ATC Abstracts

American Transplant Congress abstracts

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Articles tagged "Autoimmunity"

  • 2016 American Transplant Congress

    BATF Deficiency in Tolerant Lung Allograft Recipients Are Resistant to Anti-MHC and Anti-Self-Antigen Mediated Pathogenesis of Obliterative Airway Disease.

    Z. Xu,1,2 X. Lin,1 M. Gunasekaran,1,2 M. Sharma,1,2 A. Gelman,1 T. Mohanakumar.1,2

    1Washington Univ Sch Med, St. Louis, MO; 2Norton Thoracic Institute - St. Joseph's Hospital, Phoenix, AZ.

    Antibodies (Abs) to donor MHC and lung self-antigens (SAgs) administered following induction of lung allograft tolerance by co-stimulation blockade can result in breaking of tolerance…
  • 2016 American Transplant Congress

    The 20S Proteasome, Active within Exosome-Like Vesicles Released by Apoptotic Cells Accelerates Rejection.

    M. Dieudé,1,4,5 C. Bell,2,5 J. Turgeon,1,5 D. Beillevaire,1,4,5 S. Qi,1,5 E. Boilard,3,5 P. Thibault,2,5 M.-J. Hébert.1,4,5

    1Research Centre Centre hospitalier de l'Université de Montréal (CRCHUM), Montréal, Canada; 2Institute for research in immunology and cancer (IRIC), Montreal, Canada; 3Centre de Recherche du CHU de Québec, Québec, Canada; 4Université de Montréal, Montréal, Canada; 5Canadian National Transplant Research Program, Edmonton, Canada.

    Apoptotic bodies (ApoBodies) and apoptotic exosome-like MV (ApoExo) released by apoptotic endothelial cells in vitro were purified by sequential centrifugation and analysed by electron microscopy…
  • 2015 American Transplant Congress

    A Novel DSA Flow Cytometer Crossmatch (DSA-FXM) to Eliminate Ambiguous Auto- and Allo-FXM Results

    G. Chen, L. Lin, D. Tyan.

    Pathology, Stanford University, Palo Alto, CA.

    Introduction:Though usually rejected on theoretical grounds, a positive Auto-FXM could result from either or both auto-reactive non-HLA or HLA-antibodies (Ab). Furthermore, a positive Auto-FXM serum…
  • 2015 American Transplant Congress

    Altered Intestinal Microbiome as a Potential Biomarker for Failed Immune-Regulation in Autoimmune Type 1 Diabetes Mellitus

    P. Chhabra,1 A. Spano,2 D. Bowers,1 M. Wu,2 L. Langman,1 M. Timko,2 K. Brayman.1

    1Department of Surgery, University of Virginia, Charlottesville, VA; 2Department of Biology, University of Virginia, Charlottesville, VA.

    Purpose: Beta-cell destruction results due to a failure of immune-regulation in type 1 diabetes (T1D). We investigated alterations in the intestinal microbiome composition as a…
  • 2015 American Transplant Congress

    The 20S Proteasome Is Active in Apoptotic Nanovesicles and Controls Anti-LG3 Antibody Production

    M. Dieudé,1,4 C. Bell,2,4 J. Turgeon,1,4 D. Beillevaire,1,4 K. Hamelin,1,4 S. Qi,1,4 N. Pallet,1,4 C. Rondeau,3 D. Gingras,3 M. Desjardins,3 P. Thibault,2,4 M.-J. Hébert.1,4

    1Research Centre, Centre Hospitalier de l'Université de Montréal (CRCHUM), Montreal, QC, Canada; 2Institute for Research in Immunology and Cancer (IRIC), Montreal, QC, Canada; 3Université de Montréal, Montreal, QC, Canada; 4Canadian National Transplant Research Program (CNTRP), Montreal, Canada.

    Humoral autoreactivity to apoptotic cells and perlecan/LG3, a proteoglycan fragment released by apoptotic cells, predicts poor allograft outcomes in renal transplant patients. How apoptotic cells…
  • 2015 American Transplant Congress

    Characterization of Natural T Effector Memory Cells Specific for Collagen type V, k-α-1-Tubulin and Vimentin

    J. Sullivan,1 D. Wilkes,2 T. Mohanakumar,3 W. Burlingham.1

    1Surgery, University of Wisconsin, Madison, WI; 2Medicine, Indiana University, Indianapolis, IN; 3Surgery, Washington University, St. Louis, MO.

    Background: Injury and repair processes are highly controlled, common occurrences of healthy tissue remodeling. During this process, cellular antigens that are not normally exposed to…
  • 2015 American Transplant Congress

    Mechanisms Underlying Treg Dysfunction in DAIH- Role for PD-L1?

    A. Arterbery,1 M. Martinez,2 S. Lobritto,2 Y. Avitzur,3 K. Raddassi,1 M. Kleinewietfeld,4 U. Ekong.1

    1Yale, NH; 2Columbia, NY; 3HSC, Toronto, Canada; 4Dresden University of Technology, Dresden, Germany.

    Background: we have previously shown that ex vivo Tregs from patients with DAIH demonstrate differentiation plasticity towards TH17. To understand the mechanisms underlying this we…
  • 2015 American Transplant Congress

    Preformed IgA Antibodies to B2-Glycoprotein Is an Indepedent Risk Factor for Graft Thrombosis and Early Graft Loss After Renal Transplantation

    J. Morales,1 M. Serrano,3 J. Martinez,2 D. Perez,2 M. Sevilla,2 A. Amdres,3 E. Gonzalez,3 E. Paz-Artal,2 A. Serrano.2

    1Research Institute, hospital 12 de Octubre, Madrid, Spain; 2Immunology, Hospital 12 de Octubre, Madrid, Spain; 3Nephrology, Hospital 12 de Octubre, Madrid, Spain.

    Vessel trombosis represent the first cause of early graft loss (EGL)alter renal transplantation (RT). Our group recently described that preformed IgA antibodies to B2-Glycoprotein (…
  • 2015 American Transplant Congress

    miR-155 Different Roles in UCB iTreg and nTreg

    Y. Lu, L. Lu.

    Liver Transplantation Center of First Affiliated Hospital, Nanjing Medical University, Nanjing, Jiangsu, China.

    OBJECTIVES:miR-155 has been associated with both innate and adaptive immune responses. SOCS1, which is involved in Treg survival and function, is a direct target of…
  • 2015 American Transplant Congress

    Passive Administration of Antibodies to Cardiac Myosin Immediately Following Syngenic Cardiac Transplantation Result in Rejection

    M. Sharma, M. Gunasekaran, N. Benshoff, W. Liu, A. Gelman, T. Mohanakumar.

    Surgery, Washington Univ Sch of Med, St. Louis, MO.

    Introduction: Auto-immune responses to cardiac myosin, a heart specific protein has been proposed to be a target auto-antigen resulting in cardiac allograft vasculopathy following transplantation.…
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