Articles tagged "B cells"

2018 American Transplant Congress
Prevention and Reversal of Diabetes through Restoration of B and T Cell Regulation and Immune Homeostasis
K. Brayman,¹ P. Chhabra,¹ C. Wilson,² A. Marshall,² D. Moore.²
¹Surgery, University of Virginia, Charlottesville, VA; ²Pediatric Endocrinology, Vanderbilt University, Nashville, TN.
Goal: To determine the mechanisms by which IgM restores immune homeostasis in new-onset diabetic NOD mice.Methods: 1) 5wks old non-obese diabetic (NOD) mice received mouse…
2018 American Transplant Congress
Role of B Cell Intrinsic NLRP3 in the Development of Chronic Rejection
J. Nie,¹ B. Ramaswami,² X. Guo,³ R. Hoffman,² G. Chalasani.³
¹Thoracic Surgery, Huazhong University of Science and Technology, Wuhan, Hubei, China; ²Surgery, Starzl Transplantation Institute, Pittsburgh, PA; ³Medicine, University of Pittsburgh, Pittsburgh, PA.
Endogenous DAMPs elicited during transplantation are recognized via TLR-MyD88 and NLRP3-inflammosome pathways that are expressed in APCs including B cells. Here, we asked whether B…
2018 American Transplant Congress
Rituximab Induction to Prevent the Recurrence of PSC after Liver Transplantation-The Lessons Learned from ABO-Incompatible Living Donor Liver Transplantation-
Y. Yamada,¹ K. Hoshino,¹ M. Shinoda,¹ H. Obara,¹ S. Uemoto,³ T. Kaido,³ H. Okajima,³ T. Yagi,⁴ T. Yoshizumi,⁵ Y. Inomata,⁶ T. Hibi,⁶ K. Kubota,⁷ T. Suzuki,⁸ Y. Kitagawa,¹ H. Egawa,² T. Kuroda.¹
¹Surgery, Keio University School of Medicine, Tokyo, Japan; ²Surgery, Institute of Gastroenterology, Tokyo Women's Medical University, Tokyo, Japan; ³Division of Hepato-Biliary-Pancreatic Surgery and Transplant Surgery, Kyoto University, Kyoto, Japan; ⁴Hepato-Biliary and Pancreatic Surgery, Okayama University, Okayama, Japan; ⁵Department of Surgery, Kyushu University, Fukuoka, Japan; ⁶Transplantation and Pediatric Surgery, Kumamoto University, Kumamoto, Japan; ⁷Department of Gastroenterological Surgery, Dokkyo Medical University, Tochigi, Japan; ⁸Department of Pediatric Surgery, Fujita Health University School of Medicine, Aichi, Japan.
Background: Multiple studies have failed to reveal an effective method for preventing the recurrence of primary sclerosing cholangitis (PSC) after liver transplantation (LTx). A national…
2018 American Transplant Congress
Dependency on CD4 T Cells, Foreign Protein, and CD22 for Generation of Antibody Response to Non-Self Blood Group A-Antigen in a Mouse Model
I. Adam, B. Motyka, K. Tao, L. West.
Alberta Transplant Institute, Canadian National Transplant Research Program, University of Alberta, Edmonton, AB, Canada.
Background: ABO-incompatible heart transplantation (ABOi-HTx) is safe during infancy and allows increased donor access. B cell tolerance develops to donor A/B-antigens (Ag) after ABOi HTx…
2018 American Transplant Congress
Assessment of Immune Cell Profiles in HLA-Sensitized (HS) & Non-HS Patients (Pts) with End Stage Renal Disease (ESRD)
S. Ge,¹ M. Chu,¹ E. Ortiz,¹ A. Vo,² D. Lovato,¹ S. Jordan,² M. Toyoda.¹
¹Transplant Immunology Laboratory, Cedars-Sinai Medical Center, Los Angeles, CA; ²Comprehensive Transplant Center, Cedars-Sinai Medical Center, Los Angeles, CA.
Background: Chronic inflammation is often seen in pts w/ ESRD. HLA-sensitization may create or be driven by the cytokines responsible for chronic inflammation. Here we…
2018 American Transplant Congress
Single Center Experience of HLA-Related Donor Specific Antibody in Living Donor Liver Transplantation
H. Egawa,¹ Y. Kotera,¹ A. Ohmori,¹ S. Yamashita,¹ T. Kato,¹ S. Nemoto,¹ T. Ishizuka,² M. Yamamoto.¹
¹Surgery, Tokyo Women's Medical University, Tokyo, Japan; ²Clinical Laboratory, Tokyo Women's Medical University, Tokyo, Japan.
Although impact of donor specific antibody in liver transplantation has been recognized, significance of desensitization is not established yet. Our aim is to share our…
2018 American Transplant Congress
B Cell Immune Repertoire Sequencing Identifies Pre-Transplant Rejection Risk
S. Pineda,^1,2 T. Sigdel,¹ J. Liberto,¹ K. Roskin,³ S. Robin,³ M. Sirota,² M. Sarwal.¹
¹Surgery, UCSF, SF; ²ICHS, UCSF, SF; ³Pathology, Stanford, Stanford.
Background: The diversity of the B cell immune repertoire may drive humoral injury and rejection in organ transplantation (tx).Methods: We utilized advances in next-generation sequencing…
2018 American Transplant Congress
The Impact of Childhood Solid Organ Transplantation on B-Cell Maturation
L. Ionescu,¹ T. Blydt-Hansen,² B. Foster,⁷ S. Mital,³ L. Hamiwka,⁵ U. Allan,³ V. Phan,⁴ P. Birk,⁶ C. Morgan,¹ S. Urschel.¹
¹U of Alberta, Edmonton, Canada; ²U of BC, Vancouver, Canada; ³Hospital for Sick Children, Toronto, Canada; ⁴U de Montreal, Montreal, Canada; ⁵U of Calgary, Calgary, Canada; ⁶U of Manitoba, Winnipeg, Canada; ⁷McGill University, Montreal, Canada.
Background:The developing immune system of childhood promotes better graft acceptance and longevity but also higher risk for infections and post-transplant (Tx) lymphoproliferative disorders. This may…
2018 American Transplant Congress
TLR-Activated Bregs Promote Islet Allograft Tolerance in an IL-10-Independent and TGF-β-Dependent Manner
L. Kojima, K. Lee, K. Deng, H. Tector, C. Dai, S. Kimura, C. Rickert, H. Yeh, J. Markmann.
Center for Transplantation Sciences, Massachusetts General Hospital, Boston, MA.
Background: We previously demonstrated the potent capacity of regulatory B cells (Bregs) to mitigate allograft immunity. Recently, we produced TLR-activated B cells in vitro that…
2018 American Transplant Congress
Ex Vivo Expanded Regulatory B Cells Promote Allograft Survival through IL-10-Dependent Pathway
K. Lee, K. Deng, L. Kojima, C. Dai, C. Rickert, H. Yeh, J. Markmann.
Massachusetts General Hospital, Boston.
Immunomodulatory capacity of B cells make them a promising therapeutic tool for autoimmune and alloimmune response in patients. We found that transplant tolerance induced by…