Articles tagged "Bioengineering"

2022 American Transplant Congress
Bioink Based on the DECM for 3D-Bioprinting of Bionic Pancreas – First Results of Animal
M. Klak¹, K. Kosowska¹, T. Bryniarski¹, I. Lojszczyk¹, T. Dobrzanski², G. Tymicki¹, A. Filip¹, A. A. Szczepankiewicz³, R. Olkowski⁴, A. Kosowska⁴, A. Berman¹, A. Kaminski⁴, M. Wszola¹
¹Foundation of Research and Science Development, Warsaw, Poland, ²Polbionica LTD, Warsaw, Poland, ³Institute of Experimental Biology M. Nencki PAN, Warsaw, Poland, ⁴Medical University of Warsaw, Warsaw, Poland
*Purpose: Tissue engineering is an interdisciplinary field involving activities based on two interrelated areas: developing new methods to repair, regenerate and replace damaged tissues and…
2022 American Transplant Congress
Towards Bionic Organs: Biocompatibility Of Newly Developed Porcine Decm-based Hydrogels.
M. Rachalewski, M. Klak, D. Ujazdowska, P. Cywoniuk, T. Dobrzanski, G. Tymicki, K. Kosowska, T. Bryniarski, A. Berman, M. Wszola
Foundation of Research and Science Development, Warsaw, Poland
*Purpose: There is a growing interest in fabrication of bioinks which on one hand biocompatible and on the other hand possess mechanical properties which would…
2022 American Transplant Congress
Maturation and Evaluation of 3D Printed Bionic Pancreas with a Dedicated Bioreactor
A. Berman¹, M. Klak², T. Dobrzanski³, T. Bryniarski³, M. Kolodziejska³, G. Tymicki³, M. Wszola³
¹Polbionica Ltd., Warsaw, Poland, ²Foundation for Research and Science Development, Warsaw, Poland, ³Foundation of Research and Science Development, Warsaw, Poland
*Purpose: The technology of 3D printing of bionic organs gives an opportunity to solve the problems of classical transplantology, such as the shortage of organs,…
2022 American Transplant Congress
Optimization of Human Liver Organoid Model for Nonalcoholic Fatty Liver Disease and Nonalcoholic Steatohepatitis
Y. Park¹, D. Thadasina¹, K. Isidan¹, K. J. Lopez¹, A. Cross-Najafi¹, P. Li¹, H. Francis², G. Alpini², W. Zhang¹, B. Ekser¹
¹Surgery, Indiana University School of Medicine, Indianapolis, IN, ²Division of Gastroenterology & Hepatology, Indiana University School of Medicine, Indianapolis, IN
*Purpose: The aim of our project is to develop an in vitro 3D human liver organoid (3D-HLO) model for studying nonalcoholic fatty liver disease (NAFLD)…
2022 American Transplant Congress
Plasma from Patients with Primary Focal Segmental Glomerulosclerosis Induce Development of Sclerotic Glomeruli in Kidney Organoids
A. Kumar Gupta¹, E. Minocha¹, J. A. Wertheim¹, L. Gallon²
¹Department of Surgery, University of Arizona College of Medicine, Tucson, AZ, ²Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL
*Purpose: Primary focal segmental glomerulosclerosis (FSGS) is a kidney disorder resulting in end-stage renal disease that is associated with an elevated rate of recurrence after…
2022 American Transplant Congress
Addressing the Organ Shortage, Improving Transplant Longevity, and Enabling Minimally Invasive Kidney Transplantation: Development of an Intraoperative Kidney Anastomosis Facilitation and Regelation Device
K. S. Hansen¹, R. Meier², J. Gardner¹
¹University of California San Francisco, San Francisco, CA, ²Division of Transplant Surgery, University of Maryland, San Francisco, CA
*Purpose: Second warm ischemia time (SWIT) of a renal allograft during anastomosis increases rates of delayed graft function and premature graft failure. In the setting…
2022 American Transplant Congress
Engineered IL-2 Plus Calcineurin Inhibitor Synergistically Expands Regulatory T Cells Transduced with Engineered IL-2 Receptor and Facilitates Establishment of Transplantation Tolerance
T. Hirai¹, P. Lin², T. L Ramos², K. Garcia³, R. S Negrin²
¹Urology, Tokyo Women's Medical University, Tokyo, Japan, ²Blood and Marrow Transplantation, Stanford University, Stanford, CA, ³Molecular and Cellular Physiology and Structural Biology, Stanford University, Stanford, CA
*Purpose: Clinical trials for regulatory T cell (Treg) therapy in organ transplant has shown promising results. However, it is still under the debate which drugs…
2021 American Transplant Congress
Enhancement of Regulatory T Cell Therapies by Biomimetic Nanofiber Matrices on Single Cells
L. A. Fraser¹, S. Lee¹, Y. Sambandam², J. He², X. Huang², D. Z. Ivancic², J. Mathew², Z. J. Zhang², J. R. Leventhal², L. Gallon², S. I. Stupp¹
¹Simpson Querrey Institute, Northwestern, Chicago, IL, ²Surgery – Comprehensive Transplant Center, Northwestern, Chicago, IL
*Purpose: Here we report a new method to create an artificial and biodegradable matrix of biomimetic nanofibers on single cells with the goal of enhancing…
2021 American Transplant Congress
Development of a Lateral Flow Assay Detecting CXCL9 within Antibody Mediated and Acute T Cell Mediated Rejections After Kidney Transplantation
L. K. Seiler¹, R. Jonczyk¹, P. Lindner¹, L. Phung¹, C. Falk², C. Blume¹
¹Faculty of Natural Sciences, Institute of Technical Chemistry, Hannover, Germany, ²Institute of Transplant Immunology, Medical School Hannover, Hannover, Germany
*Purpose: Despite tremendous improvements in quality and tolerability of immunosuppressive medications after successful kidney transplantation, numerous kidney grafts undergo acute and chronic rejections with following…
2021 American Transplant Congress
Islet Allotransplantation Into Pre-vascularized Sernova Cell Pouch^TM – Preliminary Results from the University of Chicago
P. J. Bachul¹, P. E. Borek¹, G. S. Generette¹, A. Perez-Gutierrez¹, K. Jayant¹, K. Golab¹, L. Basto¹, L. Perea¹, M. Tibudan¹, C. Thomas², L. Philipson², J. Fung¹, P. Witkowski¹
¹Surgery, University of Chicago, Chicago, IL, ²Medicine, University of Chicago, Chicago, IL
*Purpose: Previous first-in-human pilot study showed safety but the conditions did not allow for detectable islet function post-transplantation into the pre-vascularized Sernova Cell Pouches (SCPs)…