Articles tagged "B cells"

2020 American Transplant Congress
The Effect of B Cell Depletion Therapies on Preformed Xenoantibodies in Transplant Recipient
S. Yeh¹, N. A. Wilson², A. Djamali², R. Redfield³
¹Pathology and Laboratory Medicine, University of Wisconsin-Madison, Madison, WI, ²Medicine/Nephrology, University of Wisconsin-Madison, Madison, WI, ³Surgery, University of Wisconsin-Madison, Madison, WI
*Purpose: To assess the effect of B cell depletion therapies on preformed xenoantibodies in transplant recipient. Preformed xenoantibodies are a significant barrier to successful xenotransplantation.…
2020 American Transplant Congress
Ex Vivo Generated Regulatory B Cells Can Suppress Donor-Specific CD4 T Cells Proliferation In Vivo
G. Huai¹, K. M. Lee¹, Q. Fu¹, K. Deng¹, N. J. Feeney¹, C. Leguern¹, N. Tanimine¹, C. G. Rickert¹, S. Deng², J. F. Markmann¹
¹Center for Transplantation Sciences, Massachusetts General Hospital, Harvard Medical School, Boston, MA, ²Organ Transplantation Center, Sichuan Provincial People's Hospital and School of Medicine, University of Electronic Science and Technology of China, Chengdu, China
*Purpose: B cells expanded in vitro via TLR9 agonist CpG and activated by LPS, PMA and ionomycin have been previously denoted “TLR-Bregs” by our team.…
2020 American Transplant Congress
Transient Cd4+ T Cell and Cd20+ B Cell Depletion Leads to Prolonged Pig-To-Primate Kidney Xenograft Survival
B. P. Lovasik¹, A. J. Matar¹, D. A. Faber¹, D. V. Mathews¹, C. Breeden¹, S. C. Kim¹, A. J. Tector², A. B. Adams¹
¹Emory University School of Medicine, Atlanta, GA, ²University of Miami, Miami, FL
*Purpose: “Delayed” antibody-mediated xenograft rejection is the one of the most important obstacle to clinical application of pig organ xenografts. The aim of this study…
2020 American Transplant Congress
Splenectomy Impedes B Cell Infiltration Associated with Rejection of Neonatal Porcine Islet Xenografts
Z. W. Fitch, M. Song, R. Schmitz, F. Leopardi, M. Ribeiro, A. Miller, G. Devi, B. Collins, X. Luo, A. D. Kirk
Duke University, Durham, NC
*Purpose: Xenotransplantation has historically been frustrated by antibody-mediated rejection. Splenectomy has shown efficacy in mediating humoral immunity. We hypothesized that adding splenectomy to a clinically…
2020 American Transplant Congress
Characterization of a Novel CD8⁺ B Cell Subset in Monkeys Tolerant of Heart Allografts
J. A. Morrissette¹, K. Pruner¹, S. Lee¹, J. Paster¹, W. Sommer¹, J. O¹, I. Hanekamp¹, P. Sage², G. Benichou¹, J. C. Madsen³
¹Center for Transplantation Sciences, Department of Surgery, Massachusetts General Hospital, Boston, MA, ²Transplantation Research Center, Renal Division, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, ³Center for Transplantation Sciences, Division of Cardiac Surgery, Department of Surgery, Massachusetts General Hospital, Boston, MA
*Purpose: We have previously reported that transient mixed hematopoietic chimerism induced via donor bone marrow transplantation can achieve tolerance to cardiac allografts in non-human primates…
2020 American Transplant Congress
Early Prediction of Human Renal Allograft Rejection (AR) by Inflammatory Transitional B Cells
A. Cherukuri¹, A. Sharma¹, R. Mehta¹, H. Sundaram¹, A. Salama², D. Rothstein¹
¹Starzl Transplantation Institute, UPMC, Pittsburgh, PA, ²UCL, London, United Kingdom
*Purpose: Early prediction of AR within the 1st post-transplant year could identify at-risk patients for targeted therapeutic interventions to mitigate risk and improve outcomes.*Methods: In…
2020 American Transplant Congress
A Two-Step Cell-Based Assay Predicts Immunosuppression-Related Adverse Events in Kidney Transplant Recipients
F. Bouchard-Boivin, O. Désy, S. Béland, S. De Serres
Transplantation Unit, Renal Division, Medecine Department, Laval University, Québec, QC, Canada
*Purpose: No clinical tool is available to dynamically access immunosuppression status, which results in serious, often life-threatening adverse effects of immunosuppressants. We recently validated that…
2020 American Transplant Congress
Naïve B Cells Regulation by TLR-Breg Cells In Vitro
Q. Fu, K. Lee, G. Huai, K. Deng, N. J. Feeney, C. Leguern, S. Deng, J. F. Markmann
Center for Transplant Science, MGH, Boston, MA
*Purpose: Regulatory B cells (Bregs) have shown great potential in cell therapies for murine organ transplantation by inhibiting the proliferation of cytotoxic and helper T…
2020 American Transplant Congress
Transplant Monitoring and PTLD Detection with B Cell Receptor Repertoire Analysis in a Large Prospective Pediatric Cohort
K. Jackson¹, O. Martinez², S. Krams², M. Robien³, M. Lapasaran², B. Armstrong⁴, C. Twist⁵, K. Weinberg⁶, D. Gratzinger¹, B. Tam¹, M. Sever⁴, M. Brown³, D. Bernstein⁶, C. Esquivel², S. D. Boyd¹
¹Department of Pathology, Stanford Univ School of Med, Stanford, CA, ²Department of Surgery/Division of Abdominal Transplantation, Stanford Univ School of Med, Stanford, CA, ³NIAID, NIH, Bethesda, MD, ⁴Rho, Chapel Hill, NC, ⁵Roswell Park, Buffalo, NY, ⁶Department of Pediatrics, Stanford Univ School of Med, Stanford, CA
*Purpose: Post-transplant lymphoproliferative disorder (PTLD) remains a serious problem in the pediatric transplant population. The Clinical Trials of Organ Transplantation in Children (CTOT-C)-06 is a…
2020 American Transplant Congress
Donor-Specific B Cell Frequency Assessed by a Novel Multiplex Bead-Based Assay Predicts Graft Failure in Kidney Transplant Recipients
Z. Ilyas, A. Akl, D. Pinelli, L. Gallon, A. R. Tambur, M. Ansari
Northwestern University Feinberg School of Medicine, Chicago, IL
*Purpose: Kidney transplant recipients with sensitization to HLA defined by a high percentage of Panel Reactive Antibodies (PRA) or Donor-specific anti-HLA antibodies (DSA) are at…

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