2018 American Transplant Congress
Combination Proteasome Inhibition and Anti-BAFF Therapy Permits Highly Sensitized Rhesus Kidney Transplantation
Duke Transplant Center, Duke University Medical Center, Durham, NC.
Purpose:HLA-sensitization is a significant immunologic barrier to successful kidney transplantation (KT). We have shown that proteasome inhibition (PI) in insolation reduces plasma cells (PCs), but…2018 American Transplant Congress
B Cell Reconstitution: 36-Month Analysis of Patients Post-Alemtuzumab Induction Followed by Belatacept-Based Immunosuppression
Alemtuzumab induction combined with belatacept and rapamycin (ABR) maintenance immunotherapy effectively prevents costimulation blockade resistant rejection (CoBRR). We longitudinally investigated kinetics of repopulating B cell…2018 American Transplant Congress
Use of Cyclin-Dependent Kinase Inhibitors to Reduce Gammaherpesvirus Reactivation
Infection with the gammaherpesvirus EBV occurs in over 90% of humans and leads to lifelong viral latency with intermittent reactivation that is typically controlled through…2018 American Transplant Congress
Evaluation of Drug Action on IgM Memory B Cell Survival and Growth In Vitro; -Application for Individualized Immunosuppression after Kidney Transplants-
(Background)Recently, the establishment of early diagnosis and treatment methods for antibody-mediated rejection (ABMR) has garnered much attention.Strong immunosuppression including desensitization is accompanied by severe side…2018 American Transplant Congress
Approaches to Prevention of Antibody Rebound after HLA Sensitization in a Mouse Model
Comprehensive Transplant Center, Cedars-Sinai Medical Center, Los Angeles, CA.
Purpose: Control of donor specific antibodies (DSA) is critical for prevention of antibody mediated rejection (ABMR). Removal of DSAs with PLEX often results in significant…2018 American Transplant Congress
In-Vivo Visualization of Regulatory B Cells Reveals Ag-Dependent T Cell Interactions That Suppress Subsequent T Cell:DC Interactions
Starzl Transplantation Institute, Univ. of Pittsburgh, Pittsburgh, PA.
We showed that regulatory B cells (Bregs) promote long-term islet allograft survival. Using mice with a novel inducible B cell-specific deletion of IL-10 (IL-10fl/flXhCD20TAM-Cre) we…2018 American Transplant Congress
Further In Vivo and In Vitro Evidence That Anti-CD40 MABS Do Not Induce Thromboembolism
Novartis Institutes for Biomedical Research, Basel, Switzerland.
Clinical trials with non-silenced anti-CD40L (anti-CD154) monoclonal antibodies (mAb) in patients with systemic lupus erythematosus (SLE) and idiopathic thrombocytopenic purpura (ITP) were halted after unexpected…2018 American Transplant Congress
Postoperative Immunological Profiles of Adult ABO-Incompatible Living Donor Liver Transplant Recipients
Background: Adult ABO-incompatible (ABOi) living donor liver transplantation has been performed for acute liver failure or end stage liver diseases when deceased liver allografts or…2017 American Transplant Congress
Antibody Mapping by Protein Microarray Revealed a Unique Repertoire in Lung Transplant Recipients That Developed Chronic Lung Allograft Dysfunction.
Background: Development of chronic lung allograft dysfunction (CLAD) limits long-term success from lung transplantation (LTx). Elicitation of de novo antibody (Ab) to mismatched donor HLA…2017 American Transplant Congress
Percentage of CD19+ B Cells as a Predictor of Acute Antibody-Mediated Rejection After Administration of Rituximab in ABO-Incompatible Kidney Transplantation.
Urology, Hokkaido University, Sapporo, Japan
[Introduction] Administration of rituximab to ABO-incompatible kidney transplant (ABOi-KTx) recipients is recognized as effective and safe. A single dose of 375 mg/m2 rituximab is generally…
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