ATC Abstracts

American Transplant Congress abstracts

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Articles tagged "B cells"

  • 2021 American Transplant Congress

    Contribution of T-bet Expressing CD27+ CD21- Activated Memory B Cells Poised for Plasma Cell Differentiation to Antibody-mediated Rejection of Kidney Transplants

    K. Louis1, E. Bailly1, C. Macedo1, B. Ramaswami1, X. Gu1, G. Chalasani1, A. Zeevi1, P. Randhawa1, H. Singh2, C. Lefaucheur3, D. Metes1

    1Surgery, University of Pittsburgh, Pittsburgh, PA, 2Center for Systems immunology, Department of Immunology, University of Pittsburgh, Pittsburgh, PA, 3Human Immunology and Immunopathology, INSERM U976, Paris, France

    *Purpose: Alloimmunity triggered by donor-specific antibodies (DSAs) and ensuing development of antibody-mediated rejection (ABMR) are detrimental to organ transplants. Yet, the cellular states underlying B…
  • 2021 American Transplant Congress

    TOLS are Novel Regulatory TLOs with A B Cell Signature

    I. Rosales1, Q. Yuan1, C. Yang1, P. Russell1, J. Madsen1, A. Alessandrini1, R. Colvin1, -. AA and RC2

    1Massachusetts General Hospital, Boston, MA, 2Co-Senior Authors, Boston, MA

    *Purpose: Our previous studies suggest that a DBA/2 kidney graft is accepted by a MHC-fully mis-matched C57/BL6 recipient. Accepted renal allografts exhibited lymphoid like structures…
  • 2021 American Transplant Congress

    CD40 Blockade by the Fc-Silent Immunosuppressive Antibody Iscalimab Results in Diminished B Cell Activation and Differentiation and is Paralleled by Whole Blood Gene Expression Data

    R. Kraaijeveld1, M. W. van den Hoogen1, A. E. de Weerd1, E. Ferroro2, G. Robert2, U. Laessing2, B. Haraldsson2, J. S. Rush2, C. C. Baan1

    1Erasmus MC, Rotterdam, Netherlands, 2Novartis Pharmaceuticals AG, Basel, Switzerland

    *Purpose: Blockade of costimulatory molecule CD40 by the Fc-silent immunosuppressive drug Iscalimab has shown to inhibit acute alloreactivity in non-human primates and is currently being…
  • 2021 American Transplant Congress

    Belatacept and Carfilzomib-based Treatment of Active Antibody-mediated Rejection in a Sensitized Nonhuman Primate Model

    J. Kwun1, R. Schmitz1, M. Manook1, Z. Fitch1, D. Olaso1, A. Choi1, J. Yoon1, Y. Bae1, J. Lambris2, S. Knechtle1

    1Surgery, Duke University, Durham, NC, 2Pathology & Laboratory Medicine, University of Pennsylvania, Philadelphia, PA

    *Purpose: One third of sensitized, HLA-incompatible transplant recipients experience antibody-mediated rejection (AMR) with limited effective treatment options. We tested a novel treatment strategy for AMR…
  • 2021 American Transplant Congress

    Single Cell RNA Sequencing of Tim1- B Cells and Tim1+ Regulatory B Cells

    Q. Fu1, K. Lee2, K. Deng2, D. Agarwal3, P. v. Galen4, C. G. Rickert2, G. Huai2, H. Yang1, C. LeGuern2, S. Deng1, J. F. Markmann2

    1Organ Transplantation Center, Sichuan Provincial People's Hospital, University of Electronic Sciences and Technology of China, Chengdu, China, 2Center for Transplantation Sciences, MGH, Boston, MA, 3Division of Transplantation, Department of Surgery, Hospital of the University of Pennsylvania, Philadelphia, PA, 4Division of Hematology, Brigham and Women's Hospital, Boston, MA

    *Purpose: Tim1 signaling has an important role in inducing and maintaining the function of Regulatory B cells. Our previous study showed that Tim1+ Bregs prolong…
  • 2021 American Transplant Congress

    Belatacept and Rapamycin Maintenance Immunosuppression in a Sensitized Nonhuman Primate Kidney Allotransplantation Model

    R. Schmitz1, Z. W. Fitch1, M. Manook1, J. Yoon1, A. B. Farris2, J. Kwun1, S. J. Knechtle1

    1Department of Surgery, Duke University Medical Center, Durham, NC, 2Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, GA

    *Purpose: Desensitization with costimulation blockade and proteasome inhibition prior to kidney transplantation prevents early antibody-mediated rejection (AMR) and prolongs graft survival in highly sensitized nonhuman…
  • 2020 American Transplant Congress

    Anti-Thymocyte Globulin Promotes Tfh Cells Differentiation and Alloantibody Production

    R. Benedetti Gassen, B. Aoyama, M. Lima, T. Borges, M. Pérez-Sáez, N. Murakami, P. Sage, J. Pascual, L. V. Riella

    Transplantation Research Center, Brigham and Women's Hospital, Boston, MA

    *Purpose: Antibody-mediated rejection is a major cause of long-term graft loss. T follicular helper (Tfh) cell is CD4+ T cell subset that is specialized in…
  • 2020 American Transplant Congress

    Non-Human Primate B Cells Into Regulatory B Cells by Activation with CpG

    K. Lee1, C. Rickert1, K. Deng1, N. Feeney1, N. Tanimine2, Q. Fu1, G. Huai1, J. Lei1, C. Leguern1, J. Markmann1

    1Center for Transplantation Sciences, Massachusetts General Hospital, Boston, MA, 2Gastroenterological Transplantation Surgery, Hiroshima University, Hiroshima, Japan

    *Purpose: We previously generated Toll like receptor (TLR)-activated B cells in rodent settings. These B cells can suppress T cell proliferation via in vitro mixed…
  • 2020 American Transplant Congress

    ABO Self-Tolerance in a Mouse Model: Evidence of Tolerance at B Cell but Not T Cell Level

    I. Adam, B. Motyka, K. Tao, L. West

    Alberta Transplant Institute, University of Alberta, Edmonton, AB, Canada

    *Purpose: We showed that human infants become tolerant to donor A/B-antigens (Ag) after ABO-incompatible heart transplantation (ABOi-HTx) by mechanisms not well-defined. To expand ABOi-HTx effectively…
  • 2020 American Transplant Congress

    Recipient Expression of C-Type Lectin Receptor Mincle Promotes Rapid T Cell Homeostatic Recovery Following Antibody Mediated Lymphoablation

    S. Hasgur, R. Fan, A. Valujskikh

    Inflammation and Immunity, Cleveland Clinic, Cleveland, OH

    *Purpose: Antibody-mediated lymphocyte depletion is widely used in transplantation. We recently established that T cell recovery in mouse heart allograft recipients treated with anti-thymocyte globulin…
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