2016 American Transplant Congress
Attenuation of Warm Hepatic Ischemia-Reperfusion Injury by Bruton's Tyrosine Kinase Inhibition.
1Surgery, Dumont-UCLA Translant Center, Los Angeles, CA; 2Pathology, UCLA, Los Angeles, CA.
Bruton's tyrosine kinase (Btk) is a central player in multiple signaling pathways in lymphoid and myeloid cells, including neutrophils. Neutrophils are crucial effectors in the…2016 American Transplant Congress
B Lymphocytes Prevent Transplantation Tolerance in NOD Mice by Limiting CD4 Treg Function.
Pediatrics, Vanderbilt University, Nashville, TN.
IntroductionType 1 Diabetes is a significant barrier to islet transplant as grafts are subject to both alloimmunity and recurrent autoimmunity. No better is this clinical…2015 American Transplant Congress
The Molecular Landscape of Atrophy-Fibrosis in Human Kidney Transplants: The Dominant Role of Acute Parenchymal Injury
University of Alberta, Edmonton, Canada.
We studied the effect of time post-transplant on atrophy-fibrosis (AF) and molecular associations with AF in 703 kidney transplant indication biopsies (bx) 3 days to…2015 American Transplant Congress
Antibody-Mediated Rejection Is Associated With Higher Serum Levels of CXCL13 and CCL21 in Renal Transplant Patients and Altered By Bortezomib/Rituximab Treatment
In renal transplant patients (pts), B- and plasma cells (PC) are crucial for donor-specific HLA antibody (DSA) formation. The underlying mechanisms, which lead to B…2015 American Transplant Congress
The Effect of Rituximab Therapy on Regulatory B Cell and Prevention of Chronic Antibody Mediated Rejection in Kidney Transplantation Recipients
Urology, Tokyo Women's Medical University, Tokyo, Japan.
We previously reported that a single administration of low dose rituximab (RIT) before kidney transplant reduced the incidence rate of chronic antibody mediated rejection (CAMR)…2015 American Transplant Congress
B-Cell Activation in Acute Kidney Injury and Delayed Graft Function
Background:Acute kidney injury (AKI) is a relevant complication after kidney transplantation and also after non-renal solid organ transplantation. Growing evidence points towards an important role…2015 American Transplant Congress
CFZ533: Assessment of Immunomodulatory Activity Following Single Doses of a Novel Anti-CD40 mAb in Healthy Volunteers
Blocking the CD40-CD154 pathway has been shown to effectively prolong renal allograft survival in non-human primates. CFZ533 is a novel, fully human, Fc-silent, anti-CD40 monoclonal…2015 American Transplant Congress
Assessing Pre-Vaccination Cytokine Levels to Predict Immunogenicity to Seasonal Trivalent Influenza Vaccine in Solid Organ Transplant Recipients
Multi-Organ Transplant Program, University Health Network, Toronto, Canada.
Background: The immunogenicity of seasonal trivalent influenza vaccine (TIV) in solid organ transplant (SOT) recipients remains suboptimal. We hypothesized that analysis of pre-vaccination T- and…2015 American Transplant Congress
LFA-1 Is Crucial for Germinal Center Reconstruction After T cell Depletion and IL-21 Biased Antibody-Mediated Rejection
1Surgery, Emory Transplant Center, Atlanta, GA; 2Surgery, Duke University, Durham, NC.
[Background] Lymphocyte depletion prior to transplantation is beneficial in reducing initial maintenance immunosuppression in transplantation. However, despite its excellent efficacy in controlling T cell mediated…2015 American Transplant Congress
Efficacy and Safety of Desensitization Protocol Based On Rituximab Plus MMF in ABO-Incompatible Kidney Transplantation Without Splenectomy
Purpose: An open-label, single arm, multicenter clinical study has been conducted in Japan for prospective examination of the efficacy and safety of desensitization protocol with…
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