Articles tagged "Bioengineering"

2018 American Transplant Congress
Biomaterial-Based Localized and Controlled Delivery of Tofacitinib to Actuate Enhanced Costimulation Blockade and Promote Long-Term Transplant Survival
G. Raimondi,¹ P. Majumder,² V. Ivanova,¹ X. Calderon-Colon,³ A. Mirdad,¹ M. Iglesias Lozano,¹ W. Lee,¹ G. Brandacher,¹ J. Schneider,² J. Patrone.³
¹Johns Hopkins School of Medicine, Baltimore; ²National Cancer Institute, Frederick; ³Johns Hopkins Applied Physics Laboratory, Laurel.
Complications from long-term use of calcineurin inhibitors remain a major issue for transplant patients and alternative therapies are highly needed. We investigated two innovative drug…
2018 American Transplant Congress
Pancreas Decellularization Protocol – Comparison of Methods
A. Berman, K. Karzynski, M. Serwanska-Swientek, N. Pilka, M. Klak, K. Kosowska, J. Cichon, F. Ambrozkiewicz, M. Wszola.
Foundation of Research and Science Development, Otwock, Poland.
Background: Whole organ decellularization is gaining a lot of popularity since its development in tissue engineering. It is a process which allows to create complex…
2018 American Transplant Congress
Re-Endothelialization of Liver Xenografts Utilizing Human Endothelial Cells
W. Hassanein,¹ P. Patel,¹ A. Werdsheim,¹ J. Brilliant,¹ E. Buckingham,¹ N. Shockcor,¹ C. Drachenberg,² R. Barth,¹ J. LaMattina.¹
¹Surgery, University of Maryland, Baltimore, MD; ²Pathology, University of Maryland, Baltimore, MD.
Introduction:Acute antibody mediated rejection due to preformed antibodies present in human serum remains a hurdle to successful xenotransplantation. Xenograft vascular endothelium represents the initial site…
2018 American Transplant Congress
Successful Patency in Blood Conduits for an Artificial Kidney Membrane with Biocompatible Coatings
R. Forbes,¹ E. Marsh,¹ S. Karp,¹ A. Buck,¹ D. Colvin,¹ P. Williams,¹ B. Chaudhuri,² S. Roy,² W. Fissell.¹
¹VUMC, Nashville; ²UCSF, San Francisco.
BACKGROUND: An implantable artificial kidney may address the growing organ shortage and improve outcomes and quality of life for those with end stage renal disease.…
2018 American Transplant Congress
Liver Preservation with Machine Perfusion and a New Human-Derived Hemoglobin-Based Oxygen Carrier Solution (HDHBOC)
W. R. Light,¹ A. Malavalli,¹ K. Vandegriff,¹ P. Fontes.²
¹VirTech Bio, Inc, Natick, MA; ²University of Pittsburgh, Pittsburgh, PA.
Introduction: Machine perfusion (MP) is becoming the new standard for liver preservation following the successful implementation of devices for kidney and lung preservation ex-vivo. Liver…
2017 American Transplant Congress
Decellularized Rat Liver Scaffolds Support Survival and Metabolic Function of Multilineage Allogenic Cells.
W. Hassanein, A. Werdesheim, A. Cimeno, B. Buckingham, A. Khalifeh, M. Uluer, J. Harrison, D. Parsell, C. Drachenberg, R. Barth, J. LaMattina.
University of Maryland School of Medcine, Baltimore, MD
Background:Organ bioengineering has the potential to completely eliminate the donor organ shortage. Here, we examine the feasibility of a decellularized liver construct to support the…
2017 American Transplant Congress
Technically Successful Miniaturization of Blood Hemofilters for an Artificial Kidney via Bioengineering Techniques.
R. Forbes,¹ C. Kensinger,¹ S. Karp,¹ J. Groszek,¹ A. Buck,² D. Colvin,² S. Roy,³ W. Fissell.¹
¹Vanderbilt University Medical Center, Nashville; ²Institute of Imagine Science, Vanderbilt University, Nashville; ³University of California San Francisco, San Francisco
Background: Creating flow channel pathways for an implantable artificial kidney with minimal risk of thrombosis is particularly difficult when miniaturizing into a multilayer bio-hybrid device.…
2017 American Transplant Congress
New Approach for Targeted Immunotherapy in Vascularized Composite Allotransplantation.
F. Feturi,¹ H. Wang,² Y. Brudno,² V. Erbas,³ Z. Zhang,³ H. Sahin,³ D. Mooney,² V. Gorantla,³ R. Venkataramanan.¹
¹Department of Pharmaceutical Science, University of Pittsburgh School of Pharmacy, Pittsburgh, PA; ²A Wyss Institute for Biologically Inspired Engineering, Harvard University, Boston, MA; ³Department of Plastic and Reconstructive Surgery, University of Pittsburgh School of Medicine, Pittsburgh, PA
Vascularized composite allotransplantation (VCA) have highly immunogenic skin component mandates high doses of systemic immunosuppressive drugs. Oral dosing leads to fluctuating, unpredictable blood levels that…
2017 American Transplant Congress
Tofacitinib-Loaded Solid Lipid Nanoparticles Inhibits Dendritic Cell Antigen Presenting Functions and Achieve Selective In Vivo Targeting.
G. Raimondi,¹ X. Calderon-Colon,² J. Budihardjo,¹ A. Mirdad,¹ M. Iglesias-Lozano,¹ J. Walch,¹ W. Lee,¹ G. Brandacher,¹ J. Patrone.²
¹Plastic & Reconstructive Surgery, Johns Hopkins University, Baltimore; ²Johns Hopkins Applied Physics Laboratory, Laurel
BackgroundComplications from long-term use of calcineurin inhibitors are a major concern for transplant patients. To develop CNI-free therapies, we investigated an innovative drug delivery method…
2017 American Transplant Congress
Measurement of Dissolved Oxygen by ¹⁹F MRI of Microcapsules Implanted IP in Non-Human Primates.
S. Safley,¹ M. Graham,² M. Garwood,³ K. Papas,⁵ B. Weegman,^3,4 G. Barber,¹ E. Lin,¹ J. Leisen,⁷ A. Sambanis,⁶ B. Hering,² C. Weber.¹
¹Surgery, Emory University, Atlanta, GA; ²Surgery, University of Minnesota, Minneapolis, MN; ³Radiology, University of Minnesota, Minneapolis, MN; ⁴Sylvatica Biotech, Inc., Charleston, SC; ⁵Surgery, University of Arizona, Tucson, AZ; ⁶School of Chemical and Biomedical Engineering, Georgia Institute of Technology, Atlanta, GA; ⁷School of Chemistry and Biochemistry, Georgia Institute of Technology, Atlanta, GA
Since our encapsulated NHP islet allografts and porcine islet xenografts fail after i.p. transplantation in immunosuppressed NHPs without a cellular or humoral immune response, we…