2018 American Transplant Congress
Elevated Levels of CD19+ B Cells before or after Rituximab Administration is a Risk Factor for the Early Rejection of a Living Kidney Transplant
1Nephrology, Ohkubo Hospital, Tokyo, Japan; 2Urology, Ohkubo Hospital, Tokyo, Japan.
[Introduction]Rituximab (RTX) is used for desensitization in highly sensitized patients, such as those undergoing ABO-incompatible (ABOi) kidney transplantation. Although RTX is generally effective, some patients…2018 American Transplant Congress
In Vivo Administration of Plerixafor and Bortezomib Results in Bone Marrow Plasma Cell Mobilization and Death While Inducing Biphasic Plasma Cell Apoptosis in Peripheral Blood
1U Cincinnati, Cincinnati; 2Cincinnati Children's, Cincinnati; 3Duke, Durham.
Bone marrow (BM) plasma cells (PC) secreting HLA antibody (Ab) remain a persistent reservoir of donor specific Ab and present a significant hurdle to allograft…2018 American Transplant Congress
Genomic Modifications Associated with Epstein Barr Virus+ Post-Transplant Lymphoproliferative Disorder
Epstein Barr Virus (EBV) is nearly ubiquitous in the human population, yet EBV infection is typically asymptomatic. Nevertheless, immunosuppressed transplant recipients are susceptible to EBV+…2018 American Transplant Congress
Pancreas Transplant for Type 2 Diabetes is Associated with Preserved Function, but Impaired Glucose Tolerance: A Comparative Analysis
Multi-Organ Transplant Program, Toronto General Hospital, Toronto, ON, Canada.
Background: The indications and outcomes of pancreas transplantation for type 2 diabetes mellitus (T2DM) remains controversial. The aim of this study was to compare the…2018 American Transplant Congress
Analysis of Circulating CD38+/CD138+ Plasma Cells during Development of De Novo Donor Specific Antibody Responses
CTC/Surgery, Cedars-Sinai Medical Center, Los Angeles, CA.
Purpose: Donor specific antibodies (DSA) that emerge following transplantation are indicative of allogenic sensitization and a predisposing factor for antibody mediated rejection. Though various methods…2018 American Transplant Congress
Pilot Study of Plasma Cell Niche-Targeted Therapy for Enhancement of Proteasome Inhibitor Effectiveness
1UCincinnati, Cincinnati; 2Cincinnati Children's, Cincinnati; 3Duke, Durham.
HLA antibody (Ab)-secreting bone marrow (BM) plasma cell (PC) survival depends on niche occupancy via a CXCR4 (PC)-CXCL12 (BM stromal cell) interaction. Plerixafor inhibits CXCR4-CXCL12…2018 American Transplant Congress
BETA-2 Score is an Excellent Tool for Monitoring of Islet Allograft Function and Early Detection of Transplant Dysfunction
1Surgery, University of Chicago, Chicago; 2Nephrology, Medical University of Gdańsk, Gdańsk, Poland.
After validation of BETA-2 scores in our cohort of patients in relation to standard stimulation tests, we decided to assess the practical utility of BETA-2…2018 American Transplant Congress
Circulating T Follicular Helper Cells Expand Following Transplantation and Exhibit a CD44hi Phenotype That Correlates with Peak Germinal Center Alloreactivity
Emory Transplant Center, Atlanta.
It is increasingly well-recognized that donor-specific antibodies (DSA) play a significant role in the development of chronic rejection and fibrosis that contribute to late renal…2018 American Transplant Congress
Impact of the New KAS on Transplant Rates in Highly-HLA Sensitized (HS) Patients after Desenstization (DES): 3yrs Post Implementation
Kidney Transplant, Cedars-Sinai Medical Center, LA, CA.
Introduction: The KAS aims to increase equity in organ allocation for broadly sensitized (HS) patients, especially (CPRA 99-100%). Coupling desensitization (DES) + KAS likely will…2018 American Transplant Congress
IL-10 Requirement in In Vitro Expanded Breg-Mediated Allograft Tolerance is Tissue Specific
Center for Transplantation Sciences, Massachusetts General Hospital, Boston, MA.
Introduction:Regulatory B cells (Bregs) have shown several multiple mechanisms of suppression, including Treg induction and IL-10 production. Consistent with work of other groups on Breg…
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