Articles tagged "Bioengineering"

2022 American Transplant Congress
Tissue Engineering Scaffolds for Minimally Invasive Immunosurveillance of Acute Cellular Graft Rejection
R. R. Urie¹, D. Farris², A. Morris¹, E. Lombard¹, J. Z. Li³, D. Goldstein², L. Shea¹
¹Biomedical Engineering, University of Michigan, Ann Arbor, MI, ²Internal Medicine, University of Michigan, Ann Arbor, MI, ³Human Genetics, University of Michigan, Ann Arbor, MI
*Purpose: As there is no assay to predict the risk of acute cellular allograft rejection (ACAR), clinicians rely on protocol graft biopsy and aggressive, one-size-fits-all…
2022 American Transplant Congress
Voxelated Bioprinting of Mechanically Robust Multiscale Porous Scaffolds for Islet Transplantation
J. Zhu, Y. He, Y. Wang, J. Oberholzer, L. Cai
University of Virginia, Charlottesvle, VA
*Purpose: Classical microencapsulation technologies for islet transplantation faces two major challenges associated with individual microcapsules. First, due to long-term gravity individual microcapsules often aggregate to…
2022 American Transplant Congress
Functional Recellularized Patient Derived Endothelium; A Human Vascular Graft Approach
H. Tejeda Mora¹, J. Willemse², Y. den Hartog¹, I. Schurink², M. M. Verstegen², J. de Jonge², R. C. Minnee², M. W. van den Hoogen², C. C. Baan¹, L. J. van der Laan², M. J. Hoogduijn¹
¹Transplant Institute - Internal Medicine, Erasmus Medical Center, Rotterdam, Netherlands, ²Transplant Institute - Department of Surgery, Erasmus Medical Center, Rotterdam, Netherlands
*Purpose: In transplantation, the endothelial lining is the first barrier between the donor organ and recipient immune system. Damaged endothelium exposes extracellular matrix (ECM) molecules…
2022 American Transplant Congress
Decellularized Human Pancreatic Extracellular Matrix-Based Physiomimetic Microenvironment for Human Islet Culture
A. Asthana¹, D. Chaimov¹, R. Tamburrini², S. J. Walker³, G. Orlando¹
¹Wake Forest Baptist Medical Center, Winston-Salem, NC, ²University of Wisconsin Hospital and Clinics, Madison, WI, ³Wake Forest Institute for Regenerative Medicine, Winston-Salem, NC
*Purpose: Maintenance of human islet viability and function ex vivo can be a significant bottleneck for both regenerative medicine as well as tissue engineering applications.…
2022 American Transplant Congress
Selective Vascular Decellularization and Endothelial Cells Replacement as a Strategy to Reduce Reperfusion Injury in Bioartificial Organs
G. Haeublein¹, G. Lombardi¹, F. Caro¹, R. Carla¹, D. Guerrieri¹, C. Incardona², D. Casadei³, E. Chuluyan¹
¹CEFYBO, Buenos Aires, Argentina, ²GADOR S.A., Buenos Aires, Argentina, ³Fundación Argentina de Trasplante, Tercer Milenio, Buenos Aires, Argentina
*Purpose: The number of kidney transplants performed each year cannot meet the increasing demand of these organs. Several strategies aim to increasing the offer of…
2022 American Transplant Congress
Bionic Pancreas – 3D Bioprinting of a Bionic Organ with a Vascular System – Results of Transplantation in Large Animals
M. Wszola¹, M. Klak², A. Berman³, M. Kolodziejska¹, T. Bryniarski¹, G. Tymicki¹, T. Dobrzanski¹, D. Szkopek⁴, K. Roszkowicz-Ostrowska⁵, J. Wolinski⁵, A. Dobrzyn⁶, A. Kaminski⁷
