2017 American Transplant Congress
Detection of Specific B Cell Memory to the Perlecan LG3 Antigen in the Normal Immune Repertoire.
Autoantibodies targeting the C-terminal fragment of perlecan (LG3) were identified in patients with kidney transplantation and are associated with rejection episodes. High anti-LG3 titers were…2017 American Transplant Congress
Antibody Mapping by Protein Microarray Revealed a Unique Repertoire in Lung Transplant Recipients That Developed Chronic Lung Allograft Dysfunction.
Background: Development of chronic lung allograft dysfunction (CLAD) limits long-term success from lung transplantation (LTx). Elicitation of de novo antibody (Ab) to mismatched donor HLA…2017 American Transplant Congress
False-Positive Flow Cytometric Crossmatch Results and the Utility of the Virtual Crossmatch.
Pathology, University of Chicago Medicine, Chicago, IL
Introduction: A negative crossmatch (XM) is critical for solid organ allocation. Flow cytometric XM (FCXM) is more sensitive than complement-dependent cytotoxicity XM (CDC-XM), and has…2017 American Transplant Congress
Circulating Exosomes Isolated from Human Lung Transplant Recipients with Rejection Are Immunogenic and Induce Antibodies to Lung Associated Self-Antigens, Kα1 Tubulin and Collagen-V.
Norton Thoracic Institute, St. Joseph's Hospital and Med Center, Phoenix
Background: Exosomes isolated from acute and chronic rejections in lung transplant recipients (LTxR) demonstrated surface expression of mismatched donor human leukocyte antigen and lung associated…2017 American Transplant Congress
Plasma Cell Hepatitis in Primary Sclerosing Cholangitis Patients: 15-Year Experience at a Transplant Center.
Background: Plasma cell hepatitis (PCH) is an uncommon liver graft dysfunction which occurs in liver transplant (LT) recipients of different etiologies other than autoimmune hepatitis.…2017 American Transplant Congress
Respiratory Viral Infections Following Human Lung Transplant Can Induce Exosomes with Lung Self-Antigens, Kα1Tubulin and Collagen V.
Background: Respiratory viral infections (RVI) following human lung transplant (LTx) have been shown to increase the risk for development of chronic lung allograft dysfunction (CLAD).…2016 American Transplant Congress
CD9+ Regulatory B Lymphocytes Control Chronic Lung Inflammation by Inducing Effector T Cell Apoptosis.
1ITUN-INSERM U1064, Nantes, France; 2Institut du thorax, INSERM U1087/CNRS U6291, Nantes, France.
Several observations highlight the relevance of regulatory B cells (Breg) to clinical transplantation. We have identified a new Breg population expressing the CD9, able to…2016 American Transplant Congress
Exosome-Like Vesicles Released in Association with Tissue Injury Trigger Anti-LG3 Production.
Pre-transplant levels of autoantibodies to perlecan/LG3 predict poor allograft outcomes in renal transplant patients. We showed previously thatapoptotic exosome-like vesicles (ApoExo) enhance anti-LG3 production and…2016 American Transplant Congress
Circulating Immune Complexes of IgA Bound to Beta 2 Glycoprotein I Is a Predictive Marker for Graft Loss in Patients Positive for IgA aB2GPI.
Immunology, Instituto de Investigación Hospital 12 de Octubre, Madrid, Spain.
Pretransplant IgA anti Beta-2-Glycoprotein 1 antibodies (IgA aB2GPI) is a risk marker for early kidney graft lost, mainly by thrombosis. About 30% of patients are…2016 American Transplant Congress
Anti-LG3 Antibodies Enhance Renal Microvascular Rarefaction, Fibrosis and Dysfunction Associated with Ischemia-Reperfusion Injury.
Delayed graft function (DGF) is associated with decreased kidney graft survival. We have shown that pre-transplant anti-LG3 autoantibodies were associated with increased risk of DGF…
- « Previous Page
- 1
- …
- 6
- 7
- 8
- 9
- 10
- Next Page »