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Articles tagged "Autoimmunity"

  • 2017 American Transplant Congress

    Plasma Cell Hepatitis in Primary Sclerosing Cholangitis Patients: 15-Year Experience at a Transplant Center.

    J. Putra,1 T. Schiano,2 M. Fiel.3

    1Pathology, Icahn School of Medicine at Mount Sinai, New York, NY; 2Division of Liver Diseases, Icahn School of Medicine at Mount Sinai, New York, NY

    Background: Plasma cell hepatitis (PCH) is an uncommon liver graft dysfunction which occurs in liver transplant (LT) recipients of different etiologies other than autoimmune hepatitis.…
  • 2017 American Transplant Congress

    Respiratory Viral Infections Following Human Lung Transplant Can Induce Exosomes with Lung Self-Antigens, Kα1Tubulin and Collagen V.

    M. Gunasekaran,1 A. Limaye,2 M. Sharma,1 S. Biswas Roy,1 S. Bansal,1 R. Walia,1 R. Bremner,1 M. Smith,1 T. Mohanakumar.1

    1Norton Thoracic Institute, St. Joseph's Hospital and Med Center, Phoenix; 2Div Allergy & Infectious Diseases, Univ Washington, Seattle

    Background: Respiratory viral infections (RVI) following human lung transplant (LTx) have been shown to increase the risk for development of chronic lung allograft dysfunction (CLAD).…
  • 2017 American Transplant Congress

    Binding of Antigens by Its Specific Antibodies Results in Exosome Formation Leading to Rejection of Syngeneic Murine Cardiac Grafts.

    M. Sharma, W. Liu, M. Gunasekaran, S. Bansal, T. Mohanakumar.

    Norton Thoracic Institute, St. Joseph's Hospital and Medical Center, Phoenix

    Background: Antibody binding to its antigen can activate complement cascades leading to cell death. In addition, it can activate intracellular signals leading to rejection of…
  • 2017 American Transplant Congress

    HLA-DR Based Murine Transplant Model for Studying Collagen Type V Autoimmunity in Chronic Allograft Rejection.

    V. Agashe, Y. Zhou, E. Jankowska-Gan, W. Burlingham.

    Dept. of Surgery/Transplant Division, UW Madison, Madison, WI

    Background: In lung and heart transplant patients, chronic rejection manifests as fibro-obliteration of airways and vessels resulting in bronchiolitis obliterans syndrome (BOS) or cardiac allograft…
  • 2017 American Transplant Congress

    Extracellular Mitochondria Cause B7 Costimulation Blockade Resistant Allograft Rejection in Mice.

    T. Brennan,1 L. Lin,1 M. Song,1 F. Feng,1 Q.-J. Li,2 A. Kirk,1,2 H. Xu.1

    1Surgery, Duke University, Durham, NC; 2Immunology, Duke University, Durham, NC

    Introduction: Mitochondria released in the setting of tissue injury and cell death are a source of damage-associated molecular patterns that activate innate immune responses. We…
  • 2017 American Transplant Congress

    Islet Rejection in Autoimmune NOD Mouse Recipients: Implications for Stem Cell Therapies.

    R. Gill,1 M. Coulombe,1 T. Kupfer,1 K. Beard,1 A. Burrack.2

    1Surgery and Immunology, University of Colorado Denver, Aurora, CO; 2University of Minnesota, Minneapolis, MN

    Several efforts are ongoing to use stem cell precursors to generate islet-like tissues suitable for transplantation in autoimmune Type 1 diabetic (T1D) recipients. During the…
  • 2016 American Transplant Congress

    CD9+ Regulatory B Lymphocytes Control Chronic Lung Inflammation by Inducing Effector T Cell Apoptosis.

    C. Brosseau,1,2 M. Durand,1 F. Braza,1 E. Durand,2 J. Loy,2 P. Lacoste,2 P. Royer,2 M.-A. Cheminant,2 A. Magnan,2 S. Brouard.1

    1ITUN-INSERM U1064, Nantes, France; 2Institut du thorax, INSERM U1087/CNRS U6291, Nantes, France.

    Several observations highlight the relevance of regulatory B cells (Breg) to clinical transplantation. We have identified a new Breg population expressing the CD9, able to…
  • 2016 American Transplant Congress

    Exosome-Like Vesicles Released in Association with Tissue Injury Trigger Anti-LG3 Production.

    M. Dieudé,1,2,3 J. Turgeon,1,3 B. Yang,1,2,3 L. Pomerleau,1,3 K. Hamelin,1,3 S. Lan,1,2,3 S. Qi,1,3 D. Gingras,1,3 W. Dhari,1 A. Rivard,1 M.-J. Hébert.1,2,3

    1Research Centre, Centre hospitalier de l'Université de Montréal, Montréal, Canada; 2Université de Montréal, Montréal, Canada; 3Canadian National Transplantation Research Program, Edmonton, Canada.

    Pre-transplant levels of autoantibodies to perlecan/LG3 predict poor allograft outcomes in renal transplant patients. We showed previously thatapoptotic exosome-like vesicles (ApoExo) enhance anti-LG3 production and…
  • 2016 American Transplant Congress

    Circulating Immune Complexes of IgA Bound to Beta 2 Glycoprotein I Is a Predictive Marker for Graft Loss in Patients Positive for IgA aB2GPI.

    J. Morales, M. Serrano, J. Martínez-Flores, D. Perez, M. Sevilla, O. Cabrera, A. Serrano.

    Immunology, Instituto de Investigación Hospital 12 de Octubre, Madrid, Spain.

    Pretransplant IgA anti Beta-2-Glycoprotein 1 antibodies (IgA aB2GPI) is a risk marker for early kidney graft lost, mainly by thrombosis. About 30% of patients are…
  • 2016 American Transplant Congress

    Anti-LG3 Antibodies Enhance Renal Microvascular Rarefaction, Fibrosis and Dysfunction Associated with Ischemia-Reperfusion Injury.

    B. Yang,1,3 K. Hamelin,1,3 M. HÉnault-Rondeau,1,3 N. Patey,1,2,3 J. Turgeon,1,3 S. Lan,1,3 L. Pomerleau,1 J. Peng,1 J. Tremblay,1 M. DieudÉ,1,3 M.-J. HÉbert,1,3 H. Cardinal.1,3

    1Research Centre, Centre Hospitalier de l'Université de Montréal (CRCHUM), Montreal, QC, Canada; 2Department of Pathology, CHU Ste-Justine, Montreal, QC, Canada; 3Canadian National Transplant Research Program, CNTRP, Canada.

    Delayed graft function (DGF) is associated with decreased kidney graft survival. We have shown that pre-transplant anti-LG3 autoantibodies were associated with increased risk of DGF…
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