2020 American Transplant Congress
Splenectomy Impedes B Cell Infiltration Associated with Rejection of Neonatal Porcine Islet Xenografts
*Purpose: Xenotransplantation has historically been frustrated by antibody-mediated rejection. Splenectomy has shown efficacy in mediating humoral immunity. We hypothesized that adding splenectomy to a clinically…2020 American Transplant Congress
Characterization of a Novel CD8+ B Cell Subset in Monkeys Tolerant of Heart Allografts
*Purpose: We have previously reported that transient mixed hematopoietic chimerism induced via donor bone marrow transplantation can achieve tolerance to cardiac allografts in non-human primates…2020 American Transplant Congress
Early Prediction of Human Renal Allograft Rejection (AR) by Inflammatory Transitional B Cells
1Starzl Transplantation Institute, UPMC, Pittsburgh, PA, 2UCL, London, United Kingdom
*Purpose: Early prediction of AR within the 1st post-transplant year could identify at-risk patients for targeted therapeutic interventions to mitigate risk and improve outcomes.*Methods: In…2020 American Transplant Congress
A Two-Step Cell-Based Assay Predicts Immunosuppression-Related Adverse Events in Kidney Transplant Recipients
Transplantation Unit, Renal Division, Medecine Department, Laval University, Québec, QC, Canada
*Purpose: No clinical tool is available to dynamically access immunosuppression status, which results in serious, often life-threatening adverse effects of immunosuppressants. We recently validated that…2020 American Transplant Congress
Naïve B Cells Regulation by TLR-Breg Cells In Vitro
Center for Transplant Science, MGH, Boston, MA
*Purpose: Regulatory B cells (Bregs) have shown great potential in cell therapies for murine organ transplantation by inhibiting the proliferation of cytotoxic and helper T…2020 American Transplant Congress
Transplant Monitoring and PTLD Detection with B Cell Receptor Repertoire Analysis in a Large Prospective Pediatric Cohort
*Purpose: Post-transplant lymphoproliferative disorder (PTLD) remains a serious problem in the pediatric transplant population. The Clinical Trials of Organ Transplantation in Children (CTOT-C)-06 is a…2020 American Transplant Congress
Donor-Specific B Cell Frequency Assessed by a Novel Multiplex Bead-Based Assay Predicts Graft Failure in Kidney Transplant Recipients
Northwestern University Feinberg School of Medicine, Chicago, IL
*Purpose: Kidney transplant recipients with sensitization to HLA defined by a high percentage of Panel Reactive Antibodies (PRA) or Donor-specific anti-HLA antibodies (DSA) are at…2020 American Transplant Congress
Sex and ABO Antibodies: High-Level Natural ABO Antibody Production and IgM to IgG Class Switch in Female vs. Male Mice
Dept Pediatrics, Alberta Transplant Institute, University of Alberta, Edmonton, AB, Canada
*Purpose: ABO histo-blood group incompatibility is a barrier in solid organ transplant due to the presence of ‘natural’ preformed ABO antibodies. However, ABO-incompatible (ABOi) heart…2020 American Transplant Congress
Tertiary Lymphoid Organs in Renal Chronic Allograft Rejection
Starzl Transplantation Institute, Pittsburgh, PA
*Purpose: Chronic allograft rejection remains a major obstacle to long-term allograft survival. Tertiary lymphoid organs (TLOs) are ectopic lymphoid structures that arise in non-lymphoid tissues…2020 American Transplant Congress
Transitional B Cell Cytokines for the Early Prediction of Long-Term Renal Allograft Decline
1Starzl Transplantation Institute, UPMC, Pittsburgh, PA, 2UCL, London, London, United Kingdom
*Purpose: Early prediction of allograft loss using potentially modifiable risk factors is vital for conceiving novel therapeutic interventions to improve outcomes.*Methods: In this prospective, multicenter…
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