Articles tagged "B cells"

2015 American Transplant Congress
Boosting the Adaptive Immune Response Prevents the High Incidence of Herpes Zoster After Lung or Heart Transplantation
N. van Besouw,¹ S. Roest,² J. Zuijderwijk,¹ R. de Kuiper,¹ J. van Weezel,³ A. van der Eijk,⁴ W. Weimar,¹ P. Hal,³ O. Manintveld.²
¹Internal Medicine - Transplantation, Erasmus MC, Rotterdam, Netherlands; ²Cardiology, Erasmus MC, Rotterdam, Netherlands; ³Respiratory Medicine, Erasmus MC, Rotterdam, Netherlands; ⁴Viroscience, Erasmus MC, Rotterdam, Netherlands.
Purpose Primary varicella zoster virus (VZV) infection causes varicella and lifelong latent infection in ganglia from which it may reactivate leading to herpes zoster (HZ).…
2015 American Transplant Congress
TIM-4 Identifies IL-17 Expressing Pro-Inflammatory Be-17 Cells That Promote Allograft Rejection
Q. Ding, K. Mohib, D. Rothstein.
Thomas E. Starzl Transplantation Institute, University of Pittsburgh Medical Center, Pittsburgh, PA.
We identified TIM-1 as an inclusive marker for IL-10+ regulatory B cells (TIM-1+ Bregs), which prolong islet allograft survival (GS). We recently found that TIM-4,…
2015 American Transplant Congress
Heart En Bloc Thymus Transplantation Permits Long-Term, Acute Rejection-Free Cardiac Allograft Survival in Nonhuman Primates (NHPs)
M. Tonsho,¹ P. Spencer,¹ T. Millington,¹ A. Muniappan,¹ A. Tena,² R. Smith,³ R. Colvin,³ J. Allan,^1,2 J. Madsen.^1,2,4
¹MGH Transplant Center, Massachusetts General Hospital and Harvard Medical School, Boston, MA; ²Transplantation Biology Research Center, Massachusetts General Hospital and Harvard Medical School, Boston, MA; ³Pathology, Massachusetts General Hospital and Harvard Medical School, Boston, MA; ⁴Cardiac Surgery, Massachusetts General Hospital and Harvard Medical School, Boston, MA.
BACKGROUNDThe role of vascularized thymus on tolerance induction has been well studied in swine recipients of kidney allografts, but not in NHP recipients of heart…
2015 American Transplant Congress
Tolerant Kidney Transplant Patients Display B Cells With Regulatory Properties
S. Brouard,^1,2 M. Chesneau,^1,3 L. Michel,^1,2,3 E. Dugast,^1,3 A. Chenouard,^1,3 A. Pallier,¹ D. Baron,^1,3 J. Durand,^1,3 F. Braza,^1,3 P. Guerif,² D.-A. Laplaud,^1,2,3 J.-P. Soulillou,^1,2,3 M. Giral,^1,2,3 N. Degauque,^1,3 E. Chiffoleau,^1,3 S. Brouard.^1,2
¹INSERM UMR 1064, Nantes, France; ²CHU de Nantes, ITUN, Nantes, France; ³Université de Nantes, Faculté de Médecine, Nantes, France.
Whereas a B cell transcriptional profile has been recorded for operationally tolerant kidney graft patients, the role that B cells may play in this process…
2015 American Transplant Congress
Controlling Alloreactive B Cell Responses in Sensitized Recipients With CTLA-4Ig
J. Chen,¹ Q. Wang,¹ D. Yin,¹ V. Vu,¹ R. Sciammas,² A. Chong.¹
¹Depart of Surgery, University of Chicago, Chicago; ²Immunobiology Transplant Center, Houston Methodist Research Institute, Houston.
Sensitized recipients are defined by the presence of pre-transplant donor-specific antibodies and have significantly poorer graft outcomes compared to unsensitized recipients despite efforts to desensitize.…
2015 American Transplant Congress
Cardiac Xenotransplantation: Reconstituted B Cells After Rituxan Treatment Maintain Their Repertoire But Have a Muted Response to Xenoantigens
A. Singh,¹ P. Corcoran,¹ B. Lewis,² M. Thomas,² D. Ayers,³ K. Horvath,¹ M. Mohiuddin.¹
¹CSRP/NIH/NHLBI, NIH, Bethesda, MD; ²DVR/ORS, NIH, Bethesda, MD; ³Revivicor Inc, Blacksburg, VA.
Background: Xentoranplantation (XTx) remains an option for end stage organ failure. Recently we have reported cardiac xenograft survival of over one year pig to baboon…
2015 American Transplant Congress
The Spleen Is the Primary Site for Breg Induction and Is Required for Anti-TIM-1 Mediated Tolerance
K. Mohib, Q. Ding, A. Cherukuri, D. Rothstein.
Thomas E. Starzl Transplantation Institute, University of Pittsburgh, Pittsburgh, PA.
B cells can exhibit potent IL-10-dependent regulatory (Breg) activity. IL-10-enriched Bregs can transfer tolerance in auto and allo-immune models. We showed that TIM-1 is an…
2015 American Transplant Congress
Blocking CD40/CD154 Co-Stimulation Prevents Acute Antibody-Mediated Renal Allograft Rejection Induced by Memory CD4 T Cells
V. Gorbacheva, R. Fan, A. Valujskikh.
Immunology, The Cleveland Clinic, Cleveland, OH.
Immunosuppression-resistant alloreactive memory CD4 T cells induce robust responses against organ transplants. In murine heart allograft recipients donor-reactive memory CD4 T cells provide help for…
2015 American Transplant Congress
Hepatic Stellate Cells Directly Inhibit B Cells Via PD-L1
Y. Li, K. Fang, S. Qian, J. Fung, L. Lu, F. Lin.
Immunology, Lerner Research Institute; 2General Surgery, Digestive Disease Institute, Cleveland Clinic, Cleveland, OH.
Hepatic stellate cells (HSCs) account for one third of the nonparenchymal cells in the liver, which are considered to be critical in maintaining the immunoprivileged…
2015 American Transplant Congress
Impact of CXCR4/CXCL12 Blockade on Normal Plasma Cells In Vivo
N. Moore,¹ M. Moreno Gonzales,² M. Stegall.¹
¹Department of Surgery, Division of Transplant Surgery and Department of Immunology, Mayo Clinic, Rochester, MN; ²Department of Surgery, Division of Transplant Surgery, Mayo Clinic, Rochester, MN.
Receptor/ligand interactions in stromal microenvironments play important roles in the localization, development and survival of normal antibody-secreting plasma cells. The goal of the current study…