Articles tagged "Autoimmunity"

2017 American Transplant Congress
Extracellular Mitochondria Cause B7 Costimulation Blockade Resistant Allograft Rejection in Mice.
T. Brennan,¹ L. Lin,¹ M. Song,¹ F. Feng,¹ Q.-J. Li,² A. Kirk,^1,2 H. Xu.¹
¹Surgery, Duke University, Durham, NC; ²Immunology, Duke University, Durham, NC
Introduction: Mitochondria released in the setting of tissue injury and cell death are a source of damage-associated molecular patterns that activate innate immune responses. We…
2017 American Transplant Congress
Islet Rejection in Autoimmune NOD Mouse Recipients: Implications for Stem Cell Therapies.
R. Gill,¹ M. Coulombe,¹ T. Kupfer,¹ K. Beard,¹ A. Burrack.²
¹Surgery and Immunology, University of Colorado Denver, Aurora, CO; ²University of Minnesota, Minneapolis, MN
Several efforts are ongoing to use stem cell precursors to generate islet-like tissues suitable for transplantation in autoimmune Type 1 diabetic (T1D) recipients. During the…
2017 American Transplant Congress
IgM Immunotherapy Restores Immune Homeostasis in Type 1 Diabetes.
P. Chhabra,¹ C. Wilson,² D. Moore,² K. Brayman.¹
¹Surgery, University of Virginia, Charlottesville, VA; ²Pediatric Endocrinology, Vanderbilt University, Nashville, TN
Goal: To determine the mechanism(s) by which IgM immunotherapy restores immune homeostasis in Type 1 Diabetes (T1D).Background: IgM immunotherapy prevents the onset and progression of…
2017 American Transplant Congress
Inflammasome, Unfolded Protein Response, and T Cell Immunity in DAIH.
A. Arterbery,¹ M. Martinez,³ S. Lobritto,³ Y. Avitzur,² U. Ekong.¹
¹Ped Gastro. and Hep., Yale University, New Haven, CT; ²Gastro., Hep., and Nutr., Hospital for Sick Children, Toronto, ON, Canada; ³Ped. Gastro., Hep., and Nutr., Columbia University, New York, NY
Background: Regulatory T cells (Tregs) of patients with de novo autoimmune hepatitis (DAIH) secrete IL-17A & IFN-g; display TH1 & TH17 pehnotypes & are functionally…
2017 American Transplant Congress
Combining Neural Stem Cell Transplantation with Mixed Hematopoietic Chimerism Promotes Restoration of Self-Tolerance in Established Experimental Autoimmune Encephalomyelitis.
W. Orent, J. Marino, B. Gonzalez Nolasco, J. Paster, A. Harney, D. Sachs, G. Benichou.
Surgery, Massachusetts General Hospital, Boston, MA
Multilineage mixed hematopoietic chimerism induces tolerance to alloantigens in rodents, large animals and kidney-transplanted patients. Here we combined mixed chimerism with neural stem cell (NSC)…
2017 American Transplant Congress
Apoptotic Exosome-Like Vesicles Released During Tissue Injury Trigger IL23/IL-17 Autoimmune Axis and Accelerate Rejection.
M. Dieudé,^1,4 J. Turgeon,^1,4 A. Karakeussian-Rimbault,^1,4 L. Pomerleau,¹ A. Robitaille,¹ N. Grandvaux,¹ É. Boilard,^2,4 M.-J. Hébert.^1,3,4
¹Research Centre, Centre Hospitalier de l'Université de Montréal, Montreal, Canada; ²CHU de Québec, Québec, Canada; ³Montreal University, Montreal, QC, Canada; ⁴Canadian National Transplantation Research Program, Edmonton, Canada
Autoantibodies to apoptotic antigens, such as perlecan/LG3, are present pre-transplantation and contribute to organ rejection. We previously showed that during tissue injury, apoptotic endothelial cells…
2016 American Transplant Congress
Exosome-Like Vesicles Released in Association with Tissue Injury Trigger Anti-LG3 Production.
M. Dieudé,^1,2,3 J. Turgeon,^1,3 B. Yang,^1,2,3 L. Pomerleau,^1,3 K. Hamelin,^1,3 S. Lan,^1,2,3 S. Qi,^1,3 D. Gingras,^1,3 W. Dhari,¹ A. Rivard,¹ M.-J. Hébert.^1,2,3
¹Research Centre, Centre hospitalier de l'Université de Montréal, Montréal, Canada; ²Université de Montréal, Montréal, Canada; ³Canadian National Transplantation Research Program, Edmonton, Canada.
Pre-transplant levels of autoantibodies to perlecan/LG3 predict poor allograft outcomes in renal transplant patients. We showed previously thatapoptotic exosome-like vesicles (ApoExo) enhance anti-LG3 production and…
2016 American Transplant Congress
Circulating Immune Complexes of IgA Bound to Beta 2 Glycoprotein I Is a Predictive Marker for Graft Loss in Patients Positive for IgA aB2GPI.
J. Morales, M. Serrano, J. Martínez-Flores, D. Perez, M. Sevilla, O. Cabrera, A. Serrano.
Immunology, Instituto de Investigación Hospital 12 de Octubre, Madrid, Spain.
Pretransplant IgA anti Beta-2-Glycoprotein 1 antibodies (IgA aB2GPI) is a risk marker for early kidney graft lost, mainly by thrombosis. About 30% of patients are…
2016 American Transplant Congress
Anti-LG3 Antibodies Enhance Renal Microvascular Rarefaction, Fibrosis and Dysfunction Associated with Ischemia-Reperfusion Injury.
B. Yang,^1,3 K. Hamelin,^1,3 M. HÉnault-Rondeau,^1,3 N. Patey,^1,2,3 J. Turgeon,^1,3 S. Lan,^1,3 L. Pomerleau,¹ J. Peng,¹ J. Tremblay,¹ M. DieudÉ,^1,3 M.-J. HÉbert,^1,3 H. Cardinal.^1,3
¹Research Centre, Centre Hospitalier de l'Université de Montréal (CRCHUM), Montreal, QC, Canada; ²Department of Pathology, CHU Ste-Justine, Montreal, QC, Canada; ³Canadian National Transplant Research Program, CNTRP, Canada.
Delayed graft function (DGF) is associated with decreased kidney graft survival. We have shown that pre-transplant anti-LG3 autoantibodies were associated with increased risk of DGF…
2016 American Transplant Congress
BATF Deficiency in Tolerant Lung Allograft Recipients Are Resistant to Anti-MHC and Anti-Self-Antigen Mediated Pathogenesis of Obliterative Airway Disease.
Z. Xu,^1,2 X. Lin,¹ M. Gunasekaran,^1,2 M. Sharma,^1,2 A. Gelman,¹ T. Mohanakumar.^1,2
¹Washington Univ Sch Med, St. Louis, MO; ²Norton Thoracic Institute - St. Joseph's Hospital, Phoenix, AZ.
Antibodies (Abs) to donor MHC and lung self-antigens (SAgs) administered following induction of lung allograft tolerance by co-stimulation blockade can result in breaking of tolerance…