2016 American Transplant Congress
Anti-LG3 Antibodies Enhance Renal Microvascular Rarefaction, Fibrosis and Dysfunction Associated with Ischemia-Reperfusion Injury.
Delayed graft function (DGF) is associated with decreased kidney graft survival. We have shown that pre-transplant anti-LG3 autoantibodies were associated with increased risk of DGF…2016 American Transplant Congress
BATF Deficiency in Tolerant Lung Allograft Recipients Are Resistant to Anti-MHC and Anti-Self-Antigen Mediated Pathogenesis of Obliterative Airway Disease.
Antibodies (Abs) to donor MHC and lung self-antigens (SAgs) administered following induction of lung allograft tolerance by co-stimulation blockade can result in breaking of tolerance…2015 American Transplant Congress
Passive Administration of Antibodies to Cardiac Myosin Immediately Following Syngenic Cardiac Transplantation Result in Rejection
Surgery, Washington Univ Sch of Med, St. Louis, MO.
Introduction: Auto-immune responses to cardiac myosin, a heart specific protein has been proposed to be a target auto-antigen resulting in cardiac allograft vasculopathy following transplantation.…2015 American Transplant Congress
Pre-Transplant Anti-LG3 Antibodies Enhance Allograft Dysfunction in Kidney Transplant Recipients With Delayed or Slow Graft Function
CHUM Research Center, Montreal, Canada.
Background: We have previously shown that autoantibodies to the LG3 fragment of perlecan enhance vascular damage in a murine model of vascular rejection, particularly when…2015 American Transplant Congress
Germinal Centre Autoimmunity Mediates Progression of Allograft Vasculopathy, With Essential Help Provided By T Follicular Cells
Dept of Surgery, University of Cambridge, Cambridge, United Kingdom.
Introduction: : In our previous work we have shown that donor CD4 T cells within heart grafts initiate anti-nuclear autoantibody responses. Here we clarify the…2015 American Transplant Congress
Donor MHC Independent Rejection of Islet Allografts in Autoimmune NOD Mice
In autoimmune Type 1 diabetes (T1D), pancreatic islet allografts have somewhat limited long-term survival, both in T1D human subjects and in spontaneously diseased non-obese diabetic…2015 American Transplant Congress
A Novel DSA Flow Cytometer Crossmatch (DSA-FXM) to Eliminate Ambiguous Auto- and Allo-FXM Results
Pathology, Stanford University, Palo Alto, CA.
Introduction:Though usually rejected on theoretical grounds, a positive Auto-FXM could result from either or both auto-reactive non-HLA or HLA-antibodies (Ab). Furthermore, a positive Auto-FXM serum…2015 American Transplant Congress
Altered Intestinal Microbiome as a Potential Biomarker for Failed Immune-Regulation in Autoimmune Type 1 Diabetes Mellitus
Purpose: Beta-cell destruction results due to a failure of immune-regulation in type 1 diabetes (T1D). We investigated alterations in the intestinal microbiome composition as a…2015 American Transplant Congress
The 20S Proteasome Is Active in Apoptotic Nanovesicles and Controls Anti-LG3 Antibody Production
Humoral autoreactivity to apoptotic cells and perlecan/LG3, a proteoglycan fragment released by apoptotic cells, predicts poor allograft outcomes in renal transplant patients. How apoptotic cells…2015 American Transplant Congress
Characterization of Natural T Effector Memory Cells Specific for Collagen type V, k-α-1-Tubulin and Vimentin
Background: Injury and repair processes are highly controlled, common occurrences of healthy tissue remodeling. During this process, cellular antigens that are not normally exposed to…
- « Previous Page
- 1
- …
- 7
- 8
- 9
- 10
- Next Page »