Articles tagged "Autoimmunity"

2017 American Transplant Congress
Combining Neural Stem Cell Transplantation with Mixed Hematopoietic Chimerism Promotes Restoration of Self-Tolerance in Established Experimental Autoimmune Encephalomyelitis.
W. Orent, J. Marino, B. Gonzalez Nolasco, J. Paster, A. Harney, D. Sachs, G. Benichou.
Surgery, Massachusetts General Hospital, Boston, MA
Multilineage mixed hematopoietic chimerism induces tolerance to alloantigens in rodents, large animals and kidney-transplanted patients. Here we combined mixed chimerism with neural stem cell (NSC)…
2017 American Transplant Congress
Apoptotic Exosome-Like Vesicles Released During Tissue Injury Trigger IL23/IL-17 Autoimmune Axis and Accelerate Rejection.
M. Dieudé,^1,4 J. Turgeon,^1,4 A. Karakeussian-Rimbault,^1,4 L. Pomerleau,¹ A. Robitaille,¹ N. Grandvaux,¹ É. Boilard,^2,4 M.-J. Hébert.^1,3,4
¹Research Centre, Centre Hospitalier de l'Université de Montréal, Montreal, Canada; ²CHU de Québec, Québec, Canada; ³Montreal University, Montreal, QC, Canada; ⁴Canadian National Transplantation Research Program, Edmonton, Canada
Autoantibodies to apoptotic antigens, such as perlecan/LG3, are present pre-transplantation and contribute to organ rejection. We previously showed that during tissue injury, apoptotic endothelial cells…
2017 American Transplant Congress
Non-Human Primate Auto-Immune Responses to Col V, Kα-1Tubulin and Vimentin Are P2X7R Dependent.
J. Sullivan,¹ E. Jankowska-Gan,¹ D. Kaufman,¹ L. Denlinger,² W. Burlingham.¹
¹Surgery, University of Wisconsin, Madison, WI; ²Medicine, University of Wisconsin, Madison, WI
Background: Auto-immune responses to Collagen type V (ColV) have been associated with coronary artery disease and lung or heart transplant rejection in humans and murine…
2017 American Transplant Congress
Predictive Value of Serum Biomarkers of Autoimmunity for Recurrence of IgA Nephropathy After Kidney Transplantation.
N. Maillard,¹ H. Suzuki,² H. Mohey,¹ C. Mariat,¹ J. Novak,³ B. Julian,⁴ F. Berthoux.¹
¹Nephrology, Dialysis and Renal Transplantation, CHU Saint Etienne, Saint Etienne, France; ²Division of Nephrology, Department of Internal Medicine, Juntendo University, Tokyo, Japan; ³Department of Microbiology, University of Alabama at Birmingham, Birmingham, AL; ⁴Department of Medicine, University of Alabama at Birmingham, Birmingham, AL
The recurrence of IgA nephropathy (IgAN) after kidney transplantation is frequent and can cause graft losses. The prediction of the recurrence cannot be performed from…
2017 American Transplant Congress
HLA, ANA, and ANCA Negative Vasculitis in Lung Transplantation Due to Overexpression of α1 Collagen V.
E. Daoud,¹ Y. Butt,¹ F. Torres,² T. Jose.¹
¹Pathology, University of Texas Southwestern Medical Center, Dallas, TX; ²Lung Transplant Program, University of Texas Southwestern Medical Center, Dallas, TX
The mechanism of fibrosing vasculopathy in lung allograft is poorly understood. A 58 year old man received a bilateral lung transplant for interstitial lung disease.…
2017 American Transplant Congress
Recognition of Islet Xenografts In Vivo by Non-Obese Diabetic (NOD) Insulin-Specific CD4 T Cells.
R. Gill, W. Dale, M. Crawford.
Surgery and Immunology, University of Colorado Denver, Aurora, CO
Xenogeneic islet transplantation has been one ongoing goal for treating autoimmune Type 1 diabetes. Autoimmune diabetes involves a T cell response restricted to the host…
2016 American Transplant Congress
The 20S Proteasome, Active within Exosome-Like Vesicles Released by Apoptotic Cells Accelerates Rejection.
M. Dieudé,^1,4,5 C. Bell,^2,5 J. Turgeon,^1,5 D. Beillevaire,^1,4,5 S. Qi,^1,5 E. Boilard,^3,5 P. Thibault,^2,5 M.-J. Hébert.^1,4,5
¹Research Centre Centre hospitalier de l'Université de Montréal (CRCHUM), Montréal, Canada; ²Institute for research in immunology and cancer (IRIC), Montreal, Canada; ³Centre de Recherche du CHU de Québec, Québec, Canada; ⁴Université de Montréal, Montréal, Canada; ⁵Canadian National Transplant Research Program, Edmonton, Canada.
Apoptotic bodies (ApoBodies) and apoptotic exosome-like MV (ApoExo) released by apoptotic endothelial cells in vitro were purified by sequential centrifugation and analysed by electron microscopy…
2016 American Transplant Congress
CD9+ Regulatory B Lymphocytes Control Chronic Lung Inflammation by Inducing Effector T Cell Apoptosis.
C. Brosseau,^1,2 M. Durand,¹ F. Braza,¹ E. Durand,² J. Loy,² P. Lacoste,² P. Royer,² M.-A. Cheminant,² A. Magnan,² S. Brouard.¹
¹ITUN-INSERM U1064, Nantes, France; ²Institut du thorax, INSERM U1087/CNRS U6291, Nantes, France.
Several observations highlight the relevance of regulatory B cells (Breg) to clinical transplantation. We have identified a new Breg population expressing the CD9, able to…
2016 American Transplant Congress
Exosome-Like Vesicles Released in Association with Tissue Injury Trigger Anti-LG3 Production.
M. Dieudé,^1,2,3 J. Turgeon,^1,3 B. Yang,^1,2,3 L. Pomerleau,^1,3 K. Hamelin,^1,3 S. Lan,^1,2,3 S. Qi,^1,3 D. Gingras,^1,3 W. Dhari,¹ A. Rivard,¹ M.-J. Hébert.^1,2,3
¹Research Centre, Centre hospitalier de l'Université de Montréal, Montréal, Canada; ²Université de Montréal, Montréal, Canada; ³Canadian National Transplantation Research Program, Edmonton, Canada.
Pre-transplant levels of autoantibodies to perlecan/LG3 predict poor allograft outcomes in renal transplant patients. We showed previously thatapoptotic exosome-like vesicles (ApoExo) enhance anti-LG3 production and…
2016 American Transplant Congress
Circulating Immune Complexes of IgA Bound to Beta 2 Glycoprotein I Is a Predictive Marker for Graft Loss in Patients Positive for IgA aB2GPI.
J. Morales, M. Serrano, J. Martínez-Flores, D. Perez, M. Sevilla, O. Cabrera, A. Serrano.
Immunology, Instituto de Investigación Hospital 12 de Octubre, Madrid, Spain.
Pretransplant IgA anti Beta-2-Glycoprotein 1 antibodies (IgA aB2GPI) is a risk marker for early kidney graft lost, mainly by thrombosis. About 30% of patients are…