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American Transplant Congress abstracts

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Articles tagged "B cells"

  • 2020 American Transplant Congress

    Dominant Negative Polymorphisms in TNFRSF13B are Associated with Poor Transplant Outcome

    M. G. de Mattos-Barbosa1, E. T. Luning Prak2, E. Farkash3, J. L. Platt4, M. Cascalho4

    1Transplant Surgery, University of Michigan, Ann Arbor, MI, 2Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, 3Pathology, University of Michigan, Ann Arbor, MI, 4Transplant Surgery and Microbiology and Immunology, University of Michigan, Ann Arbor, MI

    *Purpose: Transmembrane Activator and CAML Interactor (TACI) is a highly polymorphic receptor that controls B cell activation and differentiation into antibody-secreting cells. Allelic variants of…
  • 2020 American Transplant Congress

    Passenger Lymphocyte Syndrome Due to Anti-Rh(D) Reactivity after Kidney Transplantation: A Case Report

    S. Nemr1, S. Bani Hani1, E. Klohe2, C. Gresens3, S. Desmond1, O. Ojogho1

    1Kidney and Pancreas Transplant Program, Providence Sacred Heart Medical Center & Children's Hospital, Spokane, WA, 2HLA Laboratory, Inland Northwest Blood Center, Spokane, WA, 3Inland Northwest Blood Center, Spokane, WA

    *Purpose: PLS can occur soon after solid organ transplantation when donor-derived antibodies against recipient red cell antigens are produced and lead to hemolysis. The anemia…
  • 2020 American Transplant Congress

    Belatacept Suppresses the B-Cell Alloresponse in the Lower Range of Therapeutic Trough Concentrations

    C. Ashokkumar1, R. Townsend2, M. Roberts2, T. Lehman2, B. Gavin2, B. Spishock1, R. Sindhi1

    1Plexision, Pittsburgh, PA, 2Bristol-Myers-Squibb, Princeton, NJ

    *Purpose: Background: Kidney recipients treated with the T-cell costimulation blocker, belatacept, experience a higher incidence of acute cellular rejection (ACR) and lower incidence of donor-specific…
  • 2020 American Transplant Congress

    Humoral Sensitization Overrides Pregnancy-Induced T Cell Transplantation Tolerance

    D. Tran1, A. Suah1, S. Khiew1, J. Young1, M. Andrade1, J. Pollard1, Q. Wang1, D. Yin1, G. Chalasani2, M. Alegre1, A. Chong1

    1Department of General Surgery, University of Chicago, Chicago, IL, 2Thomas E. Starzl Transplantation Institute, University of Pittsburgh School of Medicine, Pittsburgh, PA

    *Purpose: There are ample clinical data that a major long-term consequence of pregnancy is humoral allosensitization. Paradoxically, pregnancy is also a state of spontaneous allogeneic…
  • 2020 American Transplant Congress

    Irf8-Relevant Mechanism in B Cell Regulation In Vitro

    Q. Fu1, K. Deng2, H. Yang1, J. F. Markmann2, S. Deng1

    1Organ Transplantation Center, and School of Medicine, University of Electronic Sciences and Technology of China, Chengdu, China, 2Center for Transplantation Sciences, MGH, Boston, MA

    *Purpose: Previously, we had reported that IFN regulatory factor 8 (IRF8) could be used for the identification of interstitial fibrosis and tubular atrophy (IFTA) with…
  • 2020 American Transplant Congress

    Single Cell Gene Profiling Highlights Novel B Cell Populations Associated with the Development of Bronchiolitis Obliterates Syndrome after Lung Transplantation

    N. F. Smirnova1, K. Riemondy2, S. Collins1, J. Hesselberth2, O. Eickelberg1

    1Dept of Medicine - Division of Pulmonary Sciences and Critical Care Medicine, University of Colorado - Anschutz Medical Campus, Aurora, CO, 2University of Colorado - Anschutz Medical Campus, Aurora, CO

    *Purpose: The occurence of bronchiolitis obliterans syndrome (BOS) accounts for a poor long term prognosis after lung transplantation (LTx). Despite immunosuppressive T cell-targeting therapies the…
  • 2020 American Transplant Congress

    New Everolimus Administration Targeting the Prevention of the Development of Antibody-Mediated Rejection Considering the Comparison of Growth and Survival in IgG and IgM Memory B Cells

    Y. Matsuda1, R. Imamura1, H. Tezuka2, S. Takahara1

    1Osaka University Graduate School of Medicine, Suita, Japan, 2Fujita Health University, Toyoake, Japan

    *Purpose: Some reports indicated that immunoglobulin (Ig) M antibodies corresponding to donor-specific antigen in addition to IgG antibodies are closely involved in the activation of…
  • 2020 American Transplant Congress

    HLA-Antibody Develops Preferentially in Healthy Subjects with a T-bethiB Cell Response to Vaccine

    A. Nellore, G. R. Martens, J. T. Killian, J. Houp, E. Zumaquero, B. Mousseau, J. Bradley, F. Zhou, P. A. Goepfert, F. E. Lund

    University of Alabama, Birmingham, AL

    *Purpose: Bystander B cell differentiation into antibody (Ab) secreting cells (ASCs) may augment alloimmunity in the HLA-sensitized patient. Recently, a population of FcrL5+IgDnegB cells that…
  • 2020 American Transplant Congress

    Anti-Thymocyte Globulin Promotes Tfh Cells Differentiation and Alloantibody Production

    R. Benedetti Gassen, B. Aoyama, M. Lima, T. Borges, M. Pérez-Sáez, N. Murakami, P. Sage, J. Pascual, L. V. Riella

    Transplantation Research Center, Brigham and Women's Hospital, Boston, MA

    *Purpose: Antibody-mediated rejection is a major cause of long-term graft loss. T follicular helper (Tfh) cell is CD4+ T cell subset that is specialized in…
  • 2020 American Transplant Congress

    Non-Human Primate B Cells Into Regulatory B Cells by Activation with CpG

    K. Lee1, C. Rickert1, K. Deng1, N. Feeney1, N. Tanimine2, Q. Fu1, G. Huai1, J. Lei1, C. Leguern1, J. Markmann1

    1Center for Transplantation Sciences, Massachusetts General Hospital, Boston, MA, 2Gastroenterological Transplantation Surgery, Hiroshima University, Hiroshima, Japan

    *Purpose: We previously generated Toll like receptor (TLR)-activated B cells in rodent settings. These B cells can suppress T cell proliferation via in vitro mixed…
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