ATC Abstracts

American Transplant Congress abstracts

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Articles tagged "B cells"

  • 2016 American Transplant Congress

    Attenuation of Warm Hepatic Ischemia-Reperfusion Injury by Bruton's Tyrosine Kinase Inhibition.

    A. Zarrinpar,1 T. Palumbo,1 K. Nakamura,1 C. Lassman,2 R. Busuttil,1 J. Kupiec-Weglinski.1

    1Surgery, Dumont-UCLA Translant Center, Los Angeles, CA; 2Pathology, UCLA, Los Angeles, CA.

    Bruton's tyrosine kinase (Btk) is a central player in multiple signaling pathways in lymphoid and myeloid cells, including neutrophils. Neutrophils are crucial effectors in the…
  • 2016 American Transplant Congress

    B Lymphocytes Prevent Transplantation Tolerance in NOD Mice by Limiting CD4 Treg Function.

    B. Stocks, C. Wilson, D. Meehan, A. Marshall, D. Moore.

    Pediatrics, Vanderbilt University, Nashville, TN.

    IntroductionType 1 Diabetes is a significant barrier to islet transplant as grafts are subject to both alloimmunity and recurrent autoimmunity. No better is this clinical…
  • 2015 American Transplant Congress

    The Molecular Landscape of Atrophy-Fibrosis in Human Kidney Transplants: The Dominant Role of Acute Parenchymal Injury

    J. Venner, P. Halloran.

    University of Alberta, Edmonton, Canada.

    We studied the effect of time post-transplant on atrophy-fibrosis (AF) and molecular associations with AF in 703 kidney transplant indication biopsies (bx) 3 days to…
  • 2015 American Transplant Congress

    Antibody-Mediated Rejection Is Associated With Higher Serum Levels of CXCL13 and CCL21 in Renal Transplant Patients and Altered By Bortezomib/Rituximab Treatment

    M. Duerr,1 K. Daemen,2 J. Keil,2 K. Budde,1 C. Falk.2

    1Nephrology, Charité Universitätsmedizin Berlin, Berlin, Germany; 2Institute of Transplant Immunology, IFB-Tx, MHH, Hannover, Germany.

    In renal transplant patients (pts), B- and plasma cells (PC) are crucial for donor-specific HLA antibody (DSA) formation. The underlying mechanisms, which lead to B…
  • 2015 American Transplant Congress

    The Effect of Rituximab Therapy on Regulatory B Cell and Prevention of Chronic Antibody Mediated Rejection in Kidney Transplantation Recipients

    M. Ikemiyagi, R. Ishii, S. Miyairi, T. Hirai, K. Omoto, K. Tanabe.

    Urology, Tokyo Women's Medical University, Tokyo, Japan.

    We previously reported that a single administration of low dose rituximab (RIT) before kidney transplant reduced the incidence rate of chronic antibody mediated rejection (CAMR)…
  • 2015 American Transplant Congress

    B-Cell Activation in Acute Kidney Injury and Delayed Graft Function

    M. Schiffer,1 F. Wiehler,1 R. Song,1 R. Chen,1 L. Schiffer,1 M. Mengel,2 H. Haller,1 F. Gueler.1

    1Nephrology, Hannover Medical School, Hannover, Germany; 2Pathology, University of Alberta, Edmonton, Canada.

    Background:Acute kidney injury (AKI) is a relevant complication after kidney transplantation and also after non-renal solid organ transplantation. Growing evidence points towards an important role…
  • 2015 American Transplant Congress

    CFZ533: Assessment of Immunomodulatory Activity Following Single Doses of a Novel Anti-CD40 mAb in Healthy Volunteers

    A. Slade,1 J. Doucet,2 P. Koo,1 P. Espie,2 J. Rush,2 C. Tomek,3 J. Klupp.2

    1Novartis Institute for Biomedical Research, East Hanover, NJ; 2Novartis Institute for Biomedical Research, Basel, Switzerland; 3Celerion, Inc, Lincoln, NE.

    Blocking the CD40-CD154 pathway has been shown to effectively prolong renal allograft survival in non-human primates. CFZ533 is a novel, fully human, Fc-silent, anti-CD40 monoclonal…
  • 2015 American Transplant Congress

    Assessing Pre-Vaccination Cytokine Levels to Predict Immunogenicity to Seasonal Trivalent Influenza Vaccine in Solid Organ Transplant Recipients

    M. Fernandez-Ruiz, A. Humar, S. Keshwani, S. Husain, D. Kumar.

    Multi-Organ Transplant Program, University Health Network, Toronto, Canada.

    Background: The immunogenicity of seasonal trivalent influenza vaccine (TIV) in solid organ transplant (SOT) recipients remains suboptimal. We hypothesized that analysis of pre-vaccination T- and…
  • 2015 American Transplant Congress

    LFA-1 Is Crucial for Germinal Center Reconstruction After T cell Depletion and IL-21 Biased Antibody-Mediated Rejection

    J. Kwun,1 B. Oh,1 H. Song,1 A. Farris,1 A. Kirk,2 W. Mahle,1 S. Knechtle.1

    1Surgery, Emory Transplant Center, Atlanta, GA; 2Surgery, Duke University, Durham, NC.

    [Background] Lymphocyte depletion prior to transplantation is beneficial in reducing initial maintenance immunosuppression in transplantation. However, despite its excellent efficacy in controlling T cell mediated…
  • 2015 American Transplant Congress

    Efficacy and Safety of Desensitization Protocol Based On Rituximab Plus MMF in ABO-Incompatible Kidney Transplantation Without Splenectomy

    K. Takahashi,1 K. Saito,2 S. Takahara,3 S. Fuchinoue,4 T. Yagisawa,5 A. Aikawa,6 Y. Watarai,7 N. Yoshimura,8 K. Tanabe,4 K. Morozumi,9 M. Shimazu.10

    1Niigata Organ Transplant Foundation, Niigata, Japan; 2Graduate School of Medical & Dental Sciences, Niigata University, Niigata, Japan; 3Osaka University Graduate School of Medicine, Osaka, Japan; 4Tokyo Women's Medical University, Tokyo, Japan; 5Jichi Medical University Hospital, Tochigi, Japan; 6Toho University, Faculty of Medicine, Tokyo, Japan; 7Nagoya Daini Red Cross Hospital, Aichi, Japan; 8Kyoto Prefectural University of Medicine, Kyoto, Japan; 9Masuko Memorial Hospital, Aichi, Japan; 10Tokyo Medical University Hachioji Medical Center, Tokyo, Japan.

    Purpose: An open-label, single arm, multicenter clinical study has been conducted in Japan for prospective examination of the efficacy and safety of desensitization protocol with…
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