leading…