Articles tagged "Bioengineering"

2022 American Transplant Congress
Optimization of Human Liver Organoid Model for Nonalcoholic Fatty Liver Disease and Nonalcoholic Steatohepatitis
Y. Park¹, D. Thadasina¹, K. Isidan¹, K. J. Lopez¹, A. Cross-Najafi¹, P. Li¹, H. Francis², G. Alpini², W. Zhang¹, B. Ekser¹
¹Surgery, Indiana University School of Medicine, Indianapolis, IN, ²Division of Gastroenterology & Hepatology, Indiana University School of Medicine, Indianapolis, IN
*Purpose: The aim of our project is to develop an in vitro 3D human liver organoid (3D-HLO) model for studying nonalcoholic fatty liver disease (NAFLD)…
2022 American Transplant Congress
Plasma from Patients with Primary Focal Segmental Glomerulosclerosis Induce Development of Sclerotic Glomeruli in Kidney Organoids
A. Kumar Gupta¹, E. Minocha¹, J. A. Wertheim¹, L. Gallon²
¹Department of Surgery, University of Arizona College of Medicine, Tucson, AZ, ²Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL
*Purpose: Primary focal segmental glomerulosclerosis (FSGS) is a kidney disorder resulting in end-stage renal disease that is associated with an elevated rate of recurrence after…
2022 American Transplant Congress
Addressing the Organ Shortage, Improving Transplant Longevity, and Enabling Minimally Invasive Kidney Transplantation: Development of an Intraoperative Kidney Anastomosis Facilitation and Regelation Device
K. S. Hansen¹, R. Meier², J. Gardner¹
¹University of California San Francisco, San Francisco, CA, ²Division of Transplant Surgery, University of Maryland, San Francisco, CA
*Purpose: Second warm ischemia time (SWIT) of a renal allograft during anastomosis increases rates of delayed graft function and premature graft failure. In the setting…
2022 American Transplant Congress
Engineered IL-2 Plus Calcineurin Inhibitor Synergistically Expands Regulatory T Cells Transduced with Engineered IL-2 Receptor and Facilitates Establishment of Transplantation Tolerance
T. Hirai¹, P. Lin², T. L Ramos², K. Garcia³, R. S Negrin²
¹Urology, Tokyo Women's Medical University, Tokyo, Japan, ²Blood and Marrow Transplantation, Stanford University, Stanford, CA, ³Molecular and Cellular Physiology and Structural Biology, Stanford University, Stanford, CA
*Purpose: Clinical trials for regulatory T cell (Treg) therapy in organ transplant has shown promising results. However, it is still under the debate which drugs…
2022 American Transplant Congress
Immunometabolism of Regulatory T Cells Enhanced by Lipid Nanoparticles
J. S. Rink¹, Y. Sambandam², J. He², J. Mathew³, J. R. Leventhal⁴, C. S. Thaxton⁵
¹Department of Medicine, Division of Hematology/ Oncology, Northwestern University, Chicago, IL, ²Comprehensive Transplant Center, Northwestern University, Chicago, IL, ³Northwestern University, Chicago, IL, ⁴Surgery, Northwestern Medicine, Chicago, IL, ⁵Department of Urology, Northwestern University, Chicago, IL
*Purpose: Human regulatory T cell (Treg) metabolism is highly dependent upon a number of factors, including cholesterol obtained from circulating lipoproteins. We have developed high-density…
2022 American Transplant Congress
Vitrification of Pancreatic Islets and Transplantation
J. S. Rao¹, L. Zhan¹, D. Tobolt¹, M. Q. Slama², N. Sethia¹, Z. Han¹, C. S. Dutcher¹, Q. Peterson², J. C. Bischof¹, E. B. Finger¹
¹University of Minnesota, Minneapolis, MN, ²Mayo Clinic, Rochester, MN
*Purpose: A limitation to potential cure for diabetes through islet transplantation is insufficient islet equivalence (IEQ) from a single donor to achieve insulin independence in…
2022 American Transplant Congress
Tissue Engineering Scaffolds for Minimally Invasive Immunosurveillance of Acute Cellular Graft Rejection
R. R. Urie¹, D. Farris², A. Morris¹, E. Lombard¹, J. Z. Li³, D. Goldstein², L. Shea¹
¹Biomedical Engineering, University of Michigan, Ann Arbor, MI, ²Internal Medicine, University of Michigan, Ann Arbor, MI, ³Human Genetics, University of Michigan, Ann Arbor, MI
*Purpose: As there is no assay to predict the risk of acute cellular allograft rejection (ACAR), clinicians rely on protocol graft biopsy and aggressive, one-size-fits-all…
2022 American Transplant Congress
Voxelated Bioprinting of Mechanically Robust Multiscale Porous Scaffolds for Islet Transplantation
J. Zhu, Y. He, Y. Wang, J. Oberholzer, L. Cai
University of Virginia, Charlottesvle, VA
*Purpose: Classical microencapsulation technologies for islet transplantation faces two major challenges associated with individual microcapsules. First, due to long-term gravity individual microcapsules often aggregate to…
2022 American Transplant Congress
Functional Recellularized Patient Derived Endothelium; A Human Vascular Graft Approach
H. Tejeda Mora¹, J. Willemse², Y. den Hartog¹, I. Schurink², M. M. Verstegen², J. de Jonge², R. C. Minnee², M. W. van den Hoogen², C. C. Baan¹, L. J. van der Laan², M. J. Hoogduijn¹
¹Transplant Institute - Internal Medicine, Erasmus Medical Center, Rotterdam, Netherlands, ²Transplant Institute - Department of Surgery, Erasmus Medical Center, Rotterdam, Netherlands
*Purpose: In transplantation, the endothelial lining is the first barrier between the donor organ and recipient immune system. Damaged endothelium exposes extracellular matrix (ECM) molecules…
2022 American Transplant Congress
Decellularized Human Pancreatic Extracellular Matrix-Based Physiomimetic Microenvironment for Human Islet Culture
A. Asthana¹, D. Chaimov¹, R. Tamburrini², S. J. Walker³, G. Orlando¹
¹Wake Forest Baptist Medical Center, Winston-Salem, NC, ²University of Wisconsin Hospital and Clinics, Madison, WI, ³Wake Forest Institute for Regenerative Medicine, Winston-Salem, NC
*Purpose: Maintenance of human islet viability and function ex vivo can be a significant bottleneck for both regenerative medicine as well as tissue engineering applications.…

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