ATC Abstracts

American Transplant Congress abstracts

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Articles tagged "Bioengineering"

  • 2017 American Transplant Congress

    Binding of Human Neutrophils to Activated Porcine Endothelium Is Mediated by E-Selectin.

    C. Laird,1 B. French,1 L. Burdorf,1 X. Cheng,1 W. Fogler,2 J. Magnani,2 C. Phelps,3 D. Ayares,3 A. Azimzadeh,1 R. Pierson.1

    1University of Maryland SOM, Baltimore; 2GlycoMimetics, Inc, Rockville; 3Revivicor, Inc, Blacksburg

    Purpose: Shortage of transplantable human organs motivates research into alternatives, including xenotransplantation. When porcine lungs are perfused with human blood, a majority of human neutrophils…
  • 2016 American Transplant Congress

    A Novel Humanized Mouse Model Incorporating Non-Fetal Tissue.

    M. Brown, I. Norman, Y. Zhou, W. Lou, J. Sullivan, W. Burlingham.

    Surgery/Transplant Division, University of Wisconsin-Madison, Madison, WI.

    Pre-clinical research into allogeneic tissue transplantation therapies, as well as patient-specific regenerative medicine studies, require animal models that closely mimic the typical patient's immune response.…
  • 2016 American Transplant Congress

    Mechanisms of Cellular Repopulation within Healthy or Intrinsically Scarred Kidney Extracellular Matrix Scaffolds.

    J. Uzarski,1 C. Deaton,5 H. Ward,2 A. Wandinger-Ness,3 W. Miller,4 J. Wertheim.1

    1Comprehensive Transplant Center, Northwestern University Feinberg School of Medicine, Chicago, IL; 2Department of Internal Medicine, University of New Mexico HSC, Albuquerque, NM; 3Department of Pathology, University of New Mexico HSC, Albuquerque, NM; 4Department of Chemical and Biological Engineering, Northwestern University, Evanston, IL; 5Department of Biology, University of Mexico, Albuquerque, NM.

    Background: While the number of wait-listed patients suffering from kidney failure continues to rise, the number of kidney transplants performed each year has remained stagnant.…
  • 2016 American Transplant Congress

    Decellularized Rat Liver Scaffolds Support Multilineage Xenogenic and Heterogenic Cell Growth.

    W. Hassanein, U. Dhru, J. Woodall, M. Uluer, A. Cimeno, D. Parsell, C. Rivera, S. Klepfer, C. Drachenberg, R. Barth, J. LaMattina.

    University of Maryland School of Medicine, Baltimore, MD.

    Background:Recent years have seen a proliferation of methods leading to successful organ decellularization. Nonetheless, the ability to reproducibly generate a robust recellularized construct remains challenging.…
  • 2016 American Transplant Congress

    In Vivo and In Vitro Characterization of 1.5 mm Ba2+-Alginate Macro-Encapsulated Cynomolgus Monkey Islets.

    M. Bochenek,1 J. McGarrigle,1 J. Mendoza-Elias,1 E. Marchese,1 M. Nourmohammadzadeh,1 Y. Wang,1 A. Khan,1 M. Omami,1 C.-C. Yeh,1 I. Lacik,2 B. Strand,3 J. Oberholzer.1

    1Transplant Surgery, University of Iliinois at Chicago, Chicago, IL; 2Biomaterials Research, Polymer Institute of the Slovak Academy of Sciences, Bratislava, Slovakia (Slovak Republic); 3Biotechnology, Norwegian University of Science and Technology, Trondheim, Norway.

    Introduction:Micro-encapsulation of islets for the treatment of Type I diabetes has shown limited efficacy in small-scale clinical trials. The lack of success may be related…
  • 2016 American Transplant Congress

    Microfluidics to Characterize Leukocyte Trafficking into Allografts and the Resolution of Inflammation.

    L. Boneschansker,1,2 D. Irimia,2 D. Briscoe.1

    1Transplant Research Program, Boston Children's Hospital, Boston; 2MGH, Boston.

    Pro-resolution mediators such as resolvins and axonal guidance receptor-ligand interactions are increasingly recognized to regulate leukocyte trafficking into sites of inflammation. The implication of this…
  • 2015 American Transplant Congress

    Human iPS Cell-Derived Pancreatic β-Cells Correct Hyperglycemia in Diabetic Mice

    G. Manzar,1,2,3 E.-M. Kim,1,2 P. Rotti,3 N. Zavazava.1,2,3

    1Internal Medicine, University of Iowa, Iowa City, IA; 2VA Medical Center, Iowa City, IA; 3Biomedical Engineering, University of Iowa, Iowa City, IA.

    Type I diabetes (T1D) is an autoimmune disorder that leads to the destruction of pancreatic β-cells. The consequences of T1D are dysregulation of metabolism leading…
  • 2015 American Transplant Congress

    Targeted Rapamycin Nanotherapy Dampens Memory T Cell Function

    S. Nadig,1 S. Esckilsen,1 A.-M. Broome,2 S. Dixit,2 C. Atkinson.3

    1Surgery, Microbiology and Immunology, Medical University of South Carolina, Charleston, SC; 2Radiologic Sciences, Medical University of South Carolina, Charleston, SC; 3Microbiology and Immunology, Medical University of South Carolina, Charleston, SC.

    Memory T cells (Tm) are difficult to control post-transplantation and account for early rejection episodes. Additionally, therapies exerting local immunosuppression by targeting an allograft, while…
  • 2015 American Transplant Congress

    Orthotopic Transplantation of a Tissue Engineered Skin Graft in Athymic Mice

    N. Nayakawde, P. Patil, K. Methe, M. Olausson.

    Surgery, Gothenburg University, Gothenburg, Vastra Gotaland, Sweden.

    Background: Tissue engineered (TE) skin offers promising alternative treatment in wound healing of acute and chronic skin injuries. Limited autografts from donor skin and risks…
  • 2015 American Transplant Congress

    Creation of a Functional Bio-Artificial Intestinal Segment in Rats

    T. Corsello, G. Damiano, M. Tuveri, M. Montalbano, C. Rastellini, L. Cicalese.

    Surgery, UTMB, Galveston, TX.

    Short bowel syndrome is caused by reduced intestinal length and insufficient absorption. TPN may improve life expectancy, but is potentially associated with severe complications and…
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