Articles tagged "B cells"

2017 American Transplant Congress
Persistence/Progression of Early Banff Borderline Changes (BBC) Is Associated with Chronic Renal Allograft Damage and Can Be Predicted by B Cell Cytokine Profile.
A. Cherukuri, A. Sharma, R. Mehta, S. Hariharan, D. Rothstein.
UPMC, Pittsburgh
The clinical significance of early histological BBC in kidney transplant recipients (KTR) is unclear. It is also unknown if biomarkers predict progression to acute rejection…
2017 American Transplant Congress
TACI Polymorphisms Associated with De Novo Alloantibodies in Humans and Allograft Rejection in Mice.
J. Platt,¹ E. Farkash,² A. Lefferts,¹ M. Samaniego,³ M. Cascalho.¹
¹Surgery, University of Michigan, Ann Arbor, MI; ²Pathology, University of Michigan, Ann Arbor, MI; ³Internal Medicine, University of Michigan, Ann Arbor, MI
A. Trans-membrane Activator and CAML Interactor (TACI) controls B cell differentiation and memory and exists as numerous allelic variants among healthy individuals and individuals with…
2017 American Transplant Congress
B Cells in Liver Transplant Tolerance.
M. Morita,¹ G. Asonye,¹ N. Gupta,¹ J. Fung,² C. Miller,³ S. Qian,^1,3 L. Lu.^1,3
¹Immunology, Cleveland Clinic, Cleveland; ²University of Chicago, Chicago, MI; ³General Surgery, Cleveland Clinic, Cleveland, OH
In mice liver transplantation, the liver allografts can be accepted across fully mismatched MHC without immunosuppression. After transplantation, T cells infiltrate into the graft in…
2017 American Transplant Congress
Effects of Tofacitinib (JAK-3 Inhibitor) on De Novo HLA-A2 Antibody Production in a Mouse Model of Allo-Sensitization.
N.-N. Chai, G. Wu, I. Kim, A. Klein, S. Jordan.
Comprehensive Transplant Center, Cedars-Sinai Medical Center, Los Angeles, CA
Purpose: Tofacitinib is a Janus Kinase Inhibitor currently approved by FDA for treatment of rheumatoid arthritis. In considering its effect in reducing B cell proliferation…
2017 American Transplant Congress
A Novel 3-Dimensional Culture System Enables In Vitro Study of Human Bone Marrow Plasma Cells.
J. Driscoll,¹ S. Tremblay,² S. Knechtle,³ E. Woodle.²
¹Medicine, Univ Cincinnati, Cincinnati, OH; ²Surgery, Univ Cincinnati, Cincinnati, OH; ³Transplant, Duke Univ, Durham, NC
Purpose: Historically, in vitro study of human plasma cells (PCs) has been greatly limited by their short survival (48-72 hrs). Therefore, systems that maintain viability…
2017 American Transplant Congress
Importance of B Cell Antigen Specificity in Breg Dependent Tolerance.
S. Kimura, L. Kojima, M. Aburawi, F. Fontan, J. Kim, K. Deng, H. Tector, K. Lee, H. Yeh, J. Markmann.
Transplantation Unit, Department of Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, MA
Introduction: We have previously shown that anti-CD45RB induced islet and cardiac allograft tolerance is B cell dependent and can be adoptively transferred to naïve hosts…
2017 American Transplant Congress
Prevention of Donor Specific Antibody Production After Skin Allografting by Mobilization of Endogenous Stem Cells Using a Combination of AMD3100 and Low-Dose FK506 in Rats.
A. Ahmadi,¹ L. Qi,¹ R. Wesson,¹ F. Dor,² J. Burdik,¹ B. Philosophe,¹ G. Williams,¹ A. Cameron,¹ Z. Sun.¹
¹Dept. of Surgery, Johns Hopkins University, Baltimore, MD; ²Dept. of Surgery, Imperial College Healthcare, London, United Kingdom
Background: We have developed a stem cell mobilizing strategy that enables long-term liver and kidney allograft survival without sustained immunosuppression in small and large animals…
2017 American Transplant Congress
A Prospective Iterative Trial of Carfizomib-Based Desensitization Trial: Initial Comparative Observations.
S. Tremblay,¹ A. Shields,^1,2 R. Alloway,¹ P. Brailey,¹ A. Leino,¹ A. Lichvar,¹ B. Abu Jawdeh,¹ J. Driscoll,¹ A. Girnita,¹ E. Woodle.¹
¹U of Cincinnati, Cincinnati; ²Christ Hospital, Cincinnati
Carfilzomib (CFZ) is a 2nd generation proteasome inhibitor different form bortezomib in that it irreversibly disables 20s and 26s proteasomes.Results from the first 2 phases…
2017 American Transplant Congress
IgM Immunotherapy Restores Immune Homeostasis in Type 1 Diabetes.
P. Chhabra,¹ C. Wilson,² D. Moore,² K. Brayman.¹
¹Surgery, University of Virginia, Charlottesville, VA; ²Pediatric Endocrinology, Vanderbilt University, Nashville, TN
Goal: To determine the mechanism(s) by which IgM immunotherapy restores immune homeostasis in Type 1 Diabetes (T1D).Background: IgM immunotherapy prevents the onset and progression of…
2017 American Transplant Congress
Effect of Two Anti-CD20 Abs on B Cell Depletion and Reconstitution in Non-Human Primates.
W. Sun,¹ N. O'Neill,¹ T. Zhang,¹ G. Braileanu,¹ K. Reimann,² R. Pierson,¹ A. Azimzadeh.¹
¹Dept. of Surgery, University of Maryland, School of Medicine, Baltimore, MD; ²MassBiologics, University of Massachusetts Medical School, Boston, MA
Background: B lymphocytes play a central role in host immunity, including antibody elaboration and antigen presentation, and B-cell depletion is being explored to modulate alloimmunity.…