Articles tagged "B cells"

2015 American Transplant Congress
Heart En Bloc Thymus Transplantation Permits Long-Term, Acute Rejection-Free Cardiac Allograft Survival in Nonhuman Primates (NHPs)
M. Tonsho,¹ P. Spencer,¹ T. Millington,¹ A. Muniappan,¹ A. Tena,² R. Smith,³ R. Colvin,³ J. Allan,^1,2 J. Madsen.^1,2,4
¹MGH Transplant Center, Massachusetts General Hospital and Harvard Medical School, Boston, MA; ²Transplantation Biology Research Center, Massachusetts General Hospital and Harvard Medical School, Boston, MA; ³Pathology, Massachusetts General Hospital and Harvard Medical School, Boston, MA; ⁴Cardiac Surgery, Massachusetts General Hospital and Harvard Medical School, Boston, MA.
BACKGROUNDThe role of vascularized thymus on tolerance induction has been well studied in swine recipients of kidney allografts, but not in NHP recipients of heart…
2015 American Transplant Congress
Tolerant Kidney Transplant Patients Display B Cells With Regulatory Properties
S. Brouard,^1,2 M. Chesneau,^1,3 L. Michel,^1,2,3 E. Dugast,^1,3 A. Chenouard,^1,3 A. Pallier,¹ D. Baron,^1,3 J. Durand,^1,3 F. Braza,^1,3 P. Guerif,² D.-A. Laplaud,^1,2,3 J.-P. Soulillou,^1,2,3 M. Giral,^1,2,3 N. Degauque,^1,3 E. Chiffoleau,^1,3 S. Brouard.^1,2
¹INSERM UMR 1064, Nantes, France; ²CHU de Nantes, ITUN, Nantes, France; ³Université de Nantes, Faculté de Médecine, Nantes, France.
Whereas a B cell transcriptional profile has been recorded for operationally tolerant kidney graft patients, the role that B cells may play in this process…