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Articles tagged "Bioengineering"

  • 2022 American Transplant Congress

    Selective Vascular Decellularization and Endothelial Cells Replacement as a Strategy to Reduce Reperfusion Injury in Bioartificial Organs

    G. Haeublein1, G. Lombardi1, F. Caro1, R. Carla1, D. Guerrieri1, C. Incardona2, D. Casadei3, E. Chuluyan1

    1CEFYBO, Buenos Aires, Argentina, 2GADOR S.A., Buenos Aires, Argentina, 3Fundación Argentina de Trasplante, Tercer Milenio, Buenos Aires, Argentina

    *Purpose: The number of kidney transplants performed each year cannot meet the increasing demand of these organs. Several strategies aim to increasing the offer of…
  • 2022 American Transplant Congress

    Bionic Pancreas – 3D Bioprinting of a Bionic Organ with a Vascular System – Results of Transplantation in Large Animals

    M. Wszola1, M. Klak2, A. Berman3, M. Kolodziejska1, T. Bryniarski1, G. Tymicki1, T. Dobrzanski1, D. Szkopek4, K. Roszkowicz-Ostrowska5, J. Wolinski5, A. Dobrzyn6, A. Kaminski7

    1Foundation of Research and Science Development, Warsaw, Poland, 2Foundation for Research and Science Development, Warsaw, Poland, 3Polbionica Ltd., Warsaw, Poland, 4Institute of Animal Physiology and Nutrition Jan Kielanowski of the Polish Academy of Sciences,, Jabłonna, Poland, 5Institute of Animal Physiology and Nutrition Jan Kielanowski of the Polish Academy of Sciences, Jablonna, Poland, 6Laboratory of Cell Signaling and Metabolic Disorders, Nencki Institute of Experimental Biology of Polish Academy of Sciences, Warsaw, Poland, 7Department of Transplantology and Central Tissue Bank, Medical University of Warsaw, Warsaw, Poland

    *Purpose: There is lack organs for transplantation. The transplantation of the pancreas is recommended in diabetes with complications. The combination of cell biology and 3D-bioprinting…
  • 2022 American Transplant Congress

    Bionic Pancreas – The First Results of Functionality of 3D-Bioprinted Bionic Tissue Model Transplantation with Pancreatic Islets

    M. Klak1, M. Wszola1, A. Berman1, A. Filip1, A. Kosowska2, J. Olkowska-Truchanowicz2, G. Tymicki1, M. Rachalewski1, T. Bryniarski1, M. Kolodziejska1, T. Dobrzanski3, D. Ujazdowska1, J. Wejman4, I. Uhrynowska-Tyszkiewicz2, A. Kaminski2

    1Foundation of Research and Science Development, Warsaw, Poland, 2Medical University of Warsaw, Warsaw, Poland, 3Polbionica Ltd., Warsaw, Poland, 4Center for Pathomorphological Diagnostics Ltd, Warsaw, Poland

    *Purpose: Tissue engineering is currently on advanced stage of development which gives a possibilities for novel strategy of personal treatment of type 1 diabetes. AIM:…
  • 2022 American Transplant Congress

    A Model for Medical Device Innovation in Transplantation: Using the Biodesign Process to Address the Impact of Warm Ischemic Injury

    K. Hansen1, J. Wall2

    1University of California San Francisco, San Francisco, CA, 2Stanford University, Palo Alto, CA

    *Purpose: The impact of warming during second warm-ischemia (anastomosis) of kidney transplantation has been increasingly recognized in the literature. The outsized effect on delayed graft…
  • 2022 American Transplant Congress

    Bioink Based on the DECM for 3D-Bioprinting of Bionic Pancreas – First Results of Animal

    M. Klak1, K. Kosowska1, T. Bryniarski1, I. Lojszczyk1, T. Dobrzanski2, G. Tymicki1, A. Filip1, A. A. Szczepankiewicz3, R. Olkowski4, A. Kosowska4, A. Berman1, A. Kaminski4, M. Wszola1