¹Foundation of Research and Science Development, Warsaw, Poland, ²Foundation for Research and Science Development, Warsaw, Poland, ³Polbionica Ltd., Warsaw, Poland, ⁴Institute of Animal Physiology and Nutrition Jan Kielanowski of the Polish Academy of Sciences,, Jabłonna, Poland, ⁵Institute of Animal Physiology and Nutrition Jan Kielanowski of the Polish Academy of Sciences, Jablonna, Poland, ⁶Laboratory of Cell Signaling and Metabolic Disorders, Nencki Institute of Experimental Biology of Polish Academy of Sciences, Warsaw, Poland, ⁷Department of Transplantology and Central Tissue Bank, Medical University of Warsaw, Warsaw, Poland
*Purpose: There is lack organs for transplantation. The transplantation of the pancreas is recommended in diabetes with complications. The combination of cell biology and 3D-bioprinting…
2022 American Transplant Congress
Bionic Pancreas – The First Results of Functionality of 3D-Bioprinted Bionic Tissue Model Transplantation with Pancreatic Islets
M. Klak¹, M. Wszola¹, A. Berman¹, A. Filip¹, A. Kosowska², J. Olkowska-Truchanowicz², G. Tymicki¹, M. Rachalewski¹, T. Bryniarski¹, M. Kolodziejska¹, T. Dobrzanski³, D. Ujazdowska¹, J. Wejman⁴, I. Uhrynowska-Tyszkiewicz², A. Kaminski²
¹Foundation of Research and Science Development, Warsaw, Poland, ²Medical University of Warsaw, Warsaw, Poland, ³Polbionica Ltd., Warsaw, Poland, ⁴Center for Pathomorphological Diagnostics Ltd, Warsaw, Poland
*Purpose: Tissue engineering is currently on advanced stage of development which gives a possibilities for novel strategy of personal treatment of type 1 diabetes. AIM:…
2021 American Transplant Congress
Islet Allotransplantation Into Pre-vascularized Sernova Cell Pouch^TM – Preliminary Results from the University of Chicago
P. J. Bachul¹, P. E. Borek¹, G. S. Generette¹, A. Perez-Gutierrez¹, K. Jayant¹, K. Golab¹, L. Basto¹, L. Perea¹, M. Tibudan¹, C. Thomas², L. Philipson², J. Fung¹, P. Witkowski¹
¹Surgery, University of Chicago, Chicago, IL, ²Medicine, University of Chicago, Chicago, IL
*Purpose: Previous first-in-human pilot study showed safety but the conditions did not allow for detectable islet function post-transplantation into the pre-vascularized Sernova Cell Pouches (SCPs)…
2021 American Transplant Congress
Cross-Circulation for Extracorporeal Liver Support in a Swine Model
W. K. Wu¹, A. Tumen¹, J. W. Stokes², R. Ukita², A. E. Hozain³, C. R. Flynn², M. J. Lee³, J. R. Talackine², N. L. Cardwell², J. A. Reimer³, M. Pinezich³, C. Benson², G. Vunjak-Novakovic³, S. P. Alexopoulos², M. Bacchetta²
¹co-first authors, Vanderbilt University Medical Center, Nashville, TN, ²Vanderbilt University Medical Center, Nashville, TN, ³Columbia University Medical Center, New York, NY
*Purpose: Although machine perfusion has gained momentum as an organ preservation strategy in liver transplantation, significant organ shortages and waitlist mortality persist, highlighting unmet needs…
2021 American Transplant Congress
Enhancement of Regulatory T Cell Therapies by Biomimetic Nanofiber Matrices on Single Cells
L. A. Fraser¹, S. Lee¹, Y. Sambandam², J. He², X. Huang², D. Z. Ivancic², J. Mathew², Z. J. Zhang², J. R. Leventhal², L. Gallon², S. I. Stupp¹
¹Simpson Querrey Institute, Northwestern, Chicago, IL, ²Surgery – Comprehensive Transplant Center, Northwestern, Chicago, IL
*Purpose: Here we report a new method to create an artificial and biodegradable matrix of biomimetic nanofibers on single cells with the goal of enhancing…