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American Transplant Congress abstracts

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Articles tagged "Bioengineering"

  • 2018 American Transplant Congress

    Engineering Regulatory T Cells with Interleukin (IL-)2 Nanogel for Improved Alloimmune Suppression

    S. Eskandari,1 M. Bandeira Melo,2 J. Assaker,1 A. Mansouri,1 S. Cai,1 B. Al Dulaijan,1 M. Mohamed,1 D. Irvine,2 J. Azzi.1

    1Transplantation Research Center, Brigham and Women's Hospital, Harvard Medical School, Boston, MA; 2Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA.

    Clinical trials of adoptively transferred regulatory T cells (TRegs) have been hindered by the short lifespan of these transferred TRegs. Systemic injection of low-dose interleukin…
  • 2018 American Transplant Congress

    Sensing T Cell Killing Activity with Granzyme B Activity Probes

    Q. Mac,1 D. Mathews,2 J. Kahla,1 C. Stoffers,1 O. Delmas,1 B. Holt,1 A. Adams,2 G. Kwong.1

    1Department of Biomedical Engineering, Georgia Institute of Technology, Atlanta, GA; 2Department of Surgery, Emory University School of Medicine, Atlanta, GA.

    Purpose: We developed activity-based probes that sense Granzyme B (GzmB) activity during alloreactive T cell killing of donor cellsMethods: FITC-labelled GzmB substrate (IEFDSG) was synthesized…
  • 2018 American Transplant Congress

    Biomaterial-Based Localized and Controlled Delivery of Tofacitinib to Actuate Enhanced Costimulation Blockade and Promote Long-Term Transplant Survival

    G. Raimondi,1 P. Majumder,2 V. Ivanova,1 X. Calderon-Colon,3 A. Mirdad,1 M. Iglesias Lozano,1 W. Lee,1 G. Brandacher,1 J. Schneider,2 J. Patrone.3

    1Johns Hopkins School of Medicine, Baltimore; 2National Cancer Institute, Frederick; 3Johns Hopkins Applied Physics Laboratory, Laurel.

    Complications from long-term use of calcineurin inhibitors remain a major issue for transplant patients and alternative therapies are highly needed. We investigated two innovative drug…
  • 2018 American Transplant Congress

    Pancreas Decellularization Protocol – Comparison of Methods

    A. Berman, K. Karzynski, M. Serwanska-Swientek, N. Pilka, M. Klak, K. Kosowska, J. Cichon, F. Ambrozkiewicz, M. Wszola.

    Foundation of Research and Science Development, Otwock, Poland.

    Background: Whole organ decellularization is gaining a lot of popularity since its development in tissue engineering. It is a process which allows to create complex…
  • 2018 American Transplant Congress

    Re-Endothelialization of Liver Xenografts Utilizing Human Endothelial Cells

    W. Hassanein,1 P. Patel,1 A. Werdsheim,1 J. Brilliant,1 E. Buckingham,1 N. Shockcor,1 C. Drachenberg,2 R. Barth,1 J. LaMattina.1

    1Surgery, University of Maryland, Baltimore, MD; 2Pathology, University of Maryland, Baltimore, MD.

    Introduction:Acute antibody mediated rejection due to preformed antibodies present in human serum remains a hurdle to successful xenotransplantation. Xenograft vascular endothelium represents the initial site…
  • 2017 American Transplant Congress

    New Approach for Targeted Immunotherapy in Vascularized Composite Allotransplantation.

    F. Feturi,1 H. Wang,2 Y. Brudno,2 V. Erbas,3 Z. Zhang,3 H. Sahin,3 D. Mooney,2 V. Gorantla,3 R. Venkataramanan.1

    1Department of Pharmaceutical Science, University of Pittsburgh School of Pharmacy, Pittsburgh, PA; 2A Wyss Institute for Biologically Inspired Engineering, Harvard University, Boston, MA; 3Department of Plastic and Reconstructive Surgery, University of Pittsburgh School of Medicine, Pittsburgh, PA

    Vascularized composite allotransplantation (VCA) have highly immunogenic skin component mandates high doses of systemic immunosuppressive drugs. Oral dosing leads to fluctuating, unpredictable blood levels that…
  • 2017 American Transplant Congress

    Tofacitinib-Loaded Solid Lipid Nanoparticles Inhibits Dendritic Cell Antigen Presenting Functions and Achieve Selective In Vivo Targeting.

    G. Raimondi,1 X. Calderon-Colon,2 J. Budihardjo,1 A. Mirdad,1 M. Iglesias-Lozano,1 J. Walch,1 W. Lee,1 G. Brandacher,1 J. Patrone.2

    1Plastic & Reconstructive Surgery, Johns Hopkins University, Baltimore; 2Johns Hopkins Applied Physics Laboratory, Laurel

    BackgroundComplications from long-term use of calcineurin inhibitors are a major concern for transplant patients. To develop CNI-free therapies, we investigated an innovative drug delivery method…
  • 2017 American Transplant Congress

    Measurement of Dissolved Oxygen by 19F MRI of Microcapsules Implanted IP in Non-Human Primates.

    S. Safley,1 M. Graham,2 M. Garwood,3 K. Papas,5 B. Weegman,3,4 G. Barber,1 E. Lin,1 J. Leisen,7 A. Sambanis,6 B. Hering,2 C. Weber.1

    1Surgery, Emory University, Atlanta, GA; 2Surgery, University of Minnesota, Minneapolis, MN; 3Radiology, University of Minnesota, Minneapolis, MN; 4Sylvatica Biotech, Inc., Charleston, SC; 5Surgery, University of Arizona, Tucson, AZ; 6School of Chemical and Biomedical Engineering, Georgia Institute of Technology, Atlanta, GA; 7School of Chemistry and Biochemistry, Georgia Institute of Technology, Atlanta, GA

    Since our encapsulated NHP islet allografts and porcine islet xenografts fail after i.p. transplantation in immunosuppressed NHPs without a cellular or humoral immune response, we…
  • 2017 American Transplant Congress

    Binding of Human Neutrophils to Activated Porcine Endothelium Is Mediated by E-Selectin.

    C. Laird,1 B. French,1 L. Burdorf,1 X. Cheng,1 W. Fogler,2 J. Magnani,2 C. Phelps,3 D. Ayares,3 A. Azimzadeh,1 R. Pierson.1

    1University of Maryland SOM, Baltimore; 2GlycoMimetics, Inc, Rockville; 3Revivicor, Inc, Blacksburg

    Purpose: Shortage of transplantable human organs motivates research into alternatives, including xenotransplantation. When porcine lungs are perfused with human blood, a majority of human neutrophils…
  • 2017 American Transplant Congress

    Decellularized Rat Liver Scaffolds Support Survival and Metabolic Function of Multilineage Allogenic Cells.

    W. Hassanein, A. Werdesheim, A. Cimeno, B. Buckingham, A. Khalifeh, M. Uluer, J. Harrison, D. Parsell, C. Drachenberg, R. Barth, J. LaMattina.

    University of Maryland School of Medcine, Baltimore, MD

    Background:Organ bioengineering has the potential to completely eliminate the donor organ shortage. Here, we examine the feasibility of a decellularized liver construct to support the…
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