    1Foundation of Research and Science Development, Warsaw, Poland, 2Polbionica LTD, Warsaw, Poland, 3Institute of Experimental Biology M. Nencki PAN, Warsaw, Poland, 4Medical University of Warsaw, Warsaw, Poland

    *Purpose: Tissue engineering is an interdisciplinary field involving activities based on two interrelated areas: developing new methods to repair, regenerate and replace damaged tissues and…
  • 2022 American Transplant Congress

    Towards Bionic Organs: Biocompatibility Of Newly Developed Porcine Decm-based Hydrogels.

    M. Rachalewski, M. Klak, D. Ujazdowska, P. Cywoniuk, T. Dobrzanski, G. Tymicki, K. Kosowska, T. Bryniarski, A. Berman, M. Wszola

    Foundation of Research and Science Development, Warsaw, Poland

    *Purpose: There is a growing interest in fabrication of bioinks which on one hand biocompatible and on the other hand possess mechanical properties which would…
  • 2022 American Transplant Congress

    Maturation and Evaluation of 3D Printed Bionic Pancreas with a Dedicated Bioreactor

    A. Berman1, M. Klak2, T. Dobrzanski3, T. Bryniarski3, M. Kolodziejska3, G. Tymicki3, M. Wszola3

    1Polbionica Ltd., Warsaw, Poland, 2Foundation for Research and Science Development, Warsaw, Poland, 3Foundation of Research and Science Development, Warsaw, Poland

    *Purpose: The technology of 3D printing of bionic organs gives an opportunity to solve the problems of classical transplantology, such as the shortage of organs,…
  • 2021 American Transplant Congress

    Islet Allotransplantation Into Pre-vascularized Sernova Cell PouchTM – Preliminary Results from the University of Chicago

    P. J. Bachul1, P. E. Borek1, G. S. Generette1, A. Perez-Gutierrez1, K. Jayant1, K. Golab1, L. Basto1, L. Perea1, M. Tibudan1, C. Thomas2, L. Philipson2, J. Fung1, P. Witkowski1

    1Surgery, University of Chicago, Chicago, IL, 2Medicine, University of Chicago, Chicago, IL

    *Purpose: Previous first-in-human pilot study showed safety but the conditions did not allow for detectable islet function post-transplantation into the pre-vascularized Sernova Cell Pouches (SCPs)…
  • 2021 American Transplant Congress

    Cross-Circulation for Extracorporeal Liver Support in a Swine Model

    W. K. Wu1, A. Tumen1, J. W. Stokes2, R. Ukita2, A. E. Hozain3, C. R. Flynn2, M. J. Lee3, J. R. Talackine2, N. L. Cardwell2, J. A. Reimer3, M. Pinezich3, C. Benson2, G. Vunjak-Novakovic3, S. P. Alexopoulos2, M. Bacchetta2

    1co-first authors, Vanderbilt University Medical Center, Nashville, TN, 2Vanderbilt University Medical Center, Nashville, TN, 3Columbia University Medical Center, New York, NY

    *Purpose: Although machine perfusion has gained momentum as an organ preservation strategy in liver transplantation, significant organ shortages and waitlist mortality persist, highlighting unmet needs…
  • 2021 American Transplant Congress

    Enhancement of Regulatory T Cell Therapies by Biomimetic Nanofiber Matrices on Single Cells

    L. A. Fraser1, S. Lee1, Y. Sambandam2, J. He2, X. Huang2, D. Z. Ivancic2, J. Mathew2, Z. J. Zhang2, J. R. Leventhal2, L. Gallon2, S. I. Stupp1

    1Simpson Querrey Institute, Northwestern, Chicago, IL, 2Surgery – Comprehensive Transplant Center, Northwestern, Chicago, IL

    *Purpose: Here we report a new method to create an artificial and biodegradable matrix of biomimetic nanofibers on single cells with the goal of enhancing…
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