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American Transplant Congress abstracts

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Articles tagged "Bioengineering"

  • 2022 American Transplant Congress

    Optimization of Human Liver Organoid Model for Nonalcoholic Fatty Liver Disease and Nonalcoholic Steatohepatitis

    Y. Park1, D. Thadasina1, K. Isidan1, K. J. Lopez1, A. Cross-Najafi1, P. Li1, H. Francis2, G. Alpini2, W. Zhang1, B. Ekser1

    1Surgery, Indiana University School of Medicine, Indianapolis, IN, 2Division of Gastroenterology & Hepatology, Indiana University School of Medicine, Indianapolis, IN

    *Purpose: The aim of our project is to develop an in vitro 3D human liver organoid (3D-HLO) model for studying nonalcoholic fatty liver disease (NAFLD)…
  • 2022 American Transplant Congress

    Plasma from Patients with Primary Focal Segmental Glomerulosclerosis Induce Development of Sclerotic Glomeruli in Kidney Organoids

    A. Kumar Gupta1, E. Minocha1, J. A. Wertheim1, L. Gallon2

    1Department of Surgery, University of Arizona College of Medicine, Tucson, AZ, 2Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL

    *Purpose: Primary focal segmental glomerulosclerosis (FSGS) is a kidney disorder resulting in end-stage renal disease that is associated with an elevated rate of recurrence after…
  • 2022 American Transplant Congress

    Addressing the Organ Shortage, Improving Transplant Longevity, and Enabling Minimally Invasive Kidney Transplantation: Development of an Intraoperative Kidney Anastomosis Facilitation and Regelation Device

    K. S. Hansen1, R. Meier2, J. Gardner1

    1University of California San Francisco, San Francisco, CA, 2Division of Transplant Surgery, University of Maryland, San Francisco, CA

    *Purpose: Second warm ischemia time (SWIT) of a renal allograft during anastomosis increases rates of delayed graft function and premature graft failure. In the setting…
  • 2022 American Transplant Congress

    Engineered IL-2 Plus Calcineurin Inhibitor Synergistically Expands Regulatory T Cells Transduced with Engineered IL-2 Receptor and Facilitates Establishment of Transplantation Tolerance

    T. Hirai1, P. Lin2, T. L Ramos2, K. Garcia3, R. S Negrin2

    1Urology, Tokyo Women's Medical University, Tokyo, Japan, 2Blood and Marrow Transplantation, Stanford University, Stanford, CA, 3Molecular and Cellular Physiology and Structural Biology, Stanford University, Stanford, CA

    *Purpose: Clinical trials for regulatory T cell (Treg) therapy in organ transplant has shown promising results. However, it is still under the debate which drugs…
  • 2022 American Transplant Congress

    Immunometabolism of Regulatory T Cells Enhanced by Lipid Nanoparticles

    J. S. Rink1, Y. Sambandam2, J. He2, J. Mathew3, J. R. Leventhal4, C. S. Thaxton5

    1Department of Medicine, Division of Hematology/ Oncology, Northwestern University, Chicago, IL, 2Comprehensive Transplant Center, Northwestern University, Chicago, IL, 3Northwestern University, Chicago, IL, 4Surgery, Northwestern Medicine, Chicago, IL, 5Department of Urology, Northwestern University, Chicago, IL

    *Purpose: Human regulatory T cell (Treg) metabolism is highly dependent upon a number of factors, including cholesterol obtained from circulating lipoproteins. We have developed high-density…
  • 2022 American Transplant Congress

    Vitrification of Pancreatic Islets and Transplantation

    J. S. Rao1, L. Zhan1, D. Tobolt1, M. Q. Slama2, N. Sethia1, Z. Han1, C. S. Dutcher1, Q. Peterson2, J. C. Bischof1, E. B. Finger1

    1University of Minnesota, Minneapolis, MN, 2Mayo Clinic, Rochester, MN

    *Purpose: A limitation to potential cure for diabetes through islet transplantation is insufficient islet equivalence (IEQ) from a single donor to achieve insulin independence in…
  • 2022 American Transplant Congress

    Tissue Engineering Scaffolds for Minimally Invasive Immunosurveillance of Acute Cellular Graft Rejection

    R. R. Urie1, D. Farris2, A. Morris1, E. Lombard1, J. Z. Li3, D. Goldstein2, L. Shea1

    1Biomedical Engineering, University of Michigan, Ann Arbor, MI, 2Internal Medicine, University of Michigan, Ann Arbor, MI, 3Human Genetics, University of Michigan, Ann Arbor, MI

    *Purpose: As there is no assay to predict the risk of acute cellular allograft rejection (ACAR), clinicians rely on protocol graft biopsy and aggressive, one-size-fits-all…
  • 2022 American Transplant Congress

    Voxelated Bioprinting of Mechanically Robust Multiscale Porous Scaffolds for Islet Transplantation

    J. Zhu, Y. He, Y. Wang, J. Oberholzer, L. Cai

    University of Virginia, Charlottesvle, VA

    *Purpose: Classical microencapsulation technologies for islet transplantation faces two major challenges associated with individual microcapsules. First, due to long-term gravity individual microcapsules often aggregate to…
  • 2022 American Transplant Congress

    Functional Recellularized Patient Derived Endothelium; A Human Vascular Graft Approach

    H. Tejeda Mora1, J. Willemse2, Y. den Hartog1, I. Schurink2, M. M. Verstegen2, J. de Jonge2, R. C. Minnee2, M. W. van den Hoogen2, C. C. Baan1, L. J. van der Laan2, M. J. Hoogduijn1

    1Transplant Institute - Internal Medicine, Erasmus Medical Center, Rotterdam, Netherlands, 2Transplant Institute - Department of Surgery, Erasmus Medical Center, Rotterdam, Netherlands

    *Purpose: In transplantation, the endothelial lining is the first barrier between the donor organ and recipient immune system. Damaged endothelium exposes extracellular matrix (ECM) molecules…
  • 2022 American Transplant Congress

    Decellularized Human Pancreatic Extracellular Matrix-Based Physiomimetic Microenvironment for Human Islet Culture

    A. Asthana1, D. Chaimov1, R. Tamburrini2, S. J. Walker3, G. Orlando1

    1Wake Forest Baptist Medical Center, Winston-Salem, NC, 2University of Wisconsin Hospital and Clinics, Madison, WI, 3Wake Forest Institute for Regenerative Medicine, Winston-Salem, NC

    *Purpose: Maintenance of human islet viability and function ex vivo can be a significant bottleneck for both regenerative medicine as well as tissue engineering applications.…
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